David A. Sinclair, Ph.D.
@davidsinclairphd.bsky.social
Professor @Harvard researching why we age & how to reverse it. Author & host of Lifespan. Mission: Extend healthy life for all. Views are entirely his own 🙏✌️
Pinned
Patent granted!
“Cellular reprogramming to reverse aging and promote organ and tissue regeneration.“
Super proud of the team’s invention of the first truly safe age-reversal technology - for healing injuries, treating diseases, and hopefully extending human lifespan @y_ryan_lu
“Cellular reprogramming to reverse aging and promote organ and tissue regeneration.“
Super proud of the team’s invention of the first truly safe age-reversal technology - for healing injuries, treating diseases, and hopefully extending human lifespan @y_ryan_lu
You don’t need to optimize everything. Just stop sabotaging the basics. You can do it!
January 22, 2026 at 1:45 AM
You don’t need to optimize everything. Just stop sabotaging the basics. You can do it!
The biggest mistake in longevity medicine is thinking decline is normal
January 21, 2026 at 2:28 AM
The biggest mistake in longevity medicine is thinking decline is normal
Slowing and reversing aging will reduce healthcare burden far more than treating individual diseases
January 20, 2026 at 11:13 PM
Slowing and reversing aging will reduce healthcare burden far more than treating individual diseases
Biomarkers of biological age are increasingly being used as clinical trial endpoints. That’s a shift!
January 19, 2026 at 9:32 PM
Biomarkers of biological age are increasingly being used as clinical trial endpoints. That’s a shift!
The fastest way to age is to stop caring
January 18, 2026 at 7:09 PM
The fastest way to age is to stop caring
Longevity biotech now targets root causes rather than single diseases. This is a paradigm shift in medicine
January 18, 2026 at 4:38 PM
Longevity biotech now targets root causes rather than single diseases. This is a paradigm shift in medicine
Trametinib is an approved drug for melanoma. It inhibits MEK1/2 thereby shifting cells away from “grow at all costs” to maintenance & repair🐁Trimetaprib extends lifespan ~15% & with rapamycin a whopping 30%
January 18, 2026 at 3:18 PM
Trametinib is an approved drug for melanoma. It inhibits MEK1/2 thereby shifting cells away from “grow at all costs” to maintenance & repair🐁Trimetaprib extends lifespan ~15% & with rapamycin a whopping 30%
Aging is now widely considered a druggable biological process, not an inevitability
January 18, 2026 at 3:00 PM
Aging is now widely considered a druggable biological process, not an inevitability
In the new year, it’s worth remembering you don’t need extreme habits. You need durable ones
January 18, 2026 at 2:53 PM
In the new year, it’s worth remembering you don’t need extreme habits. You need durable ones
Longevity isn’t about the latest biohacking fad.
It’s about doing the basics consistently
It’s about doing the basics consistently
January 18, 2026 at 1:56 PM
Longevity isn’t about the latest biohacking fad.
It’s about doing the basics consistently
It’s about doing the basics consistently
Anyone else feel that since next-gen sequencing and bioinformatics, publishing a paper in biology has become increasingly about quantity than quality?
January 16, 2026 at 11:53 PM
Anyone else feel that since next-gen sequencing and bioinformatics, publishing a paper in biology has become increasingly about quantity than quality?
The most dangerous sentence in medicine is:
“That’s just normal for your age.”
“That’s just normal for your age.”
January 1, 2026 at 1:45 AM
The most dangerous sentence in medicine is:
“That’s just normal for your age.”
“That’s just normal for your age.”
If restoring youthful function in old tissues sounds radical, remember that surgery without pain once did to
December 31, 2025 at 2:28 AM
If restoring youthful function in old tissues sounds radical, remember that surgery without pain once did to
Every generation before us accepted aging.
We’re the first with tools to challenge it
We’re the first with tools to challenge it
December 30, 2025 at 11:13 PM
Every generation before us accepted aging.
We’re the first with tools to challenge it
We’re the first with tools to challenge it
If cells can be reminded who they are,
aging becomes a reversible state, not an inevitable fate
aging becomes a reversible state, not an inevitable fate
December 29, 2025 at 9:32 PM
If cells can be reminded who they are,
aging becomes a reversible state, not an inevitable fate
aging becomes a reversible state, not an inevitable fate
Scientific misinformation is rampant. Journals known as "paper mills" are profiting by charging academics to quickly publish low quality or fraudulent work, which is then hyped on social media or disseminated for profit to the unsuspecting public by deepfaked scientists on YouTube & TikTok
December 29, 2025 at 6:49 AM
Scientific misinformation is rampant. Journals known as "paper mills" are profiting by charging academics to quickly publish low quality or fraudulent work, which is then hyped on social media or disseminated for profit to the unsuspecting public by deepfaked scientists on YouTube & TikTok
Followers on X: 520,000
Followers on Bluesky: 520
Crushing it 😆
Followers on Bluesky: 520
Crushing it 😆
December 29, 2025 at 4:49 AM
Followers on X: 520,000
Followers on Bluesky: 520
Crushing it 😆
Followers on Bluesky: 520
Crushing it 😆
When it comes to longevity, life has three parts:
1–30: Your body takes care of you
30–80: You take care of your body
80+: Your body reflects how well you did in part two
1–30: Your body takes care of you
30–80: You take care of your body
80+: Your body reflects how well you did in part two
December 29, 2025 at 4:47 AM
When it comes to longevity, life has three parts:
1–30: Your body takes care of you
30–80: You take care of your body
80+: Your body reflects how well you did in part two
1–30: Your body takes care of you
30–80: You take care of your body
80+: Your body reflects how well you did in part two
The greatest medical breakthroughs ahead
won’t cure one disease. They’ll cure many.
won’t cure one disease. They’ll cure many.
December 28, 2025 at 4:38 PM
The greatest medical breakthroughs ahead
won’t cure one disease. They’ll cure many.
won’t cure one disease. They’ll cure many.
The end of aging as we know it won’t arrive overnight. But it has already begun
December 28, 2025 at 3:00 PM
The end of aging as we know it won’t arrive overnight. But it has already begun
Every time someone says “aging is natural,”
remember that death from an infected was once considered natural too
remember that death from an infected was once considered natural too
December 28, 2025 at 2:53 PM
Every time someone says “aging is natural,”
remember that death from an infected was once considered natural too
remember that death from an infected was once considered natural too
Once you see age reversal as an information problem, it’s no longer unsolvable
December 28, 2025 at 1:56 PM
Once you see age reversal as an information problem, it’s no longer unsolvable
What we call “normal aging” is often just untreated pathology
December 27, 2025 at 10:59 PM
What we call “normal aging” is often just untreated pathology
The future of medicine isn’t about treating one disease at a time. It’s about targeting the process that causes most of them
December 27, 2025 at 9:10 PM
The future of medicine isn’t about treating one disease at a time. It’s about targeting the process that causes most of them
Aging doesn’t happen because cells accumulate damage. It happens because their response to damage changes their identity
December 27, 2025 at 6:20 PM
Aging doesn’t happen because cells accumulate damage. It happens because their response to damage changes their identity