David A. Sinclair, Ph.D.
@davidsinclairphd.bsky.social
Professor @Harvard researching why we age & how to reverse it. Author & host of Lifespan. Mission: Extend healthy life for all. Views are entirely his own 🙏✌️
Trametinib is an approved drug for melanoma. It inhibits MEK1/2 thereby shifting cells away from “grow at all costs” to maintenance & repair🐁Trimetaprib extends lifespan ~15% & with rapamycin a whopping 30%
January 18, 2026 at 3:18 PM
Trametinib is an approved drug for melanoma. It inhibits MEK1/2 thereby shifting cells away from “grow at all costs” to maintenance & repair🐁Trimetaprib extends lifespan ~15% & with rapamycin a whopping 30%
Scientific misinformation is rampant. Journals known as "paper mills" are profiting by charging academics to quickly publish low quality or fraudulent work, which is then hyped on social media or disseminated for profit to the unsuspecting public by deepfaked scientists on YouTube & TikTok
December 29, 2025 at 6:49 AM
Scientific misinformation is rampant. Journals known as "paper mills" are profiting by charging academics to quickly publish low quality or fraudulent work, which is then hyped on social media or disseminated for profit to the unsuspecting public by deepfaked scientists on YouTube & TikTok
Merry Christmas from down under 🦘
December 26, 2025 at 8:50 AM
Merry Christmas from down under 🦘
One of the most rewarding things is inspiring a talented student to work on a problem that initially seems impossible
December 26, 2025 at 8:40 AM
One of the most rewarding things is inspiring a talented student to work on a problem that initially seems impossible
Up to 40% of drugs that would work in humans fail in mice & are therefore never developed. But mice aren’t humans
In aging research, one government-sanctioned single mouse breed lifespan test can kill future funding, even for a promising therapy
That’s politics, not science
In aging research, one government-sanctioned single mouse breed lifespan test can kill future funding, even for a promising therapy
That’s politics, not science
December 23, 2025 at 10:00 PM
Up to 40% of drugs that would work in humans fail in mice & are therefore never developed. But mice aren’t humans
In aging research, one government-sanctioned single mouse breed lifespan test can kill future funding, even for a promising therapy
That’s politics, not science
In aging research, one government-sanctioned single mouse breed lifespan test can kill future funding, even for a promising therapy
That’s politics, not science
Pancreatic cancer has a 5-year survival of 13% often driven by KRASG12D mutations
New paper shows KRASG12D suppresses SIRT3 & forced SIRT3 expression inhibits cancer in mice
Could SIRT3 boosters (e.g. NMN & NR) prevent pancreatic cancer or treat patients?
www.jbc.org/article/S002...
New paper shows KRASG12D suppresses SIRT3 & forced SIRT3 expression inhibits cancer in mice
Could SIRT3 boosters (e.g. NMN & NR) prevent pancreatic cancer or treat patients?
www.jbc.org/article/S002...
December 15, 2025 at 4:25 PM
Pancreatic cancer has a 5-year survival of 13% often driven by KRASG12D mutations
New paper shows KRASG12D suppresses SIRT3 & forced SIRT3 expression inhibits cancer in mice
Could SIRT3 boosters (e.g. NMN & NR) prevent pancreatic cancer or treat patients?
www.jbc.org/article/S002...
New paper shows KRASG12D suppresses SIRT3 & forced SIRT3 expression inhibits cancer in mice
Could SIRT3 boosters (e.g. NMN & NR) prevent pancreatic cancer or treat patients?
www.jbc.org/article/S002...
The ITOA paper from 2023, in which Michael played a seminal role, not just in generating data, but keeping the team and especially the young students motivated, despite the difficulty of the decade-long project and the harsh scientific critics of the day. R.I.P. Michael 🍻🙏🧎
November 29, 2025 at 5:11 PM
The ITOA paper from 2023, in which Michael played a seminal role, not just in generating data, but keeping the team and especially the young students motivated, despite the difficulty of the decade-long project and the harsh scientific critics of the day. R.I.P. Michael 🍻🙏🧎
Five years ago today, our dear friend and colleague Michael Bonkowski passed away unexpectedly. For a decade, he was the life of the Sinclair lab, a major force testing The Information Theory of Aging & cared so deeply about his students they still speak of him like a father🙏
November 29, 2025 at 5:11 PM
Five years ago today, our dear friend and colleague Michael Bonkowski passed away unexpectedly. For a decade, he was the life of the Sinclair lab, a major force testing The Information Theory of Aging & cared so deeply about his students they still speak of him like a father🙏
Patent granted!
“Cellular reprogramming to reverse aging and promote organ and tissue regeneration.“
Super proud of the team’s invention of the first truly safe age-reversal technology - for healing injuries, treating diseases, and hopefully extending human lifespan @y_ryan_lu
“Cellular reprogramming to reverse aging and promote organ and tissue regeneration.“
Super proud of the team’s invention of the first truly safe age-reversal technology - for healing injuries, treating diseases, and hopefully extending human lifespan @y_ryan_lu
November 26, 2025 at 8:58 PM
Patent granted!
“Cellular reprogramming to reverse aging and promote organ and tissue regeneration.“
Super proud of the team’s invention of the first truly safe age-reversal technology - for healing injuries, treating diseases, and hopefully extending human lifespan @y_ryan_lu
“Cellular reprogramming to reverse aging and promote organ and tissue regeneration.“
Super proud of the team’s invention of the first truly safe age-reversal technology - for healing injuries, treating diseases, and hopefully extending human lifespan @y_ryan_lu
RIP James D. Watson, co-discoverer of DNAs double helix🥇Jim was a kind, generous mentor to me, who never hesitated to meet, give feedback, or share stories from the early days of molecular biology. His signed double helix hangs in my office as a reminder how one discovery can change the world 🙏
November 8, 2025 at 7:06 PM
RIP James D. Watson, co-discoverer of DNAs double helix🥇Jim was a kind, generous mentor to me, who never hesitated to meet, give feedback, or share stories from the early days of molecular biology. His signed double helix hangs in my office as a reminder how one discovery can change the world 🙏
Dr. Haghighi is Chief Executive and Director, Harvard Medical School International Center for Genetic Disease, Principal Investigator and Director, Bahrain National Genome Program at Harvard and Assistant Professor of Medicine, Harvard Medical School, and Brigham and Women's Hospital
October 15, 2025 at 11:30 PM
Dr. Haghighi is Chief Executive and Director, Harvard Medical School International Center for Genetic Disease, Principal Investigator and Director, Bahrain National Genome Program at Harvard and Assistant Professor of Medicine, Harvard Medical School, and Brigham and Women's Hospital
This is more than a regional milestone. It reflects our broader commitment to working with governments, academia, and industry worldwide to responsibly unlock the full potential of genomics and AI
October 15, 2025 at 11:30 PM
This is more than a regional milestone. It reflects our broader commitment to working with governments, academia, and industry worldwide to responsibly unlock the full potential of genomics and AI
Dr. Alireza Haghighi, my cofounder and I, are proud to announce an exciting partnership with Asia University to develop a "Sovereign AI Life Science Data Platform for Taiwan", a national system for secure health data sharing, AI-powered analytics, and collaborative research
October 15, 2025 at 11:30 PM
Dr. Alireza Haghighi, my cofounder and I, are proud to announce an exciting partnership with Asia University to develop a "Sovereign AI Life Science Data Platform for Taiwan", a national system for secure health data sharing, AI-powered analytics, and collaborative research
With ER-100 on track for human trials in Q1 2026, this program is moving quickly 💉👁️ Jerry McLaughlin, our CEO, and I are so grateful for the creativity, dedication, and persistence the board & entire R&D team led by Dr. Sharon Rosenzweig-Lipson
August 26, 2025 at 7:12 PM
With ER-100 on track for human trials in Q1 2026, this program is moving quickly 💉👁️ Jerry McLaughlin, our CEO, and I are so grateful for the creativity, dedication, and persistence the board & entire R&D team led by Dr. Sharon Rosenzweig-Lipson
In liver disease (MASH), ER-300, an AAV-delivered package of reprogramming genes, improved multiple key liver health biomarkers in an animal model, from ALT/AST to cholesterol and steatosis (fat content) scores
August 26, 2025 at 7:12 PM
In liver disease (MASH), ER-300, an AAV-delivered package of reprogramming genes, improved multiple key liver health biomarkers in an animal model, from ALT/AST to cholesterol and steatosis (fat content) scores
This news is strong evidence that the original vision to develop therapies that reversal of aging to prevent and cure diseases of aging and injuries isn’t just a fanciful idea
August 26, 2025 at 7:12 PM
This news is strong evidence that the original vision to develop therapies that reversal of aging to prevent and cure diseases of aging and injuries isn’t just a fanciful idea
All NIH grants supporting my lab's trainees and medical research have been terminated. I am not alone. We scientists work hard to make the world a better place & we will not go down without a fight 🥊
May 16, 2025 at 1:17 AM
All NIH grants supporting my lab's trainees and medical research have been terminated. I am not alone. We scientists work hard to make the world a better place & we will not go down without a fight 🥊
Just posted our manuscript on "mPhenoAge," the first composite biological age measure for mice 🐭🧵 Proud of Alice and the entire team! 👏
@biorxivpreprint.bsky.social @volofoundation.bsky.social
tinyurl.com/544kzccz
@biorxivpreprint.bsky.social @volofoundation.bsky.social
tinyurl.com/544kzccz
May 6, 2025 at 5:50 PM
Just posted our manuscript on "mPhenoAge," the first composite biological age measure for mice 🐭🧵 Proud of Alice and the entire team! 👏
@biorxivpreprint.bsky.social @volofoundation.bsky.social
tinyurl.com/544kzccz
@biorxivpreprint.bsky.social @volofoundation.bsky.social
tinyurl.com/544kzccz
Link to the review: link.springer.com/article/10.1...
March 24, 2025 at 9:06 PM
Link to the review: link.springer.com/article/10.1...
Where to get polyphenols? From berries, apples with skin, cherries, plums, pomegranates, spinach, red onions, artichokes, broccoli, asparagus, matcha green tea, black tea, coffee, dark chocolate, turmeric, beans, EVOO and any deeply-colored vegetable
March 24, 2025 at 9:06 PM
Where to get polyphenols? From berries, apples with skin, cherries, plums, pomegranates, spinach, red onions, artichokes, broccoli, asparagus, matcha green tea, black tea, coffee, dark chocolate, turmeric, beans, EVOO and any deeply-colored vegetable
The authors of this new review discuss how polyphenols like curcumin, quercetin, resveratrol, and genistein seems to also target cancer-related miRNAs, thereby slowing cancer progression...
March 24, 2025 at 9:06 PM
The authors of this new review discuss how polyphenols like curcumin, quercetin, resveratrol, and genistein seems to also target cancer-related miRNAs, thereby slowing cancer progression...
In the 1990s, Victor Ambros and Gary Ruvkun (in my Department @harvardmed.bsky.social) were interested in how different cell types develop in worms. They discovered microRNA, a new class of tiny RNA molecules that regulate genes called miRNAs...
March 24, 2025 at 9:06 PM
In the 1990s, Victor Ambros and Gary Ruvkun (in my Department @harvardmed.bsky.social) were interested in how different cell types develop in worms. They discovered microRNA, a new class of tiny RNA molecules that regulate genes called miRNAs...
In the 1990's, antioxidants were all the rage. Today, we know so much more, while the food and beverage industry still promotes antioxidants as though they were the most important thing...
March 24, 2025 at 9:06 PM
In the 1990's, antioxidants were all the rage. Today, we know so much more, while the food and beverage industry still promotes antioxidants as though they were the most important thing...
Polyphenols aren't just antioxidants. They signal to the body ➡️ defend and heal. New evidence indicates that polyphenols might prevent cancer by modulating small RNAs...a thread 🧵
March 24, 2025 at 9:06 PM
Polyphenols aren't just antioxidants. They signal to the body ➡️ defend and heal. New evidence indicates that polyphenols might prevent cancer by modulating small RNAs...a thread 🧵
Omega-3 plus vitamin D “slows biological aging by 3-4 months over 3 years, particularly when combined with exercise.” 👏
t.co/XGexiZFQg3
t.co/XGexiZFQg3
February 4, 2025 at 5:13 PM
Omega-3 plus vitamin D “slows biological aging by 3-4 months over 3 years, particularly when combined with exercise.” 👏
t.co/XGexiZFQg3
t.co/XGexiZFQg3