David Usharauli
@davidusharauli.bsky.social
Immunologist & biotech startup co-founder (tregeutix.com) on a mission to harness the power of Tregs & microbiota | Calling on visionary investors to join our journey 🚀
Pretty remarkable finding. The only question is, why isn’t everyone bald, given how common stress is?
#science
#immunology
#autoimmunity
#hair
buff.ly/TgR8aEl
#science
#immunology
#autoimmunity
#hair
buff.ly/TgR8aEl
Stress-induced sympathetic hyperactivation drives hair follicle necrosis to trigger autoimmunity
Acute stress causes immediate hair follicle necrosis and hair loss via sympathetic nerves, which in turn activates and expands autoreactive CD8⁺ T cells targeting hair follicles. Thus, a single…
www.cell.com
November 26, 2025 at 8:51 PM
Pretty remarkable finding. The only question is, why isn’t everyone bald, given how common stress is?
#science
#immunology
#autoimmunity
#hair
buff.ly/TgR8aEl
#science
#immunology
#autoimmunity
#hair
buff.ly/TgR8aEl
A new study from the Germain lab delivers a stark reality. In a lethal flu mouse model testing 50 regimens, only Tamiflu alone or with IFN I blockade or CD8 depletion improved survival.
#science
#Immunology
www.science.org/doi/10.1126/...
#science
#Immunology
www.science.org/doi/10.1126/...
November 26, 2025 at 8:38 PM
A new study from the Germain lab delivers a stark reality. In a lethal flu mouse model testing 50 regimens, only Tamiflu alone or with IFN I blockade or CD8 depletion improved survival.
#science
#Immunology
www.science.org/doi/10.1126/...
#science
#Immunology
www.science.org/doi/10.1126/...
Jawless vertebrate Lamprey FOXN1 restores mouse thymus function, highlighting 500 million years of conserved roles in T cell negative selection and likely Treg-driven self–nonself discrimination.
#science
#immunology
buff.ly/dwYJB1X
#science
#immunology
buff.ly/dwYJB1X
Lamprey FOXN1 rescues the block of thymic epithelial cell development in the mouse Foxn1-deficient thymic rudiment | PNAS
All vertebrate adaptive immune systems exhibit distinct lymphocyte lineages. In jawless vertebrates, such as lampreys, T-like cells are thought to ...
www.pnas.org
November 25, 2025 at 8:46 PM
Jawless vertebrate Lamprey FOXN1 restores mouse thymus function, highlighting 500 million years of conserved roles in T cell negative selection and likely Treg-driven self–nonself discrimination.
#science
#immunology
buff.ly/dwYJB1X
#science
#immunology
buff.ly/dwYJB1X
IL-9, the little-known cytokine, finally found its calling, helping CAR T cells take on solid tumors. More staying power, more memory, more punch.
#science
#immunology
buff.ly/KVCvRFo
#science
#immunology
buff.ly/KVCvRFo
IL-9 signaling redirects CAR T cell fate toward CD8+ memory and CD4+ cycling states, enhancing antitumor efficacy
Castelli et al. show that incorporating interleukin-9 (IL-9) signaling reprograms chimeric antigen receptor (CAR) T cells to expand, persist, and resist dysfunction in solid tumors. This strategy…
buff.ly
November 25, 2025 at 8:28 PM
IL-9, the little-known cytokine, finally found its calling, helping CAR T cells take on solid tumors. More staying power, more memory, more punch.
#science
#immunology
buff.ly/KVCvRFo
#science
#immunology
buff.ly/KVCvRFo
Why are tumor vaccines not more effective? This preprint points to dosage: more boosts, better results. But can the body tolerate that, and would the FDA allow it?
#mRNA
#tumor
#immunotherapy
#immunology
#science
buff.ly/1SS1SoB
#mRNA
#tumor
#immunotherapy
#immunology
#science
buff.ly/1SS1SoB
November 23, 2025 at 8:27 PM
Why are tumor vaccines not more effective? This preprint points to dosage: more boosts, better results. But can the body tolerate that, and would the FDA allow it?
#mRNA
#tumor
#immunotherapy
#immunology
#science
buff.ly/1SS1SoB
#mRNA
#tumor
#immunotherapy
#immunology
#science
buff.ly/1SS1SoB
The Weekend Tunes
Žemaitukai - Nebūna nieko per klaidą (🇱🇹Lithuania)
This melody feels a bit like their track with Adrina, but it’s still great.
Shared for educational and/or commentary purposes only.
#WorldMusic 🌍🎧
#MusicUnites ❤️🎵
www.youtube.com/watch?v=Kccs...
Žemaitukai - Nebūna nieko per klaidą (🇱🇹Lithuania)
This melody feels a bit like their track with Adrina, but it’s still great.
Shared for educational and/or commentary purposes only.
#WorldMusic 🌍🎧
#MusicUnites ❤️🎵
www.youtube.com/watch?v=Kccs...
November 23, 2025 at 1:14 AM
The Weekend Tunes
Žemaitukai - Nebūna nieko per klaidą (🇱🇹Lithuania)
This melody feels a bit like their track with Adrina, but it’s still great.
Shared for educational and/or commentary purposes only.
#WorldMusic 🌍🎧
#MusicUnites ❤️🎵
www.youtube.com/watch?v=Kccs...
Žemaitukai - Nebūna nieko per klaidą (🇱🇹Lithuania)
This melody feels a bit like their track with Adrina, but it’s still great.
Shared for educational and/or commentary purposes only.
#WorldMusic 🌍🎧
#MusicUnites ❤️🎵
www.youtube.com/watch?v=Kccs...
Mucosal-associated invariant T (MAIT) cells are ‘conserved’ in name only.
#science
#immunology
buff.ly/UW5le4o
#science
#immunology
buff.ly/UW5le4o
CD4+ mucosal-associated invariant T cells express highly diverse T cell receptors
Abstract. Mucosal-associated invariant T (MAIT) cells are highly conserved innate-like T cells in mammals recognized for their high baseline frequency in h
buff.ly
November 22, 2025 at 8:20 PM
Mucosal-associated invariant T (MAIT) cells are ‘conserved’ in name only.
#science
#immunology
buff.ly/UW5le4o
#science
#immunology
buff.ly/UW5le4o
This aligns with previous observations that the main function of TGF-β is to facilitate tissue residency and the transition of immune cells into a quiescent state.
#science
#immunology
buff.ly/Vr3HzAE
#science
#immunology
buff.ly/Vr3HzAE
GPR25 promotes the formation of lung and liver tissue-resident memory CD8 T cells
GPR25 promotes the generation and maintenance of TRM cells by enhancing TGF-β signaling.
buff.ly
November 22, 2025 at 6:32 PM
This aligns with previous observations that the main function of TGF-β is to facilitate tissue residency and the transition of immune cells into a quiescent state.
#science
#immunology
buff.ly/Vr3HzAE
#science
#immunology
buff.ly/Vr3HzAE
We don’t need to focus on one more state within the virtually infinite spectrum a T cell can adopt along its differentiation path. That line of thought is futile and reflects a troubling decline in conceptual rigor within #immunology.
buff.ly/dq2gV5O
buff.ly/dq2gV5O
Joint profiling of gene expression and chromatin accessibility in pancreatic lymph nodes and spleens in human type 1 diabetes
Joint chromatin accessibility and transcriptomic profiling of human and mouse pancreatic lymph nodes uncovers distinct features of CD4 T cells in T1D.
buff.ly
November 22, 2025 at 12:13 AM
We don’t need to focus on one more state within the virtually infinite spectrum a T cell can adopt along its differentiation path. That line of thought is futile and reflects a troubling decline in conceptual rigor within #immunology.
buff.ly/dq2gV5O
buff.ly/dq2gV5O
As the saying goes, one man’s trash is another man’s treasure: the flow-cytometry doublets that are routinely excluded from analysis are in fact a rich source of tumor-reactive T cells.
#immunology
#science
#tumor
#immunotherapy
buff.ly/pETJPEH
#immunology
#science
#tumor
#immunotherapy
buff.ly/pETJPEH
Tumour-reactive heterotypic CD8 T cell clusters from clinical samples
Tumour-reactive CD8+ T cells are enriched in functional clusters with tumour cells and/or antigen-presenting cells and can be isolated and expanded from clinical samples.
www.nature.com
November 19, 2025 at 7:32 PM
As the saying goes, one man’s trash is another man’s treasure: the flow-cytometry doublets that are routinely excluded from analysis are in fact a rich source of tumor-reactive T cells.
#immunology
#science
#tumor
#immunotherapy
buff.ly/pETJPEH
#immunology
#science
#tumor
#immunotherapy
buff.ly/pETJPEH
The finding that tirzepatide can quiet “food noise” is remarkable. Imagine having similarly precise treatments for other intrusive or compulsive mental states, like those seen across many anxiety disorders.
#GLP1
#Mounjaro
#Zepbound
buff.ly/cY6wfc0
#GLP1
#Mounjaro
#Zepbound
buff.ly/cY6wfc0
How obesity drugs quiet ‘food noise’ in the brain
Researchers have identified a neural biomarker of compulsive food cravings, and showed that it is suppressed by the weight-loss drug Mounjaro.
buff.ly
November 18, 2025 at 12:59 AM
The finding that tirzepatide can quiet “food noise” is remarkable. Imagine having similarly precise treatments for other intrusive or compulsive mental states, like those seen across many anxiety disorders.
#GLP1
#Mounjaro
#Zepbound
buff.ly/cY6wfc0
#GLP1
#Mounjaro
#Zepbound
buff.ly/cY6wfc0
"We initially assumed the AI Scientist could autonomously conduct research based solely on a
prompt. However, it requires a user-defined “template,” which significantly limits the autonomy
of the AI Scientist."
#Sakana_ai
#AI
#AI_Scientist
buff.ly/7vHuX3M
prompt. However, it requires a user-defined “template,” which significantly limits the autonomy
of the AI Scientist."
#Sakana_ai
#AI
#AI_Scientist
buff.ly/7vHuX3M
Evaluating Sakana's AI Scientist: Bold Claims, Mixed Results, and a Promising Future?
A major step toward Artificial General Intelligence (AGI) and Super Intelligence is AI's ability to autonomously conduct research - what we term Artificial Research Intelligence (ARI). If machines…
arxiv.org
November 17, 2025 at 12:25 AM
"We initially assumed the AI Scientist could autonomously conduct research based solely on a
prompt. However, it requires a user-defined “template,” which significantly limits the autonomy
of the AI Scientist."
#Sakana_ai
#AI
#AI_Scientist
buff.ly/7vHuX3M
prompt. However, it requires a user-defined “template,” which significantly limits the autonomy
of the AI Scientist."
#Sakana_ai
#AI
#AI_Scientist
buff.ly/7vHuX3M
Let’s say an antigenic challenge produces clones A, B, C, and D, each with different specificity. Which ones become effectors and which become memory? Do all clones pass through the same effector-to-memory path, or do they split early?
1/
#immunology
#science
#memory
1/
#immunology
#science
#memory
November 16, 2025 at 11:19 PM
Let’s say an antigenic challenge produces clones A, B, C, and D, each with different specificity. Which ones become effectors and which become memory? Do all clones pass through the same effector-to-memory path, or do they split early?
1/
#immunology
#science
#memory
1/
#immunology
#science
#memory
The clonal bifurcation model of effector vs memory CD8 T cells faces a key paradox: if effector cells that clear infection die while unproven memory cells persist, how can the immune system know they will protect during secondary challenge?
#immunology
buff.ly/PpihJ0O
#immunology
buff.ly/PpihJ0O
Atomistic TCR-ligand interactions instruct memory T-cell differentiation
Memory T cells endow the mammalian host with an essential form of adaptive immunity that generates durable and rapid protection following re-exposure to an infectious pathogen or a cancerous…
buff.ly
November 16, 2025 at 8:58 PM
The clonal bifurcation model of effector vs memory CD8 T cells faces a key paradox: if effector cells that clear infection die while unproven memory cells persist, how can the immune system know they will protect during secondary challenge?
#immunology
buff.ly/PpihJ0O
#immunology
buff.ly/PpihJ0O
"An AI pioneer is convinced that most in his field have been led astray by the siren song of large language models"
on.wsj.com/4qYDZCB
on.wsj.com/4qYDZCB
on.wsj.com
November 16, 2025 at 6:31 PM
"An AI pioneer is convinced that most in his field have been led astray by the siren song of large language models"
on.wsj.com/4qYDZCB
on.wsj.com/4qYDZCB
"Scientists are warning that this winter's flu vaccine will be less effective against an emerging variant of H3N2 flu named subclade K."
buff.ly/06MszhT
buff.ly/06MszhT
A Surprise Flu Variant Threw Off the Vaccine. Get Ready for a Brutal Winter
Scientists are warning that this winter's flu vaccine will be less effective against an emerging variant of H3N2 flu named subclade K.
gizmodo.com
November 16, 2025 at 6:24 PM
"Scientists are warning that this winter's flu vaccine will be less effective against an emerging variant of H3N2 flu named subclade K."
buff.ly/06MszhT
buff.ly/06MszhT
The Weekend Tunes
Anita Abgariani - Shine Like a Star (🇬🇪 Georgia)
One of the best Junior Eurovision entries with great vocals and presentation, an ode to Georgia’s past and future. I get goosebumps when she sings “once upon a time or maybe never was”.
www.youtube.com/watch?v=rGil...
Anita Abgariani - Shine Like a Star (🇬🇪 Georgia)
One of the best Junior Eurovision entries with great vocals and presentation, an ode to Georgia’s past and future. I get goosebumps when she sings “once upon a time or maybe never was”.
www.youtube.com/watch?v=rGil...
November 15, 2025 at 12:55 AM
The Weekend Tunes
Anita Abgariani - Shine Like a Star (🇬🇪 Georgia)
One of the best Junior Eurovision entries with great vocals and presentation, an ode to Georgia’s past and future. I get goosebumps when she sings “once upon a time or maybe never was”.
www.youtube.com/watch?v=rGil...
Anita Abgariani - Shine Like a Star (🇬🇪 Georgia)
One of the best Junior Eurovision entries with great vocals and presentation, an ode to Georgia’s past and future. I get goosebumps when she sings “once upon a time or maybe never was”.
www.youtube.com/watch?v=rGil...
Notable observation.
"Although Ms4a7−/− mice showed normal cDC1 development and turnover, they failed to prime antigen-specific CD8+ T cells following infection or tumor development. "
#immunology
#science
#cancer
#immunotherapy
"Although Ms4a7−/− mice showed normal cDC1 development and turnover, they failed to prime antigen-specific CD8+ T cells following infection or tumor development. "
#immunology
#science
#cancer
#immunotherapy
Ms4a7 expression in cDC1s determines cross-presentation and antitumor immunity
Conventional type 1 dendritic cells (cDC1s) capture antigens in peripheral tissues and migrate to draining lymph nodes (dLNs) to prime antigen-specific CD8+ T cells. How tumor antigens are processed…
buff.ly
November 13, 2025 at 8:28 PM
Notable observation.
"Although Ms4a7−/− mice showed normal cDC1 development and turnover, they failed to prime antigen-specific CD8+ T cells following infection or tumor development. "
#immunology
#science
#cancer
#immunotherapy
"Although Ms4a7−/− mice showed normal cDC1 development and turnover, they failed to prime antigen-specific CD8+ T cells following infection or tumor development. "
#immunology
#science
#cancer
#immunotherapy
Interleukin-1β (IL-1β) is secreted primarily by dying monocytes rather than by live bystander monocytes, challenging established models.
#cryopyrin
#pyrin
#immunology
#science
buff.ly/2cBb3sk
#cryopyrin
#pyrin
#immunology
#science
buff.ly/2cBb3sk
Single-cell analysis reveals cell death as driver of NLRP3-mediated secretion of IL-1β in human monocytes - Nature Immunology
Lamkanfi, Shirasaki, Izawa and colleagues show that IL-1β release in human monocytes stimulated with lipopolysaccharide or carrying NLRP3 activatory mutations is mostly restricted to cells undergoing…
buff.ly
November 11, 2025 at 7:58 PM
Interleukin-1β (IL-1β) is secreted primarily by dying monocytes rather than by live bystander monocytes, challenging established models.
#cryopyrin
#pyrin
#immunology
#science
buff.ly/2cBb3sk
#cryopyrin
#pyrin
#immunology
#science
buff.ly/2cBb3sk
There’s growing talk that personalized cancer medicine is the future usually meaning individualized #cancer #immunotherapy using mRNA or peptide #vaccines. But before that vision makes sense, some key questions about what cancer suppression really is must be clarified.
1/
1/
November 9, 2025 at 11:16 PM
There’s growing talk that personalized cancer medicine is the future usually meaning individualized #cancer #immunotherapy using mRNA or peptide #vaccines. But before that vision makes sense, some key questions about what cancer suppression really is must be clarified.
1/
1/
The Weekend Tunes
JUNG HYE RIN _Melty Love(샤르르 샤르르)
(South Korea🇰🇷)
Korean trot music sounds like those songs that, when played, signaled everyone to jump up and start dancing at rural weddings in the USSR.
#WorldMusic 🌍 🎧
#MusicUnites ❤️🎵
youtu.be/G-4Oj7ztVyo?...
JUNG HYE RIN _Melty Love(샤르르 샤르르)
(South Korea🇰🇷)
Korean trot music sounds like those songs that, when played, signaled everyone to jump up and start dancing at rural weddings in the USSR.
#WorldMusic 🌍 🎧
#MusicUnites ❤️🎵
youtu.be/G-4Oj7ztVyo?...
November 8, 2025 at 9:16 PM
The Weekend Tunes
JUNG HYE RIN _Melty Love(샤르르 샤르르)
(South Korea🇰🇷)
Korean trot music sounds like those songs that, when played, signaled everyone to jump up and start dancing at rural weddings in the USSR.
#WorldMusic 🌍 🎧
#MusicUnites ❤️🎵
youtu.be/G-4Oj7ztVyo?...
JUNG HYE RIN _Melty Love(샤르르 샤르르)
(South Korea🇰🇷)
Korean trot music sounds like those songs that, when played, signaled everyone to jump up and start dancing at rural weddings in the USSR.
#WorldMusic 🌍 🎧
#MusicUnites ❤️🎵
youtu.be/G-4Oj7ztVyo?...
Reposted by David Usharauli
🎬 OC REVIEWS: Caucasian Blues — a fun romp bringing together Armenians, Azerbaijanis, and Georgians.
oc-media.org/review-cauca...
oc-media.org/review-cauca...
Review | Caucasian Blues — a fun romp bringing together Armenians, Azerbaijanis, and Georgians
While the ostensibly first true South Caucasian co-production Caucasian Blues falters technically, it makes up for it in humour and sentiment.
oc-media.org
November 8, 2025 at 8:12 AM
🎬 OC REVIEWS: Caucasian Blues — a fun romp bringing together Armenians, Azerbaijanis, and Georgians.
oc-media.org/review-cauca...
oc-media.org/review-cauca...
If you fund the same researchers the NIH would have funded anyway, the result is just incremental progress: two papers instead of one.
The Chan Zuckerberg Initiative (CZI) @ChanZuckerberg
buff.ly/2jQm2yP
The Chan Zuckerberg Initiative (CZI) @ChanZuckerberg
buff.ly/2jQm2yP
AI drives dramatic expansion of Chan Zuckerberg Initiative’s funding to end all diseases
Entering its second decade, philanthropy with Facebook fortune has shed social causes and now focuses on ambitious science dream
buff.ly
November 6, 2025 at 8:04 PM
If you fund the same researchers the NIH would have funded anyway, the result is just incremental progress: two papers instead of one.
The Chan Zuckerberg Initiative (CZI) @ChanZuckerberg
buff.ly/2jQm2yP
The Chan Zuckerberg Initiative (CZI) @ChanZuckerberg
buff.ly/2jQm2yP
mRNA vaccines have a fundamental issue of generating short-lived immune responses. They are useful as a fast, stopgap approach but not as a vaccination strategy intended to provide lifelong protection with one or two doses.
#science
#mRNA
#vaccine
buff.ly/6zAdCF4
#science
#mRNA
#vaccine
buff.ly/6zAdCF4
Moderna leans on cost cuts, pipeline as vaccine sales dip
Despite quarterly revenue totals that were nearly cut in half compared to the same period last year, Moderna still expects to break even financially in 2028 with the help of more disciplined spending.
buff.ly
November 6, 2025 at 6:27 PM
mRNA vaccines have a fundamental issue of generating short-lived immune responses. They are useful as a fast, stopgap approach but not as a vaccination strategy intended to provide lifelong protection with one or two doses.
#science
#mRNA
#vaccine
buff.ly/6zAdCF4
#science
#mRNA
#vaccine
buff.ly/6zAdCF4