Lightnews — Scholar-powered news

David Usharauli @davidusharauli.bsky.social · 9h

The Weekend Tunes

Damiano David, Tyla, Nile Rodgers - Talk to Me
(🇮🇹 Italy 🇿🇦 South Africa 🇺🇸 USA)

#WorldMusic 🌍🎧
#MusicUnites ❤️🎵

www.youtube.com/watch?v=PLTJ...

David Usharauli @davidusharauli.bsky.social · 2d

Type I interferon deficiency redirects antiviral immunity into NF-κB–driven inflammatory pathways, representing a maladaptive compensation that likely underlies the most common forms of virus-induced #immunopathology.

#immunology
#immunity
#virus

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Role for NF-κB in herpes encephalitis pathology in mice genocopying an inborn error of IRF3-IFN immunity | Journal of Experimental Medicine | Rockefeller University Press

Idorn et al. characterized a mouse strain harboring a mutation identified in an HSE patient. Defective IFN-driven antiviral responses led to hyperactivatio

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David Usharauli @davidusharauli.bsky.social · 2d

Mary Brunkow’s #FOXP3 discovery earned her a Nobel, though she left the field soon afterward. Douglas Prasher cloned #GFP in 1992, left the field too, and was notably left out of the #Nobel for its discovery.

#Brunkow
#Prasher

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The Man Who Wasn't There

What does the tale of Douglas Prasher, the protein, and the Nobel Prize reveal about the scientific labor market?

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David Usharauli @davidusharauli.bsky.social · 2d

Looks like cGAS evolved a trade-off: it stays in the nucleus to aid DNA repair and longevity in naked mole rats but shows less immune sensing of foreign DNA, likely the cost of living virus-free underground (?). Opposite in mice and humans.

#longevity

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A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging

Efficient DNA repair might make possible the longevity of naked mole-rats. However, whether they have distinctive mechanisms to optimize functions of DNA repair suppressors is unclear. We find that…

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David Usharauli @davidusharauli.bsky.social · 4d

NIH decision looms about caps on scholarly-journal publishing fees

#NIH
#science
#publishing
#openaccess

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NIH decision looms about caps on scholarly-journal publishing fees

Researchers are pleased about possible limit to publishers’ profits but say the proposed change is imperfect

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David Usharauli @davidusharauli.bsky.social · 8d

The Weekend Tunes

Kalifarniya- QYLYQ (🇰🇿 Kazakhstan)

#WorldMusic 🌍🎧
#MusicUnites ❤️🎵

www.youtube.com/watch?v=KOOk...

Reposted by David Usharauli

Waggoner Lab @labwaggoner.bsky.social · 9d

Foreign epitope–specific naïve Treg cells fine-tune the primary response of Tconv cells specific for the same epitope by curbing the Th1 fate while allowing a robust response @jimmunol.bsky.social @uminnpress.bsky.social
academic.oup.com/jimmunol/adv...

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David Usharauli @davidusharauli.bsky.social · 11d

Listened to a Global ImmunoTalks seminar by Marc Jenkins on rare antigen-specific T cells in the naïve repertoire, including Tregs. Now it’s published in JI. Submission date June 30, one day later and it would’ve been free to read. Now? Nope.

#immunology

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Foreign epitope–specific regulatory T cells respond robustly to vaccination and limit Th1 differentiation by conventional T cells specific for the same epitope

Abstract. Foxp3+ regulatory T (Treg) cells with antigen receptors (TCRs) specific for host peptides suppress autoimmunity. Paradoxically, Treg cells are al

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David Usharauli @davidusharauli.bsky.social · 13d

New evidence shows that long-lived IgE plasma cells exist and are found mainly in the spleen rather than the bone marrow. This could add another layer to our understanding of how IgE drives persistent allergy.

#allergy
#immunology

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Long-lived IgE plasma cells that reside in the spleen contribute to the persistence of the IgE response

IgE plasma cells (PC) producing high affinity antibodies are critical players in allergic diseases. Allergies may persist or resolve over time, but the factors involved in their evolution are not…

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David Usharauli @davidusharauli.bsky.social · 13d

Oncolytic viruses looked promising, but trials showed they could not eradicate metastasis. New experiments reveal why: they prime T cells against the virus, not the cancer.

#cancer
#immunotherapy
#oncolytic

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The anti-virus T cell response dominates the anti-cancer response in oncolytic virus therapy

Oncolytic viruses have strong potential as immunotherapies. By causing cancer cells to die and relieve antigens, these viruses can stimulate robust, systemic immune responses that may eliminate…

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David Usharauli @davidusharauli.bsky.social · 14d

#Bacteroides fragilis was hyped for 15 years as a Treg inducer and anti-inflammatory so much so that biotech companies were founded on it to capitalize on the early data . Now? Oops.

#immunology
#science
#gut
#inflammation

A Bacteroides fragilis protease activates host PAR2 to induce intestinal pain and inflammation

Lakemeyer and colleagues analyze the secretome of gut bacteria to identify factors that target host PAR2. They find that the Bacteroides fragilis protease Bfp1 cleaves and activates PAR2, disrupting…

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David Usharauli @davidusharauli.bsky.social · 14d

The Weekend Tunes

FLM - Ráncok a szemem alatt (🇭🇺 Hungary)

FLM has returned after 30 years with a genuine new synthpop track.

#WorldMusic 🌍 🎧
#MusicUnites ❤️🎵

www.youtube.com/watch?v=gydv...

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David Usharauli @davidusharauli.bsky.social · 14d

IL-21 mimic "21h10 led to lethal pancreatitis in mice, this toxicity could be mitigated by TNF blockade"

Yet it is still being described as a #breakthrough, which points to a serious lapse in both experimental judgment and peer review.

#immunology

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David Usharauli @davidusharauli.bsky.social · 14d

For now, the EU cannot turn away from Georgia, since Azerbaijani oil and gas flow through it. But once the Azerbaijan–Armenia–Türkiye corridor opens, Georgia could be discarded if Bidzina is still unwilling to meet EU expectations.

#Georgia
#GeorgiaProtest

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David Usharauli @davidusharauli.bsky.social · 16d

This form of complex decision-making in the termite nervous system approaches that of primate, or at least mammalian, brains. It illustrates how nature often reuses fundamental neural architectures rather than constructing them anew.

#science

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David Usharauli @davidusharauli.bsky.social · 18d

"Science winnows submissions using a team of full-time professional editors" [former scientists]
This arrangement highlights a paradox of gatekeeping in #science, where editors with modest academic records decide the fate of more accomplished researchers.
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Reposted by David Usharauli

Adrian Liston @labliston.bsky.social · 19d

My only regret is that we didn't go with the title "One buffer to rule them all, and in the darkness bind them", although "Squeaky clean staining" was a pretty good options too!

Adrian Liston @labliston.bsky.social · 22d

For our #flowcytometry peeps, would you like to have a single fix/perm protocol that is optimised for everything? One that preserves fluorophores while allowing simultaneous TF and cytokine staining? How about 100-fold cheaper?

You got it:
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...

currentprotocols.onlinelibrary.wiley.com

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Reposted by David Usharauli

Batumelebi&Netgazeti @netgazeti.org · 18d

🟥On the 255th day of her unlawful detention, Mzia Amaglobeli was nominated for #SakharovPrize

🟥Nomination “Mzia Amaglobeli and Georgia’s Pro-Democracy Protest Movement,” was initiated by Rasa Juknevičienė, Tobias Cremer, Petras Austrevicius, Sergey Lagodinsky, and co-signed by 66 MEPs from 5 groups

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David Usharauli @davidusharauli.bsky.social · 19d

13. In summary: tolerance to self is a fixed, static system established at birth. It does not change dynamically during an individual’s life.

#immunology
#tolerance
#selfnonself
#science
#theory
#Foxp3
#Tregs

David Usharauli @davidusharauli.bsky.social · 19d

12. To tolerate such peptides, the corresponding Tregs would already need to exist at birth. This implies that the peptides or their mimics are already present in the thymus, allowing Tregs to develop.

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David Usharauli @davidusharauli.bsky.social · 19d

11. Some argue that the appearance of new self-peptides in the absence of inflammation could inactivate T cells or induce Tregs to suppress reactions. This does not work, because the timing of new self-peptides cannot be perfectly controlled to occur only without inflammation.

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David Usharauli @davidusharauli.bsky.social · 19d

10. Thymic negative selection and thymus-derived Tregs work to maintain this rigid system of self-nonself discrimination. Another reason self cannot be dynamic: if a self-peptide appeared later in life, how would T cells know it is self?

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David Usharauli @davidusharauli.bsky.social · 19d

9. Why must the self-peptide pool be fixed and static? Because otherwise, self-nonself discrimination at the T cell level would fail. The only way to separate peptides that are physically identical is temporal: peptides present at birth = self, peptides appearing later = nonself.

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David Usharauli @davidusharauli.bsky.social · 19d

8. All relevant self-peptides or their cross-reactive mimics that need to be assigned as self are already present at birth. No dynamic changes are necessary later.

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David Usharauli @davidusharauli.bsky.social · 19d

7. Initially, some thought that self-peptides appearing later in life should also be categorized as self, implying a dynamic learning process. This is incorrect.

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