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decision4liver.bsky.social
DECISION Horizon2020
@decision4liver.bsky.social
220 followers 300 following 49 posts
DECISION is an international, EU-funded research project on decompensated cirrhosis to identify new combinatorial therapies based on systems approaches.
🌐 https://decision-for-liver.eu/

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decision4liver.bsky.social
DECISION Horizon2020 @decision4liver.bsky.social · Dec 10

Hi! We're the DECISION consortium, an EU-funded research project striving to better understand the #pathophysiology of decompensated #cirrhosis leading to acute-on-chronic liver failure ( #ACLF ) at the systems level.
We're 21 institutions form 10 European countries 💪
DECISION project member map across Europe. The coordinating institution is in pink: EF CLIF (European Foundation for the Study of Chronic Liver Failure), Barcelona, SPAIN The other partners are in blue: APHP (Assistance Publique-Hôpitaux de Paris), Clichy, FRANCE CEA (Commissariat à l’Energie Atomique et Aux Énergies Alternatives), Gif sur Yvette, FRANCE concentris (concentris research management gmbh), Fürstenfeldbruck, GERMANY EASL (European Association for the Study of the Liver), Geneva, SWITZERLAND ELPA (European Liver Patients’ Association), Brussels, BELGIUM EMC (Erasmus Universitair Medish Centrum Rotterdam), Rotterdam, NETHERLANDS FCRB (Fundació Clínic per la Recerca Biomèdica), Barcelona, SPAIN ICS-HUVH (Institut Catala de la Salut) Passeig Vall d’Hebron, SPAIN INSERM (Institut National de la Sante et de la Recherche Medicale), Paris, FRANCE NBM-FMS (Navarrabiomed – Public Foundation Miguel Servet), Pamplona, SPAIN SERMAS (Servicio Madrileno de Salud), Madrid, SPAIN NordicBio (Nordic Bioscience A/S), Herlev, DENMARK UB (Universitat de Barcelona), Barcelona, SPAIN UCL (University College London), London, UNITED KINGDOM UKA (Universitäts-Klinikum Aachen), Aachen, GERMANY UNIBO (Alma Mater Studiorum - Universita di Bologna), Bologna, ITALY UNIPD (Universita Degli Studi di Padova), Padova, ITALY UNITO (Università degli Studi di Torino), Torino, ITALY YouHealth (YH YouHealth AB), Stockholm, SWEDEN Universitätsklinikum Münster (WWU), Münster, Germany
decision4liver.bsky.social
New DECISION study in @jhepatology.bsky.social: maladaptive emergency granulopoiesis predicts poor outcomes in acutely #decompensatedcirrhosis.
This could guide early identification and novel therapies.
www.sciencedirect.com/science/arti...

#ACLF #LiverSky #Hepatology @easlnews.bsky.social
Maladaptive emergency granulopoiesis predicts poor outcomes in patients hospitalized with decompensated cirrhosis
Whether analysis of whole blood transcriptome assessed on admission of patients with acutely decompensated cirrhosis (ADC) without acute-on-chronic li…
www.sciencedirect.com
November 27, 2025 at 9:29 AM
decision4liver.bsky.social
That’s a wrap on our final DECISION GA!

From COMBAT & PROSPECT updates to forward-looking discussions and feedback, we’re proud of our shared achievements and motivated to keep advancing ACLF & decompensated cirrhosis research together.

#LiverSky
October 10, 2025 at 10:31 AM
decision4liver.bsky.social
Our final GA is a look back and forward - from major scientific milestones to future discoveries!
After a keynote by Prof. Rubén Francés, partners shared results on omics integration, biomarkers & systems medicine - and closed today with a masterclass on data repositories. #cirrhosis
October 9, 2025 at 2:47 PM
decision4liver.bsky.social
Next week: the final DECISION General Assembly in Madrid! 🎉
Celebrating 5+ years of science, collaboration, & results
@rautoupe.bsky.social  @concentris.bsky.social 
@navarrabiomed.bsky.social 
@bioeticayderecho.bsky.social 
@medblab.bsky.social 
@europeliver.bsky.social 
@easlnews.bsky.social et al
October 1, 2025 at 8:02 AM
decision4liver.bsky.social
The latest DECISION Masterclass is live!
💡 Clinical Bioinformatics – It’s More Than Pressing a Button with Núria Planell, Cristina Sanchez & David Gomez-Cabrero.

Watch here: https://youtu.be/UBm1_JGhw6M

#Bioinformatics #ClinicalResearch #ACLF
September 24, 2025 at 8:02 AM
decision4liver.bsky.social
Today is #WorldHepatitisDay! We spotlight two DECISION partners deeply committed to #liverhealth:
🔬 @easlnews.bsky.social – advancing #hepatology research
🧡 @europeliver.bsky.social – amplifying the voice of liver patients
Together, we work toward a healthier future beyond ACLF.

#Cirrhosis
July 28, 2025 at 8:55 AM
decision4liver.bsky.social
🔥 We’ve hit 50% recruitment in the #COMBATtrial!
Huge thanks to all involved!💙
@rautoupe.bsky.social @hopitalbeaujon.bsky.social @hospitalclinic.bsky.social @rwth.bsky.social @uni-muenster.de @brunslab.bsky.social @medblab.bsky.social @frankuschner.bsky.social

#LiverSky #ClinicalTrial
June 30, 2025 at 3:55 PM
decision4liver.bsky.social
🎥 New keynote online!
Prof. Richard Moreau, Director of #EFCLIF, explores immune dysfunction in AD & #ACLF and suggests a common mechanism behind inflammation & immune deficiency.
Watch now 👉 https://youtu.be/KWoUbTsNjQM 
#LiverSky #Hepatology
June 26, 2025 at 11:20 AM
decision4liver.bsky.social
🎉 Exciting news: We’ve surpassed 500 followers on @linkedin.com!
Follow us there for updates on trials, science, and more 👉 www.linkedin.com/company/deci...

#ClinicalResearch #DECISIONproject
June 17, 2025 at 12:14 PM
decision4liver.bsky.social
Consider joining this event by @a-tango.bsky.social and @crowdhelix.com!
"Industrial Perspective on Drug Development Challenges for Clinical Trials"

📅 4th June 2025
🕚 11:00 am CEST / 🕙 10:00 am BST

Register via this link: inevent.uk/en/Crowdheli...
June 2, 2025 at 7:45 AM
decision4liver.bsky.social
It’s #ClinicalTrialsDay! At DECISION, we’re proud of our COMBAT & PROSPECT trials advancing care in decompensated cirrhosis.
💡COMBAT Q&A videos in multiple languages help engage patients ➡️ www.youtube.com/playlist?lis...

Thanks to all who make our trials possible! #LiverResearch
May 20, 2025 at 6:52 AM
Reposted by DECISION Horizon2020
concentris.bsky.social
✨ #PosterTour today at #EASLCongress 2025:
All our 3 Horizon2020 #LiverResearch projects in 1 session!

Topic: #Cirrhosis & #PortalHypertension
Chair: Maria Papp

💡 Big moments:

#AMMON-OHE model for post-#TIPS #encephalopathy (Rajiv Jalan)

#Terlipressin response in AKI-HRS w/ CKD (Frank Uschner)
May 10, 2025 at 12:04 PM
decision4liver.bsky.social
Clinical trajectories of patients with cirrhosis and ascites receiving long-term albumin
#POSTER SAT-145-YI by Enrico Pompili (UNIBO) proposes a personalized management approach for patients with cirrhosis and ascites, based on real-world data from long-term albumin therapy. #EASL2025
May 10, 2025 at 10:58 AM
decision4liver.bsky.social
🩺 Impact of diabetes mellitus on clinical outcomes in patients with acutely decompensated cirrhosis

#E_POSTER SAT-184-YI by Mimma Bonomo (UNITO) explores how coexisting diabetes mellitus affects prognosis in patients hospitalized with acute decompensation of cirrhosis.

#EASL2025
May 10, 2025 at 10:45 AM
decision4liver.bsky.social
🦠The recovery failure of fecal microbiota diversity in patients after liver transplant is associated with a complicated postoperative course

#POSTER SAT-518 by @beccsipollsi.bsky.social from @rwth.bsky.social at #EASL2025

@brunslab.bsky.social
@easlnews.bsky.social
May 10, 2025 at 10:35 AM
decision4liver.bsky.social
🧪 Acute kidney disease in acutely decompensated cirrhosis: impact on clinical outcomes

#POSTER SAT-122-YI by Alberto Calleri (UNITO) examines how acute kidney disease affects outcomes in patients with acutely decompensated cirrhosis.

📅 Presented at #EASLCongress | #EASL2025
@easlnews.bsky.social
May 10, 2025 at 10:20 AM
decision4liver.bsky.social
❤️ Cardiac performance is impaired in patients with proven alcohol-related hepatitis and predicts 3-month mortality in this patient population

#POSTER SAT-503-YI by Pierre-Emmanuel Rautou (@inserm.fr, APHP, EF CLIF)

📅 Presented at the #EASLCongress | #EASL2025
@easlnews.bsky.social
May 10, 2025 at 10:07 AM
decision4liver.bsky.social
Back in the Abstract Session: Theresa Wirtz presents her scRNA-seq work on monocyte subsets and ACLF risk.

@rwth.bsky.social
@brunslab.bsky.social
@easlnews.bsky.social

#Cirrhosis #ACLF #EASL2025"
May 10, 2025 at 8:58 AM
decision4liver.bsky.social
Estefania Huergo presents methylation data in AD patients, selected as best Young Investigator abstract in Basic Science at #EASL2025 - Congrats! 🎉
@navarrabiomed.bsky.social
@easlnews.bsky.social
#Epigenetics #LiverResearch
May 10, 2025 at 8:42 AM
decision4liver.bsky.social
Javier Fernandez (FCRB) is giving the hepatologist perspective on management of MDR infections in cirrhosis as part of the EASL/ESCMID Symposium: MDR infections - a challenge in decompensated cirrhosis at #EASL2025

#LiverDisease #Cirrhosis #Hepatology @easlnews.bsky.social
May 10, 2025 at 7:13 AM
decision4liver.bsky.social
Is the etiological work-up of #PSVD a one-size-fits-all?

DECISION consortium member Lucile Moga from APHP takes part in EASL/ VALDIG's session on "Do's and Don'ts in the management of Porto-Sinusoidal Vascular Disease".

#EASLCongress #EASL2025 #LiverResearch
@easlnews.bsky.social
May 10, 2025 at 7:00 AM
decision4liver.bsky.social
How do you build&lead a successful research team?
The next generation of PIs learned straight from the best in today's workshop “How to Start a Research Group: From Postdoc to PI" as @rautoupe.bsky.social shared practical insights on building&maintaining a high-performing team.
@inserm.fr #EASL2025
May 9, 2025 at 4:33 PM
decision4liver.bsky.social
DECISION consortium member Sophie Lotersztajn from the French research institute @inserm.fr at a late-afternoon abstract session today at #EASLCongress in Amsterdam, the Netherlands, about #fibrosis, #hepatocyte and #liver #regeneration. 🩺

#EASL2025 @easlnews.bsky.social
May 9, 2025 at 3:13 PM
decision4liver.bsky.social
🔬 #POSTER FRI-222 by Thierry Gustot (EF CLIF) proposes one-week criteria to assess the appropriateness of continuing intensive care in ACLF patients who are not candidates for liver transplantation.

#EASL2025 @easlnews.bsky.social
May 9, 2025 at 11:46 AM
decision4liver.bsky.social
📊 Fibroblast growth factor 19 (FGF-19) predicts transplant free-survival in critically ill patients with acute-onchronic liver failure

#POSTER FRI-199 by @beccsipollsi.bsky.social

📅 #EASLCongress | #EASL2025
@easlnews.bsky.social
May 9, 2025 at 10:41 AM