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DECISION Horizon2020

@decision4liver.bsky.social

220 followers 300 following 46 posts

DECISION is an international, EU-funded research project on decompensated cirrhosis to identify new combinatorial therapies based on systems approaches. 🌐 https://decision-for-liver.eu/

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DECISION Horizon2020 @decision4liver.bsky.social · Dec 10

Hi! We're the DECISION consortium, an EU-funded research project striving to better understand the #pathophysiology of decompensated #cirrhosis leading to acute-on-chronic liver failure ( #ACLF ) at the systems level.
We're 21 institutions form 10 European countries 💪

DECISION project member map across Europe.
The coordinating institution is in pink:
EF CLIF (European Foundation for the Study of Chronic Liver Failure), Barcelona, SPAIN
The other partners are in blue:
APHP (Assistance Publique-Hôpitaux de Paris), Clichy, FRANCE
CEA (Commissariat à l’Energie Atomique et Aux Énergies Alternatives), Gif sur Yvette, FRANCE
concentris (concentris research management gmbh), Fürstenfeldbruck, GERMANY
EASL (European Association for the Study of the Liver), Geneva, SWITZERLAND
ELPA (European Liver Patients’ Association), Brussels, BELGIUM
EMC (Erasmus Universitair Medish Centrum Rotterdam), Rotterdam, NETHERLANDS
FCRB (Fundació Clínic per la Recerca Biomèdica), Barcelona, SPAIN
ICS-HUVH (Institut Catala de la Salut) Passeig Vall d’Hebron, SPAIN
INSERM (Institut National de la Sante et de la Recherche Medicale), Paris, FRANCE
NBM-FMS (Navarrabiomed – Public Foundation Miguel Servet), Pamplona, SPAIN
SERMAS (Servicio Madrileno de Salud), Madrid, SPAIN
NordicBio (Nordic Bioscience A/S), Herlev, DENMARK
UB (Universitat de Barcelona), Barcelona, SPAIN
UCL (University College London), London, UNITED KINGDOM
UKA (Universitäts-Klinikum Aachen), Aachen, GERMANY
UNIBO (Alma Mater Studiorum - Universita di Bologna), Bologna, ITALY
UNIPD (Universita Degli Studi di Padova), Padova, ITALY
UNITO (Università degli Studi di Torino), Torino, ITALY
YouHealth (YH YouHealth AB), Stockholm, SWEDEN
Universitätsklinikum Münster (WWU), Münster, Germany

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DECISION Horizon2020 @decision4liver.bsky.social · 8d

Next week: the final DECISION General Assembly in Madrid! 🎉
Celebrating 5+ years of science, collaboration, & results
@rautoupe.bsky.social @concentris.bsky.social
@navarrabiomed.bsky.social
@bioeticayderecho.bsky.social
@medblab.bsky.social
@europeliver.bsky.social
@easlnews.bsky.social et al

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DECISION Horizon2020 @decision4liver.bsky.social · 15d

The latest DECISION Masterclass is live!
💡 Clinical Bioinformatics – It’s More Than Pressing a Button with Núria Planell, Cristina Sanchez & David Gomez-Cabrero.

Watch here: https://youtu.be/UBm1_JGhw6M

#Bioinformatics #ClinicalResearch #ACLF

DECISION Horizon2020 @decision4liver.bsky.social · Jul 28

Today is #WorldHepatitisDay! We spotlight two DECISION partners deeply committed to #liverhealth:
🔬 @easlnews.bsky.social – advancing #hepatology research
🧡 @europeliver.bsky.social – amplifying the voice of liver patients
Together, we work toward a healthier future beyond ACLF.

#Cirrhosis

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DECISION Horizon2020 @decision4liver.bsky.social · Jun 30

🔥 We’ve hit 50% recruitment in the #COMBATtrial!
Huge thanks to all involved!💙
@rautoupe.bsky.social @hopitalbeaujon.bsky.social @hospitalclinic.bsky.social @rwth.bsky.social @uni-muenster.de @brunslab.bsky.social @medblab.bsky.social @frankuschner.bsky.social

#LiverSky #ClinicalTrial

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DECISION Horizon2020 @decision4liver.bsky.social · Jun 26

🎥 New keynote online!
Prof. Richard Moreau, Director of #EFCLIF, explores immune dysfunction in AD & #ACLF and suggests a common mechanism behind inflammation & immune deficiency.
Watch now 👉 https://youtu.be/KWoUbTsNjQM
#LiverSky #Hepatology

DECISION Horizon2020 @decision4liver.bsky.social · Jun 17

🎉 Exciting news: We’ve surpassed 500 followers on @linkedin.com!
Follow us there for updates on trials, science, and more 👉 www.linkedin.com/company/deci...

#ClinicalResearch #DECISIONproject

DECISION Horizon2020 @decision4liver.bsky.social · Jun 2

Consider joining this event by @a-tango.bsky.social and @crowdhelix.com!
"Industrial Perspective on Drug Development Challenges for Clinical Trials"

📅 4th June 2025
🕚 11:00 am CEST / 🕙 10:00 am BST

Register via this link: inevent.uk/en/Crowdheli...

DECISION Horizon2020 @decision4liver.bsky.social · May 20

It’s #ClinicalTrialsDay! At DECISION, we’re proud of our COMBAT & PROSPECT trials advancing care in decompensated cirrhosis.
💡COMBAT Q&A videos in multiple languages help engage patients ➡️ www.youtube.com/playlist?lis...

Thanks to all who make our trials possible! #LiverResearch

Reposted by DECISION Horizon2020

concentris research management gmbh @concentris.bsky.social · May 10

✨ #PosterTour today at #EASLCongress 2025:
All our 3 Horizon2020 #LiverResearch projects in 1 session!

Topic: #Cirrhosis & #PortalHypertension
Chair: Maria Papp

💡 Big moments:

#AMMON-OHE model for post-#TIPS #encephalopathy (Rajiv Jalan)

#Terlipressin response in AKI-HRS w/ CKD (Frank Uschner)

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DECISION Horizon2020 @decision4liver.bsky.social · May 10

Clinical trajectories of patients with cirrhosis and ascites receiving long-term albumin
#POSTER SAT-145-YI by Enrico Pompili (UNIBO) proposes a personalized management approach for patients with cirrhosis and ascites, based on real-world data from long-term albumin therapy. #EASL2025

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DECISION Horizon2020 @decision4liver.bsky.social · May 10

🩺 Impact of diabetes mellitus on clinical outcomes in patients with acutely decompensated cirrhosis

#E_POSTER SAT-184-YI by Mimma Bonomo (UNITO) explores how coexisting diabetes mellitus affects prognosis in patients hospitalized with acute decompensation of cirrhosis.

#EASL2025

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DECISION Horizon2020 @decision4liver.bsky.social · May 10

🦠The recovery failure of fecal microbiota diversity in patients after liver transplant is associated with a complicated postoperative course

#POSTER SAT-518 by @beccsipollsi.bsky.social from @rwth.bsky.social at #EASL2025

@brunslab.bsky.social
@easlnews.bsky.social

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DECISION Horizon2020 @decision4liver.bsky.social · May 10

🧪 Acute kidney disease in acutely decompensated cirrhosis: impact on clinical outcomes

#POSTER SAT-122-YI by Alberto Calleri (UNITO) examines how acute kidney disease affects outcomes in patients with acutely decompensated cirrhosis.

📅 Presented at #EASLCongress | #EASL2025
@easlnews.bsky.social

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DECISION Horizon2020 @decision4liver.bsky.social · May 10

❤️ Cardiac performance is impaired in patients with proven alcohol-related hepatitis and predicts 3-month mortality in this patient population

#POSTER SAT-503-YI by Pierre-Emmanuel Rautou (@inserm.fr, APHP, EF CLIF)

📅 Presented at the #EASLCongress | #EASL2025
@easlnews.bsky.social

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DECISION Horizon2020 @decision4liver.bsky.social · May 10

Back in the Abstract Session: Theresa Wirtz presents her scRNA-seq work on monocyte subsets and ACLF risk.

@rwth.bsky.social
@brunslab.bsky.social
@easlnews.bsky.social

#Cirrhosis #ACLF #EASL2025"

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DECISION Horizon2020 @decision4liver.bsky.social · May 10

Estefania Huergo presents methylation data in AD patients, selected as best Young Investigator abstract in Basic Science at #EASL2025 - Congrats! 🎉
@navarrabiomed.bsky.social
@easlnews.bsky.social
#Epigenetics #LiverResearch

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DECISION Horizon2020 @decision4liver.bsky.social · May 10

Javier Fernandez (FCRB) is giving the hepatologist perspective on management of MDR infections in cirrhosis as part of the EASL/ESCMID Symposium: MDR infections - a challenge in decompensated cirrhosis at #EASL2025

#LiverDisease #Cirrhosis #Hepatology @easlnews.bsky.social

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DECISION Horizon2020 @decision4liver.bsky.social · May 10

Is the etiological work-up of #PSVD a one-size-fits-all?

DECISION consortium member Lucile Moga from APHP takes part in EASL/ VALDIG's session on "Do's and Don'ts in the management of Porto-Sinusoidal Vascular Disease".

#EASLCongress #EASL2025 #LiverResearch
@easlnews.bsky.social

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DECISION Horizon2020 @decision4liver.bsky.social · May 9

How do you build&lead a successful research team?
The next generation of PIs learned straight from the best in today's workshop “How to Start a Research Group: From Postdoc to PI" as @rautoupe.bsky.social shared practical insights on building&maintaining a high-performing team.
@inserm.fr #EASL2025

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DECISION Horizon2020 @decision4liver.bsky.social · May 9

DECISION consortium member Sophie Lotersztajn from the French research institute @inserm.fr at a late-afternoon abstract session today at #EASLCongress in Amsterdam, the Netherlands, about #fibrosis, #hepatocyte and #liver #regeneration. 🩺

#EASL2025 @easlnews.bsky.social

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DECISION Horizon2020 @decision4liver.bsky.social · May 9

Congrats on presenting your poster in the Track Hub 4 this afternoon, @beccsipollsi.bsky.social ! 🙌

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DECISION Horizon2020 @decision4liver.bsky.social · May 9

🔬 #POSTER FRI-222 by Thierry Gustot (EF CLIF) proposes one-week criteria to assess the appropriateness of continuing intensive care in ACLF patients who are not candidates for liver transplantation.

#EASL2025 @easlnews.bsky.social

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DECISION Horizon2020 @decision4liver.bsky.social · May 9

📊 Fibroblast growth factor 19 (FGF-19) predicts transplant free-survival in critically ill patients with acute-onchronic liver failure

#POSTER FRI-199 by @beccsipollsi.bsky.social

📅 #EASLCongress | #EASL2025
@easlnews.bsky.social

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DECISION Horizon2020 @decision4liver.bsky.social · May 9

🧊 Hypothermic oxygenated machine perfusion (HOPE) treatment prior to organ transplant alters key immune modulators in patients receiving liver transplantation

#POSTER FRI-495-YI by @beccsipollsi.bsky.social

📅 #EASLCongress | #EASL2025
@brunslab.bsky.social @easlnews.bsky.social

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DECISION Horizon2020 @decision4liver.bsky.social · May 9

Greetings from the DECISION Investigator Meeting at #EASL2025: Study updates and collaborative discussions with Paolo Caraceni & @rautoupe.bsky.social

#ClinicalTrials #cirrhosis

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