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concentris research management gmbh @concentris.bsky.social · 18h

Register for this exciting and high-calibre panel discussion on early cancer detection and the impact of artificial intelligence!
📅 15 October 2025
🕑 14 - 15:00 CEST
📍 online

Register using this link: events.teams.microsoft.com/event/1fba7a...

#oncology #MedSky #OncoSky

PANCAID @pancaid.bsky.social · 21d

🎙️Join us for the webinar “Approaches to Early Cancer Diagnosis & the Impact of #AIinOncology”
🗣️ Moderated by Federica Zanca, EIC Programme Manager
👥 Panelists:
@phireproject.bsky.social – Massimo Alfano
@pancaid.bsky.social – @nuriamalats.bsky.social
#PANCAIM – John Hermans

#Webinar

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Reposted by concentris research management gmbh

DECISION Horizon2020 @decision4liver.bsky.social · 8d

Next week: the final DECISION General Assembly in Madrid! 🎉
Celebrating 5+ years of science, collaboration, & results
@rautoupe.bsky.social @concentris.bsky.social
@navarrabiomed.bsky.social
@bioeticayderecho.bsky.social
@medblab.bsky.social
@europeliver.bsky.social
@easlnews.bsky.social et al

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Reposted by concentris research management gmbh

QSPainRelief EU Project @qspainrelief.bsky.social · 5d

✨Final spotlight of this series: Our open access protocol on a self-medication #MouseModel of #ChronicPain that helps assess spontaneous #PainRelief & #DrugAbuse liability

🔗 doi.org/10.21769/Bio...
Cabañero et al. (2022), co-authored by Beltrán Álvarez & Rafael Maldonado

#Neuroscience #Analgesics

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Reposted by concentris research management gmbh

QSPainRelief EU Project @qspainrelief.bsky.social · 5d

youtu.be/nIpZY5Msaec?...

Food addiction vulnerability in mice and humans and miRNA signatures

YouTube video by Journal of Clinical Investigation

youtu.be

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Reposted by concentris research management gmbh

QSPainRelief EU Project @qspainrelief.bsky.social · 5d

5️⃣ García-Blanco et al. (2002): www.jci.org/articles/vie...
📖 miRNA signatures associated with vulnerability to food addiction in mice & humans

💡Common #miRNA #signatures in mice & humans may underlie vulnerability to #FoodAddiction.
💡Targeting those miRNAs may modify maladaptive eating phenotypes.

JCI - miRNA signatures associated with vulnerability to food addiction in mice and humans

www.jci.org

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Reposted by concentris research management gmbh

QSPainRelief EU Project @qspainrelief.bsky.social · 5d

4️⃣ academic.oup.com/ismej/articl...
📖 Presence of #Blastocystis in #GutMicrobiota associated with decreased executive function

💡Blastocystis colonisation in the gut is associated with measurable deficits in executive #CognitiveFunction, suggesting a possible #GutBrainAxis influence on cognition.

Presence of Blastocystis in gut microbiota is associated with cognitive traits and decreased executive function

AbstractGrowing evidence implicates the gut microbiome in cognition. Blastocystis is a common gut single-cell eukaryote parasite frequently detected in hum

academic.oup.com

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Reposted by concentris research management gmbh

QSPainRelief EU Project @qspainrelief.bsky.social · 5d

3️⃣ doi.org/10.3389/fpsy...
📖 Tetrahydrocannabinol #THC exposure in #adolescence elevates #impulsivity-like behaviour in #adulthood in a self-administration mouse model

💡Young-age THC exposure may produce a lasting impulsivity increase & neurochemical changes that predispose to #AddictiveBehaviour.

Frontiers | THC exposure during adolescence increases impulsivity-like behavior in adulthood in a WIN 55,212-2 self-administration mouse model

Cannabis addiction is a chronically relapsing disorder lacking effective treatment. Regular cannabis consumption typically begins during adolescence, and thi...

doi.org

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Reposted by concentris research management gmbh

QSPainRelief EU Project @qspainrelief.bsky.social · 5d

1️⃣ Del Mar Cajiao-Manrique, Maldonado & Martín-García (2023) doi.org/10.3389/fpha...
📖 A self-administration mouse model to study #CannabinoidAddiction

💡This novel #MouseModel provides a rigorous tool to study #CannabinoidAddiction & the neurobiological mechanisms of #vulnerability vs. #resilience.

Frontiers | A male mouse model of WIN 55,212–2 self-administration to study cannabinoid addiction

We have established for the first time a mouse model of cannabinoid addiction using WIN 55,212-2 intravenous self-administration (0.0125 mg/kg/infusion) in C...

doi.org

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Reposted by concentris research management gmbh

QSPainRelief EU Project @qspainrelief.bsky.social · 5d

🧬🐭👩‍🦰👨‍🦰 Translational research - from mice to humans - was central to #QSPainRelief: For better #PainRelief, safer #PainMedication and improved #ChronicPain treatment.

✅ Less pain
😵‍💫 Fewer side effects
☺️ Better QoL

✨ Here are 5 key papers about 🧠-mechanisms linked to #addiction #cognition #impulsivity

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Reposted by concentris research management gmbh

QSPainRelief EU Project @qspainrelief.bsky.social · 5d

A more #PainRelief-relevant follow-up of the 2020 Sci. Rep. paper is this article by Ricarte, Dalton & Giraldo (2021), a year later:

🔗 doi.org/10.1021/acs....

🧬 Structural assessment of #agonist #efficacy at the μ-opioid receptor #MOR

👉 #morphine and #fentanyl elicit different activation patterns

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Reposted by concentris research management gmbh

QSPainRelief EU Project @qspainrelief.bsky.social · 5d

🔬 Wanna know the P-values for #agonist-dependent #GPCR activation?

👏 One of our 2 high-impact Nature publications was also the 1st QSPainRelief article:

📈 Bruzzese, Dalton & Giraldo (2020) present their #MolecularDynamics work & the best statistics to analyse it.

🔗 www.nature.com/articles/s41...

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Reposted by concentris research management gmbh

QSPainRelief EU Project @qspainrelief.bsky.social · 5d

Here's another important QSPainRelief publication about allosteric sites at #GPCRs: They can be identified by looking at how strongly certain receptor sites are coupled to #conformational changes that occur during activation.

🔗 doi.org/10.3390/ijms...

#allostery #pharmacology #receptors #ligands

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Reposted by concentris research management gmbh

QSPainRelief EU Project @qspainrelief.bsky.social · 5d

Speaking of #allostery: What happens when you mutate the #CannabinoidReceptor (CB1) in silico with a single-point mutation?

Find out👉: doi.org/10.1021/acso...

Spoiler😉: The F237L mutation mimics #allosteric #ligand effects, globally altering #receptor conformations and hindering activation

#GPCR

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Reposted by concentris research management gmbh

QSPainRelief EU Project @qspainrelief.bsky.social · 5d

🎯Feature Alert 🚨
This paper delves into how #BindingKinetics reshape our understanding of #allosteric modulation. When it comes to cooperativity effects, it's all about

👉 WHERE molecules bind
👉 HOW FAST
👉 and in WHICH SEQUENCE

🔗 doi.org/10.1016/j.dr...

#allostery #pharmacology #DrugDesign #GPCRs

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Reposted by concentris research management gmbh

QSPainRelief EU Project @qspainrelief.bsky.social · 5d

🚀 Time-dependent #ligand-receptor #BindingKinetics and functionality in a #heterodimeric receptor model by Ortiz et al. (2024): Predicting how 2 drugs bind to a receptor complex over time - with implications for combination-therapies and #DrugDesign💊

🔗 doi.org/10.1016/j.bc...

#Pharmacology #GPCRs

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Reposted by concentris research management gmbh

QSPainRelief EU Project @qspainrelief.bsky.social · 5d

🔦 Spotlight on link.springer.com/article/10.1...

🧠 Using the LeiCNS-PK3.0 PBPK model, they predicted mouse #brainECF #pharmacokinetics for 10 drugs

✅ Accurate for 7 drugs
✅ First mechanistic #CNS PBPK #model in mice
✅ Strong translational potential

#TranslationalPharmacology #DrugDevelopment

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Reposted by concentris research management gmbh

QSPainRelief EU Project @qspainrelief.bsky.social · 5d

The paper by Budda et al. (2024) relates to the earlier publication by Gülave et al. (2023): doi.org/10.1016/j.ej...

🧠The transport of #morphine across the #BBB is non-linear - this is important for #receptor #occupancy predictions. Find out how BBB dynamics inform smarter, safer dosing strategies!

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Reposted by concentris research management gmbh

QSPainRelief EU Project @qspainrelief.bsky.social · 5d

🧠 Non-linear blood-brain barrier #BBB transport & dosing influence #receptor #occupancy ratios of #morphine and #MorphineMetabolites (M3G + M6G) in the #pain matrix.

💡This might also explain some inter-individual differences!

🔗 bpspubs.onlinelibrary.wiley.com/doi/10.1111/...
#ChronicPain #opioids

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Reposted by concentris research management gmbh

QSPainRelief EU Project @qspainrelief.bsky.social · 6d

🔬By Bertayli et al (2024): PK-PD modelling of #morphine, #pregabalin & their combination shows synergistic #analgesia.

Potential impact:

👉 Lowering #opioid doses
👉 Maintaining treatment efficacy
👉 Reducing side effects & abuse liability

🔗 www.page-meeting.org/default.asp?...

#ChronicPain #Pain

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Reposted by concentris research management gmbh

QSPainRelief EU Project @qspainrelief.bsky.social · 6d

📖 Just published 💊

👉 Introducing a rigorous theoretical framework for better #quantification of #drug-target #ResidenceTime (RT) - a key metric in #BindingKinetics that has lacked a firm quantitative foundation to date 👏

🔗 www.sciencedirect.com/science/arti...

#Pharmacology #ComputationalBiology

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Reposted by concentris research management gmbh

QSPainRelief EU Project @qspainrelief.bsky.social · 6d

🧪 Our new paper on the #pharmacokinetics of P-glycoprotein substrates in #brainECF shows how #invitro transport data can guide #invivo 🧠🐭🚶‍♀️predictions, but that high variability still limits the robustness of these predictions.

🔗 link.springer.com/article/10.1...
👉LeiCNS-PK3.4 PBPK model #CNS #brain

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Reposted by concentris research management gmbh

QSPainRelief EU Project @qspainrelief.bsky.social · 6d

🫶 Our recent review shows that #SocialSupport is a powerful boost for #MentalHealth in #ChronicPain ⚡ , but its impact on pain intensity and daily function is less clear.

👉 Social support is crucial, but HOW matters

🔗 doi.org/10.1371/jour...

#QoL #PainResearch #Pain
@plosone.org @efic.bsky.social

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Reposted by concentris research management gmbh

QSPainRelief EU Project @qspainrelief.bsky.social · 7d

🧠 Predicting how well #drug molecules cross the blood-brain barrier: Gülave et al. built a #MachineLearning model for the unbound brain-to-plasma partition coefficient (98 compounds).
link.springer.com/article/10.1...

👉Best algorithm: Random Forest

💡Great for #CNS drug discovery!

#BBB #PBPK #ML

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Reposted by concentris research management gmbh

QSPainRelief EU Project @qspainrelief.bsky.social · 8d

💊 Morphine is a P-glycoprotein substrate, but do P-gp inhibitors meaningfully change #CNS exposure?

🧠 Likely not: A physiology-based pharmacokinetic #PBPK model predicts negligible impact across populations.

#BBB #DrugInteractions #morphine #modelling #brain

🔗 link.springer.com/article/10.1...

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