Deepanshu Singh
@deepanshund.bsky.social
Post-Doc researcher at University of Manchester
Drosophila neurobiology, Alternative splicing, Sex-peptide and Infection
Drosophila neurobiology, Alternative splicing, Sex-peptide and Infection
Pinned
Deepanshu Singh
@deepanshund.bsky.social
· Feb 14
Toll-1-dependent immune evasion induced by fungal infection leads to cell loss in the Drosophila brain
This study identifies a new step in the evolutionary arms race between host and fungus in the Drosophila brain. The fungus B. bassiana exploits the Toll-1 host response to activate the MyD88 inhibitor...
journals.plos.org
🚨 Our paper out in @plosbiology.org! A fungal pathogen hijacks #immune receptor to drive immune evasion and cause #neurodegeneration in the brain. Thanks to the incredible @aliciahidalgolab.bsky.social, our amazing collaborators and the funding from DarwinTrust, @wellcometrust.bsky.social & BBSRC.
It was a pleasure to host Dr Ines Hahn (University of York) @exdrososcientia.bsky.social for the Manchester Fly Club, where she delivered a fantastic talk on GSK-3β’s role in organising microtubules and maintaining mitochondrial homeostasis. #FlySeminar #ManchesterFlyClub
November 17, 2025 at 2:39 PM
It was a pleasure to host Dr Ines Hahn (University of York) @exdrososcientia.bsky.social for the Manchester Fly Club, where she delivered a fantastic talk on GSK-3β’s role in organising microtubules and maintaining mitochondrial homeostasis. #FlySeminar #ManchesterFlyClub
Reposted by Deepanshu Singh
Published in the summer holidays: Roles for TET in speckles. Thanks @cardosolab.bsky.social @deepanshund.bsky.social @roliarnold.bsky.social and the others for this exciting collaboration.
www.tandfonline.com/doi/10.1080/...
www.tandfonline.com/doi/10.1080/...
TET dioxygenases localize at splicing speckles and promote RNA splicing
The dynamic regulation of RNA metabolism plays a crucial part in cellular function, with emerging evidence suggesting an important role for RNA modifications in this process. This study explores th...
www.tandfonline.com
September 12, 2025 at 7:33 AM
Published in the summer holidays: Roles for TET in speckles. Thanks @cardosolab.bsky.social @deepanshund.bsky.social @roliarnold.bsky.social and the others for this exciting collaboration.
www.tandfonline.com/doi/10.1080/...
www.tandfonline.com/doi/10.1080/...
Reposted by Deepanshu Singh
Many conserved exons in the heart and brain utilize weak 5 ′ splice sites, yet they are accurately spliced. But how? We show that splicing fidelity is actively enforced through a QKI-U6 checkpoint at the U1→U6 handover in essential cardiac genes during organogenesis.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
QKI ensures splicing fidelity during cardiogenesis by engaging the U6 tri-snRNP to activate splicing at weak 5ʹ splice sites
During organogenesis, precise pre-mRNA splicing is essential to assemble tissue architecture. Many developmentally essential exons bear weak 5'splice sites (5'SS) yet are spliced with high precision, ...
www.biorxiv.org
September 8, 2025 at 6:12 AM
Many conserved exons in the heart and brain utilize weak 5 ′ splice sites, yet they are accurately spliced. But how? We show that splicing fidelity is actively enforced through a QKI-U6 checkpoint at the U1→U6 handover in essential cardiac genes during organogenesis.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Deepanshu Singh
New preprint - varied routes to ⬆️ infection susceptibility over age - via bona fide immunosenescence, but also often via reduced tolerance 🪰🕰️🦠☠️
⬆️ risk to die from infection predicts lifespan in males. Great group effort from the lab!
www.biorxiv.org/content/10.1...
⬆️ risk to die from infection predicts lifespan in males. Great group effort from the lab!
www.biorxiv.org/content/10.1...
Different ways to die: harnessing variation in Drosophila reveals loss of tolerance and resistance over age and sex-specific association between infection susceptibility and lifespan
It is widely accepted that susceptibility to infection increases with age. The reason often invoked is the dysregulation of the immune system, which is both cause and consequence of ageing. However, w...
www.biorxiv.org
July 11, 2025 at 2:02 PM
New preprint - varied routes to ⬆️ infection susceptibility over age - via bona fide immunosenescence, but also often via reduced tolerance 🪰🕰️🦠☠️
⬆️ risk to die from infection predicts lifespan in males. Great group effort from the lab!
www.biorxiv.org/content/10.1...
⬆️ risk to die from infection predicts lifespan in males. Great group effort from the lab!
www.biorxiv.org/content/10.1...
Engaging young minds with tiny flies!
Fantastic outreach session introducing Drosophila as a model to explore brain, behaviour, and disease.
Big thanks to Sanjai Patel for organizing the event and @rituparna-uom24.bsky.social @matthiassoller.bsky.social
#FlyLab #Drosophila #Outreach
Fantastic outreach session introducing Drosophila as a model to explore brain, behaviour, and disease.
Big thanks to Sanjai Patel for organizing the event and @rituparna-uom24.bsky.social @matthiassoller.bsky.social
#FlyLab #Drosophila #Outreach
July 4, 2025 at 10:08 AM
Engaging young minds with tiny flies!
Fantastic outreach session introducing Drosophila as a model to explore brain, behaviour, and disease.
Big thanks to Sanjai Patel for organizing the event and @rituparna-uom24.bsky.social @matthiassoller.bsky.social
#FlyLab #Drosophila #Outreach
Fantastic outreach session introducing Drosophila as a model to explore brain, behaviour, and disease.
Big thanks to Sanjai Patel for organizing the event and @rituparna-uom24.bsky.social @matthiassoller.bsky.social
#FlyLab #Drosophila #Outreach
Reposted by Deepanshu Singh
We're hiring! Two exciting opportunities in our Lab @unibirmingham.bsky.social
Come work with us on decision-making and neural circuits in Drosophila. Please share!
Senior Research Technician + Postdoctoral Research Fellow
Deadline: 10 July
More info here: www.rezavallab.org
Come work with us on decision-making and neural circuits in Drosophila. Please share!
Senior Research Technician + Postdoctoral Research Fellow
Deadline: 10 July
More info here: www.rezavallab.org
June 26, 2025 at 10:34 AM
We're hiring! Two exciting opportunities in our Lab @unibirmingham.bsky.social
Come work with us on decision-making and neural circuits in Drosophila. Please share!
Senior Research Technician + Postdoctoral Research Fellow
Deadline: 10 July
More info here: www.rezavallab.org
Come work with us on decision-making and neural circuits in Drosophila. Please share!
Senior Research Technician + Postdoctoral Research Fellow
Deadline: 10 July
More info here: www.rezavallab.org
Big thanks to @clarahowcroft.bsky.social y.social, @toraks.bsky.social ks.bsky.social, @dpdoupe.bsky.social for organising the first NE Fly Meeting! It was inspiring to see the Northern Drosophila community come together with such warmth and energy. Here’s to more science, support, and shared ideas!
June 23, 2025 at 2:08 PM
Big thanks to @clarahowcroft.bsky.social y.social, @toraks.bsky.social ks.bsky.social, @dpdoupe.bsky.social for organising the first NE Fly Meeting! It was inspiring to see the Northern Drosophila community come together with such warmth and energy. Here’s to more science, support, and shared ideas!
A post-meeting hub for North England Drosophilists — to share, connect, and collaborate beyond the room. Please share and add more people to this starter pack.
go.bsky.app/KJXNZVg
go.bsky.app/KJXNZVg
June 23, 2025 at 1:56 PM
A post-meeting hub for North England Drosophilists — to share, connect, and collaborate beyond the room. Please share and add more people to this starter pack.
go.bsky.app/KJXNZVg
go.bsky.app/KJXNZVg
Reposted by Deepanshu Singh
New insights into alternative splicing of ever fascinating Down syndrome Cell Adhesion Molecule in Drosophila and honey bees thanks to @annalassota.bsky.social and T.C.Dix.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Stochastic splicing and deterministic inclusion of exon variables promote diversification of Down Syndrome Cell Adhesion Molecule expression
Mutually alternative splicing in Down Syndrome Cell Adhesion Molecule ( Dscam ) gene of arthropods generates extraordinary molecular diversity producing tens of thousands of isoforms. From three clust...
www.biorxiv.org
May 27, 2025 at 8:09 AM
New insights into alternative splicing of ever fascinating Down syndrome Cell Adhesion Molecule in Drosophila and honey bees thanks to @annalassota.bsky.social and T.C.Dix.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Honoured to be invited for a talk at IISER Tirupati! Grateful for the warm welcome — it was a real pleasure catching up with the brilliant faculty and curious minds of IISER. Until next time! 🍄🧬🐞
May 29, 2025 at 6:31 AM
Honoured to be invited for a talk at IISER Tirupati! Grateful for the warm welcome — it was a real pleasure catching up with the brilliant faculty and curious minds of IISER. Until next time! 🍄🧬🐞
Reposted by Deepanshu Singh
Here's the link to our latest review, emphasizing the tools required to dig into the RNA world in the brain.
doi.org/10.1016/j.nl...
doi.org/10.1016/j.nl...
Redirecting
doi.org
March 29, 2025 at 12:54 AM
Here's the link to our latest review, emphasizing the tools required to dig into the RNA world in the brain.
doi.org/10.1016/j.nl...
doi.org/10.1016/j.nl...
Reposted by Deepanshu Singh
We paid ~£80 to validate our CRISPR edit - still a good price.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
March 23, 2025 at 9:50 AM
We paid ~£80 to validate our CRISPR edit - still a good price.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Deepanshu Singh
Male quality assessment: Venerose seminal fluid sugar sensed by female brain neurons after mating. See our comment thanks to @deepanshund.bsky.social about an exiting story from the Young-Joon Kim lab.
www.tandfonline.com/doi/epdf/10....
www.tandfonline.com/doi/epdf/10....
Venerose: a nuptial gift with implications
www.tandfonline.com
March 10, 2025 at 7:54 AM
Male quality assessment: Venerose seminal fluid sugar sensed by female brain neurons after mating. See our comment thanks to @deepanshund.bsky.social about an exiting story from the Young-Joon Kim lab.
www.tandfonline.com/doi/epdf/10....
www.tandfonline.com/doi/epdf/10....
Reposted by Deepanshu Singh
Fungus on the brain. @deepanshund.bsky.social @aliciahidalgolab.bsky.social &co show that the #fungus Beauveria bassiana exploits the Toll-1 host response to activate the MyD88 inhibitor Sarm, enabling immune evasion and triggering #neurodegeneration in #Drosophila 🧪 @plosbiology.org plos.io/3EIxgZN
February 17, 2025 at 10:16 AM
Fungus on the brain. @deepanshund.bsky.social @aliciahidalgolab.bsky.social &co show that the #fungus Beauveria bassiana exploits the Toll-1 host response to activate the MyD88 inhibitor Sarm, enabling immune evasion and triggering #neurodegeneration in #Drosophila 🧪 @plosbiology.org plos.io/3EIxgZN
🚨 Our paper out in @plosbiology.org! A fungal pathogen hijacks #immune receptor to drive immune evasion and cause #neurodegeneration in the brain. Thanks to the incredible @aliciahidalgolab.bsky.social, our amazing collaborators and the funding from DarwinTrust, @wellcometrust.bsky.social & BBSRC.
Toll-1-dependent immune evasion induced by fungal infection leads to cell loss in the Drosophila brain
This study identifies a new step in the evolutionary arms race between host and fungus in the Drosophila brain. The fungus B. bassiana exploits the Toll-1 host response to activate the MyD88 inhibitor...
journals.plos.org
February 14, 2025 at 11:42 AM
🚨 Our paper out in @plosbiology.org! A fungal pathogen hijacks #immune receptor to drive immune evasion and cause #neurodegeneration in the brain. Thanks to the incredible @aliciahidalgolab.bsky.social, our amazing collaborators and the funding from DarwinTrust, @wellcometrust.bsky.social & BBSRC.
Reposted by Deepanshu Singh
Thrilled to see our paper out today @plosbiology.org! By wonderful PhD student @deepanshund.bsky.social & great team of collaborating authors. Fungi hack immune receptor to drive immune evasion in the brain & cause neurodegeration. Thanx DarwinTrust @wellcometrust.bsky.social @BBSRC for funding. 😃
Toll-1-dependent immune evasion induced by fungal infection leads to cell loss in the Drosophila brain
This study identifies a new step in the evolutionary arms race between host and fungus in the Drosophila brain. The fungus B. bassiana exploits the Toll-1 host response to activate the MyD88 inhibitor...
journals.plos.org
February 13, 2025 at 9:27 PM
Thrilled to see our paper out today @plosbiology.org! By wonderful PhD student @deepanshund.bsky.social & great team of collaborating authors. Fungi hack immune receptor to drive immune evasion in the brain & cause neurodegeration. Thanx DarwinTrust @wellcometrust.bsky.social @BBSRC for funding. 😃
Reposted by Deepanshu Singh
Doing CRISPR: Check out our PlatinumCRISPr server update now including Cas12a sgRNA selection, thanks to @roliarnold.bsky.social
February 1, 2025 at 6:09 PM
Doing CRISPR: Check out our PlatinumCRISPr server update now including Cas12a sgRNA selection, thanks to @roliarnold.bsky.social
Reposted by Deepanshu Singh
Or what about the #Drosophila computer game? Loads of stuff that I almost forgot about: scratch.mit.edu/projects/744...
January 15, 2025 at 4:01 PM
Or what about the #Drosophila computer game? Loads of stuff that I almost forgot about: scratch.mit.edu/projects/744...
Reposted by Deepanshu Singh
New preprint from @haraipapilio.bsky.social with @bolinabug.bsky.social @daisukekageyama.bsky.social and others not on bluesky #symbiosky www.biorxiv.org/content/10.1...
Evolution of Wolbachia male-killing mechanism within a host species
Male-killing bacterial symbionts, prevalent in arthropods, skew population sex ratios by selectively killing male progeny, profoundly impacting ecology and evolution of their hosts. Male-killing is a ...
www.biorxiv.org
January 15, 2025 at 12:01 PM
New preprint from @haraipapilio.bsky.social with @bolinabug.bsky.social @daisukekageyama.bsky.social and others not on bluesky #symbiosky www.biorxiv.org/content/10.1...
Reposted by Deepanshu Singh
Reposted by Deepanshu Singh
Excited to see our new gut hormone paper in @naturecomms.bsky.social in collaboration with our alumnus Dr. Yuto Yoshinari (Gunma Univ.) and others!
A high-protein diet-responsive gut hormone regulates behavioral and metabolic optimization in Drosophila melanogaster.
www.nature.com/articles/s41...
A high-protein diet-responsive gut hormone regulates behavioral and metabolic optimization in Drosophila melanogaster.
www.nature.com/articles/s41...
A high-protein diet-responsive gut hormone regulates behavioral and metabolic optimization in Drosophila melanogaster - Nature Communications
Organisms regulate their feeding behavior to prevent overconsumption of certain nutrients. Here, the authors identify the importance of gut hormones in suppressing protein overfeeding.
www.nature.com
January 10, 2025 at 6:54 AM
Excited to see our new gut hormone paper in @naturecomms.bsky.social in collaboration with our alumnus Dr. Yuto Yoshinari (Gunma Univ.) and others!
A high-protein diet-responsive gut hormone regulates behavioral and metabolic optimization in Drosophila melanogaster.
www.nature.com/articles/s41...
A high-protein diet-responsive gut hormone regulates behavioral and metabolic optimization in Drosophila melanogaster.
www.nature.com/articles/s41...
What an engaging talk by Fiona Whelan @whelanfj.bsky.social , who recently moved her group to Manchester from Nottingham! Thank you all for attending the session and contributing to such an interesting discussion. @mcf-uom.bsky.social @official-uom.bsky.social #manchesterflyclub
January 9, 2025 at 2:39 PM
What an engaging talk by Fiona Whelan @whelanfj.bsky.social , who recently moved her group to Manchester from Nottingham! Thank you all for attending the session and contributing to such an interesting discussion. @mcf-uom.bsky.social @official-uom.bsky.social #manchesterflyclub
Excited to share our new paper on molecular mechanism for circuit structural plasticity in the Drosophila adult brain. Congratulations @aliciahidalgolab.bsky.social and the amazing postdocs Dr. Jun Sun, Dr. Fran Rojo-Cortes & all contributing authors. doi.org/10.7554/eLif... doi.org/10.7554/eLif...
A neurotrophin functioning with a Toll regulates structural plasticity in a dopaminergic circuit
A novel molecular mechanism linking a neurotrophin with a Toll-family and kinase-less Trk-like receptors provides a direct link from molecules to structural circuit plasticity and modification of beha...
doi.org
December 22, 2024 at 2:03 PM
Excited to share our new paper on molecular mechanism for circuit structural plasticity in the Drosophila adult brain. Congratulations @aliciahidalgolab.bsky.social and the amazing postdocs Dr. Jun Sun, Dr. Fran Rojo-Cortes & all contributing authors. doi.org/10.7554/eLif... doi.org/10.7554/eLif...
Incredible energy at the 7th Insect Reproductive Molecules Meeting at Rydal Hall! 🚀 Huge thanks to Prof. Matthias Soller @matthiassoller.bsky.social and Prof. Tracey Chapmen for co-organizing and @gensocuk.bsky.social for the funding. 🧬✨ #InsectReproduction #lakedistrict #RydalHall
December 10, 2024 at 6:49 AM
Incredible energy at the 7th Insect Reproductive Molecules Meeting at Rydal Hall! 🚀 Huge thanks to Prof. Matthias Soller @matthiassoller.bsky.social and Prof. Tracey Chapmen for co-organizing and @gensocuk.bsky.social for the funding. 🧬✨ #InsectReproduction #lakedistrict #RydalHall
Reposted by Deepanshu Singh
Fantastic talks at the 7th Insect Reproductive Molecules Meeting at Rydal Hall. Thanks to Tracey Chapman @deepanshund.bsky.social for co-organizing and @gensocuk.bsky.social for support.
December 9, 2024 at 8:50 PM
Fantastic talks at the 7th Insect Reproductive Molecules Meeting at Rydal Hall. Thanks to Tracey Chapman @deepanshund.bsky.social for co-organizing and @gensocuk.bsky.social for support.