Deepanshu Singh
@deepanshund.bsky.social
160 followers
400 following
9 posts
Post-Doc researcher at University of Manchester
Drosophila neurobiology, Alternative splicing, Sex-peptide and Infection
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Deepanshu Singh
@deepanshund.bsky.social
· Feb 14
Toll-1-dependent immune evasion induced by fungal infection leads to cell loss in the Drosophila brain
This study identifies a new step in the evolutionary arms race between host and fungus in the Drosophila brain. The fungus B. bassiana exploits the Toll-1 host response to activate the MyD88 inhibitor...
journals.plos.org
Reposted by Deepanshu Singh
Kurianlab
@kurianlab.bsky.social
· Sep 8
QKI ensures splicing fidelity during cardiogenesis by engaging the U6 tri-snRNP to activate splicing at weak 5ʹ splice sites
During organogenesis, precise pre-mRNA splicing is essential to assemble tissue architecture. Many developmentally essential exons bear weak 5'splice sites (5'SS) yet are spliced with high precision, ...
www.biorxiv.org
Reposted by Deepanshu Singh
Jenny Regan
@jennyregan.bsky.social
· Jul 11
Different ways to die: harnessing variation in Drosophila reveals loss of tolerance and resistance over age and sex-specific association between infection susceptibility and lifespan
It is widely accepted that susceptibility to infection increases with age. The reason often invoked is the dysregulation of the immune system, which is both cause and consequence of ageing. However, w...
www.biorxiv.org
Deepanshu Singh
@deepanshund.bsky.social
· Jul 10
Reposted by Deepanshu Singh
Deepanshu Singh
@deepanshund.bsky.social
· Jun 23
Reposted by Deepanshu Singh
Reposted by Deepanshu Singh
Reposted by Deepanshu Singh
Reposted by Deepanshu Singh
Deepanshu Singh
@deepanshund.bsky.social
· Feb 14
Toll-1-dependent immune evasion induced by fungal infection leads to cell loss in the Drosophila brain
This study identifies a new step in the evolutionary arms race between host and fungus in the Drosophila brain. The fungus B. bassiana exploits the Toll-1 host response to activate the MyD88 inhibitor...
journals.plos.org
Reposted by Deepanshu Singh
Reposted by Deepanshu Singh
Reposted by Deepanshu Singh
Greg Hurst
@greghurst.bsky.social
· Jan 15
Evolution of Wolbachia male-killing mechanism within a host species
Male-killing bacterial symbionts, prevalent in arthropods, skew population sex ratios by selectively killing male progeny, profoundly impacting ecology and evolution of their hosts. Male-killing is a ...
www.biorxiv.org
Reposted by Deepanshu Singh
Kurianlab
@kurianlab.bsky.social
· Jan 14
Structural basis of 5′ splice site recognition by the minor spliceosome
Zhao et al. present two cryo-EM structures of apo and substrate-bound U11 snRNP complexes,
elucidating their architecture and the mechanism of the U12-type 5′ splice site recognition.
The unique struc...
www.cell.com
Reposted by Deepanshu Singh
Ryusuke Niwa
@ryuniwa.bsky.social
· Jan 10
A high-protein diet-responsive gut hormone regulates behavioral and metabolic optimization in Drosophila melanogaster - Nature Communications
Organisms regulate their feeding behavior to prevent overconsumption of certain nutrients. Here, the authors identify the importance of gut hormones in suppressing protein overfeeding.
www.nature.com
Deepanshu Singh
@deepanshund.bsky.social
· Dec 22
A neurotrophin functioning with a Toll regulates structural plasticity in a dopaminergic circuit
A novel molecular mechanism linking a neurotrophin with a Toll-family and kinase-less Trk-like receptors provides a direct link from molecules to structural circuit plasticity and modification of beha...
doi.org
Reposted by Deepanshu Singh
