Defne Büyükyazgan
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defneb.bsky.social
Defne Büyükyazgan
@defneb.bsky.social
neuro phd student @Brown // Desrochers Lab
studying how cells code primitives of sequences and generalize & relationships between the BOLD signal and LFPs
non-science things:📚💃🏽🏋🏻‍♀️🎾
uchicago’22 🇹🇷
Reposted by Defne Büyükyazgan
I've written two @nature.com stories this week looking at whether EU efforts to lure US scientists are working 🧪

They are: the number of US applicants wanting to take up ERC grants has doubled. www.nature.com/articles/d41...
US applications for prestigious European research grants surge
Rush for funds to relocate laboratories to Europe is latest sign of a US brain drain.
www.nature.com
February 12, 2026 at 10:04 AM
Reposted by Defne Büyükyazgan
As promised: a detailed figure-by-figure thread on our @pnas.org paper:

doi.org/10.1073/pnas...

We use signal correlations and noise correlations in chronic imaging data to show that representational drift is shaped by a balance between Hebbian and stochastic changes.

Let’s dive in 👇

🧠🧪 1/9
February 13, 2026 at 3:10 PM
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Thrilled that my paper is out in the @nature.com. We explored how the brain builds complex tasks by compositionally combining simpler sub-task representations. The brain flexibly performs multiple tasks by dynamically reusing neural subspaces for sensory inputs and motor actions

rdcu.be/eRVUk
Building compositional tasks with shared neural subspaces
Nature - The brain can flexibly perform multiple tasks by compositionally combining task-relevant neural representations.
rdcu.be
February 11, 2026 at 10:40 PM
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Iranians are experiencing a collective trauma. Thousands have been killed/injured in recent events, the economy is crippled & the threat of a wider conflict is real. This is especially difficult for those living in Iran, as many have lost (or fear losing) loved ones. www.nature.com/articles/d41...
February 3, 2026 at 2:11 PM
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Hey y’all! My institute started a new set of training programs for people interested in careers in the neurotech space.

Spread the word!
The Master of Science in Neural Technologies (MiNT) – jointly offered by CMU's Neuroscience Institute and the Department of Biomedical Engineering — places students at the edge of a fast-moving field where neuroscience meets engineering and AI.

www.cmu.edu/ni/news-even...
CMU Offers New Master's in Neural Technologies
www.cmu.edu
January 20, 2026 at 4:34 PM
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If you'd like to study Computational Neuroscience in Berlin, don't miss this info event on Wednesday! 👉 bit.ly/4aX4Yc8 #CompNeuro #BernsteinNetwork
Information Day 2026 - "International Graduate Program(s) Computational Neuroscience" - BCCN
When: January 14th, 2026, 15:00-18:00 CET Where: BCCN Berlin Lecture Hall (Philippstr. 12, Haus 6, 10115 Berlin) & Live-streamed via Zoom Registration: Registration will open in December 2026.…
bit.ly
January 12, 2026 at 4:15 PM
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very excited to share some of the final bits of work from my PhD! 🎉 we find that phasic DA in the accumbens simultaneously tracks persistent motivation towards reward cues in addition to new learning (but maybe not RPE?!) in sign-tracking rats. check out the preprint below!
Phasic dopamine encodes persistent attraction to reward cues https://www.biorxiv.org/content/10.64898/2025.12.09.693300v1
December 12, 2025 at 6:29 PM
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paper🚨
When we learn a category, do we learn the structure of the world, or just where to draw the line? In a cross-species study, we show that humans, rats & mice adapt optimally to changing sensory statistics, yet rely on fundamentally different learning algorithms.
www.biorxiv.org/content/10.1...
Different learning algorithms achieve shared optimal outcomes in humans, rats, and mice
Animals must exploit environmental regularities to make adaptive decisions, yet the learning algorithms that enabels this flexibility remain unclear. A central question across neuroscience, cognitive science, and machine learning, is whether learning relies on generative or discriminative strategies. Generative learners build internal models the sensory world itself, capturing its statistical structure; discriminative learners map stimuli directly onto choices, ignoring input statistics. These strategies rely on fundamentally different internal representations and entail distinct computational trade-offs: generative learning supports flexible generalisation and transfer, whereas discriminative learning is efficient but task-specific. We compared humans, rats, and mice performing the same auditory categorisation task, where category boundaries and rewards were fixed but sensory statistics varied. All species adapted their behaviour near-optimally, consistent with a normative observer constrained by sensory and decision noise. Yet their underlying algorithms diverged: humans predominantly relied on generative representations, mice on discriminative boundary-tracking, and rats spanned both regimes. Crucially, end-point performance concealed these differences, only learning trajectories and trial-to-trial updates revealed the divergence. These results show that similar near-optimal behaviour can mask fundamentally different internal representations, establishing a comparative framework for uncovering the hidden strategies that support statistical learning. ### Competing Interest Statement The authors have declared no competing interest. Wellcome Trust, https://ror.org/029chgv08, 219880/Z/19/Z, 225438/Z/22/Z, 219627/Z/19/Z Gatsby Charitable Foundation, GAT3755 UK Research and Innovation, https://ror.org/001aqnf71, EP/Z000599/1
www.biorxiv.org
November 17, 2025 at 7:18 PM
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Good morning #SfN25! Looking for some posters to see this afternoon? Check out two by our lab: GG15 and HH1 🧠🧪👩🏻‍🔬
November 16, 2025 at 5:26 PM
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Chand lab is at SfN! (And I’m looking for postdocs on cells types and dynamics; reach out if you want to chat!)
November 15, 2025 at 3:40 PM
The best (and only) uni merch I have ever purchased in my life 🦴
November 14, 2025 at 9:56 PM
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A sad day for Neuroscience in the Netherlands.
October 30, 2025 at 11:56 PM
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I'm recruiting PhD students for my lab at Northwestern! I'm reviewing applications for the Department of Psychology for the Cognitive Affective Neuroscience and Clinical areas, due 12/1. 🧠

Come join the CATS Lab: nucatslab.com

Learn about our latest research: iamh.northwestern.edu/research/res...
CATS Lab
Child & Adolescent Translational Science Lab at Northwestern University
nucatslab.com
October 29, 2025 at 6:39 PM
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Between October 13-17th we ran the second edition of Ibn Sina Neurotech School hosted and sponsored by NYUAD Center for Brain and Health and @ibroorg.bsky.social
We welcomed 18 students from across the world to learn hands-on about fMRI data collection and processing
October 26, 2025 at 9:06 PM
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Current trends in European Research funding... 😵‍💫 erc.europa.eu/news-events/...
October 23, 2025 at 1:24 PM
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Six of the nine Nobel Prize winners this year work in the U.S.
Three of the six were born outside the U.S., which is the pattern most years. No country has benefited more from welcoming immigrants from around the world.
www.nobelprize.org
The official website of the Nobel Prize - NobelPrize.org
The Nobel Prize rewards science, humanism and peace efforts. This is one of the central concepts in the will of Alfred Nobel, and it also permeates the outreach activities that have been developed for...
www.nobelprize.org
October 8, 2025 at 12:37 PM
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🚨ATTN: Prospective Psych & Neuro doctoral students 🚨
Sign-up for the @BostonCollege Pre-Doctoral Mentorship Program (PDMP) for one-on-one mentorship to psychology & neuroscience doctoral programs. Sign-up ASAP, deadline 11/15. See the link in the flyer.
September 18, 2025 at 7:45 PM
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This rule would have meant I couldn't do my Ph.D. in America.

I did do it in America. Became a professor. 12 thriving U.S. labs are now headed by trainees from my research lab. Like me, they are all working hard to enrich American knowledge and society.

With this self-harming rule, none of that.
Trump admin planning to change student visas from lasting for duration of academic program to fixed 4-yr term, and then much harder to renew
Could destroy US ability to attract global talent, particularly those seeking advanced degrees in STEM. The median time to complete a PhD is 5.7 yrs per NSF.
Trump Deals A New Immigration Blow To International Students
Trump officials have proposed a new rule limiting international students to fixed periods of entry, making a U.S. education more precarious.
www.forbes.com
August 29, 2025 at 11:48 PM
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Congratulations to all ERC @erc.europa.eu #STG winners @tum.de and around Europe! 🎉👏🏻🧪 Can’t wait to hear about the exciting science you will all be doing!
September 4, 2025 at 11:53 AM
found this old intergenerational notebook while I was packing at home. probably from covid times. eventually one of us is becoming a scientist 👩🏽‍🔬 and the other one is already a banker 👩🏽‍💻. #womeninSTEM #womeninfinance
September 2, 2025 at 10:06 AM
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I can't quite believe it – I got a new NSF grant! 😲🤯

I'm incredibly grateful to the program officers & reviewers for their dedication and efforts to keep science going 🌟👏🏼

So, I'll be hiring! Looking for a postdoc to study competition in memory-guided attention. See flyer for details! 🎉
August 22, 2025 at 6:04 PM
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Support a student to attend #ISNeurotech25
We are looking to support ten more students to attend the Ibn Sina Neurotech school to learn all about fMRI and brain science
www.zeffy.com/en-CA/donati...
August 18, 2025 at 2:44 PM
that time of the year when this is how your email finds me 🏡🌊
August 18, 2025 at 10:07 PM
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presented my first data blitz on our MDMA-assisted therapy work at the first new england addiction neuroscience (NEAN) research conference, hosted at brown. thanks to the organizers for the opportunity! @karlakaun.bsky.social
August 15, 2025 at 9:48 PM
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The rumors are true! #CCN2026 will be held at NYU. @toddgureckis.bsky.social and I will be executive-chairing. Get in touch if you want to be involved!
August 15, 2025 at 4:43 PM