Daan de Groot
@dhdegroot.bsky.social
120 followers 70 following 7 posts
Postdoc at Biozentrum in Basel. How do single cells decide what to become? What to do? When? Where? In fact, how do humans?
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dhdegroot.bsky.social
Bonsai is out! Finally, we can visually explore high-dimensional data in a distortion-free way. Try it out! It works from scRNA-seq data (bonsai.unibas.ch/bonsai-scout...) up to football statistics (bonsai.unibas.ch/bonsai-scout...). 
Ever wondered why low-dimensional embeddings like t-SNE
Reposted by Daan de Groot
erikvannimwegen.bsky.social
Are you excited to pursue your own research interests and contribute to our group’s experimental research in the quantitative biology of microbes? We have an opening for a potentially permanent position as research associate.
Please repost and notify potential candidates!
biozentrum.unibas.ch
Research Associate (100%)
Starting from 1 November 2025 or as per agreement

Group @erikvannimwegen.bsky.social

@biozentrum.unibas.ch
@unibas.ch

www.biozentrum.unibas.ch/open-positio...

#job #research #biology #microbiology #science #basel #recruiting #career
Reposted by Daan de Groot
dhdegroot.bsky.social
Let us know what you think after reading everything!
dhdegroot.bsky.social
I'm surprised you're the first to make this joke. Congrats
dhdegroot.bsky.social
Oh yes, and check out my debut as a failed YouTuber. I'm really much more excited about this than I sound in the video, because look how nice our Bonsai-scout app actually works to explore the data!
erikvannimwegen.bsky.social
Bonsai-scout allows different layouts, zooming in
and out on areas, visualizing gene expression or annotations on the tree, finding 'clusters' (well-separated clades), and finding marker genes that distinguish any pair of clades. Check out our tutorial videos!
www.youtube.com/watch?v=TE7T...
Bonsai-scout: Highlights
YouTube video by ISMARA: inferring gene regulatory interactions
www.youtube.com
dhdegroot.bsky.social
Represent the data by a tree structure! That’s the idea that @erikvannimwegen.bsky.social‬ proposed 3 years ago, and what we’ve been working on ever since. It came with many theoretical and computational challenges, but now I’m confident that we’ve created something truly worthwhile.
dhdegroot.bsky.social
and UMAP are so popular, even though everyone agrees they severely mess up your data? It's because there was nothing better, and some data, just demand a visual tool for exploration. Indeed, it’s hard to beat UMAP in the low-dimensional embedding game, unless you just change the game:
dhdegroot.bsky.social
Bonsai is out! Finally, we can visually explore high-dimensional data in a distortion-free way. Try it out! It works from scRNA-seq data (bonsai.unibas.ch/bonsai-scout...) up to football statistics (bonsai.unibas.ch/bonsai-scout...). 
Ever wondered why low-dimensional embeddings like t-SNE
dhdegroot.bsky.social
New publication! We identify growth coupled sensitivity: a deceivingly simple mechanism that makes E. coli switch to the best sugar. We combined neat theory (due to @erikvannimwegen.bsky.social, and to which I contributed) with clean experiments (due to @thomasjulou.bsky.social and Theo Gervais).
erikvannimwegen.bsky.social
The most profound insights are often also the most simple:
growth-rate, by setting the dilution rate of intra-cellular molecules, controls the sensitivity of gene regulatory circuits. In retrospect it seems crazy that this effect seems to have been overlooked so far.
www.science.org/doi/10.1126/...
Growth rate controls the sensitivity of gene regulatory circuits
Through the simple effect of dilution rate, regulatory circuits systematically change their sensitivity with growth rate.
www.science.org
Reposted by Daan de Groot
neher.io
Um die grossen Herausforderungen unserer Zeit (KI, Klimawandel, Pandemien, etc) richtig beurteilen zu können, brauchen wir fundierten Wissenschaftsjournalismus.

Es ist ein Fehler, dass #SRF ausgerechnet hier spart.

bajour.ch/a/die-srf-sp...
Sparmassnahmen treffen SRF Standort in Basel
SRF streicht Formate in den Bereichen Kultur und Wissenschaft. Das wird auch der Standort in Basel zu spüren bekommen. Bei Politiker*innen und in der Bajour-Community lösen die jüngst angekündigten Ma...
bajour.ch
Reposted by Daan de Groot
mmolari.bsky.social
Thrilled to announce that our work (w. with fantastic @neher.io and Liam Shaw) has been published on Molecular Biology and Evolution! 🎉

academic.oup.com/mbe/advance-...

Are you curious about how fast the genome of E.coli evolves structurally (gains, rearrangements...) ? 🧬

A summary thread [1/N]🧵
Quantifying the evolutionary dynamics of structure and content in closely-related E. coli genomes
Abstract. Bacterial genomes primarily diversify via gain, loss, and rearrangement of genetic material in their flexible accessory genome. Yet the dynamics
academic.oup.com