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Differentiation Journal @diffjournal.bsky.social · 13d

“Inhibition of Atg13-mediated autophagy enhances the anti-osteoclastogenic effect of sirolimus by counteracting its pro-autophagic activity,” by Tingwei Gao et al.: doi.org/10.1016/j.di...

Fig. 7. Atg13 knockdown in vivo enhanced the role of sirolimus in alleviating bone loss in OVX mice. OVX-operated female mice were treated with sirolimus (10 mg/kg, orally, 5 times/week) along with Cont-shRNA-AAVs or Atg13-shRNA-AAVs (5 × 1010 PFU/mL, marrow-cavity injection) for 45 days. (A) Representative 3D micro-CT reconstructed images of the tibiae from each group. Scale bar, 1 mm. (B) Representative H&E-stained tibial sections from each group. Scale bar, 20 μm. (C) LC3-puncta formation in bone marrow RANK+ CSF1R+ cells sorted by FACS was evaluated via immunofluorescence staining. Representative images of LC3 puncta, including single and merged fluorescence, were obtained under a fluorescent microscope. Scale bar, 25 μm.

Differentiation Journal @diffjournal.bsky.social · 15d

📢 Deadline extended: Submit to the "Splicing in Development and Disease" special issue by December 30, 2025!

Guest editors: Natoya Peart and Karine Choquet

Learn more and submit: https://www.sciencedirect.com/special-issue/322731/splicing-in-development-and-disease

Call for Papers! Submit to the Splicing in Development and Disease special issue! Submission deadline: December 30, 2025. Guest editors: Natoya Peart and Karine Choquet

This special issue will address and highlight current understanding and gaps in knowledge about the role of splicing both constitutive and alternative in the development and how disruption of these processes leads to disease.

Differentiation Journal @diffjournal.bsky.social · Sep 8

Arne C. Lekven, Sarah Empie, and Richard Saoud review the history of Wnt1, its gene structure and regulation, expression, loss-of-function consequences, and connection to human disease. Read “One Wnt to lead them all: a Wnt1 primer” to learn more: doi.org/10.1016/j.di...

$Fig. 5. Osteogenesis imperfecta observed in X-rays of patients homozygous for WNT1 loss of function alleles. A) Limb fracture. B) Vertebral compression and deformation. C) Severe leg deformities.$

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Differentiation Journal @diffjournal.bsky.social · Jun 23

@rogerslabucd.bsky.social @uribelab.bsky.social @siegenthalerlab.bsky.social

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Differentiation Journal @diffjournal.bsky.social · Jun 23

Join the editors-in-chief of Differentiation on July 11 at 1:30 p.m. Central for a virtual seminar with Julie Siegenthaler on retinoic acid signaling in retina endothelial cells and early angiogenesis. 👁️🔬💉 Register for free: www.isdifferentiation.org/Events/Semin...

Biological Differentiation Across the Scales—July 11, 2025, at 1:30 p.m. Central—Retinoic acid signaliing in mouse retina endothelial cells is required for early angiogenic growth—Register Now!

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Differentiation Journal @diffjournal.bsky.social · May 19

“The primary cilia: Orchestrating cranial neural crest cell development,” by Hiroyuki Yamaguchi et al., discusses the current understanding of the role of cilia and potential mechanisms of ciliogenesis in cranial neural crest cells. Learn more: Learn more: doi.org/10.1016/j.di...

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Differentiation Journal @diffjournal.bsky.social · May 6

The "Biological Differentiation Across the Scales" virtual seminar series kicked off on April 28 with an insightful, engaging talk by @ecbrooks96.bsky.social. Missed it live? Watch the recording: www.isdifferentiation.org/Journal/Page... @rogerslabucd.bsky.social @uribelab.bsky.social #devbio

The ciliary protein C2cd3 is required for mandibular musculoskeletal tissue patterning. Evan C. Brooks, Ph.D. Graduate Student Alumnis, Brugmann Lab, Cinicinnati Children's Hospital Medical Center. Currently: Postdoctoral Fellow, University of Colorado School of Dental Medicine. "Biological Differentiation Across the Scales" Seminar, April 28, 2025.

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Reposted by Differentiation Journal

Crystal Rogers, PhD @rogerslabucd.bsky.social · Mar 28

This paper is now published at @diffjournal.bsky.social! Congratulations to all the hardworking students who made it happen! Shout out to authors 1 & 2! MJ is our “axolotl whisperer” and Raneesh is our computational wizard- both DVM/PhD students @ucdavisvetmed.bsky.social! 💫 doi.org/10.1016/j.di...

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Reposted by Differentiation Journal

Evan C. Brooks, Ph.D. @ecbrooks96.bsky.social · Mar 17

Excited to be the inaugural speaker for this new seminar series from @diffjournal.bsky.social. I’ll be presenting on work from my PhD thesis focused on the role of cilia in lower jaw development.

Thanks to Loydie Jerome-Majewska, @rogerslabucd.bsky.social, and @uribelab.bsky.social for the invite!

Differentiation Journal @diffjournal.bsky.social · Mar 17

Join us for Biological Differentiation Across the Scales, a free virtual seminar series from Differentiation. Hear from authors and the editors-in-chief as they discuss key research. Stay at the forefront of biological differentiation—register now: www.isdifferentiation.org/Events/Semin... #devbio

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Differentiation Journal @diffjournal.bsky.social · Mar 17

Join us for Biological Differentiation Across the Scales, a free virtual seminar series from Differentiation. Hear from authors and the editors-in-chief as they discuss key research. Stay at the forefront of biological differentiation—register now: www.isdifferentiation.org/Events/Semin... #devbio

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Differentiation Journal @diffjournal.bsky.social · Jan 31

Hello everyone! Differentiation has arrived on Bluesky! We are the flagship journal for the International Society of Differentiation with EICs- Loydie Jerome-Majewska, Crystal Rogers (@rogerslabucd.bsky.social), and Rosa Uribe @uribelab.bsky.social). Please consider us when you are submitting!

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