Dan Lavery
@djlavery.bsky.social
Loulou Foundation, tackling CDKL5 Deficiency Disorder in collaboration with our amazing patient families.
Reposted by Dan Lavery
Congratulations to the 2025 CDKL5 Program of Excellence Pilot Grant awardees! The Loulou Foundation is excited to provide these awards, in collaboration with the Orphan Disease Center at the University of Pennsylvania Perelman School of Medicine, to support CDKL5 research. #CDKL5
May 1, 2025 at 1:38 PM
Congratulations to the 2025 CDKL5 Program of Excellence Pilot Grant awardees! The Loulou Foundation is excited to provide these awards, in collaboration with the Orphan Disease Center at the University of Pennsylvania Perelman School of Medicine, to support CDKL5 research. #CDKL5
Congratulations to the 2025 CDKL5 Program of Excellence Pilot Grant awardees! The Loulou Foundation is excited to provide these awards, in collaboration with the Orphan Disease Center at the University of Pennsylvania Perelman School of Medicine, to support CDKL5 research. #CDKL5
May 1, 2025 at 1:38 PM
Congratulations to the 2025 CDKL5 Program of Excellence Pilot Grant awardees! The Loulou Foundation is excited to provide these awards, in collaboration with the Orphan Disease Center at the University of Pennsylvania Perelman School of Medicine, to support CDKL5 research. #CDKL5
Reposted by Dan Lavery
Francis Crick called it “impossible” in 1979. Now it’s real.
A 1 mm cube of mouse brain, 200k cells, 500M synapses, all mapped alongside neuronal activity.
This new MICrONS dataset maps brain structure and function in a way that we've never seen🧪
🔗 www.microns-explorer.org
📄 doi.org/10.1038/s415...
A 1 mm cube of mouse brain, 200k cells, 500M synapses, all mapped alongside neuronal activity.
This new MICrONS dataset maps brain structure and function in a way that we've never seen🧪
🔗 www.microns-explorer.org
📄 doi.org/10.1038/s415...
April 9, 2025 at 6:45 PM
Francis Crick called it “impossible” in 1979. Now it’s real.
A 1 mm cube of mouse brain, 200k cells, 500M synapses, all mapped alongside neuronal activity.
This new MICrONS dataset maps brain structure and function in a way that we've never seen🧪
🔗 www.microns-explorer.org
📄 doi.org/10.1038/s415...
A 1 mm cube of mouse brain, 200k cells, 500M synapses, all mapped alongside neuronal activity.
This new MICrONS dataset maps brain structure and function in a way that we've never seen🧪
🔗 www.microns-explorer.org
📄 doi.org/10.1038/s415...
Reposted by Dan Lavery
Cells are swapping their mitochondria. What does this mean for our health?
Researchers are studying why the energy factories are moving between cells and whether the process can be harnessed to treat cancer and other diseases. 🧪🦠💊
www.nature.com/articles/d41...
Researchers are studying why the energy factories are moving between cells and whether the process can be harnessed to treat cancer and other diseases. 🧪🦠💊
www.nature.com/articles/d41...
April 10, 2025 at 8:16 PM
Cells are swapping their mitochondria. What does this mean for our health?
Researchers are studying why the energy factories are moving between cells and whether the process can be harnessed to treat cancer and other diseases. 🧪🦠💊
www.nature.com/articles/d41...
Researchers are studying why the energy factories are moving between cells and whether the process can be harnessed to treat cancer and other diseases. 🧪🦠💊
www.nature.com/articles/d41...
100%. Everyone in the US please call your representatives to let them know how devastating these cuts and firings are to rare disease families who already have so many challenges.
Please read, then call your legislators to demand they protect the most vulnerable in our society. Our daughter with complex medical needs (CDKL5) relies on the protections and supports provided by IDEA and Medicaid to preserve her quality of life. open.substack.com/pub/erinraff...
Our Medicaid Story
Cuts to Medicaid will devastate poor and disabled people in America. Please call your representative THIS WEEK and tell them you oppose these cuts!
open.substack.com
February 23, 2025 at 12:09 AM
100%. Everyone in the US please call your representatives to let them know how devastating these cuts and firings are to rare disease families who already have so many challenges.
Reposted by Dan Lavery
Excited to share a new paper from our lab out this week in Molecular Psychiatry on an mTORopathy, PTEN Hamartoma Tumor Syndrome.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Phenotypic rescue via mTOR inhibition in neuron-specific Pten knockout mice reveals AKT and mTORC1-site specific changes - Molecular Psychiatry
Molecular Psychiatry - Phenotypic rescue via mTOR inhibition in neuron-specific Pten knockout mice reveals AKT and mTORC1-site specific changes
www.nature.com
February 15, 2025 at 1:27 PM
Excited to share a new paper from our lab out this week in Molecular Psychiatry on an mTORopathy, PTEN Hamartoma Tumor Syndrome.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Great funding opportunity for a rare DEE/NDD, #CDKL5 Deficiency Disorder. Send in your LOI today!
The ODC and Loulou Foundation are pleased to announce the 2025 CDKL5 Program of Excellence Pilot Grant Program. This funding opportunity is open to the international community! Apply today! bit.ly/CDKL5grant2025 #cdkl5 #grant #funding #cdd
2025 CDKL5 Pilot Grant Program LOI — Orphan Disease Center
The ODC and Loulou Foundation CDKL5 Pilot Grant Program provides a one‐year grant for $150,000.00 (total cost) to support research related to CDKL5 Deficiency Disorder (CDD). The number of awards is...
bit.ly
February 6, 2025 at 7:16 PM
Great funding opportunity for a rare DEE/NDD, #CDKL5 Deficiency Disorder. Send in your LOI today!
Reposted by Dan Lavery
Key point: Cenobamate is a promising and safe treatment for SCN8A-related DEEs, even during early childhood.
doi.org/10.1111/epi....
#epilepsy #ILAE #drugresistantepilepsy #geneticepilepsy #sodiumchannelopathy #DEE
doi.org/10.1111/epi....
#epilepsy #ILAE #drugresistantepilepsy #geneticepilepsy #sodiumchannelopathy #DEE
January 24, 2025 at 5:54 PM
Key point: Cenobamate is a promising and safe treatment for SCN8A-related DEEs, even during early childhood.
doi.org/10.1111/epi....
#epilepsy #ILAE #drugresistantepilepsy #geneticepilepsy #sodiumchannelopathy #DEE
doi.org/10.1111/epi....
#epilepsy #ILAE #drugresistantepilepsy #geneticepilepsy #sodiumchannelopathy #DEE
Reposted by Dan Lavery
Maybe if the NSF just stands really, really still, Trump will forget it exists
January 24, 2025 at 8:57 PM
Maybe if the NSF just stands really, really still, Trump will forget it exists
Reposted by Dan Lavery
Shutting down medical research — not just within NIH, but everywhere that’s funded by NIH — will have long-term effects on medicine & short-term effects on state, higher education & hospital budgets. This affects all of us, not just researchers.
The assault on NIH is a test for how the national media covers the Trump admin: Trump is shutting down medical research!
That is easy to communicate. Will they treat it as a 5 alarm fire in a way that forces the government to respond, or will they downplay & caveat it?
That is easy to communicate. Will they treat it as a 5 alarm fire in a way that forces the government to respond, or will they downplay & caveat it?
January 23, 2025 at 1:37 AM
Shutting down medical research — not just within NIH, but everywhere that’s funded by NIH — will have long-term effects on medicine & short-term effects on state, higher education & hospital budgets. This affects all of us, not just researchers.
Reposted by Dan Lavery
This administration's policy is effectively freezing healthcare and scientific research. Worried? I am.
www.science.org/content/arti...
www.science.org/content/arti...
Trump hits NIH with ‘devastating’ freezes on meetings, travel, communications, and hiring
Researchers facing
www.science.org
January 23, 2025 at 12:37 AM
This administration's policy is effectively freezing healthcare and scientific research. Worried? I am.
www.science.org/content/arti...
www.science.org/content/arti...
Reposted by Dan Lavery
New evidence that it was the economic vibes, stupid open.substack.com/pub/paulkrug...
A Win for the Vibecession Story
Guess what? Popular economic narratives aren’t reliable
open.substack.com
December 21, 2024 at 12:06 PM
New evidence that it was the economic vibes, stupid open.substack.com/pub/paulkrug...
Reposted by Dan Lavery
Looking forward to getting into LAX early to catch up with the traditional #SYNGAP1 Conference by @curesyngap1.bsky.social and the #Dravet Roundtable by @curedravet.bsky.social both on December 5th just before #AES2024
Who else is coming? 💚
Who else is coming? 💚
December 3, 2024 at 2:18 PM
Looking forward to getting into LAX early to catch up with the traditional #SYNGAP1 Conference by @curesyngap1.bsky.social and the #Dravet Roundtable by @curedravet.bsky.social both on December 5th just before #AES2024
Who else is coming? 💚
Who else is coming? 💚
Reposted by Dan Lavery
Please share-we are hosting an in person (travel support available!) for trainees who want to consider CHOP/Penn labs for postdoc. Apply to have a chance to check out our top notch science and get a trip to Philly!
Late-stage graduate students and junior postdoctoral fellows are invited to attend the 2025 Recruitment Summit for CHOP/Penn Postdoctoral Scholars in Cell Biology and Genomics
careers.chop.edu/us/en/event/...
careers.chop.edu/us/en/event/...
Recruitment Summit for Postdoctoral Scholars in Cell Biology and Genomics | Children’s Hospital of Philadelphia
Recruitment Summit for Postdoctoral Scholars in Cell Biology and Genomics in Philadelphia, Pennsylvania, United States. null at Children’s Hospital of Philadelphia
careers.chop.edu
November 25, 2024 at 6:19 PM
Please share-we are hosting an in person (travel support available!) for trainees who want to consider CHOP/Penn labs for postdoc. Apply to have a chance to check out our top notch science and get a trip to Philly!
Reposted by Dan Lavery
As I've been seeing a lot of job postings here, I've set up a NeuroJobs feed. Add #NeuroJobs to your post if you're recruiting or looking for a PhD, Postdoc, or faculty position in Neuro or an adjacent field.
bsky.app/profile/did:...
bsky.app/profile/did:...
November 27, 2024 at 5:59 PM
As I've been seeing a lot of job postings here, I've set up a NeuroJobs feed. Add #NeuroJobs to your post if you're recruiting or looking for a PhD, Postdoc, or faculty position in Neuro or an adjacent field.
bsky.app/profile/did:...
bsky.app/profile/did:...
Reposted by Dan Lavery
PhD Alert! We have a fully funded (UK residents only, I'm afraid 😟) #NeuroSkyence PhD to move towards developing an at-home EEG system to monitor sleep oscillations for brain health monitoring and early dementia diagnosis. Please share with your network!
www.gla.ac.uk/colleges/mvl...
www.gla.ac.uk/colleges/mvl...
University of Glasgow - Colleges - College of Medical, Veterinary & Life Sciences - MVLS Graduate School - PhD Research Opportunities - College Futures PhD Programme - Projects - Advanced Diagnostics ...
www.gla.ac.uk
November 27, 2024 at 12:07 PM
PhD Alert! We have a fully funded (UK residents only, I'm afraid 😟) #NeuroSkyence PhD to move towards developing an at-home EEG system to monitor sleep oscillations for brain health monitoring and early dementia diagnosis. Please share with your network!
www.gla.ac.uk/colleges/mvl...
www.gla.ac.uk/colleges/mvl...
Reposted by Dan Lavery
Please keep the date for HUMAN CEREBRAL CORTEX DEVELOPMENT III - Anatomical Society Meeting 14-16th July 2025, St John’s College, Oxford
Follow up to two meetings in 2010 and in 2018 issues of the Journal of Anatomy onlinelibrary.wiley.com/doi/10.1111/... and onlinelibrary.wiley.com/toc/14697580...
Follow up to two meetings in 2010 and in 2018 issues of the Journal of Anatomy onlinelibrary.wiley.com/doi/10.1111/... and onlinelibrary.wiley.com/toc/14697580...
November 17, 2024 at 5:56 PM
Please keep the date for HUMAN CEREBRAL CORTEX DEVELOPMENT III - Anatomical Society Meeting 14-16th July 2025, St John’s College, Oxford
Follow up to two meetings in 2010 and in 2018 issues of the Journal of Anatomy onlinelibrary.wiley.com/doi/10.1111/... and onlinelibrary.wiley.com/toc/14697580...
Follow up to two meetings in 2010 and in 2018 issues of the Journal of Anatomy onlinelibrary.wiley.com/doi/10.1111/... and onlinelibrary.wiley.com/toc/14697580...
So cool.
Excited to publish a broad set of enhancers to target interneuron types in the brain, along with a broad set of collaborators. Part of the BI armamentarium. Together this will help revolutionize the targeting of brain circuits.https://www.biorxiv.org/content/10.1101/2024.07.17.603924v2
November 24, 2024 at 3:26 PM
So cool.
Reposted by Dan Lavery
Quantitative EEG biomarkers for STXBP1-related disorders 🧬
Relative Delta Power is even higher in #STXBP1-DEE than in other developmental & epileptic encephalopathies - highest in the frontal areas 🧠
For more info 👉
onlinelibrary.wiley.com/doi/10.1111/...
#Epilepsy #Genetics
Relative Delta Power is even higher in #STXBP1-DEE than in other developmental & epileptic encephalopathies - highest in the frontal areas 🧠
For more info 👉
onlinelibrary.wiley.com/doi/10.1111/...
#Epilepsy #Genetics
November 20, 2024 at 7:33 PM
Quantitative EEG biomarkers for STXBP1-related disorders 🧬
Relative Delta Power is even higher in #STXBP1-DEE than in other developmental & epileptic encephalopathies - highest in the frontal areas 🧠
For more info 👉
onlinelibrary.wiley.com/doi/10.1111/...
#Epilepsy #Genetics
Relative Delta Power is even higher in #STXBP1-DEE than in other developmental & epileptic encephalopathies - highest in the frontal areas 🧠
For more info 👉
onlinelibrary.wiley.com/doi/10.1111/...
#Epilepsy #Genetics
Reposted by Dan Lavery
🧬 If you work on a neurological #RareDisease you should be following the news around Neurogene's gene therapy for #Rett syndrome.
They have very positive results in the clinic and also a really bad safety problem at a higher dose. Good chat with CEO in link: ir.neurogene.com/events/event...
They have very positive results in the clinic and also a really bad safety problem at a higher dose. Good chat with CEO in link: ir.neurogene.com/events/event...
November 20, 2024 at 11:00 AM
🧬 If you work on a neurological #RareDisease you should be following the news around Neurogene's gene therapy for #Rett syndrome.
They have very positive results in the clinic and also a really bad safety problem at a higher dose. Good chat with CEO in link: ir.neurogene.com/events/event...
They have very positive results in the clinic and also a really bad safety problem at a higher dose. Good chat with CEO in link: ir.neurogene.com/events/event...