Katherine Borges
@dnakath.bsky.social
Director of International Society of Genetic Genealogy (ISOGG.org) and founding member of The Coalition for Responsible use of AI in Genealogy (CRAIGEN.org)
Interested in genealogy, family history, epigenetics, null alleles, and #AI #DNA #Epigenetics
Interested in genealogy, family history, epigenetics, null alleles, and #AI #DNA #Epigenetics
“Hydrogen-rich water alleviates asthma airway inflammation by modulating tryptophan metabolism and activating aryl hydrocarbon receptor via gut microbiota regulation” #ISOGG #asthma #epigenetics #hydrogen
“Regarding the underlying mechanisms of action, it is tentatively believed that the primary intracellular target of hydrogen is the mitochondria. “…hydrogen can activate Nrf2 receptors, which can have beneficial effects on cardiovascular health and anti-aging." www.sciencedirect.com/science/arti...
Hydrogen-rich water alleviates asthma airway inflammation by modulating tryptophan metabolism and activating aryl hydrocarbon receptor via gut microbiota regulation
Hydrogen-rich water (HRW) is a beverage containing a high concentration of hydrogen that has been researched for its antioxidant, anti-apoptotic, and …
www.sciencedirect.com
November 11, 2025 at 3:50 PM
“Hydrogen-rich water alleviates asthma airway inflammation by modulating tryptophan metabolism and activating aryl hydrocarbon receptor via gut microbiota regulation” #ISOGG #asthma #epigenetics #hydrogen
I thought this was a Monarch but my neighbor knew it was a Painted Lady butterfly. #Autumn #Autumn2025 #Fall2025 #November #PaintedLadyButterfly #butterfly #California
November 11, 2025 at 2:15 AM
I thought this was a Monarch but my neighbor knew it was a Painted Lady butterfly. #Autumn #Autumn2025 #Fall2025 #November #PaintedLadyButterfly #butterfly #California
“According to the report: The mortality risk associated with high temperatures appears to be increasing over time, emphasizing the need for adaptation, even in high-latitude regions." #heartfailure #heartdisease
“The study showed a statistical association with low and high temperature exposure and increased risk of all-cause and cardiovascular death in patients with heart failure.” #DNA #ISOGG #epigenetics
www.yahoo.com/news/article...
www.yahoo.com/news/article...
Researchers issue warning after discovering unexpected link to heart failure: 'Appears to be increasing over time'
This is not the first research to highlight a connection.
www.yahoo.com
November 10, 2025 at 5:18 AM
“According to the report: The mortality risk associated with high temperatures appears to be increasing over time, emphasizing the need for adaptation, even in high-latitude regions." #heartfailure #heartdisease
November 9, 2025 at 4:10 AM
November 3, 2025 at 2:38 AM
Reposted by Katherine Borges
New #AI vocabulary term “Vibe Coding”: “…coined by OpenAI cofounder Andrej Karpathy in February. "There's a new kind of coding I call 'vibe coding,' where you fully give in to the vibes, embrace exponentials, and forget that the code even exists," #vibecoding #CRAIGEN @craigenorg.bsky.social
October 27, 2025 at 8:46 PM
New #AI vocabulary term “Vibe Coding”: “…coined by OpenAI cofounder Andrej Karpathy in February. "There's a new kind of coding I call 'vibe coding,' where you fully give in to the vibes, embrace exponentials, and forget that the code even exists," #vibecoding #CRAIGEN @craigenorg.bsky.social
“But the new study, published Friday (Oct. 24) in the journal Current Biology, indicates these soldiers may have been weakened by fevers caused by B. recurrentis & then killed by paratyphoid (a disease unrelated to typhus), which is caused by S. enterica and spreads via contaminated food & water.”
“The new study examined DNA from the teeth of 13 French soldiers buried during the retreat in a mass grave in Vilnius, Lithuania. (The grave was discovered during construction in 2001.)” #DNA #ISOGG #Napolean #French
news.yahoo.com/articles/dna...
news.yahoo.com/articles/dna...
DNA reveals what killed Napoleon's soldiers during their disastrous retreat from Russia in 1812
A mass grave holding soldiers from Napoleon Bonaparte's French army reveals some of the diseases that killed the Grande Armée during its disastrous retreat from Russia in 1812.
news.yahoo.com
October 26, 2025 at 5:53 AM
“But the new study, published Friday (Oct. 24) in the journal Current Biology, indicates these soldiers may have been weakened by fevers caused by B. recurrentis & then killed by paratyphoid (a disease unrelated to typhus), which is caused by S. enterica and spreads via contaminated food & water.”
“Our findings show that symptoms are more often triggered by fermentable carbohydrates, commonly known as FODMAPs, by other wheat components or by people’s expectations and prior experiences with food.”
“Until causative agents are identified and diagnostic tests developed, NCGS remains a diagnosis of exclusion, requiring careful systematic evaluation.” #DNA #ISOGG #epigenetics #gluten #FODMAPS www.unimelb.edu.au/newsroom/new...
Redirecting...
www.facebook.com
October 24, 2025 at 11:50 AM
“Our findings show that symptoms are more often triggered by fermentable carbohydrates, commonly known as FODMAPs, by other wheat components or by people’s expectations and prior experiences with food.”
“Chiari Malformation Type 1 occurs when the back of a human’s skull is too small to hold the brain, causing part of the base of the brain to herniate out the skull & into spinal canal. This can pinch, leading to headaches, neck pain, dizziness & severely-death if too much of the brain herniates out”
“Their findings suggest that Chiari Malformation Type 1, a serious and sometimes fatal neurological condition, may be linked to Neanderthal genes that entered the human gene pool through interbreeding tens of thousands of years ago.” #DNA #ISOGG #AncientDNA #epigenetics www.sfu.ca/sfunews/medi...
Interbreeding with Neanderthals may be responsible for modern-day brain condition, SFU study finds
A new Simon Fraser University-led study reveals interbreeding between humans and their ancient cousins, Neanderthals, as the likely origin of a neurological condition estimated to impact up to one per...
www.sfu.ca
October 22, 2025 at 4:32 PM
“Chiari Malformation Type 1 occurs when the back of a human’s skull is too small to hold the brain, causing part of the base of the brain to herniate out the skull & into spinal canal. This can pinch, leading to headaches, neck pain, dizziness & severely-death if too much of the brain herniates out”
A rip in the clouds send beams of sunlight upon this ship at Fells Point, Baltimore. #Baltimore #Maryland #FellsPoint #ships
October 19, 2025 at 2:55 PM
A rip in the clouds send beams of sunlight upon this ship at Fells Point, Baltimore. #Baltimore #Maryland #FellsPoint #ships
Live oak planted at the Old Stone House (Poe Museum) in Richmond, Virginia by the Thomas Jefferson Garden Club for the Bicentennial. #liveoak #poemuseum #richmondva #oldstonehouse #virginia
October 6, 2025 at 1:28 AM
Live oak planted at the Old Stone House (Poe Museum) in Richmond, Virginia by the Thomas Jefferson Garden Club for the Bicentennial. #liveoak #poemuseum #richmondva #oldstonehouse #virginia
September 17, 2025 at 4:28 AM
“Lithium was the only metal that had markedly different levels across groups and changed at the earliest stages of memory loss. Its levels were high in the cognitively healthy donors but greatly diminished in those with mild impairment or full-blown Alzheimer’s.” #ISOGG #epigenetics #Alzheimers #DNA
“The authors identified a class of lithium compounds that can evade capture by amyloid beta. Treating mice with the most potent amyloid-evading compound, called lithium orotate, reversed Alzheimer’s disease pathology, prevented brain cell damage, and restored memory.”
hms.harvard.edu/news/could-l...
hms.harvard.edu/news/could-l...
Could Lithium Explain — and Treat — Alzheimer’s Disease?
Study: Lithium loss ignites Alzheimer’s, but lithium compound can reverse disease in mice
hms.harvard.edu
September 14, 2025 at 4:53 PM
“Lithium was the only metal that had markedly different levels across groups and changed at the earliest stages of memory loss. Its levels were high in the cognitively healthy donors but greatly diminished in those with mild impairment or full-blown Alzheimer’s.” #ISOGG #epigenetics #Alzheimers #DNA
This sounds really interesting!
September 9, 2025 at 3:12 AM
This sounds really interesting!
Reposted by Katherine Borges
Ireland’s Genealogical Gazette FREE talk on 9 Sept 2025 at 20:00 “Isotopes and Ancestry: Exploring how Archaeochemistry can answer Genealogical Questions,” given by Dr Ashley McCall, an independent researcher based in Dublin. Join via Zoom ID 844 6097 4398 and passcode 66 18 37
#DNA #ISOGG #Ireland
#DNA #ISOGG #Ireland
September 9, 2025 at 2:59 AM
“Scientists have found that neurons don’t just store sugar for fuel—they reroute it to power antioxidant defenses, but only if an enzyme called GlyP is active. When this sugar-clearing system is blocked, toxic tau protein builds up and accelerates brain degeneration.” #Alzheimers #dementia #sugar
“Scientists just found a sugar switch that protects your brain from Alzheimer's. In addition to a new approach in Alzheimer’s research, study from Buck Institute could explain why GLP-1 drugs show promise against dementia.” #isogg #DNA #epigenetics #glp1
www.sciencedaily.com/releases/202...
www.sciencedaily.com/releases/202...
Scientists just found a sugar switch that protects your brain from Alzheimer's
Scientists have uncovered a surprising sugar-related mechanism inside brain cells that could transform how we fight Alzheimer’s and other dementias. It turns out neurons don’t just store sugar for fue...
www.sciencedaily.com
September 6, 2025 at 1:52 PM
“Scientists have found that neurons don’t just store sugar for fuel—they reroute it to power antioxidant defenses, but only if an enzyme called GlyP is active. When this sugar-clearing system is blocked, toxic tau protein builds up and accelerates brain degeneration.” #Alzheimers #dementia #sugar
Glad Ancestry is working to preserve privacy. Review the other genealogy AI Principles at craigen.org
“Ancestry’s AI are now using natural language processing (NLP) to cross-reference records across languages & eras. NLP apps are indexing birth, marriage, & newspapers. This allows users to link a 19th-century immigrant’s manifest to modern DNA matches.” #CRAIGEN
www.webpronews.com/ancestry-com...
www.webpronews.com/ancestry-com...
September 5, 2025 at 3:10 AM
Glad Ancestry is working to preserve privacy. Review the other genealogy AI Principles at craigen.org
“...the J-T group displayed higher FI score of mtDNA variants than other Euro macrohaplogroups, suggesting higher pathogenicity in the J-T group, whereas the H-HV group exhibited lower FI score of the mtDNA variants than other European macrohaplogroups, suggesting lower pathogenicity in H-HV group.”
“Moreover, we demonstrated that a higher FI score of mtDNA variants was associated with both premature epigenetic aging in the early 20s and premature biological aging in the late 20s." #isogg #DNA #epigenetics #haplogroups
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Mitochondrial DNA variants and their impact on epigenetic and biological aging in young adulthood - Translational Psychiatry
Translational Psychiatry - Mitochondrial DNA variants and their impact on epigenetic and biological aging in young adulthood
www.nature.com
September 5, 2025 at 1:23 AM
“...the J-T group displayed higher FI score of mtDNA variants than other Euro macrohaplogroups, suggesting higher pathogenicity in the J-T group, whereas the H-HV group exhibited lower FI score of the mtDNA variants than other European macrohaplogroups, suggesting lower pathogenicity in H-HV group.”
Goal is “best available”…
@craigenorg.bsky.social Accuracy principle is even more important to follow when you might be using the worst available AI. craigen.org
August 12, 2025 at 2:33 PM
Goal is “best available”…
Reposted by Katherine Borges
Interestingly including random words “to take inspiration from” in the system prompt made a big difference.
August 12, 2025 at 1:55 PM
Interestingly including random words “to take inspiration from” in the system prompt made a big difference.
“The genetic data for this study also provides further evidence that the Hay noble lineage originated in Normandy as they share the Y-SNP R1a-YP4138 with several individuals who have a surname of Norman origin.” #Normandy #geneticgenealogy #isogg
Well done study on the HAY surname! #ISOGG #DNA #FTDNA #FamilyTreeDNA #BigY #Ychromosome #Hay #geneticgenealogy
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
What can Y-DNA analysis reveal about the surname Hay?
The family name Hay (plus associated spelling variants) is a prominent Anglo-Norman-in-origin surname that has been well-documented as a Scottish noble lineage since the 12th century CE. Their histori...
www.biorxiv.org
August 12, 2025 at 2:29 PM
“The genetic data for this study also provides further evidence that the Hay noble lineage originated in Normandy as they share the Y-SNP R1a-YP4138 with several individuals who have a surname of Norman origin.” #Normandy #geneticgenealogy #isogg
“When your cells are low on energy, AMPK kicks in to help them cope,” explains Dr Charalampos (Babis) Rallis, Reader in Genetics, Genomics and Fundamental Cell Biology at Queen Mary University of London, the study’s senior author. “And our results show that caffeine helps flip that switch.” #isogg
“…scientists made a surprising discovery: caffeine doesn’t act on this growth switch directly. Instead, it works by activating another important system called AMPK, a cellular fuel gauge that is evolutionarily conserved in yeast and humans.” #DNA #epigenetics #coffee
www.qmul.ac.uk/media/news/2...
www.qmul.ac.uk/media/news/2...
Caffeine could slow cellular ageing, new research shows how
www.qmul.ac.uk
August 5, 2025 at 2:09 AM
“When your cells are low on energy, AMPK kicks in to help them cope,” explains Dr Charalampos (Babis) Rallis, Reader in Genetics, Genomics and Fundamental Cell Biology at Queen Mary University of London, the study’s senior author. “And our results show that caffeine helps flip that switch.” #isogg
“…the findings from the University of Oxford suggest "that the AS01 adjuvant itself plays a direct role in lowering dementia risk.”
Have you had the Shingles vaccine? If you’ve had the Shingles vaccine (and/or RSV vax) then you may have given yourself a dementia preventative. #isogg #dna #shingles #shingrix #RSV #epigenetics www.sciencealert.com/huge-study-r...
Huge Study Reveals 2 Vaccines That Appear to Reduce Dementia Risk
Some immunizations may be quietly protecting us from cognitive decline.
www.sciencealert.com
August 1, 2025 at 2:21 PM
“…the findings from the University of Oxford suggest "that the AS01 adjuvant itself plays a direct role in lowering dementia risk.”
Reposted by Katherine Borges
Huzzah!
We just got notice that a Freedom of Information request we made for a certain state's vital records index in August 2020, heard as a contested case in August 2021, was finally decided in our favor...
That's nearly five years. FIVE YEARS! 😤
But we won. New data coming soon. 😊
That's nearly five years. FIVE YEARS! 😤
But we won. New data coming soon. 😊
July 31, 2025 at 4:14 AM
Huzzah!
Reposted by Katherine Borges
@emollick.bsky.social points out a conundrum of #AI literacy. @craigenorg.bsky.social Education principle: “The use of AI creates new opportunities and risks. Therefore, members of the genealogical community educate themselves about AI to maximize its benefits and minimize its risks to their work.”
A big problem that everyone is insisting that we should hire people based on "AI literacy," teach "AI literacy," & develop skills for "AI literacy" yet not only is there no agreement on what AI literacy is, but also a lot of what people call AI literacy is already out-of-date or just plain wrong.
July 31, 2025 at 4:17 AM
@emollick.bsky.social points out a conundrum of #AI literacy. @craigenorg.bsky.social Education principle: “The use of AI creates new opportunities and risks. Therefore, members of the genealogical community educate themselves about AI to maximize its benefits and minimize its risks to their work.”