International Society of Genetic Genealogy
@isogg.bsky.social
Founded in 2005, the mission of the International Society of Genetic Genealogy is to advocate for and educate about the use of genetics as a tool for genealogical research. ISOGG is FREE! To join: isogg.org #ISOGG #DNA #epigenetics
Just finished watching the fascinating documentary “Secrets of the Neanderthals” on Netflix. Not a lot of DNA discussion but there is one part where they can identify whether the remains are male or female based on a dental protein. Here’s a link to the trailer: youtu.be/b5YtgLSU_sE?...
Secrets of the Neanderthals | Official Trailer | Netflix
YouTube video by Netflix
youtu.be
November 19, 2025 at 10:46 PM
“Our findings raise the possibility that this delta–theta band oscillation could serve as a target engagement biomarker, but its relationship to food preoccupation warrants more controlled investigation," authors of the study conclude. #ISOGG #tirzepetide #epigenetics
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Brain activity associated with breakthrough food preoccupation in an individual on tirzepatide - Nature Medicine
This study provides the first evidence in humans that tirzepatide modulates brain electrophysiology, with changes in low-frequency accumbens power linked to food preoccupation.
www.nature.com
November 19, 2025 at 3:10 AM
“Our findings raise the possibility that this delta–theta band oscillation could serve as a target engagement biomarker, but its relationship to food preoccupation warrants more controlled investigation," authors of the study conclude. #ISOGG #tirzepetide #epigenetics
www.nature.com/articles/s41...
www.nature.com/articles/s41...
“In individuals with adequate TRPM7 function, Mg supplementation increases the abundance of C. maltaromaticum and F. prausnitzii.” #DNA #ISOGG #epigenetics #coloncancer #colorectalcancer #magnesium #TRPM7
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Magnesium treatment increases gut microbiome synthesizing vitamin D and inhibiting colorectal cancer: results from a double-blind precision-based randomized placebo-controlled trial
Carnobacterium maltaromaticum and Faecalibacterium prausnitzii induce de novo gut synthesis of vitamin D to inhibit colorectal carcinogenesis in mice.…
www.sciencedirect.com
November 16, 2025 at 5:08 PM
“In individuals with adequate TRPM7 function, Mg supplementation increases the abundance of C. maltaromaticum and F. prausnitzii.” #DNA #ISOGG #epigenetics #coloncancer #colorectalcancer #magnesium #TRPM7
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
“Researchers have linked the death of a 47-year-old man in New Jersey to alpha-gal syndrome, which usually starts with a bite from a lone star tick. The man died four hours after eating a hamburger. NBC News’ Anne Thompson.” #ISOGG #epigenetics #AlphaGal #tick #allergy
youtu.be/Tp96QZfzNlU?...
youtu.be/Tp96QZfzNlU?...
First reported death from meat allergy caused by tick bite
YouTube video by NBC News
youtu.be
November 14, 2025 at 10:17 PM
“Researchers have linked the death of a 47-year-old man in New Jersey to alpha-gal syndrome, which usually starts with a bite from a lone star tick. The man died four hours after eating a hamburger. NBC News’ Anne Thompson.” #ISOGG #epigenetics #AlphaGal #tick #allergy
youtu.be/Tp96QZfzNlU?...
youtu.be/Tp96QZfzNlU?...
“Regarding the underlying mechanisms of action, it is tentatively believed that the primary intracellular target of hydrogen is the mitochondria. “…hydrogen can activate Nrf2 receptors, which can have beneficial effects on cardiovascular health and anti-aging." www.sciencedirect.com/science/arti...
Hydrogen-rich water alleviates asthma airway inflammation by modulating tryptophan metabolism and activating aryl hydrocarbon receptor via gut microbiota regulation
Hydrogen-rich water (HRW) is a beverage containing a high concentration of hydrogen that has been researched for its antioxidant, anti-apoptotic, and …
www.sciencedirect.com
November 11, 2025 at 3:48 PM
“Regarding the underlying mechanisms of action, it is tentatively believed that the primary intracellular target of hydrogen is the mitochondria. “…hydrogen can activate Nrf2 receptors, which can have beneficial effects on cardiovascular health and anti-aging." www.sciencedirect.com/science/arti...
“The study showed a statistical association with low and high temperature exposure and increased risk of all-cause and cardiovascular death in patients with heart failure.” #DNA #ISOGG #epigenetics
www.yahoo.com/news/article...
www.yahoo.com/news/article...
Researchers issue warning after discovering unexpected link to heart failure: 'Appears to be increasing over time'
This is not the first research to highlight a connection.
www.yahoo.com
November 10, 2025 at 4:49 AM
“The study showed a statistical association with low and high temperature exposure and increased risk of all-cause and cardiovascular death in patients with heart failure.” #DNA #ISOGG #epigenetics
www.yahoo.com/news/article...
www.yahoo.com/news/article...
“The researchers hope that by targeting FTL1, future therapies may not only improve natural cognitive decline, but will also benefit people with neurodegenerative diseases.” #DNA #ISOGG #Alzheimers #epigentics #cognitivedecline #neutrites
www.yahoo.com/news/article...
www.yahoo.com/news/article...
Scientists Found a Hidden Switch in Your Brain That Could Reverse Memory Loss
A new discovery shows that a protein called the ferritin light chain 1, or FTL1, plays a big role in the decline of our mental faculties as we age.
www.yahoo.com
November 9, 2025 at 1:33 AM
“The researchers hope that by targeting FTL1, future therapies may not only improve natural cognitive decline, but will also benefit people with neurodegenerative diseases.” #DNA #ISOGG #Alzheimers #epigentics #cognitivedecline #neutrites
www.yahoo.com/news/article...
www.yahoo.com/news/article...
“Many systemic challenges to the brain can be mitigated by the phytochemical sulforaphane (SF), which is important in supporting mitochondrial function. SF or its precursor glucoraphanin; broccoli seeds or sprouts, confers neuroprotective & cognitive benefits.” #ISOGG www.mdpi.com/2072-6643/17...
www.mdpi.com
October 29, 2025 at 2:04 PM
“Many systemic challenges to the brain can be mitigated by the phytochemical sulforaphane (SF), which is important in supporting mitochondrial function. SF or its precursor glucoraphanin; broccoli seeds or sprouts, confers neuroprotective & cognitive benefits.” #ISOGG www.mdpi.com/2072-6643/17...
“Depression is linked to overly rigid brain circuits that resist change, and by softening these circuits and altering how their mitochondria function, fluoxetine may create a window of plasticity or flexibility in the brain. #DNA #ISOGG #Prozac #Epigenetics
www.technologynetworks.com/neuroscience...
www.technologynetworks.com/neuroscience...
Antidepressant Fluoxetine Promotes Brain Plasticity in Key Cells, Reshaping Their Energy Systems
A new study shows that the antidepressant fluoxetine does more than boost serotonin levels: it changes how brain cells manage their energy and rebuild their connections, potentially helping the brain ...
www.technologynetworks.com
October 27, 2025 at 7:32 PM
“Depression is linked to overly rigid brain circuits that resist change, and by softening these circuits and altering how their mitochondria function, fluoxetine may create a window of plasticity or flexibility in the brain. #DNA #ISOGG #Prozac #Epigenetics
www.technologynetworks.com/neuroscience...
www.technologynetworks.com/neuroscience...
“The new study examined DNA from the teeth of 13 French soldiers buried during the retreat in a mass grave in Vilnius, Lithuania. (The grave was discovered during construction in 2001.)” #DNA #ISOGG #Napolean #French
news.yahoo.com/articles/dna...
news.yahoo.com/articles/dna...
DNA reveals what killed Napoleon's soldiers during their disastrous retreat from Russia in 1812
A mass grave holding soldiers from Napoleon Bonaparte's French army reveals some of the diseases that killed the Grande Armée during its disastrous retreat from Russia in 1812.
news.yahoo.com
October 26, 2025 at 5:45 AM
“The new study examined DNA from the teeth of 13 French soldiers buried during the retreat in a mass grave in Vilnius, Lithuania. (The grave was discovered during construction in 2001.)” #DNA #ISOGG #Napolean #French
news.yahoo.com/articles/dna...
news.yahoo.com/articles/dna...
“Until causative agents are identified and diagnostic tests developed, NCGS remains a diagnosis of exclusion, requiring careful systematic evaluation.” #DNA #ISOGG #epigenetics #gluten #FODMAPS www.unimelb.edu.au/newsroom/new...
Redirecting...
www.facebook.com
October 24, 2025 at 11:29 AM
“Until causative agents are identified and diagnostic tests developed, NCGS remains a diagnosis of exclusion, requiring careful systematic evaluation.” #DNA #ISOGG #epigenetics #gluten #FODMAPS www.unimelb.edu.au/newsroom/new...
“Their findings suggest that Chiari Malformation Type 1, a serious and sometimes fatal neurological condition, may be linked to Neanderthal genes that entered the human gene pool through interbreeding tens of thousands of years ago.” #DNA #ISOGG #AncientDNA #epigenetics www.sfu.ca/sfunews/medi...
Interbreeding with Neanderthals may be responsible for modern-day brain condition, SFU study finds
A new Simon Fraser University-led study reveals interbreeding between humans and their ancient cousins, Neanderthals, as the likely origin of a neurological condition estimated to impact up to one per...
www.sfu.ca
October 22, 2025 at 4:20 PM
“Their findings suggest that Chiari Malformation Type 1, a serious and sometimes fatal neurological condition, may be linked to Neanderthal genes that entered the human gene pool through interbreeding tens of thousands of years ago.” #DNA #ISOGG #AncientDNA #epigenetics www.sfu.ca/sfunews/medi...
“The pediatric neurologist was studying whether leucovorin could help autistic children with cerebral folate deficiency — or a shortage of vitamin B9 in the brain.” #DNA #ISOGG #epigenetics #autism #folate #B9 nypost.com/2025/10/14/h...
Exclusive | My nonverbal autistic son began speaking at age 8 after taking wonder drug — he’d understood everything for years and had complaints
Nathaniel Schnier had notes — years’ worth of them.
nypost.com
October 15, 2025 at 12:28 PM
“The pediatric neurologist was studying whether leucovorin could help autistic children with cerebral folate deficiency — or a shortage of vitamin B9 in the brain.” #DNA #ISOGG #epigenetics #autism #folate #B9 nypost.com/2025/10/14/h...
"Furthermore, patients with RLS who were not treated with dopamine agonists tended to be at increased risk of developing Parkinson's disease, whereas those who were treated with dopamine agonists tended to be at decreased risk compared with the control group."
www.sciencealert.com/restless-leg...
www.sciencealert.com/restless-leg...
Restless Legs Treatment Slashes Increased Risk of Parkinson's Disease
A condition that compels people to move their legs could indicate they have a greater chance of developing Parkinson's disease.
www.sciencealert.com
October 14, 2025 at 12:58 AM
"Furthermore, patients with RLS who were not treated with dopamine agonists tended to be at increased risk of developing Parkinson's disease, whereas those who were treated with dopamine agonists tended to be at decreased risk compared with the control group."
www.sciencealert.com/restless-leg...
www.sciencealert.com/restless-leg...
Registration ends 30 Sept 2025 for the virtual East Coast Genetic Genealogy Conference. You have until 31 Dec 2025 to watch all of the recordings. There’s an ISOGG presentation where we celebrated ISOGG’s 20th year, review the history and discuss future goals. #ISOGG #DNA #ECGGC ecggc.org
2025 East Coast Genetic Genealogy Conference - ECGGC
East Coast Genetic Genealogy Conference
ecggc.org
September 29, 2025 at 6:42 PM
“Another mutation of a protein in the virus’s membrane improved its ability to bind to entry point receptors in human cells, making it more resilient and infectious.” #isogg #DNA #epigentics #1918Flu #SpanishFlu
www.the-independent.com/news/science...
www.the-independent.com/news/science...
Century-old lungs stored in jar reveal how 1918 Spanish flu pandemic began
Findings could lead to better understanding of how viruses adapt to humans during a pandemic
www.the-independent.com
September 29, 2025 at 4:33 AM
“Another mutation of a protein in the virus’s membrane improved its ability to bind to entry point receptors in human cells, making it more resilient and infectious.” #isogg #DNA #epigentics #1918Flu #SpanishFlu
www.the-independent.com/news/science...
www.the-independent.com/news/science...
“Riding a bike is associated with a 19% lower risk of all-cause dementia and a 22% lower risk of Alzheimer’s disease, compared with taking nonactive travel modes such as a car, bus or train…” #ISOGG #DNA #epigenetics www.cnn.com/2025/09/20/h...
Cycling linked with lower dementia risk, study finds | CNN
Cycling instead of driving has been linked with a lower risk of dementia and Alzheimer’s disease, a large study has found.
www.cnn.com
September 24, 2025 at 11:39 PM
“Riding a bike is associated with a 19% lower risk of all-cause dementia and a 22% lower risk of Alzheimer’s disease, compared with taking nonactive travel modes such as a car, bus or train…” #ISOGG #DNA #epigenetics www.cnn.com/2025/09/20/h...
New finding on #osteoporosis: “Researchers from the University of Leipzig in Germany and Shandong University in China, identified the cell receptor GPR133 (also known as ADGRD1) as being crucial to bone density, via bone-building cells called osteoblasts.” www.sciencealert.com/new-breakthr...
New Breakthrough to Strengthen Bones Could Reverse Osteoporosis
A new study points to a key bone-strengthening mechanism at work in the body, which could be targeted to treat the bone-weakening disease, osteoporosis.
www.sciencealert.com
September 23, 2025 at 4:52 AM
New finding on #osteoporosis: “Researchers from the University of Leipzig in Germany and Shandong University in China, identified the cell receptor GPR133 (also known as ADGRD1) as being crucial to bone density, via bone-building cells called osteoblasts.” www.sciencealert.com/new-breakthr...
Nice blog post by Linda Yip on the East Coast Genetic Genealogy Conference which you can STILL sign up to watch the recordings through Dec 31, 2025. Registration ends Sept 30,2025 so don’t procrastinate on registering. #geneticgenealogy #ISOGG #DNA #ECGGC
past-presence.com/2025/09/14/k...
past-presence.com/2025/09/14/k...
East Coast Genetic Genealogy Conference 2025: My Experience
Explore my review of the East Coast Genetic Genealogy Conference 2025, featuring insights, sessions, and a virtual learning experience.
past-presence.com
September 18, 2025 at 2:16 AM
Nice blog post by Linda Yip on the East Coast Genetic Genealogy Conference which you can STILL sign up to watch the recordings through Dec 31, 2025. Registration ends Sept 30,2025 so don’t procrastinate on registering. #geneticgenealogy #ISOGG #DNA #ECGGC
past-presence.com/2025/09/14/k...
past-presence.com/2025/09/14/k...
“The authors identified a class of lithium compounds that can evade capture by amyloid beta. Treating mice with the most potent amyloid-evading compound, called lithium orotate, reversed Alzheimer’s disease pathology, prevented brain cell damage, and restored memory.”
hms.harvard.edu/news/could-l...
hms.harvard.edu/news/could-l...
Could Lithium Explain — and Treat — Alzheimer’s Disease?
Study: Lithium loss ignites Alzheimer’s, but lithium compound can reverse disease in mice
hms.harvard.edu
September 14, 2025 at 4:45 PM
“The authors identified a class of lithium compounds that can evade capture by amyloid beta. Treating mice with the most potent amyloid-evading compound, called lithium orotate, reversed Alzheimer’s disease pathology, prevented brain cell damage, and restored memory.”
hms.harvard.edu/news/could-l...
hms.harvard.edu/news/could-l...
"Moreover, G2a2* is represented by only one sub-lineage (G2a2b2a1a1b*, L497) except for the Iceman, which carries a different one (G2a2a1a2a1a1b, G-Z6208, or formerly G2a2a1a2 L-91"
#DNA #ISOGG #YHaplogroupG #AncientDNA #Iceman
www.nature.com/articles/s41...
#DNA #ISOGG #YHaplogroupG #AncientDNA #Iceman
www.nature.com/articles/s41...
Genomic diversity and structure of prehistoric alpine individuals from the Tyrolean Iceman’s territory - Nature Communications
Here, the authors perform genomic analysis of prehistoric individuals from the Italian Alps, to reveal a genetic shift from the Mesolithic to the Neolithic and genetic continuity from the Neolithic to...
www.nature.com
September 10, 2025 at 2:17 AM
"Moreover, G2a2* is represented by only one sub-lineage (G2a2b2a1a1b*, L497) except for the Iceman, which carries a different one (G2a2a1a2a1a1b, G-Z6208, or formerly G2a2a1a2 L-91"
#DNA #ISOGG #YHaplogroupG #AncientDNA #Iceman
www.nature.com/articles/s41...
#DNA #ISOGG #YHaplogroupG #AncientDNA #Iceman
www.nature.com/articles/s41...
Ireland’s Genealogical Gazette FREE talk on 9 Sept 2025 at 20:00 “Isotopes and Ancestry: Exploring how Archaeochemistry can answer Genealogical Questions,” given by Dr Ashley McCall, an independent researcher based in Dublin. Join via Zoom ID 844 6097 4398 and passcode 66 18 37
#DNA #ISOGG #Ireland
#DNA #ISOGG #Ireland
September 9, 2025 at 2:59 AM
“Scientists just found a sugar switch that protects your brain from Alzheimer's. In addition to a new approach in Alzheimer’s research, study from Buck Institute could explain why GLP-1 drugs show promise against dementia.” #isogg #DNA #epigenetics #glp1
www.sciencedaily.com/releases/202...
www.sciencedaily.com/releases/202...
Scientists just found a sugar switch that protects your brain from Alzheimer's
Scientists have uncovered a surprising sugar-related mechanism inside brain cells that could transform how we fight Alzheimer’s and other dementias. It turns out neurons don’t just store sugar for fue...
www.sciencedaily.com
September 6, 2025 at 1:47 PM
“Scientists just found a sugar switch that protects your brain from Alzheimer's. In addition to a new approach in Alzheimer’s research, study from Buck Institute could explain why GLP-1 drugs show promise against dementia.” #isogg #DNA #epigenetics #glp1
www.sciencedaily.com/releases/202...
www.sciencedaily.com/releases/202...
“Moreover, we demonstrated that a higher FI score of mtDNA variants was associated with both premature epigenetic aging in the early 20s and premature biological aging in the late 20s." #isogg #DNA #epigenetics #haplogroups
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Mitochondrial DNA variants and their impact on epigenetic and biological aging in young adulthood - Translational Psychiatry
Translational Psychiatry - Mitochondrial DNA variants and their impact on epigenetic and biological aging in young adulthood
www.nature.com
September 5, 2025 at 1:18 AM
“Moreover, we demonstrated that a higher FI score of mtDNA variants was associated with both premature epigenetic aging in the early 20s and premature biological aging in the late 20s." #isogg #DNA #epigenetics #haplogroups
www.nature.com/articles/s41...
www.nature.com/articles/s41...
“Results from a randomized controlled trial reveal that vitamin D supplementation helps maintain telomeres, protective caps at the ends of chromosomes that shorten during aging and are linked to the development of certain diseases.” #isogg #telomeres #epigenetics news.harvard.edu/gazette/stor...
Vitamin D supplements may slow biological aging — Harvard Gazette
Trial shows protection against telomere shortening, which heightens disease risk.
news.harvard.edu
August 31, 2025 at 1:13 PM
“Results from a randomized controlled trial reveal that vitamin D supplementation helps maintain telomeres, protective caps at the ends of chromosomes that shorten during aging and are linked to the development of certain diseases.” #isogg #telomeres #epigenetics news.harvard.edu/gazette/stor...