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David Griffin 🦠🧫💉 @drdavidwjg.bsky.social · 27d

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#HIV has minimal influence on organ allocation in respondents, but is a significant barrier to the selection of a potential donor, even an appropriate recipient. Organ quality was the most influential factor in selection of a prospective donor.

David Griffin 🦠🧫💉 @drdavidwjg.bsky.social · 27d

Pleased to share results of our discrete choice experiment of the influence of HIV on organ procurement and allocation in Australia #HIVAIDS2025

#healthequity #IDsky #HIVsky #TxIDsky #PhD

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David Griffin 🦠🧫💉 @drdavidwjg.bsky.social · Aug 15

🚨Review just out in @hivmedicine.bsky.social 🚨

“Solid organ transplantation in people with #HIV: Outcomes, obstacles and opportunities”

#IDSky #HIVSky #TxIDSky

ft. David Ruschena, Prof. James McMahon, Prof. Jenny Hoy

doi.org/10.1111/hiv....

Solid organ transplantation in people with HIV: Outcomes, obstacles and opportunities

Objective People with HIV experience disparate access to solid organ transplantation (SOT), despite mounting evidence for comparable outcomes. This review aims to understand the outcomes following S...

doi.org

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David Griffin 🦠🧫💉 @drdavidwjg.bsky.social · Mar 12

Important #latebreaker study at #CROI2025 SCORPIO-PEP phase III RCT showed ensitrelvir (Day 1: 375mg, Day 2-5: 125mg) reduced PCR positive, symptomatic #COVID19 in HHC if started w/in 72 hrs of index case symptomatic C19 by 67%. Including in those with high risk progression. Need ICH and RACF data!

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David Griffin 🦠🧫💉 @drdavidwjg.bsky.social · Mar 11

#CROI2025

Published today:

#Pharmacokinetics and safety of once-yearly lenacapavir: a phase 1, open-label study www.thelancet.com/journals/lan...

Great to see truly “long acting” therapies for HIV and PrEP emerging. the bar for #HIV #vaccines is ever higher!

Pharmacokinetics and safety of once-yearly lenacapavir: a phase 1, open-label study

Following administration of once-yearly intramuscular lenacapavir, median plasma concentrations exceeded those associated with efficacy in phase 3 studies of twice-yearly subcutaneous lenacapavir for ...

www.thelancet.com

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Reposted by David Griffin 🦠🧫💉

Juan Michael Porter II @juanmichaelii.bsky.social · Dec 10

Calling Our Patients “High Risk” Hurts Them

"Being called risky or associated w risk b/c of your sexual health decisions makes most people feel ashamed. And that shame is nothing more than another barrier to care. "

A banger op-ed by @jncherabiemd.bsky.social
www.thebodypro.com/hiv/calling-...

www.thebodypro.com

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Reposted by David Griffin 🦠🧫💉

JAMA @jama.com · Nov 28

Cervical cancer mortality in US women younger than 25 years significantly declined between 2016 and 2021, likely due to the widespread adoption of HPV vaccination.

ja.ma/4i9ghPC

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David Griffin 🦠🧫💉 @drdavidwjg.bsky.social · Nov 24

100%

There was some really interesting data presented at #CROI2024 which explored racial disparities in the lifetime risk of acquiring HIV and highlighted some of those issues of intersectionality.

www.aidsmap.com/news/mar-202...

#HIVsky #IDsky

Progress in reducing new HIV diagnoses much slower for Black men in the US

Lifetime risk of acquiring HIV has decreased for Black gay and bisexual men in the US, from 1 in 2 from 2010 to 2014 to 1 in 3 from 2017 to 2021, according to data presented to the Conference on Retro...

www.aidsmap.com

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David Griffin 🦠🧫💉 @drdavidwjg.bsky.social · Nov 23

Ten Americas: a systematic analysis of life expectancy disparities in the USA - @thelancet.bsky.social

Somber update on the 8 Americas study; highlights growing inequities in life expectancy, impact of structural racism and disproportionate impact of #COVID19

www.thelancet.com/journals/lan...

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David Griffin 🦠🧫💉 @drdavidwjg.bsky.social · Nov 23

Dr Eloise Williams gave an important update confirmatory testing for #HIV in Australia.

#MicroSky #HIVsky #IDsky
#HIVinFocus

- Use of accredited NAAT in diagnostics (cf monitoring) on separate sample to initial serology
- p24 Ag immunoassay (no longer available)
- (traditional) western blot

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David Griffin 🦠🧫💉 @drdavidwjg.bsky.social · Nov 23

Vikas Parwani from HIV/AIDS Legal Center shares a brief insight into immigration to Aus for #PWH.

Immigration exempt from discrimination laws that protect #PWH.

#HIV can be barrier due to perceived cost, but opportunities for ‘health waiver’ exist. HIV not the only barrier #PWH face. #HIVinFocus

David Griffin 🦠🧫💉 @drdavidwjg.bsky.social · Nov 23

None, though I don’t have many people on injectables at this stage.

I think more will be inclined to switch, once LAI are Q6M, or can be self administered. (LEN + ? 👀)

Frequent clinical attendance and frequent injections seem major deterrents.

Cab-LA not yet funded as PrEP here either.

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David Griffin 🦠🧫💉 @drdavidwjg.bsky.social · Nov 23

A/Prof. Mina John from Royal Perth Hospital, presents Western Australian data on implementation LAI ART in hard to reach populations, mirroring #UCSF data; improved retention in care and virological suppression.

Multiple other benefits.

#HIVsky #IDsky

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David Griffin 🦠🧫💉 @drdavidwjg.bsky.social · Nov 23

👍🏼

Same! (Plus Simva-, and Pravastatin, thou not sure why anyone would use these preferentially…)

We have:
Rosuvastatin 5-40mg
Atorvastatin 10-80mg

I typically start with rosuvastatin 10mg, unless pt on boosted PI (then typically half)

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David Griffin 🦠🧫💉 @drdavidwjg.bsky.social · Nov 23

Do you have access to pitavastatin?

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David Griffin 🦠🧫💉 @drdavidwjg.bsky.social · Nov 23

Interesting!

We use www.cvdcheck.org.au/calculator which is based on the NZ PREDICT-1° equation.

I mostly use it in conversations about risk and impact of risk factor modification (eg smoking cessation). None of our calculators incorporate HIV, ART, etc, and likely underestimate risk.

Australian cardiovascular disease risk calculator | AusCVDRisk

www.cvdcheck.org.au

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David Griffin 🦠🧫💉 @drdavidwjg.bsky.social · Nov 22

3/ #HIVinFocus

International guidelines recommend implementing the #Reprievestudy findings with different thresholds of #CVD risk statin therapy.

Australian guidance most closely aligns with the EACS recommendation.

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David Griffin 🦠🧫💉 @drdavidwjg.bsky.social · Nov 22

2/ Australian CVD risk calculators typically assign a lower risk to #PWH than AHA/ACC score.

International guidelines recommend implementing this evidence differently.

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David Griffin 🦠🧫💉 @drdavidwjg.bsky.social · Nov 22

A/Prof Janine Trevillyan from #AustinHealth describes the challenges of applying the #REPRIEVEstudy in Australia; we don’t have pitavastatin and use different risk calculators. #IDsky #HIVsky

Atorva- and rosuvastatin reduce surrogates of CVD risk, though choosing ideal biomarker can be challenging.

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David Griffin 🦠🧫💉 @drdavidwjg.bsky.social · Nov 22

6/ #REPRIEVEstudy also highlighted that #CVD risk calculators tend to overestimate CVD risk in developing countries, but underestimate risk in women.

David Griffin 🦠🧫💉 @drdavidwjg.bsky.social · Nov 22

5/ #REPRIEVEstudy showed that statins were safe (pitavastatin was chosen because it doesn’t interact with PIs), with a non-sig trend towards incident #diabetes, though glycaemic control was curiously unchanged.

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David Griffin 🦠🧫💉 @drdavidwjg.bsky.social · Nov 22

4/ #REPRIEVEstudy demonstrated definitively that statins reduce CVD risk in people with #HIV 35% with low to moderate #ASCVD risk at baseline.

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David Griffin 🦠🧫💉 @drdavidwjg.bsky.social · Nov 22

3/ mechanistically statins reduce CVD risk through several mechanisms; LDL lowering, plaque stabilization, dampening inflammation. Interestingly #REPRIEVEstudy proteomic analysis suggested PCOLCE may be important in pitavastatin impact on collagen deposition.

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David Griffin 🦠🧫💉 @drdavidwjg.bsky.social · Nov 22

2/ importance of identifying and addressing lifestyle factors, social and psychological determinants of health to reduce #CVD risk

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David Griffin 🦠🧫💉 @drdavidwjg.bsky.social · Nov 22

Day 2 #HIVinFocus

Prof. Currier from #UCLA offering insights into CVD risk in #PWH.

First, association between clonal hematopoiesis and #CVD risk in #HIV demonstrated in several cohorts.

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