Jonathan Hedley
@drjonhedley.bsky.social
Novo Nordisk Postdoctoral Research Fellow in the Torr Vision Group @ University of Oxford 🧬👨🔬 PhD in Chemical Physics ⚗️🧪Opera singer on the side 🎶🎵
Happy to have developed the theory here, linking sequence-dependent charge patterns to favourable electrostatic interactions between homologous dsDNA🧬🧬
Matching theory & expt suggests a physical basis for sequence recognition that may underpin aspects of recombination, DNA repair, and replication.
Matching theory & expt suggests a physical basis for sequence recognition that may underpin aspects of recombination, DNA repair, and replication.
It turns out sDNA 🧬 interacts selectively! Andy Stannard measured these interactions very (very) precisely, and Ehud Haimov, @drjonhedley.bsky.social, Alexei Kornyshev worked out how it all works. It has to do with charge correlation... Check it out here
chemrxiv.org/engage/chemr...
chemrxiv.org/engage/chemr...
Detection and quantification of counterion-mediated homologous recognition in double-stranded DNA
Stretches of double-stranded DNA sharing the same sequence can recognise each other in cells. This phenomenon, known as homologous recognition, is essential for DNA recombination and repair. Yet, its ...
chemrxiv.org
September 4, 2025 at 5:37 PM
Happy to have developed the theory here, linking sequence-dependent charge patterns to favourable electrostatic interactions between homologous dsDNA🧬🧬
Matching theory & expt suggests a physical basis for sequence recognition that may underpin aspects of recombination, DNA repair, and replication.
Matching theory & expt suggests a physical basis for sequence recognition that may underpin aspects of recombination, DNA repair, and replication.