Prof. Zoë Waller
@drzoewaller.bsky.social
Professor in Drug Discovery at UCL School of Pharmacy. Mum of 3. Researching. Lecturing. Chemistry. Pharmacy. DNA. RNA. i-Motif. G-Quadruplex. Cycling. Commuting. Legs. Shoes.
It was a pleasure to examine Bella! Really interesting work. Congratulations 🎊
Many congratulations to Bella Law from @Spencer_D60 jointly with our group @BristolChem on passing her MRes Viva today 🥳. Many thanks to @drzoewaller.bsky.social and Angela Nobbs for examining. Wish I could have been there in person to celebrate with you. 🍾
November 24, 2025 at 6:07 PM
It was a pleasure to examine Bella! Really interesting work. Congratulations 🎊
White coat ceremony for UCL School of Pharmacy underway @ucllifesciences.bsky.social
November 19, 2025 at 3:31 PM
White coat ceremony for UCL School of Pharmacy underway @ucllifesciences.bsky.social
So wonderful to finally meet Prof Angela Russell today - and see her final stop on her RSC Jeremy Knowles Prize tour. Absolutely inspirational talk about her experiences in the drug development process. Grateful for her insights and advice.
November 19, 2025 at 3:23 PM
So wonderful to finally meet Prof Angela Russell today - and see her final stop on her RSC Jeremy Knowles Prize tour. Absolutely inspirational talk about her experiences in the drug development process. Grateful for her insights and advice.
Congratulations to all the prize winners 🏆 👏
Join us for a celebration of this year’s Education Prizes winners!
We are honouring inspirational, innovative and dedicated people working in primary, secondary, further and higher education. Follow the thread and learn about all 12 winners of our #RSCPrizes as we congratulate… #ChemSky
We are honouring inspirational, innovative and dedicated people working in primary, secondary, further and higher education. Follow the thread and learn about all 12 winners of our #RSCPrizes as we congratulate… #ChemSky
November 19, 2025 at 8:25 AM
Congratulations to all the prize winners 🏆 👏
Reposted by Prof. Zoë Waller
#Gquadruplexes can form within fungal pathogens and represent new #antifungal targets ➡️ doi.org/10.1038/s443...
By G. Middleton, F. Mahamud, I. Storer, Z. Waller, S. Bidula & colleagues at @ucl.ac.uk & @uniofeastanglia.bsky.social
By G. Middleton, F. Mahamud, I. Storer, Z. Waller, S. Bidula & colleagues at @ucl.ac.uk & @uniofeastanglia.bsky.social
November 17, 2025 at 4:43 PM
#Gquadruplexes can form within fungal pathogens and represent new #antifungal targets ➡️ doi.org/10.1038/s443...
By G. Middleton, F. Mahamud, I. Storer, Z. Waller, S. Bidula & colleagues at @ucl.ac.uk & @uniofeastanglia.bsky.social
By G. Middleton, F. Mahamud, I. Storer, Z. Waller, S. Bidula & colleagues at @ucl.ac.uk & @uniofeastanglia.bsky.social
New paper!
Evidence that G-quadruplexes form in pathogenic fungi and represent promising antifungal targets
@ucllifesciences.bsky.social
| EMBO Molecular Medicine
www.embopress.org/doi/full/10....
Evidence that G-quadruplexes form in pathogenic fungi and represent promising antifungal targets
@ucllifesciences.bsky.social
| EMBO Molecular Medicine
www.embopress.org/doi/full/10....
Evidence that G-quadruplexes form in pathogenic fungi and represent promising antifungal targets | EMBO Molecular Medicine
imageimageIn this study, we show that G-quadruplexes can form within fungal pathogens and represent
new antifungal targets. PhenDC3 and/or pyridostatin are antifungal against Aspergillus fumigatus, C...
www.embopress.org
November 17, 2025 at 8:55 PM
New paper!
Evidence that G-quadruplexes form in pathogenic fungi and represent promising antifungal targets
@ucllifesciences.bsky.social
| EMBO Molecular Medicine
www.embopress.org/doi/full/10....
Evidence that G-quadruplexes form in pathogenic fungi and represent promising antifungal targets
@ucllifesciences.bsky.social
| EMBO Molecular Medicine
www.embopress.org/doi/full/10....
Dr Chris Morris and I have a new paper in Nucleic Acids Research.
This paper has been a long time in the making & was affected by COVID so we are proud to have it published!
@shozebhaider.bsky.social
@effrosynialexandr.bsky.social
@chriswaudby.bsky.social
academic.oup.com/nar/article/...
This paper has been a long time in the making & was affected by COVID so we are proud to have it published!
@shozebhaider.bsky.social
@effrosynialexandr.bsky.social
@chriswaudby.bsky.social
academic.oup.com/nar/article/...
Affinity-selected peptide ligands specifically bind i-motif DNA and modulate c-Myc gene expression
Abstract. c-Myc is an oncogene that is dysregulated in ∼70% of cancers. Its multifaceted function complicates effective drug targeting of the protein. i-Mo
academic.oup.com
November 7, 2025 at 4:34 PM
Dr Chris Morris and I have a new paper in Nucleic Acids Research.
This paper has been a long time in the making & was affected by COVID so we are proud to have it published!
@shozebhaider.bsky.social
@effrosynialexandr.bsky.social
@chriswaudby.bsky.social
academic.oup.com/nar/article/...
This paper has been a long time in the making & was affected by COVID so we are proud to have it published!
@shozebhaider.bsky.social
@effrosynialexandr.bsky.social
@chriswaudby.bsky.social
academic.oup.com/nar/article/...
Congratulations to Yaxuan for passing your upgrade viva - many thanks to @cjserpell.bsky.social and Chris Morris for examining
November 6, 2025 at 8:06 PM
Congratulations to Yaxuan for passing your upgrade viva - many thanks to @cjserpell.bsky.social and Chris Morris for examining
In my sadness that Irregular Choice is going out of business I'm making more effort to wear my collection - today are black flats with Queen and Corgi #irregularchoice
October 17, 2025 at 9:25 AM
In my sadness that Irregular Choice is going out of business I'm making more effort to wear my collection - today are black flats with Queen and Corgi #irregularchoice
DNA docs and Halloween vibes today ✨️
October 16, 2025 at 10:59 AM
DNA docs and Halloween vibes today ✨️
Green tomato or mitochondrion?
October 15, 2025 at 6:20 PM
Green tomato or mitochondrion?
DNA dress on today!
October 8, 2025 at 7:23 AM
DNA dress on today!
Reposted by Prof. Zoë Waller
Reposted by Prof. Zoë Waller
Primatologist Jane Goodall's recent passing left an incredible legacy that transformed our understanding of chimpanzee behavior and intelligence. New insights show that great apes use medicinal plants to treat wounds like humans. cen.acs.org/pharmaceutic... #chemsky 🧪
Chimpanzees use the same plants we do to treat similar illnesses
A new review of recent studies shows the great apes rely on medicinal plants to heal infections, but the plants’ chemistry remains mostly a mystery
cen.acs.org
October 2, 2025 at 3:06 PM
Primatologist Jane Goodall's recent passing left an incredible legacy that transformed our understanding of chimpanzee behavior and intelligence. New insights show that great apes use medicinal plants to treat wounds like humans. cen.acs.org/pharmaceutic... #chemsky 🧪
Reposted by Prof. Zoë Waller
A study found that at cellular concentrations of magnesium, the Cas9 enzyme often nicks only one strand—and this small cut is enough to defend against phages. cen.acs.org/biological-c... #chemsky 🧪
Low magnesium dulls Cas9 molecular scissors
But even when the CRISPR-Cas system is less efficient, it’s still enough to protect against phages
cen.acs.org
October 3, 2025 at 9:27 AM
A study found that at cellular concentrations of magnesium, the Cas9 enzyme often nicks only one strand—and this small cut is enough to defend against phages. cen.acs.org/biological-c... #chemsky 🧪
Reposted by Prof. Zoë Waller
From finding a "universal language" in science, to comedy, conferences and following her passion, Prof Dame Ijeoma Uchegbu @ucllifesciences.bsky.social tells BBC World Service about her fascinating path to becoming a pioneer of pharmaceutical nanoscience and champion for race equality
Outlook - One suitcase, three kids: a broke scientist pursues a dream - BBC Sounds
Once a homeless single mum, Dame Ijeoma Uchegbu is now a nanomedicine pioneer
www.bbc.co.uk
October 2, 2025 at 4:53 PM
From finding a "universal language" in science, to comedy, conferences and following her passion, Prof Dame Ijeoma Uchegbu @ucllifesciences.bsky.social tells BBC World Service about her fascinating path to becoming a pioneer of pharmaceutical nanoscience and champion for race equality
Reposted by Prof. Zoë Waller
Gain insights into regulatory affairs by learning from professionals who work in this field. Hear about their career journeys, their roles, & the skills needed to work in this sector – plus you’ll have the chance to ask questions. Attendance is free for RSC members: https://rsc.li/3IAEnWv #ChemSky
October 3, 2025 at 8:03 AM
Gain insights into regulatory affairs by learning from professionals who work in this field. Hear about their career journeys, their roles, & the skills needed to work in this sector – plus you’ll have the chance to ask questions. Attendance is free for RSC members: https://rsc.li/3IAEnWv #ChemSky
Reposted by Prof. Zoë Waller
Thanks to @jesspanch.bsky.social at Trends in Chemistry for handling this review article on DNA-peptide self-assembly which is just out. This outlook is going to frame some more papers you'll see coming out my lab over the next year or so.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Self-assembly of (poly)peptide-oligonucleotide conjugates: from orthogonality to emergence
Peptides and DNA both display characteristic self-assembly motifs which underpin the spectacularly varied and functional nanostructures of biology. Ea…
www.sciencedirect.com
October 3, 2025 at 8:08 AM
Thanks to @jesspanch.bsky.social at Trends in Chemistry for handling this review article on DNA-peptide self-assembly which is just out. This outlook is going to frame some more papers you'll see coming out my lab over the next year or so.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Meeting Tutees from Drug Discovery and Development today!
October 3, 2025 at 9:23 AM
Meeting Tutees from Drug Discovery and Development today!
Reposted by Prof. Zoë Waller
It's #ChemNobel season again!
Surely this year should go to the most important chemical breakthrough of our lifetimes: DNA synthesis/Marvin Caruthers 🧬
Phosphoramidite DNA synthesis is the bedrock of modern biology and enabled the development of therapies for untreatable diseases
#chemsky 🧪
Surely this year should go to the most important chemical breakthrough of our lifetimes: DNA synthesis/Marvin Caruthers 🧬
Phosphoramidite DNA synthesis is the bedrock of modern biology and enabled the development of therapies for untreatable diseases
#chemsky 🧪
It's Chem Nobel Prize season, so your reminder that DNA synthesis/Marvin Caruthers needs to win! chemsky 🧪
Without DNA synthesis there is NO *PCR*, *sequencing*, *cloning*, *CRISPR*, *siRNA*, *synthetic biology*, *mRNA vaccines*, *nucleic acid therapeutics*, *Nanotech*
What more am I missing?
Without DNA synthesis there is NO *PCR*, *sequencing*, *cloning*, *CRISPR*, *siRNA*, *synthetic biology*, *mRNA vaccines*, *nucleic acid therapeutics*, *Nanotech*
What more am I missing?
October 1, 2025 at 9:13 AM
It's #ChemNobel season again!
Surely this year should go to the most important chemical breakthrough of our lifetimes: DNA synthesis/Marvin Caruthers 🧬
Phosphoramidite DNA synthesis is the bedrock of modern biology and enabled the development of therapies for untreatable diseases
#chemsky 🧪
Surely this year should go to the most important chemical breakthrough of our lifetimes: DNA synthesis/Marvin Caruthers 🧬
Phosphoramidite DNA synthesis is the bedrock of modern biology and enabled the development of therapies for untreatable diseases
#chemsky 🧪
Twenty years today I started my PhD - tempus fugit
a clock that has the hands on the numbers 10 and 12
ALT: a clock that has the hands on the numbers 10 and 12
media.tenor.com
October 1, 2025 at 8:17 PM
Twenty years today I started my PhD - tempus fugit
Congratulations to Dilek to getting a position as a Lecturer! It's not goodbye - just a pivot from Postdoc to collaborator ❤️
September 30, 2025 at 8:56 PM
Congratulations to Dilek to getting a position as a Lecturer! It's not goodbye - just a pivot from Postdoc to collaborator ❤️
Reposted by Prof. Zoë Waller
The fabulous Naked Scientists have just produced a podcast episode about colour in art, a topic about which I was of course delighted to speak to them.
www.thenakedscientists.com/podcasts/nak...
www.thenakedscientists.com/podcasts/nak...
Painting: where art meets science
The chemistry behind the craft...
www.thenakedscientists.com
September 30, 2025 at 3:50 PM
The fabulous Naked Scientists have just produced a podcast episode about colour in art, a topic about which I was of course delighted to speak to them.
www.thenakedscientists.com/podcasts/nak...
www.thenakedscientists.com/podcasts/nak...
Reposted by Prof. Zoë Waller
It gets earlier every year... Next Wednesday, join me and an expert panel to discuss who might win the 2025 #ChemNobel. Free to attend.
Date: Wednesday, October 1, 2025
Time: 2–3 PM ET
Register here: lnkd.in/eD8cdWRS
Date: Wednesday, October 1, 2025
Time: 2–3 PM ET
Register here: lnkd.in/eD8cdWRS
September 24, 2025 at 3:19 PM
It gets earlier every year... Next Wednesday, join me and an expert panel to discuss who might win the 2025 #ChemNobel. Free to attend.
Date: Wednesday, October 1, 2025
Time: 2–3 PM ET
Register here: lnkd.in/eD8cdWRS
Date: Wednesday, October 1, 2025
Time: 2–3 PM ET
Register here: lnkd.in/eD8cdWRS