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Billy Li

@dsrna.bsky.social

580 followers 51 following 13 posts

ADAR, RNA editing, RNA sensing, interferon, innate immunity, inflammation, human genetics | Professor @ Stanford University | Co-founder @ AIRNA

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Billy Li @dsrna.bsky.social · Apr 15

I’m excited that this review co-written with my colleague and friend Carl Walkley is now published! We focused on genetic studies, from mouse to human, that uncover the functional importance and mechanisms of RNA editing enzyme ADAR1 and reveal exciting therapeutic potential. #ADAR #RNAediting

Nature Reviews Genetics @natrevgenet.nature.com · Apr 14

New online! Leveraging genetics to understand ADAR1-mediated RNA editing in health and disease

Leveraging genetics to understand ADAR1-mediated RNA editing in health and disease

Nature Reviews Genetics, Published online: 14 April 2025; doi:10.1038/s41576-025-00830-5ADAR1-mediating RNA editing enables the cell to distinguish between endogenous and viral RNA. Li and Walkley review findings from human and mouse genetics that have revealed the mechanisms of ADAR1-mediated RNA editing, which are now providing insights for the development of potential therapies that target these mechanisms.

www.nature.com

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Billy Li @dsrna.bsky.social · Apr 2

Immensely grateful for the tireless dedication of the entire OneAIRNA team! The potential of the ADAR-mediated RNA base editing modality is truly extraordinary, and this is just the beginning. I look forward to AIRNA's continued pioneering innovations as we embrace the next chapter together.

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Billy Li @dsrna.bsky.social · Apr 2

Happy April Fool’s Day! But the news from AIRNA is no joke! It’s been incredibly rewarding and humbling to witness the journey of RNA base editing, from the early days in the labs of my co-founder Thorsten Stafforst and mine, to the remarkable progress we see today. #ADAR #RNAediting

AIRNA Raises Oversubscribed $155 Million Series B Financing to Fund Phase 1/2 Clinical Trial for Alpha-1 Antitrypsin Deficiency and Future Pipeline — Airna

Financing led by Venrock Healthcare Capital Partners with co-lead Forbion Growth, and participation from RTW Investments, Nextech Invest, and other new

airna.com

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Billy Li @dsrna.bsky.social · Mar 4

Sri, thanks for the update! Sending good luck and best wishes to you and your family!

Billy Li @dsrna.bsky.social · Feb 9

I am so sorry Sri about what your daughter and your family are going through. I cannot imagine how difficult this has been for you all. Sending my best wishes!

Billy Li @dsrna.bsky.social · Feb 5

A nice article written by Vivien Marx @naturemethods.bsky.social featuring RNA editing, from biology to therapy. I enjoyed talking with her to offer my 2 cents. Exciting times ahead! #ADAR

www.nature.com/articles/s41...

Taking control with RNA - Nature Methods

As they study the emerging roles of RNA in disease and homeostasis, some scientists use RNA editing to direct precise RNA changes that shape cellular events.

www.nature.com

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Billy Li @dsrna.bsky.social · Jan 3

Congratulations Klaus and team!

Billy Li @dsrna.bsky.social · Dec 20

Congratulations Nandan!

Billy Li @dsrna.bsky.social · Dec 7

Would love to be added, thanks!

Reposted by Billy Li

Jacki Heraud-Farlow @jackiheraudfarlow.bsky.social · Dec 6

Time for a 🧵 on our new paper from the Walkley lab in @scienceimmuno.bsky.social.

If you're into RNA editing by ADARs, double-stranded RNA (dsRNA) sensing, post-transcriptional gene regulation and CRISPR screening, then read on! 1/X

www.science.org/doi/10.1126/...

#RNASky #ImmunoSky

GGNBP2 regulates MDA5 sensing triggered by self double-stranded RNA following loss of ADAR1 editing

GGNBP2, CNOT10, and CNOT11 are required for innate immune response after the loss of ADAR1-mediated editing of self dsRNA.

www.science.org

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Billy Li @dsrna.bsky.social · Nov 25

Would love to be added. Thanks!

Billy Li @dsrna.bsky.social · Nov 25

Would love to be added. Thanks!

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Billy Li @dsrna.bsky.social · Nov 24

Happy birthday and congratulations Jacki! I’m glad to be part of this great story!

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Billy Li @dsrna.bsky.social · Nov 24

Please add me to this starter pack. Thanks!

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