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Jacki Heraud-Farlow

@jackiheraudfarlow.bsky.social

1.6K followers 1.2K following 57 posts

RNA biologist working at Hudson Institute in Melbourne. Interested in intersection of RNA modifications (A-to-I editing), dsRNA structure and RBPs with innate immunity and autoinflammatory disease. She/her.

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Jacki Heraud-Farlow @jackiheraudfarlow.bsky.social · Dec 6

Time for a 🧵 on our new paper from the Walkley lab in @scienceimmuno.bsky.social.

If you're into RNA editing by ADARs, double-stranded RNA (dsRNA) sensing, post-transcriptional gene regulation and CRISPR screening, then read on! 1/X

www.science.org/doi/10.1126/...

#RNASky #ImmunoSky

GGNBP2 regulates MDA5 sensing triggered by self double-stranded RNA following loss of ADAR1 editing

GGNBP2, CNOT10, and CNOT11 are required for innate immune response after the loss of ADAR1-mediated editing of self dsRNA.

www.science.org

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Reposted by Jacki Heraud-Farlow

Minni Änkö @rnaminni.bsky.social · 28d

Happy to share our review on the Interplay between RNA-protein interactions and RNA structures. The open access article can be accessed here: doi.org/10.1002/2211...

FEBS Press

Methodological advances in mapping transcriptome-wide RNA-protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA...

doi.org

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Reposted by Jacki Heraud-Farlow

Natalia Sampaio @drnatsampaio.bsky.social · Sep 3

Last day of #ARNASydney2025 and this cartoon from @xkcd.com is just particularly appropriate, so I had to re-share! #RNAsky

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Reposted by Jacki Heraud-Farlow

Natalia Sampaio @drnatsampaio.bsky.social · Sep 2

Super fun presenting some of our #MDA5 #RNA sensor work to an RNA-centric audience! The different point of view from my usual infection and immunity background led to some great questions and discussions. More ideas forming!!! #ARNASydney2025 #virus 🧪🧫🦠

Selene FeRNAndez @selfdz.bsky.social · Sep 2

We had a set of amazing talks in the #RNA in immunity session at #ARNASydney2025. Presentations by Stacey Horner, @drnatsampaio.bsky.social, Elizabeth Chan and Kitty McCaffrey. From viral infections to bacterial toxins, a really great session.

#RNASky

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Reposted by Jacki Heraud-Farlow

Minni Änkö @rnaminni.bsky.social · Aug 17

Application for 2025/2026 RNA Salons is now open. Please apply by 31st August to receive support your local or regional RNA activities. @rnasociety.bsky.social #Lexogen www.rnasociety.org/salons

www.rnasociety.org

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Reposted by Jacki Heraud-Farlow

Caleb Lareau @caleblareau.bsky.social · Jul 22

Excited to share a new preprint from the lab with @ryandhindsa.bsky.social ! www.biorxiv.org/content/10.1...

Led by @sherrynyeo.bsky.social, @erinmayc.bsky.social, and friends, we continue our journey to find viral DNA in our favorite place-- the overlooked and discarded reads in existing data! 1/

the treasure trove of all sequencing datasets

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Reposted by Jacki Heraud-Farlow

Selene FeRNAndez @selfdz.bsky.social · Jun 17

Registration for A-RNA 2025 is now open!!!

Join us in September for 3 days of #RNA Science. We have an excellent lineup of invited speakers (www.a-rnameeting.org.au/invited-spea...) & networking events

Register: www.a-rnameeting.org.au/registration

Early bird rate ends July 30th, 2025

#RNASky

Promotional tile for A-RNA 2025 meeting in Sydney, Australia. List of international speakers and registration link

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Reposted by Jacki Heraud-Farlow

Billy Li @dsrna.bsky.social · Apr 15

I’m excited that this review co-written with my colleague and friend Carl Walkley is now published! We focused on genetic studies, from mouse to human, that uncover the functional importance and mechanisms of RNA editing enzyme ADAR1 and reveal exciting therapeutic potential. #ADAR #RNAediting

Nature Reviews Genetics @natrevgenet.nature.com · Apr 14

New online! Leveraging genetics to understand ADAR1-mediated RNA editing in health and disease

Leveraging genetics to understand ADAR1-mediated RNA editing in health and disease

Nature Reviews Genetics, Published online: 14 April 2025; doi:10.1038/s41576-025-00830-5ADAR1-mediating RNA editing enables the cell to distinguish between endogenous and viral RNA. Li and Walkley review findings from human and mouse genetics that have revealed the mechanisms of ADAR1-mediated RNA editing, which are now providing insights for the development of potential therapies that target these mechanisms.

www.nature.com

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Reposted by Jacki Heraud-Farlow

Randall Munroe @xkcd.com · Feb 26

RNA xkcd.com/3056

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Reposted by Jacki Heraud-Farlow

Jeff Craig @drchromo.bsky.social · Feb 27

Today is Rare Disease Day

Rare diseases affect millions worldwide, often with limited treatment options. Rare Voices Australia (RVA) advocates for those living with rare diseases, connecting them to vital resources. Learn more: rarevoices.org.au
Five rare diseases and support groups:

Peak body for Australians with rare diseases including genetic disorders

An estimated two million Australians live with a rare disease. Approximately 80% of rare diseases are genetic disorders.

rarevoices.org.au

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Reposted by Jacki Heraud-Farlow

Ivan Zanoni @lozanzi.bsky.social · Feb 27

Cool stuff @cp-cell.bsky.social by @raflynn5.bsky.social & friends on presence & functions of glycoRNA microdomains on the plasma membrane! 👇👇👇

Ryan Flynn @raflynn5.bsky.social · Feb 27

Excited to share the work of Jonathan Perr where he uncovered a surprisingly common feature of cell surfaces - the presentation and clustering of RNA binding proteins with #glycoRNA.

Critically support by #NIH @cp-cell.bsky.social www.cell.com/cell/abstrac...

RNA-binding proteins and glycoRNAs form domains on the cell surface for cell-penetrating peptide entry

Mammalian cells present RNA-binding proteins on the cell surface that form clustered domains containing glycoRNAs.

www.cell.com

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Jacki Heraud-Farlow @jackiheraudfarlow.bsky.social · Feb 19

Good point, I mean we know that’s true right?! Maybe the reduced coverage we see of these elements we always see in sequencing data is actually due to splicing, not structure like we have always assumed ….

Jacki Heraud-Farlow @jackiheraudfarlow.bsky.social · Feb 19

Wow, looking forward to reading this one. Do the spliced TEs trigger nucleic acid sensors like PKR or MDA5?

#RNASky #ImmunoSky

Oded Rechavi @odedrechavi.bsky.social · Feb 18

What an amazing discovery from Scott Kennedy's lab! A new splicing system that recognizes transposons and removes them from mRNAs! t.co/3p3wyxkYXX

https://www.biorxiv.org/content/10.1101/2025.02.14.638102v1?ct=

t.co

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Jacki Heraud-Farlow @jackiheraudfarlow.bsky.social · Feb 18

Attention all Melbourne #RNA researchers. The next RNAVic minisymposium is now open for FREE registration. To be held at @hudsonresearch.bsky.social on March 27th with a great lineup of local speakers from research and industry. This is an RNA salon event supported by @rnasociety.bsky.social.

Michael Gantier @gantierlab.bsky.social · Feb 15

For all RNA scientists in the Melbourne area: Join us at the next RNA Victoria Minisymposium on 27th of March at the Hudson Institute of Medical Research - details about the speakers and free registration at www.rnavic.com

RNA Victoria minisymposium | RNA Victoria Network

www.rnavic.com

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Reposted by Jacki Heraud-Farlow

Eugene Valkov @eugenevalkov.bsky.social · Feb 7

#RNAsky #RNAbiology

PLOS Biology @plosbiology.org · Feb 7

How does the regulation of RNA stability contribute to cortical development? This study profiles the #RNAstability landscape of the #cortex across development, revealing that the CCR4-NOT deadenylase complex is essential for corticogenesis in vivo 🧪 @plosbiology.org plos.io/3EtZjvN

Left: Immunofluorescence for the indicated markers (BrdU, EdU, Ki67 and merge) in E12.5 cortical sections from control mice (top panel) and CNOT3 knockout mice (bottom panel). Right: Models for relationship between RNA turnover and gene expression, and the role of Cnot3 in cortical development. The schematic shows cortical development in WT (top panel) and Cnot3 cKO embryos (bottom panel). Loss of Cnot3 impacts development by p53-dependent and p53-independent mechanisms leading to apoptosis of progenitors and neurons, reduced neurogenic divisions, and longer cell cycle duration.

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Reposted by Jacki Heraud-Farlow

Gal Haimovich ☣ 🧪🔬🎗 @grnfluoresceblg.bsky.social · Feb 5

#IL_NAT25
Yuval Dor on RNA editing in diabetes.
Thought inflamation caused by virus, but no virus found.
Can initial process that lead to diabetes trigerred by endogenous dsRNA induced inflamation?
Data indicates yes, by ADAR KO mouse model.
Phenotype similar to progression of diabetes in humans

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Jacki Heraud-Farlow @jackiheraudfarlow.bsky.social · Feb 7

The world of RNA modifications expands again! ADP-ribosylation discovered in the arms race of host-pathogen interactions.

#RNASky #Immunosky

Carolyn Bertozzi @carolynbertozzi.bskyverified.social · Feb 6

Check it out! Another novel RNA modification - ADP-ribosylation - that was previously only known on proteins. A cousin to #glycoRNA 👏

www.nature.com/articles/s41...

Graphic showing modification of mRNA with ADP-ribose mediated by bacterial enzyme cmdTAC

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Jacki Heraud-Farlow @jackiheraudfarlow.bsky.social · Feb 5

No problems. I always enjoy a conference recap from those I’ve missed too! Most of the talks will be available to stream for a limited time too if you’ve got regrets (and can afford it!)

Jacki Heraud-Farlow @jackiheraudfarlow.bsky.social · Feb 4

Capped off the trip with a visit to the lovely group at the Kampmann lab @kampmann.bsky.social in San Francisco full of awesome discussions about all their cool screens and presenting some of our data too.

Jacki Heraud-Farlow @jackiheraudfarlow.bsky.social · Feb 4

...
- All the talks on LINE1 and HUSH complex - I learned a lot! Kathleen Burns, Paul Lehner, Helen Rowe,
- Kristin Patrick from @thepwlab.bsky.social with very cool imaging of nuclear condensates in macrophage immune response.
- and so many others but I've run out of steam!

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Jacki Heraud-Farlow @jackiheraudfarlow.bsky.social · Feb 4

A few other talk highlights that are not yet published:

- Tiffany Hsu from Sun Hur's lab presenting on MDA5 in Dermatomyositis.
- @kseskv.bsky.social with awesome datasets on B cell development
- Qin Li on RNA editing in T1D
...

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Jacki Heraud-Farlow @jackiheraudfarlow.bsky.social · Feb 4

Eric Poeschla presented this fascinating story on a mouse with chronic dsRNA production that develops SIngleton-Merton syndrome like phenotype following haploinsufficiency of Adar1. This one really had me thinking!

www.biorxiv.org/content/10.1...

ADAR1 haploinsufficiency and sustained viral RdRp dsRNA synthesis synergize to dysregulate RNA editing and cause multi-system interferonopathy

Sensing of viral double-stranded RNA by MDA5 triggers abundant but transient interferon-stimulated gene (ISGs) expression. If dsRNA synthesis is made persistent by transgenically expressing a picornav...

www.biorxiv.org

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Jacki Heraud-Farlow @jackiheraudfarlow.bsky.social · Feb 4

Yorgo Modis presented a really interesting story on the trade off of different MDA5 variants.

www.medrxiv.org/content/10.1...

MDA5 variants trade antiviral activity for protection from autoimmune disease

Loss-of-function variants in MDA5, a key sensor of double-stranded RNA from viruses and retroelements, have been associated with protection from type 1 diabetes (T1D) in genome-wide association studie...

www.medrxiv.org

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Jacki Heraud-Farlow @jackiheraudfarlow.bsky.social · Feb 4

@dulinlab.bsky.social did an impressive job explaining biophysics to biologists to uncover a new model of MDA5 activation which is super cool.

www.biorxiv.org/content/10.1...

An alternative mechanism for activation of innate immune signaling by MDA5

Long double-stranded (ds) RNA in the cytosol acts as a potent inflammatory molecule recognized by the receptor MDA5, triggering the innate immune response. Mutations in MDA5 affecting dsRNA recognitio...

www.biorxiv.org

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Jacki Heraud-Farlow @jackiheraudfarlow.bsky.social · Feb 4

Fellow @hudsonresearch.bsky.social researcher @gantierlab.bsky.social presented his incredible story on new modes of TLR7/8 antagonism by tiny RNA fragments.

www.biorxiv.org/content/10.1...

2’-O-Methyl-guanosine 3-base RNA fragments mediate essential natural TLR7/8 antagonism

Recognition of RNA fragments by Toll-like receptors (TLR) 7 and 8 is a key contributor to the initiation of a protective innate immune response against pathogens. A long-standing enigma is how degrada...

www.biorxiv.org

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Jacki Heraud-Farlow @jackiheraudfarlow.bsky.social · Feb 4

Sun Hur presented this preprint on how PACT regulates PKR activation which was super impressive as always.

www.biorxiv.org/content/10.1...

PACT prevents aberrant activation of PKR by endogenous dsRNA without sequestration

The innate immune sensor PKR for double-stranded RNA (dsRNA) is critical for antiviral defense, but its aberrant activation by cellular dsRNA is linked to various diseases. The dsRNA-binding protein P...

www.biorxiv.org

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