Caleb Lareau
@caleblareau.bsky.social
assistant professor @mskcancercenter.bsky.social
clareaulab.com
clareaulab.com
Reposted by Caleb Lareau
Re-analysis of human population-scale whole genome seq data elucidates genetic architecture of EBV DNA persistence, a framework for the broader human virome
@nature.com @caleblareau.bsky.social @sherrynyeo.bsky.social @erinmayc.bsky.social @ryandhindsa.bsky.social
www.nature.com/articles/s41...
@nature.com @caleblareau.bsky.social @sherrynyeo.bsky.social @erinmayc.bsky.social @ryandhindsa.bsky.social
www.nature.com/articles/s41...
January 28, 2026 at 10:25 PM
Re-analysis of human population-scale whole genome seq data elucidates genetic architecture of EBV DNA persistence, a framework for the broader human virome
@nature.com @caleblareau.bsky.social @sherrynyeo.bsky.social @erinmayc.bsky.social @ryandhindsa.bsky.social
www.nature.com/articles/s41...
@nature.com @caleblareau.bsky.social @sherrynyeo.bsky.social @erinmayc.bsky.social @ryandhindsa.bsky.social
www.nature.com/articles/s41...
Reposted by Caleb Lareau
This was a fun and rewarding collaboration! A great example of extracting biological signal from data hiding in plain sight
Today in @nature.com, we describe how discarded reads in biobank-scale WGS can help resolve the genetic predictors and consequences of Epstein-Barr Virus (EBV) infection.
Wonderful working with @ryandhindsa.bsky.social @sherrynyeo.bsky.social @erinmayc.bsky.social
www.nature.com/articles/s41...
Wonderful working with @ryandhindsa.bsky.social @sherrynyeo.bsky.social @erinmayc.bsky.social
www.nature.com/articles/s41...
Population-scale sequencing resolves determinants of persistent EBV DNA - Nature
Population-scale WGS reveals genetic determinants of persistent EBV DNA, linking immune regulation—especially antigen processing and MHC class II variation—to EBV persistence and heterogeneous di...
www.nature.com
January 28, 2026 at 6:09 PM
This was a fun and rewarding collaboration! A great example of extracting biological signal from data hiding in plain sight
Today in @nature.com, we describe how discarded reads in biobank-scale WGS can help resolve the genetic predictors and consequences of Epstein-Barr Virus (EBV) infection.
Wonderful working with @ryandhindsa.bsky.social @sherrynyeo.bsky.social @erinmayc.bsky.social
www.nature.com/articles/s41...
Wonderful working with @ryandhindsa.bsky.social @sherrynyeo.bsky.social @erinmayc.bsky.social
www.nature.com/articles/s41...
Population-scale sequencing resolves determinants of persistent EBV DNA - Nature
Population-scale WGS reveals genetic determinants of persistent EBV DNA, linking immune regulation—especially antigen processing and MHC class II variation—to EBV persistence and heterogeneous di...
www.nature.com
January 28, 2026 at 5:07 PM
Today in @nature.com, we describe how discarded reads in biobank-scale WGS can help resolve the genetic predictors and consequences of Epstein-Barr Virus (EBV) infection.
Wonderful working with @ryandhindsa.bsky.social @sherrynyeo.bsky.social @erinmayc.bsky.social
www.nature.com/articles/s41...
Wonderful working with @ryandhindsa.bsky.social @sherrynyeo.bsky.social @erinmayc.bsky.social
www.nature.com/articles/s41...
Reposted by Caleb Lareau
The Cancer Signaling & Microenvironment Program at Fox Chase Cancer Center is looking for tenure track faculty (assist./assoc./full) in computational & experimental protein design. CV & 3-page research statement by Feb 15.
More info here:
www.linkedin.com/feed/update/...
Questions: DM/Email me.
More info here:
www.linkedin.com/feed/update/...
Questions: DM/Email me.
Now hiring: Tenure-track faculty (Asst/Assoc/Full) in Computational & Experimental Protein Design at Fox Chase Cancer Center, Philadelphia PA
Join the Cancer Signaling & Microenvironment Pro...
Now hiring: Tenure-track faculty (Asst/Assoc/Full) in Computational & Experimental Protein Design at Fox Chase Cancer Center, Philadelphia PA
Join the Cancer Signaling & Microenvironment Program at ...
www.linkedin.com
January 19, 2026 at 3:57 AM
The Cancer Signaling & Microenvironment Program at Fox Chase Cancer Center is looking for tenure track faculty (assist./assoc./full) in computational & experimental protein design. CV & 3-page research statement by Feb 15.
More info here:
www.linkedin.com/feed/update/...
Questions: DM/Email me.
More info here:
www.linkedin.com/feed/update/...
Questions: DM/Email me.
Reposted by Caleb Lareau
i see this all the time with no mention of structural suppression:
- Electoral College winner-take-all
- working day elections
- voter registration burden
turnout in battleground states is fairly high. people aren't lazy. they are responding to disincentivization and disenfranchisement.
- Electoral College winner-take-all
- working day elections
- voter registration burden
turnout in battleground states is fairly high. people aren't lazy. they are responding to disincentivization and disenfranchisement.
Close to 90 million people did NOT vote in the 2024 election.
90 million.
It bears repeating over and over and over.
90 million.
It bears repeating over and over and over.
January 12, 2026 at 10:15 PM
i see this all the time with no mention of structural suppression:
- Electoral College winner-take-all
- working day elections
- voter registration burden
turnout in battleground states is fairly high. people aren't lazy. they are responding to disincentivization and disenfranchisement.
- Electoral College winner-take-all
- working day elections
- voter registration burden
turnout in battleground states is fairly high. people aren't lazy. they are responding to disincentivization and disenfranchisement.
We are very excited to share the first preprint of a new direction for our group. Led by the fearless duo of @arthurwchow.bsky.social and @hoyinchu.bsky.social, our foray into computational protein design—
Sequence and structural determinants of efficacious de novo chimeric antigen receptors https://www.biorxiv.org/content/10.64898/2025.12.12.694033v1
December 14, 2025 at 10:38 AM
We are very excited to share the first preprint of a new direction for our group. Led by the fearless duo of @arthurwchow.bsky.social and @hoyinchu.bsky.social, our foray into computational protein design—
I had an unbelievable first time running the NYC Marathon with
@fredsteammskcc.bsky.social and
@mskcancercenter.bsky.social! Shout out to the lab for supporting us!
@fredsteammskcc.bsky.social and
@mskcancercenter.bsky.social! Shout out to the lab for supporting us!
November 3, 2025 at 3:45 PM
I had an unbelievable first time running the NYC Marathon with
@fredsteammskcc.bsky.social and
@mskcancercenter.bsky.social! Shout out to the lab for supporting us!
@fredsteammskcc.bsky.social and
@mskcancercenter.bsky.social! Shout out to the lab for supporting us!
October 31, 2025 at 4:47 PM
Reposted by Caleb Lareau
We're excited to share that Dr. Omar Abdel-Wahab, a leukemia specialist at MSK, has been elected to the @nam.edu.
With Dr. Abdel-Wahab’s appointment, a total of 28 MSK faculty members have been conferred with this recognition.
Congratulations, Dr. Abdel-Wahab!
bit.ly/49ezKw0
With Dr. Abdel-Wahab’s appointment, a total of 28 MSK faculty members have been conferred with this recognition.
Congratulations, Dr. Abdel-Wahab!
bit.ly/49ezKw0
Memorial Sloan Kettering Cancer Center Physician-Scientist Elected to the Prestigious National Academy of Medicine
Omar Abdel-Wahab, MD, Chair of the Molecular Pharmacology Program at Sloan Kettering Institute (SKI); Evnin Family Chair in Molecular Pharmacology and Attending Physician on the Leukemia Service at Me...
bit.ly
October 21, 2025 at 5:49 PM
We're excited to share that Dr. Omar Abdel-Wahab, a leukemia specialist at MSK, has been elected to the @nam.edu.
With Dr. Abdel-Wahab’s appointment, a total of 28 MSK faculty members have been conferred with this recognition.
Congratulations, Dr. Abdel-Wahab!
bit.ly/49ezKw0
With Dr. Abdel-Wahab’s appointment, a total of 28 MSK faculty members have been conferred with this recognition.
Congratulations, Dr. Abdel-Wahab!
bit.ly/49ezKw0
Reposted by Caleb Lareau
Zero arrests. 100,000 people. No violence. This who we are.
October 18, 2025 at 10:43 PM
Zero arrests. 100,000 people. No violence. This who we are.
October 18, 2025 at 5:09 PM
Reposted by Caleb Lareau
Penn and USC have also rejected the Compact!
That makes 4 - stronger together.
www.insidehighered.com/news/faculty...
That makes 4 - stronger together.
www.insidehighered.com/news/faculty...
Penn, U. of Southern California Reject Trump Compact
The universities follow the Massachusetts Institute of Technology and Brown University in rejecting the Trump administration’s proposal that would require sweeping changes.
www.insidehighered.com
October 16, 2025 at 10:24 PM
Penn and USC have also rejected the Compact!
That makes 4 - stronger together.
www.insidehighered.com/news/faculty...
That makes 4 - stronger together.
www.insidehighered.com/news/faculty...
Reposted by Caleb Lareau
The data is from April but holy moly
October 11, 2025 at 5:11 PM
The data is from April but holy moly
Reposted by Caleb Lareau
How can mitophagy be an effective quality control mechanism if mtDNA mutations reach high enough levels to cause disease?
This question led us into a dark path, full of concepts of evolutionary genetics, germline stem cell biology and mito-nuclear compatibility.
www.science.org/doi/10.1126/...
This question led us into a dark path, full of concepts of evolutionary genetics, germline stem cell biology and mito-nuclear compatibility.
www.science.org/doi/10.1126/...
Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations
Mitochondrial synthesis of adenosine triphosphate is essential for eukaryotic life but is dependent on the cooperation of two genomes: nuclear and mitochondrial DNA (mtDNA). mtDNA mutates ~15 times as...
www.science.org
October 10, 2025 at 8:45 AM
How can mitophagy be an effective quality control mechanism if mtDNA mutations reach high enough levels to cause disease?
This question led us into a dark path, full of concepts of evolutionary genetics, germline stem cell biology and mito-nuclear compatibility.
www.science.org/doi/10.1126/...
This question led us into a dark path, full of concepts of evolutionary genetics, germline stem cell biology and mito-nuclear compatibility.
www.science.org/doi/10.1126/...
Reposted by Caleb Lareau
Now that I'm settled in at @umasschan.bsky.social, I'm hiring at all levels: grad students, post-docs, and software engineers/bioinformaticians!
The goal of my lab is to understand the regulatory role of every nucleotide in our genomes and how this changes across every cell in our bodies.
The goal of my lab is to understand the regulatory role of every nucleotide in our genomes and how this changes across every cell in our bodies.
October 7, 2025 at 3:24 PM
Now that I'm settled in at @umasschan.bsky.social, I'm hiring at all levels: grad students, post-docs, and software engineers/bioinformaticians!
The goal of my lab is to understand the regulatory role of every nucleotide in our genomes and how this changes across every cell in our bodies.
The goal of my lab is to understand the regulatory role of every nucleotide in our genomes and how this changes across every cell in our bodies.
Reposted by Caleb Lareau
Two group leader positions available in the broader areas of RNA science, RNA technologies, and RNA medicine. Attractive packages and a great environment. Come and join us at Helmholtz RNA Würzburg, Bavaria.
October 8, 2025 at 9:45 PM
Two group leader positions available in the broader areas of RNA science, RNA technologies, and RNA medicine. Attractive packages and a great environment. Come and join us at Helmholtz RNA Würzburg, Bavaria.
Reposted by Caleb Lareau
We’re excited to report work led by postdoc Jennifer Porat in the lab, finding that DNA accumulates on the surface of living cells and that the secreted extracellular protein DNASE1L3 can modulate its levels on B and T cells. With a new twist for ATAC-seq as well www.biorxiv.org/content/10.1...
DNASE1L3 surveils mitochondrial DNA on the surface of distinct mammalian cells
The extracellular space is a critical environment for discriminating self versus non-self nucleic acids and initiating the appropriate immune responses through signaling cascades to relay information ...
www.biorxiv.org
October 7, 2025 at 1:22 PM
We’re excited to report work led by postdoc Jennifer Porat in the lab, finding that DNA accumulates on the surface of living cells and that the secreted extracellular protein DNASE1L3 can modulate its levels on B and T cells. With a new twist for ATAC-seq as well www.biorxiv.org/content/10.1...
Reposted by Caleb Lareau
A new Nature Medicine study analyzing health records from >100 million people in the US offers compelling evidence that reactivation of varicella-zoster virus (VZV) ,the same virus that causes chickenpox and shingles may contribute to dementia risk.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Varicella-zoster virus reactivation and the risk of dementia - Nature Medicine
Large-scale longitudinal health records reveal consistent association of varicella-zoster virus reactivation with dementia.
www.nature.com
October 6, 2025 at 4:46 PM
A new Nature Medicine study analyzing health records from >100 million people in the US offers compelling evidence that reactivation of varicella-zoster virus (VZV) ,the same virus that causes chickenpox and shingles may contribute to dementia risk.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Caleb Lareau
BREAKING: The Nobel Prize in Physiology or Medicine has been awarded jointly to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi "for their discoveries concerning peripheral immune tolerance"
Stay tuned for more.
#NobelPrize
Stay tuned for more.
#NobelPrize
October 6, 2025 at 9:34 AM
BREAKING: The Nobel Prize in Physiology or Medicine has been awarded jointly to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi "for their discoveries concerning peripheral immune tolerance"
Stay tuned for more.
#NobelPrize
Stay tuned for more.
#NobelPrize
Reposted by Caleb Lareau
Great article from @stephaniemlee.bsky.social at @chronicle.com on the NIH Autism Data Science Initiative (ADSI) www.chronicle.com/article/what...
ADSI funding went to reputable scientists because and only because dedicated NIH civil servants fought hard to ensure a rigorous, science-based process.
ADSI funding went to reputable scientists because and only because dedicated NIH civil servants fought hard to ensure a rigorous, science-based process.
What It’s Like to Be an Autism Scientist Funded by the Trump Administration
The government is funding respected scholars to study autism’s causes, at a time when experts say it’s also sowing misinformation about the same topic.
www.chronicle.com
October 4, 2025 at 2:59 AM
Great article from @stephaniemlee.bsky.social at @chronicle.com on the NIH Autism Data Science Initiative (ADSI) www.chronicle.com/article/what...
ADSI funding went to reputable scientists because and only because dedicated NIH civil servants fought hard to ensure a rigorous, science-based process.
ADSI funding went to reputable scientists because and only because dedicated NIH civil servants fought hard to ensure a rigorous, science-based process.
Reposted by Caleb Lareau
Does anyone have a good, reasonably up-to-date review of cryo-EM uses and methodology for (relatively) high-resolution protein structure determination? For someone who doesn't have a cryo-EM background.
September 27, 2025 at 11:57 PM
Does anyone have a good, reasonably up-to-date review of cryo-EM uses and methodology for (relatively) high-resolution protein structure determination? For someone who doesn't have a cryo-EM background.
Reposted by Caleb Lareau
Reminder starting in October NIH NOFOs won’t be posted in the Guide for grants and contracts.
Tips on how to search for opportunities & set up a subscription for custom searches here: grants.nih.gov/news-events/...
Tips on how to search for opportunities & set up a subscription for custom searches here: grants.nih.gov/news-events/...
New Tool to Explore NIH Grant Opportunities | Grants & Funding
grants.nih.gov
September 26, 2025 at 2:48 PM
Reminder starting in October NIH NOFOs won’t be posted in the Guide for grants and contracts.
Tips on how to search for opportunities & set up a subscription for custom searches here: grants.nih.gov/news-events/...
Tips on how to search for opportunities & set up a subscription for custom searches here: grants.nih.gov/news-events/...
Reposted by Caleb Lareau
Introducing Spacelink, a unified framework for identifying and prioritizing spatially variable gene programs at tissue and cell type resolution and linking them to disease GWAS studies. Led by Hanbyul Lee & Haochen Sun www.biorxiv.org/content/10.1...
September 25, 2025 at 5:04 PM
Introducing Spacelink, a unified framework for identifying and prioritizing spatially variable gene programs at tissue and cell type resolution and linking them to disease GWAS studies. Led by Hanbyul Lee & Haochen Sun www.biorxiv.org/content/10.1...
Reposted by Caleb Lareau
🚨 New preprints from our lab!
First, we introduce Cryo-mtscATAC-seq, led by Maren (@ms-maren.bsky.social ), enabling high-throughput clonal tracing from frozen human samples by isolating nuclei with their mitochondria (“CryoCells”).
👉 www.biorxiv.org/content/10.1...
Cryo-mtscATAC-seq for single-cell mitochondrial DNA genotyping and clonal tracing in archived human tissues
High-throughput clonal tracing of primary human samples relies on naturally occurring barcodes, such as somatic mitochondrial DNA (mtDNA) mutations detected via single-cell ATAC-seq (mtscATAC-seq). Fr...
www.biorxiv.org
September 24, 2025 at 12:39 PM
🚨 New preprints from our lab!
First, we introduce Cryo-mtscATAC-seq, led by Maren (@ms-maren.bsky.social ), enabling high-throughput clonal tracing from frozen human samples by isolating nuclei with their mitochondria (“CryoCells”).
👉 www.biorxiv.org/content/10.1...
Reposted by Caleb Lareau
I'd like to announce the medRxiv preprint of our latest work:
A multimodal atlas of COVID-19 severity identifies hallmarks of dysregulated immunity.
www.medrxiv.org/content/10.1...
A multimodal atlas of COVID-19 severity identifies hallmarks of dysregulated immunity.
www.medrxiv.org/content/10.1...
September 22, 2025 at 11:44 PM
I'd like to announce the medRxiv preprint of our latest work:
A multimodal atlas of COVID-19 severity identifies hallmarks of dysregulated immunity.
www.medrxiv.org/content/10.1...
A multimodal atlas of COVID-19 severity identifies hallmarks of dysregulated immunity.
www.medrxiv.org/content/10.1...