Sylvia Erhardt
@erhardtlab.bsky.social
Centromeres, Repetitive RNAs, Epigenetic inheritance and everything chromatin-related. Professor @ kit.edu/. Love my girls and running hills. She/Her. Personal account (views are mine).
Reposted by Sylvia Erhardt
We are thrilled to share our new pre-print: “System-wide extraction of cis-regulatory rules from sequence-to-function models in human neural development”. S2F-deeplearning models can accurately encode enhancers, yet decoding these models into human-interpretable rules remains a major challenge.
January 15, 2026 at 11:57 AM
We are thrilled to share our new pre-print: “System-wide extraction of cis-regulatory rules from sequence-to-function models in human neural development”. S2F-deeplearning models can accurately encode enhancers, yet decoding these models into human-interpretable rules remains a major challenge.
Reposted by Sylvia Erhardt
Our Mini Review went online last night in Current Opinion in Genetics & Development
"Block copolymer concepts of how transcription organizes the stem cell genome"
doi.org/10.1016/j.gd...
Fig. 1: Stem cell–typical organization of the genome and transcription, and the block copolymer sorting concept.
"Block copolymer concepts of how transcription organizes the stem cell genome"
doi.org/10.1016/j.gd...
Fig. 1: Stem cell–typical organization of the genome and transcription, and the block copolymer sorting concept.
January 15, 2026 at 8:04 AM
Our Mini Review went online last night in Current Opinion in Genetics & Development
"Block copolymer concepts of how transcription organizes the stem cell genome"
doi.org/10.1016/j.gd...
Fig. 1: Stem cell–typical organization of the genome and transcription, and the block copolymer sorting concept.
"Block copolymer concepts of how transcription organizes the stem cell genome"
doi.org/10.1016/j.gd...
Fig. 1: Stem cell–typical organization of the genome and transcription, and the block copolymer sorting concept.
Reposted by Sylvia Erhardt
Human eggs must segregate their chromosomes with exquisite precision — yet errors rise with maternal age, causing miscarriage & infertility.
Our new article on @biorxivpreprint.bsky.social shows why chromosome cohesion fails in aging eggs & how to improve it.
www.biorxiv.org/content/10.6... (1/10)
Our new article on @biorxivpreprint.bsky.social shows why chromosome cohesion fails in aging eggs & how to improve it.
www.biorxiv.org/content/10.6... (1/10)
January 12, 2026 at 11:23 AM
Human eggs must segregate their chromosomes with exquisite precision — yet errors rise with maternal age, causing miscarriage & infertility.
Our new article on @biorxivpreprint.bsky.social shows why chromosome cohesion fails in aging eggs & how to improve it.
www.biorxiv.org/content/10.6... (1/10)
Our new article on @biorxivpreprint.bsky.social shows why chromosome cohesion fails in aging eggs & how to improve it.
www.biorxiv.org/content/10.6... (1/10)
Reposted by Sylvia Erhardt
BIG FIGHT AT POLAND’S WROCLAW ZOO!!!
January 9, 2026 at 8:02 PM
BIG FIGHT AT POLAND’S WROCLAW ZOO!!!
Reposted by Sylvia Erhardt
Paper alert 🚨
Are you interested in the connection between epigenetics and metabolism? Then check out our new paper 🎁 👉 www.sciencedirect.com/science/arti... 🧵1/3
Are you interested in the connection between epigenetics and metabolism? Then check out our new paper 🎁 👉 www.sciencedirect.com/science/arti... 🧵1/3
H4K16 acylations destabilize chromatin architecture and facilitate transcriptional response during metabolic perturbations
Histone modifications play crucial roles in genome function. However, how chromatin integrates physiological and metabolic responses at the molecular …
www.sciencedirect.com
December 23, 2025 at 1:30 PM
Paper alert 🚨
Are you interested in the connection between epigenetics and metabolism? Then check out our new paper 🎁 👉 www.sciencedirect.com/science/arti... 🧵1/3
Are you interested in the connection between epigenetics and metabolism? Then check out our new paper 🎁 👉 www.sciencedirect.com/science/arti... 🧵1/3
Reposted by Sylvia Erhardt
Our renent paper on CENP-A deposition was just out in EMBO J. Please check it out. Congrats Tetsuta! link.springer.com/article/10.1...
Dual pathways via CENP-C and Mis18C recruit HJURP for CENP-A deposition into vertebrate centromeres - The EMBO Journal
Centromere position is specified and maintained by sequence-independent epigenetic mechanisms in vertebrate cells, with the incorporation of the centromere-specific histone H3 variant CENP-A into chro...
link.springer.com
January 8, 2026 at 10:42 AM
Our renent paper on CENP-A deposition was just out in EMBO J. Please check it out. Congrats Tetsuta! link.springer.com/article/10.1...
Reposted by Sylvia Erhardt
Interested in the unexpected? How about a link between piRNAs and maternal histone mRNAs … Great collab with @sebastianfalk.bsky.social, @koenig-lab.bsky.social and Florian Steiner.
#piRNA #histone #mRNA #maternal #RNAbiology #RNASky
www.biorxiv.org/content/10.6...
#piRNA #histone #mRNA #maternal #RNAbiology #RNASky
www.biorxiv.org/content/10.6...
www.biorxiv.org
January 8, 2026 at 8:51 AM
Interested in the unexpected? How about a link between piRNAs and maternal histone mRNAs … Great collab with @sebastianfalk.bsky.social, @koenig-lab.bsky.social and Florian Steiner.
#piRNA #histone #mRNA #maternal #RNAbiology #RNASky
www.biorxiv.org/content/10.6...
#piRNA #histone #mRNA #maternal #RNAbiology #RNASky
www.biorxiv.org/content/10.6...
Reposted by Sylvia Erhardt
In case anyone needs it for their syllabi, my statement in gen-Ai from the minicomic I made as a syllabus for class last semester. All online and printable here spinweaveandcut.com/fall-2025-sy...
January 6, 2026 at 4:54 PM
In case anyone needs it for their syllabi, my statement in gen-Ai from the minicomic I made as a syllabus for class last semester. All online and printable here spinweaveandcut.com/fall-2025-sy...
Reposted by Sylvia Erhardt
Maman (1999) by artist Louise Bourgeois #womensart #January
January 6, 2026 at 6:13 AM
Maman (1999) by artist Louise Bourgeois #womensart #January
Reposted by Sylvia Erhardt
SMC and recombination enthusiasts: we updated our work describing the loop extrusion properties of budding yeast condensin and its function in biasing donor usage for mating-type switching. Lots of cool new data, check it out!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
January 6, 2026 at 6:58 AM
SMC and recombination enthusiasts: we updated our work describing the loop extrusion properties of budding yeast condensin and its function in biasing donor usage for mating-type switching. Lots of cool new data, check it out!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Sylvia Erhardt
Online Now: RNA-coupled CRISPR screens reveal ZNF207 as a regulator of LMNA aberrant splicing in progeria Online now:
RNA-coupled CRISPR screens reveal ZNF207 as a regulator of LMNA aberrant splicing in progeria
This study introduces CRASP-seq, an RNA-coupled CRISPR screening platform designed to systematically identify regulatory factors and domains of alternative pre-mRNA splicing. Using this technology, ZNF207 is identified as a bona fide splicing regulator through its interaction with U1 snRNP components. ZNF207 modulates aberrant LMNA splicing, a critical event linked to progeria.
dlvr.it
December 30, 2025 at 4:19 PM
Online Now: RNA-coupled CRISPR screens reveal ZNF207 as a regulator of LMNA aberrant splicing in progeria Online now:
Reposted by Sylvia Erhardt
Reposted by Sylvia Erhardt
Absolutely thrilled to share the latest work from my lab focused on the variation and evolution of human centromeres among global populations! We assembled 2,110 human centromeres, identifying 226 new major haplotypes and 1,870 α-satellite HOR variants. www.biorxiv.org/content/10.6...
December 16, 2025 at 4:06 PM
Absolutely thrilled to share the latest work from my lab focused on the variation and evolution of human centromeres among global populations! We assembled 2,110 human centromeres, identifying 226 new major haplotypes and 1,870 α-satellite HOR variants. www.biorxiv.org/content/10.6...
Reposted by Sylvia Erhardt
🪱 Selfish genes are everywhere and drive some of biology’s biggest innovations (CRISPR, antibody recombination, epigenetics). Yet almost no one asks the obvious question: how does a selfish gene begin? Our new manuscript uncovers how selfishness can emerge directly from the host genome.
November 24, 2025 at 1:03 PM
🪱 Selfish genes are everywhere and drive some of biology’s biggest innovations (CRISPR, antibody recombination, epigenetics). Yet almost no one asks the obvious question: how does a selfish gene begin? Our new manuscript uncovers how selfishness can emerge directly from the host genome.
Reposted by Sylvia Erhardt
Well, that wasn’t what I expected. Outstanding book. Interesting plot twist. Discusses the deep disturbing ugliness of the eugenics movement in America. Heartbreaking but, hopeful too. Opens eyes to the limitations we place onto the natural world and ourselves in our attempts to order it.
Getting ready for holiday reading. Provocative title, @mads100tist.bsky.social @chrmosimann.bsky.social 😉
December 27, 2025 at 8:31 PM
Well, that wasn’t what I expected. Outstanding book. Interesting plot twist. Discusses the deep disturbing ugliness of the eugenics movement in America. Heartbreaking but, hopeful too. Opens eyes to the limitations we place onto the natural world and ourselves in our attempts to order it.
Reposted by Sylvia Erhardt
'The Running of the Deer' by contemporary UK artist Catherine Hyde #womensart
December 24, 2025 at 10:46 AM
'The Running of the Deer' by contemporary UK artist Catherine Hyde #womensart
Reposted by Sylvia Erhardt
look, I think a child called Typhus would be destined for great things
Top ten names that would make a decent baby name if it wasn’t already the name of a medical condition or medication…
10. Amnesia
9. Rubella
8. Codeine
7. Malaria
6. Paxil
5. Alopecia
4. Bonjela
3. Aphasia
2. Typhus
1. Chlamydia
10. Amnesia
9. Rubella
8. Codeine
7. Malaria
6. Paxil
5. Alopecia
4. Bonjela
3. Aphasia
2. Typhus
1. Chlamydia
December 24, 2025 at 6:03 AM
look, I think a child called Typhus would be destined for great things
Reposted by Sylvia Erhardt
Felt a little festive at the microscope this morning for #FluorescenceFriday 🎄
Here’s the nervous system of a juvenile sea star ⭐️
Green = acetylated tubulin, red = nuclei
Happy holidays!
Here’s the nervous system of a juvenile sea star ⭐️
Green = acetylated tubulin, red = nuclei
Happy holidays!
December 19, 2025 at 5:32 PM
Felt a little festive at the microscope this morning for #FluorescenceFriday 🎄
Here’s the nervous system of a juvenile sea star ⭐️
Green = acetylated tubulin, red = nuclei
Happy holidays!
Here’s the nervous system of a juvenile sea star ⭐️
Green = acetylated tubulin, red = nuclei
Happy holidays!
Reposted by Sylvia Erhardt
The discovery of the first kinetochore proteins (CENP-A, CENP-B, CENP-C) was reported by Bill Earnshaw and Naomi Rothfield in 1985 in Chromosoma. Forty years later, Chromosoma/Chromosome Research has published a special issue (most articles are open access)
link.springer.com/collections/...
link.springer.com/collections/...
40 years of CENP-A
In 1985, Earnshaw and Rothfield published in Chromosoma a landmark discovery of the centromere-specific protein CENP-A. Subsequent research has shown that ...
link.springer.com
December 22, 2025 at 10:09 AM
The discovery of the first kinetochore proteins (CENP-A, CENP-B, CENP-C) was reported by Bill Earnshaw and Naomi Rothfield in 1985 in Chromosoma. Forty years later, Chromosoma/Chromosome Research has published a special issue (most articles are open access)
link.springer.com/collections/...
link.springer.com/collections/...
Reposted by Sylvia Erhardt
Exciting new paper out! @allanaschooley.bsky.social and Sergey Venev led this project that let to the discovery of two chromosome folding programs: one inherited via mitotic chromosomes and one mitotic inherited through the cytoplasm!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Interphase chromosome conformation is specified by distinct folding programmes inherited through mitotic chromosomes or the cytoplasm - Nature Cell Biology
Schooley et al. find that mitotically bookmarked loci drive a transient chromosome folding state during G1 entry that is subsequently modulated by factors inherited through the cytoplasm.
www.nature.com
December 22, 2025 at 11:45 AM
Exciting new paper out! @allanaschooley.bsky.social and Sergey Venev led this project that let to the discovery of two chromosome folding programs: one inherited via mitotic chromosomes and one mitotic inherited through the cytoplasm!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Sylvia Erhardt
Excited to share our latest fully in-house paper! 🎉
We show how cohesin integrates loop extrusion with sister tethering to guide the homology search during DNA repair.
Huge congratulations to all authors, and to @fedeteloni.bsky.social for leading this work 👏
We’re excited to see his next steps!
We show how cohesin integrates loop extrusion with sister tethering to guide the homology search during DNA repair.
Huge congratulations to all authors, and to @fedeteloni.bsky.social for leading this work 👏
We’re excited to see his next steps!
I am happy to share that my postdoctoral work in the @gerlichlab.bsky.social at @imbavienna.bsky.social is finally out 🎉!
Our study reveals how cohesin guides focused and accurate homology search.
Read more 👉 www.science.org/doi/10.1126/...
Follow along for key insights and updates! 🧵
Our study reveals how cohesin guides focused and accurate homology search.
Read more 👉 www.science.org/doi/10.1126/...
Follow along for key insights and updates! 🧵
Cohesin guides homology search during DNA repair using loops and sister chromatid linkages
Accurate repair of DNA double-strand breaks (DSBs) is essential for genome stability, and defective repair underlies diseases such as cancer. Homologous recombination uses an intact homologous sequenc...
www.science.org
December 5, 2025 at 7:46 AM
Excited to share our latest fully in-house paper! 🎉
We show how cohesin integrates loop extrusion with sister tethering to guide the homology search during DNA repair.
Huge congratulations to all authors, and to @fedeteloni.bsky.social for leading this work 👏
We’re excited to see his next steps!
We show how cohesin integrates loop extrusion with sister tethering to guide the homology search during DNA repair.
Huge congratulations to all authors, and to @fedeteloni.bsky.social for leading this work 👏
We’re excited to see his next steps!
Reposted by Sylvia Erhardt
Aujourd'hui c'est le solstice d'hiver dans l'hémisphère Nord. Les journées vont commencer à rallonger! Le soleil ne se lève à l'Est (centre de l'image avec Nord à gauche, Sud a droite) que lors des équinoxes. La position du lever change un peu tous les jours! (©Z. Al-Abbadi)
December 21, 2025 at 8:48 AM
Aujourd'hui c'est le solstice d'hiver dans l'hémisphère Nord. Les journées vont commencer à rallonger! Le soleil ne se lève à l'Est (centre de l'image avec Nord à gauche, Sud a droite) que lors des équinoxes. La position du lever change un peu tous les jours! (©Z. Al-Abbadi)
Reposted by Sylvia Erhardt
"We find that while TAD boundaries pair more frequently than non-boundary regions, these interactions are infrequent and are uncorrelated with transcriptional activity of genes within the TAD. (...) These results suggest that TAD boundary architecture and gene activity are largely uncoupled"
TAD boundary architecture and gene activity are uncoupled
Topologically associating domains (TADs) are prominent features of genome organization. A proposed function of TADs is to contribute to gene regulation by promoting chromatin interactions within a TAD...
www.biorxiv.org
December 18, 2025 at 11:43 AM
"We find that while TAD boundaries pair more frequently than non-boundary regions, these interactions are infrequent and are uncorrelated with transcriptional activity of genes within the TAD. (...) These results suggest that TAD boundary architecture and gene activity are largely uncoupled"
Reposted by Sylvia Erhardt
Can one map the genome-wide binding (1) and its protein partners (2) simultaneously from the same sample?
Yes, one can. with CUT&ID ✂️🪪
Spearheaded — singlehandedly — by @annanordin.bsky.social
No need of transgenesis, cloning and overexpression.
Check it out, it's fast and its works.
Yes, one can. with CUT&ID ✂️🪪
Spearheaded — singlehandedly — by @annanordin.bsky.social
No need of transgenesis, cloning and overexpression.
Check it out, it's fast and its works.
December 13, 2025 at 7:00 AM
Can one map the genome-wide binding (1) and its protein partners (2) simultaneously from the same sample?
Yes, one can. with CUT&ID ✂️🪪
Spearheaded — singlehandedly — by @annanordin.bsky.social
No need of transgenesis, cloning and overexpression.
Check it out, it's fast and its works.
Yes, one can. with CUT&ID ✂️🪪
Spearheaded — singlehandedly — by @annanordin.bsky.social
No need of transgenesis, cloning and overexpression.
Check it out, it's fast and its works.
It's gift-giving season and here's an idea: www.allourkitchens.com
All Our Kitchens - A Cookbook for a Free Palestine
29 chefs uniting to raise funds for Gaza - get your copy of the digital exclusive cookbook
www.allourkitchens.com
December 11, 2025 at 1:42 PM
It's gift-giving season and here's an idea: www.allourkitchens.com