Eva Estébanez-Perpiñá, Ph.D.
@estebanezlab.bsky.social
Prof. Eva Estébanez-Perpiñá @UniBarcelona / Leading the Nuclear Receptor Lab @IBUB_UB @PCB_UB/ Psychologist + Structural Biologist + Proud Mom 🚀🪐
Pinned
The multimerization pathway of the glucocorticoid receptor
Abstract. The glucocorticoid receptor (GR) is a leading drug target due to its antiinflammatory and immunosuppressive roles. The functional oligomeric conf
academic.oup.com
🎯 We are incredibly thrilled to share our newest paper on #NucleicAcidsResearch on Glucocorticoid Receptor Multimerization 👇
academic.oup.com/nar/article/...
@ibub-ub.bsky.social @bqbiomedmolub.bsky.social @biologiaub.bsky.social @www.pcb.ub.edu
academic.oup.com/nar/article/...
@ibub-ub.bsky.social @bqbiomedmolub.bsky.social @biologiaub.bsky.social @www.pcb.ub.edu
Reposted by Eva Estébanez-Perpiñá, Ph.D.
📢 Read our new bioRx in colab with Gordon Hager NIH @PabloFuentesP #FRecio @aguslafuent @PresmanLab @WaghKaustubh #IGoldstein et al where we found glucocorticoid receptor GR self-assembly, chromatin binding & activity is modulated by bile acids binding to a novel druggable site
June 7, 2025 at 2:26 PM
📢 Read our new bioRx in colab with Gordon Hager NIH @PabloFuentesP #FRecio @aguslafuent @PresmanLab @WaghKaustubh #IGoldstein et al where we found glucocorticoid receptor GR self-assembly, chromatin binding & activity is modulated by bile acids binding to a novel druggable site
Reposted by Eva Estébanez-Perpiñá, Ph.D.
🎯 We are so thrilled our new paper @narjournal.bsky.social is out! Fantastic collab with the labs of Gordon Hager NIH & Franck Dequiedt. Heaviest lifting from Greg Fettweiss, Kaustub Wagh, Diana Stavreva & Alba Jiménez-Panizo. Big thanks to Andrea Alegre-Marti JdC 🥳✨️
academic.oup.com/nar/article/...
academic.oup.com/nar/article/...
May 16, 2025 at 3:06 PM
🎯 We are so thrilled our new paper @narjournal.bsky.social is out! Fantastic collab with the labs of Gordon Hager NIH & Franck Dequiedt. Heaviest lifting from Greg Fettweiss, Kaustub Wagh, Diana Stavreva & Alba Jiménez-Panizo. Big thanks to Andrea Alegre-Marti JdC 🥳✨️
academic.oup.com/nar/article/...
academic.oup.com/nar/article/...
Reposted by Eva Estébanez-Perpiñá, Ph.D.
Check out our new findings showing BRD4's role in preventing the premature activation of developmental transcription factors via #Polycomb, providing new mechanistic insights into the pathogenesis of neurodevelopmental disorder #CdLS #NDDs, #chromatinopathies www.biorxiv.org/content/10.6...
February 2, 2026 at 7:19 AM
Check out our new findings showing BRD4's role in preventing the premature activation of developmental transcription factors via #Polycomb, providing new mechanistic insights into the pathogenesis of neurodevelopmental disorder #CdLS #NDDs, #chromatinopathies www.biorxiv.org/content/10.6...
Reposted by Eva Estébanez-Perpiñá, Ph.D.
Latest publication from our lab! A part of our ongoing efforts to identify estrogen receptor ligands that influence structural and oligomeric states in unique ways. pubs.acs.org/doi/10.1021/...
Allosteric Induction of Estrogen Receptor Ligand Binding Domain Tetramerization by a Distinct Complete Estrogen Receptor Antagonist
Complete estrogen receptor antagonists (CERANs) are effective against advanced estrogen receptor-positive (ER+) breast cancers, but current chemical scaffolds limit our ability to explore the full ran...
pubs.acs.org
January 17, 2026 at 3:41 PM
Latest publication from our lab! A part of our ongoing efforts to identify estrogen receptor ligands that influence structural and oligomeric states in unique ways. pubs.acs.org/doi/10.1021/...
Reposted by Eva Estébanez-Perpiñá, Ph.D.
AlphaFold protein interaction modeling tutorial and workshop thenode.biologists.com/https-www-yo...
AlphaFold protein interaction modeling tutorial and workshop - the Node
This video is the culmination of several years attempting to: (1) Figure out best practices for modeling protein-protein interactions; (2) Understand the This video is the culmination of several years...
thenode.biologists.com
January 18, 2026 at 4:36 PM
AlphaFold protein interaction modeling tutorial and workshop thenode.biologists.com/https-www-yo...
Reposted by Eva Estébanez-Perpiñá, Ph.D.
Our new review, looking into the roles of SWI/SNF in the chromatin environment around centromeres, is just out in Open Biology! @kezlane.bsky.social @thedownslab.bsky.social
Some Friday reading...new review in Open Biology where we discuss how SWI/SNF maintains the chromatin environment around centromeres, building on recent work from ourselves and others. Lots of fun putting this together with @alison-harrod.bsky.social and @thedownslab.bsky.social!
Boundary issues: SWI/SNF shapes chromatin patterns in and around centromeres
Abstract. The SWI/SNF family of chromatin remodelling complexes, comprising BAF, PBAF and ncBAF, is known for their critical roles in regulating chromatin
royalsocietypublishing.org
December 5, 2025 at 4:57 PM
Our new review, looking into the roles of SWI/SNF in the chromatin environment around centromeres, is just out in Open Biology! @kezlane.bsky.social @thedownslab.bsky.social
Reposted by Eva Estébanez-Perpiñá, Ph.D.
Online now! Online now! An interactive resource mapping the proteome and reactive cysteine landscape across the NCI-60 reveals cell and tissue-specific profiles #chembiol
An interactive resource mapping the proteome and reactive cysteine landscape across the NCI-60 reveals cell and tissue-specific profiles
Montaño et al. generate an integrated proteomic and cysteine reactivity resource for the NCI-60 cancer cell line panel, offering quantitative data on over 12,000 proteins and 36,000 cysteines to enable future studies on protein function, cysteine biology, and covalent drug discovery.
dlvr.it
December 31, 2025 at 4:30 PM
Online now! Online now! An interactive resource mapping the proteome and reactive cysteine landscape across the NCI-60 reveals cell and tissue-specific profiles #chembiol
Reposted by Eva Estébanez-Perpiñá, Ph.D.
Is arginine the new cysteine?! Check out our lab's latest in collaboration with @ianseiple.bsky.social's team where we introduce ninhydrin as a selective covalent warhead and probe targeting reactive arginines.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Ninhydrin as a covalent warhead for chemical proteomic-enabled discovery and selective engagement of reactive arginines
Covalent molecules have emerged as next-generation therapeutics and as powerful tools for perturbing fundamental biological processes. Chemical proteomic methods to screen for reactive proteinaceous a...
www.biorxiv.org
January 6, 2026 at 3:40 PM
Is arginine the new cysteine?! Check out our lab's latest in collaboration with @ianseiple.bsky.social's team where we introduce ninhydrin as a selective covalent warhead and probe targeting reactive arginines.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Eva Estébanez-Perpiñá, Ph.D.
Evidence suggests that transcriptionally similar cells can be functionally diverse
go.nature.com/3N4lT2d
go.nature.com/3N4lT2d
Does a cell’s gene expression always reflect its function?
Transcriptionally similar neurons can be functionally diverse.
go.nature.com
December 30, 2025 at 10:08 AM
Evidence suggests that transcriptionally similar cells can be functionally diverse
go.nature.com/3N4lT2d
go.nature.com/3N4lT2d
We look very much forward to keeping doing Science together in 2026! ✨️🎄🚀🪐
Stay tunned 🪇
@ibub-ub.bsky.social @bqbiomedmolub.bsky.social @ub.edu
Stay tunned 🪇
@ibub-ub.bsky.social @bqbiomedmolub.bsky.social @ub.edu
December 19, 2025 at 4:08 PM
We look very much forward to keeping doing Science together in 2026! ✨️🎄🚀🪐
Stay tunned 🪇
@ibub-ub.bsky.social @bqbiomedmolub.bsky.social @ub.edu
Stay tunned 🪇
@ibub-ub.bsky.social @bqbiomedmolub.bsky.social @ub.edu
Reposted by Eva Estébanez-Perpiñá, Ph.D.
#ArticleOfTheMonth I November 2025
✒️The multimerization pathway of the glucocorticoid receptor
🔗Access the full article here 👉 www.biorxiv.org/content/10.1...
@ub.edu @biologiaub.bsky.social @farmaciaub.bsky.social @www.pcb.ub.edu @estebanezlab.bsky.social
✒️The multimerization pathway of the glucocorticoid receptor
🔗Access the full article here 👉 www.biorxiv.org/content/10.1...
@ub.edu @biologiaub.bsky.social @farmaciaub.bsky.social @www.pcb.ub.edu @estebanezlab.bsky.social
November 10, 2025 at 11:06 AM
#ArticleOfTheMonth I November 2025
✒️The multimerization pathway of the glucocorticoid receptor
🔗Access the full article here 👉 www.biorxiv.org/content/10.1...
@ub.edu @biologiaub.bsky.social @farmaciaub.bsky.social @www.pcb.ub.edu @estebanezlab.bsky.social
✒️The multimerization pathway of the glucocorticoid receptor
🔗Access the full article here 👉 www.biorxiv.org/content/10.1...
@ub.edu @biologiaub.bsky.social @farmaciaub.bsky.social @www.pcb.ub.edu @estebanezlab.bsky.social
Reposted by Eva Estébanez-Perpiñá, Ph.D.
🎯 Researchers decipher a mechanism that determines the complexity of the glucocorticoid receptor - Current events - University of Barcelona web.ub.edu/en/web/actua...
Researchers decipher a mechanism that determines the complexity of the glucocorticoid receptor
web.ub.edu
October 27, 2025 at 11:33 AM
🎯 Researchers decipher a mechanism that determines the complexity of the glucocorticoid receptor - Current events - University of Barcelona web.ub.edu/en/web/actua...
Reposted by Eva Estébanez-Perpiñá, Ph.D.
(1/4) Congrats @estebanezlab.bsky.social & team for your new paper deciphering the mechanism determining #GlucocorticoidReceptor complex @bqbiomedmolub.bsky.social @biologiaub.bsky.social
web.ub.edu/en/web/actua...
web.ub.edu/en/web/actua...
Researchers decipher a mechanism that determines the complexity of the glucocorticoid receptor
web.ub.edu
November 18, 2025 at 8:36 AM
(1/4) Congrats @estebanezlab.bsky.social & team for your new paper deciphering the mechanism determining #GlucocorticoidReceptor complex @bqbiomedmolub.bsky.social @biologiaub.bsky.social
web.ub.edu/en/web/actua...
web.ub.edu/en/web/actua...
Reposted by Eva Estébanez-Perpiñá, Ph.D.
#PCBCommunity |🔬 L'@ibub-ub.bsky.social
@bqbiomedmolub.bsky.social @biologiaub.bsky.social desxifra el mecanisme de multimerització del receptor de #glucocorticoides (GR), obrint una via crucial per desenvolupar #fàrmacs més selectius capaços de minimitzar efectes adversos greus.
👉 tuit.cat/eDIgJ
@bqbiomedmolub.bsky.social @biologiaub.bsky.social desxifra el mecanisme de multimerització del receptor de #glucocorticoides (GR), obrint una via crucial per desenvolupar #fàrmacs més selectius capaços de minimitzar efectes adversos greus.
👉 tuit.cat/eDIgJ
October 31, 2025 at 11:09 AM
#PCBCommunity |🔬 L'@ibub-ub.bsky.social
@bqbiomedmolub.bsky.social @biologiaub.bsky.social desxifra el mecanisme de multimerització del receptor de #glucocorticoides (GR), obrint una via crucial per desenvolupar #fàrmacs més selectius capaços de minimitzar efectes adversos greus.
👉 tuit.cat/eDIgJ
@bqbiomedmolub.bsky.social @biologiaub.bsky.social desxifra el mecanisme de multimerització del receptor de #glucocorticoides (GR), obrint una via crucial per desenvolupar #fàrmacs més selectius capaços de minimitzar efectes adversos greus.
👉 tuit.cat/eDIgJ
Reposted by Eva Estébanez-Perpiñá, Ph.D.
🔊Nova recerca al dpt @bqbiomedmolub.bsky.social pel grup @estebanezlab.bsky.social @ibub-ub.bsky.social @biologiaub.bsky.social‼️
Desxifrat el mecanisme que determina la complexitat del receptor de glucocorticoides - Actualitat - Universitat de Barcelona web.ub.edu/ca/web/actua...
Desxifrat el mecanisme que determina la complexitat del receptor de glucocorticoides - Actualitat - Universitat de Barcelona web.ub.edu/ca/web/actua...
Desxifrat el mecanisme que determina la complexitat del receptor de glucocorticoides
web.ub.edu
October 27, 2025 at 5:25 PM
🔊Nova recerca al dpt @bqbiomedmolub.bsky.social pel grup @estebanezlab.bsky.social @ibub-ub.bsky.social @biologiaub.bsky.social‼️
Desxifrat el mecanisme que determina la complexitat del receptor de glucocorticoides - Actualitat - Universitat de Barcelona web.ub.edu/ca/web/actua...
Desxifrat el mecanisme que determina la complexitat del receptor de glucocorticoides - Actualitat - Universitat de Barcelona web.ub.edu/ca/web/actua...
🎯 Researchers decipher a mechanism that determines the complexity of the glucocorticoid receptor - Current events - University of Barcelona web.ub.edu/en/web/actua...
Researchers decipher a mechanism that determines the complexity of the glucocorticoid receptor
web.ub.edu
October 27, 2025 at 11:33 AM
🎯 Researchers decipher a mechanism that determines the complexity of the glucocorticoid receptor - Current events - University of Barcelona web.ub.edu/en/web/actua...
The multimerization pathway of the glucocorticoid receptor url: academic.oup.com/nar/article/...
The multimerization pathway of the glucocorticoid receptor
Abstract. The glucocorticoid receptor (GR) is a leading drug target due to its antiinflammatory and immunosuppressive roles. The functional oligomeric conf
academic.oup.com
October 26, 2025 at 9:02 AM
The multimerization pathway of the glucocorticoid receptor url: academic.oup.com/nar/article/...
Reposted by Eva Estébanez-Perpiñá, Ph.D.
Happy to share the latest publication led by Pablo Fuentes-Prior, G. Hager, and @estebanezlab.bsky.social, with talented co-first authors Andrea, Alba, and Agustina.
This one feels special to me, as I explain in this thread below....
This one feels special to me, as I explain in this thread below....
🎯 With absolut joy we share our newest #NucleicAcidsResearch on Glucocorticoid Receptor Multimerization. Enormous team work by Pablo Fuentes, Gordon Hager, Alba Jiménez, Andrea Alegre, Agustina Lafuente, Tom Johnson Nuria Peralta, Diego Presman, JRecio, Jaime Rubio, Pilar Montanyà, Josep Ponsetí 🥳🚀
October 23, 2025 at 3:39 PM
Happy to share the latest publication led by Pablo Fuentes-Prior, G. Hager, and @estebanezlab.bsky.social, with talented co-first authors Andrea, Alba, and Agustina.
This one feels special to me, as I explain in this thread below....
This one feels special to me, as I explain in this thread below....
Reposted by Eva Estébanez-Perpiñá, Ph.D.
🎯 With absolut joy we share our newest #NucleicAcidsResearch on Glucocorticoid Receptor Multimerization. Enormous team work by Pablo Fuentes, Gordon Hager, Alba Jiménez, Andrea Alegre, Agustina Lafuente, Tom Johnson Nuria Peralta, Diego Presman, JRecio, Jaime Rubio, Pilar Montanyà, Josep Ponsetí 🥳🚀
October 22, 2025 at 10:02 AM
🎯 With absolut joy we share our newest #NucleicAcidsResearch on Glucocorticoid Receptor Multimerization. Enormous team work by Pablo Fuentes, Gordon Hager, Alba Jiménez, Andrea Alegre, Agustina Lafuente, Tom Johnson Nuria Peralta, Diego Presman, JRecio, Jaime Rubio, Pilar Montanyà, Josep Ponsetí 🥳🚀
Reposted by Eva Estébanez-Perpiñá, Ph.D.
🔊 Nova publicació del Dpt @bqbiomedmolub.bsky.social pel grup liderat per la Dra Eva Estébanez-Perpiñá @estebanezlab.bsky.social @ibub-ub.bsky.social @biologiaub.bsky.social
Enhorabona! 👋👋
Enhorabona! 👋👋
🎯 We are incredibly thrilled to share our newest paper on #NucleicAcidsResearch on Glucocorticoid Receptor Multimerization 👇
academic.oup.com/nar/article/...
@ibub-ub.bsky.social @bqbiomedmolub.bsky.social @biologiaub.bsky.social @www.pcb.ub.edu
academic.oup.com/nar/article/...
@ibub-ub.bsky.social @bqbiomedmolub.bsky.social @biologiaub.bsky.social @www.pcb.ub.edu
The multimerization pathway of the glucocorticoid receptor
Abstract. The glucocorticoid receptor (GR) is a leading drug target due to its antiinflammatory and immunosuppressive roles. The functional oligomeric conf
academic.oup.com
October 22, 2025 at 11:07 AM
🔊 Nova publicació del Dpt @bqbiomedmolub.bsky.social pel grup liderat per la Dra Eva Estébanez-Perpiñá @estebanezlab.bsky.social @ibub-ub.bsky.social @biologiaub.bsky.social
Enhorabona! 👋👋
Enhorabona! 👋👋
🎯 We are incredibly thrilled to share our newest paper on #NucleicAcidsResearch on Glucocorticoid Receptor Multimerization 👇
academic.oup.com/nar/article/...
@ibub-ub.bsky.social @bqbiomedmolub.bsky.social @biologiaub.bsky.social @www.pcb.ub.edu
academic.oup.com/nar/article/...
@ibub-ub.bsky.social @bqbiomedmolub.bsky.social @biologiaub.bsky.social @www.pcb.ub.edu
The multimerization pathway of the glucocorticoid receptor
Abstract. The glucocorticoid receptor (GR) is a leading drug target due to its antiinflammatory and immunosuppressive roles. The functional oligomeric conf
academic.oup.com
October 22, 2025 at 10:09 AM
🎯 We are incredibly thrilled to share our newest paper on #NucleicAcidsResearch on Glucocorticoid Receptor Multimerization 👇
academic.oup.com/nar/article/...
@ibub-ub.bsky.social @bqbiomedmolub.bsky.social @biologiaub.bsky.social @www.pcb.ub.edu
academic.oup.com/nar/article/...
@ibub-ub.bsky.social @bqbiomedmolub.bsky.social @biologiaub.bsky.social @www.pcb.ub.edu
🎯 With absolut joy we share our newest #NucleicAcidsResearch on Glucocorticoid Receptor Multimerization. Enormous team work by Pablo Fuentes, Gordon Hager, Alba Jiménez, Andrea Alegre, Agustina Lafuente, Tom Johnson Nuria Peralta, Diego Presman, JRecio, Jaime Rubio, Pilar Montanyà, Josep Ponsetí 🥳🚀
October 22, 2025 at 10:02 AM
🎯 With absolut joy we share our newest #NucleicAcidsResearch on Glucocorticoid Receptor Multimerization. Enormous team work by Pablo Fuentes, Gordon Hager, Alba Jiménez, Andrea Alegre, Agustina Lafuente, Tom Johnson Nuria Peralta, Diego Presman, JRecio, Jaime Rubio, Pilar Montanyà, Josep Ponsetí 🥳🚀
Reposted by Eva Estébanez-Perpiñá, Ph.D.
📢 Another bioRxiv on GR from our lab in collaboration with Pablo Fuentes, Gordon Hager NIH, Diego Presman @palomaperezlab.bsky.social FRecio & the amazing Andrea Alegre, Alba Jiménez @aguslafuent.bsky.social Inés Montoya Montse Abella 🚀
doi: doi.org/10.1101/2024.1…
doi: doi.org/10.1101/2024.1…
June 8, 2025 at 3:50 PM
📢 Another bioRxiv on GR from our lab in collaboration with Pablo Fuentes, Gordon Hager NIH, Diego Presman @palomaperezlab.bsky.social FRecio & the amazing Andrea Alegre, Alba Jiménez @aguslafuent.bsky.social Inés Montoya Montse Abella 🚀
doi: doi.org/10.1101/2024.1…
doi: doi.org/10.1101/2024.1…
📢 Today we had the IBUB-Day with top Science, scientific discussions and absolutely gorgeous venue at Reial Cercle Artístic @ibub-ub.bsky.social @biologiaub.bsky.social
October 3, 2025 at 4:30 PM
📢 Today we had the IBUB-Day with top Science, scientific discussions and absolutely gorgeous venue at Reial Cercle Artístic @ibub-ub.bsky.social @biologiaub.bsky.social