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Reposted by Eva Estébanez-Perpiñá, Ph.D.

Eva Estébanez-Perpiñá, Ph.D. @estebanezlab.bsky.social · Jun 8

📢 Another bioRxiv on GR from our lab in collaboration with Pablo Fuentes, Gordon Hager NIH, Diego Presman @palomaperezlab.bsky.social FRecio & the amazing Andrea Alegre, Alba Jiménez @aguslafuent.bsky.social Inés Montoya Montse Abella 🚀
doi: doi.org/10.1101/2024.1…

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Reposted by Eva Estébanez-Perpiñá, Ph.D.

Eva Estébanez-Perpiñá, Ph.D. @estebanezlab.bsky.social · Jun 7

📢 Read our new bioRx in colab with Gordon Hager NIH @PabloFuentesP #FRecio @aguslafuent @PresmanLab @WaghKaustubh #IGoldstein et al where we found glucocorticoid receptor GR self-assembly, chromatin binding & activity is modulated by bile acids binding to a novel druggable site

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Eva Estébanez-Perpiñá, Ph.D. @estebanezlab.bsky.social · 5d

📢 Today we had the IBUB-Day with top Science, scientific discussions and absolutely gorgeous venue at Reial Cercle Artístic @ibub-ub.bsky.social @biologiaub.bsky.social

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Eva Estébanez-Perpiñá, Ph.D. @estebanezlab.bsky.social · 8d

🎯 We do research at the University of Barcelona where we study Nuclear Receptors from a structural & functional perspective using X-ray crystallography and several complementary biochemical/physical tecniques 💎⚡️ @ibub-ub.bsky.social @biologiaub.bsky.social

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Reposted by Eva Estébanez-Perpiñá, Ph.D.

Daniel Jost - Physical Biology of Chromatin group @djost-physbiol.bsky.social · 9d

New preprint from the lab !! Loop extrusion may provide mechanical robustness to chromatin. Great work by Hossein Salari. @cnrs.fr @lbmcinlyon.bsky.social
www.biorxiv.org/content/10.1...

Loop extrusion provides mechanical robustness to chromatin

Chromosomes are complex biopolymers folded into dynamic loops via a loop extrusion process and may experience various mechanical forces in vivo . We develop a force-dependent model of chromatin loop e...

www.biorxiv.org

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Reposted by Eva Estébanez-Perpiñá, Ph.D.

mspielmann.bsky.social @mspielmann.bsky.social · Jul 7

🚀 Thrilled to share our new review on how structural variants reshape 3D genome architecture and cause disease! 🧬🔀
Out now in Nature Reviews Genetics: www.nature.com/articles/s41...
#3D-Genome #StructuralVariants #uksh

Structural variants in the 3D genome as drivers of disease - Nature Reviews Genetics

Disruption of the 3D genome caused by structural variation contributes to developmental disorders and cancer. The authors review the causes and molecular and clinical consequences of position effects ...

www.nature.com

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Eva Estébanez-Perpiñá, Ph.D. @estebanezlab.bsky.social · 11d

🙏🙏

Eva Estébanez-Perpiñá, Ph.D. @estebanezlab.bsky.social · 12d

Thanks so much!

Reposted by Eva Estébanez-Perpiñá, Ph.D.

Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · Aug 28

If you like transcription regulation and its mechanisms, this WIP list is for you.

I'm sure I've forgotten lots of people, so don't hesitate to let me know so I can add you to the list.

go.bsky.app/8vTgeXB

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Eva Estébanez-Perpiñá, Ph.D. @estebanezlab.bsky.social · 13d

Would love to be added thank you in advance

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Eva Estébanez-Perpiñá, Ph.D. @estebanezlab.bsky.social · 29d

📢 Thrilled to present & attend the EMBO Workshop in marvellous Palermo on When Predictions Meet Experiments. Fantastic speaker lineup, venue & organizers Caterina Alfano, Sandra Macedo & Pedro Pereira ✨️🚀🔥

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Reposted by Eva Estébanez-Perpiñá, Ph.D.

Genes & Development @genesdev.bsky.social · Sep 8

REVIEW: Timing is everything: transcription bursting in development
By Jee Min Kim and Daniel Larson
➡️ https://tinyurl.com/gd352465

#transcription #molecularbiology #transcriptionbursting #embryonicdevelopment #stemcell #differentiation #mRNA #development #molecularmechanism

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Reposted by Eva Estébanez-Perpiñá, Ph.D.

Matthew Cobb @matthewcobb.bsky.social · Sep 8

News in the history of molecular biology. The Science History Institute in Philadelphia has acquired a huge archive of correspondence and other scientific material from the pioneers of molecular biology (Franklin, Klug, Perutz, Delbrück etc, with items from Crick and Watson, too). 1/n

History of Molecular Biology Collection

This unparalleled collection includes Rosalind Franklin's historic 'Photo 51,' which revealed the double-helix structure of DNA.

www.sciencehistory.org

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Reposted by Eva Estébanez-Perpiñá, Ph.D.

biomolstructure.bsky.social @biomolstructure.bsky.social · Mar 24

meetings.embo.org/event/25-str...
#EMBOStructuralBio

When predictions meet experiments: the next challenges in structural biology

Building on the success of the 2022 EMBO Workshop “When Predictions Meet Experiments: The Future of Structure Determination”, this second edition continues the journey at the interface of computation…

meetings.embo.org

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Reposted by Eva Estébanez-Perpiñá, Ph.D.

Eva Estébanez-Perpiñá, Ph.D. @estebanezlab.bsky.social · Jul 19

📢 New publication on the Glucocorticoid Receptor IDP domain in collaboration with @alirezamashaghi.bsky.social lab. Always a pleasure to learn from new approaches & techniques. So much still to understand from #nuclearreceptors

Alireza Mashaghi @alirezamashaghi.bsky.social · Jul 19

On disordered topologically compact states in intrinsically disordered proteins! We explored this concept in the context of the human Glucocorticoid Receptor.
pubs.acs.org/doi/10.1021/...

#ChemSky #IDP #Protein #Biophysics #Topology #CompChem

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Eva Estébanez-Perpiñá, Ph.D. @estebanezlab.bsky.social · Sep 7

📢 Looking so much forward to present our work at EMBO Workshop Palermo (Sicilia, Italy) to meet structural biologists tackling structure-function from complementary approaches to undestand, predict & design macromolecules 🚀⚡️

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Reposted by Eva Estébanez-Perpiñá, Ph.D.

Eva Estébanez-Perpiñá, Ph.D. @estebanezlab.bsky.social · Sep 1

🎯 Inés Montoya-Novoa, PhD student in our lab has presented successfully in the FEBS Spetses on Nuclear Receptors and Metabolism, thanks to the organizers for this fantastic opportunity to learn and show our team research! @ibub-ub.bsky.social @biologiaub.bsky.social #Spetses2026

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Reposted by Eva Estébanez-Perpiñá, Ph.D.

Eva Estébanez-Perpiñá, Ph.D. @estebanezlab.bsky.social · Jun 21

📢 Grateful talented Inés Montoya was selected to FEBS Functional Genomics in Spetses Greece She will show our work on bile acids binding to GR that modulate activity, oligomerization & chromatin binding 🎯 Thrilled to collab with Fuentes, Hager, Recio, Presman, Goldstein Labs

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Reposted by Eva Estébanez-Perpiñá, Ph.D.

EMBO @embo.org · Mar 21

Register now for EMBO Workshop "When predictions meet experiments: The next challenges in structural biology" in Palermo, Italy, 9 – 12 September 2025

Abstract submission & registration deadline: 1 July

meetings.embo.org/event/25-str...
#EMBOStructuralBio #EMBOevents 🧪

When predictions meet experiments: the next challenges in structural biology

Building on the success of the 2022 EMBO Workshop “When Predictions Meet Experiments: The Future of Structure Determination”, this second edition continues the journey at the interface of computation…

meetings.embo.org

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Eva Estébanez-Perpiñá, Ph.D. @estebanezlab.bsky.social · Sep 1

🎯 Inés Montoya-Novoa, PhD student in our lab has presented successfully in the FEBS Spetses on Nuclear Receptors and Metabolism, thanks to the organizers for this fantastic opportunity to learn and show our team research! @ibub-ub.bsky.social @biologiaub.bsky.social #Spetses2026

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Reposted by Eva Estébanez-Perpiñá, Ph.D.

Eva Estébanez-Perpiñá, Ph.D. @estebanezlab.bsky.social · May 15

🎯 We are very happy to announce that the collaboration with the great Lab of Alireza Tabari with first author Laurens Heling is out in Protein Science! 🥳 👇 @alirezamashaghi.bsky.social
dx.doi.org/10.1002/pro....

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Reposted by Eva Estébanez-Perpiñá, Ph.D.

Nelson Lab, UIUC @nelsonlab.bsky.social · Aug 4

Help shape ENDO2026! Submit your suggestions for great endocrine society science now!

Endocrine Society @endocrinesociety.bsky.social · Aug 4

Help Shape the Education Program for ENDO 2026 | Share what you want to see at ENDO 2026, taking place June 13–16 in Chicago, IL. Whether you have a fully developed session in mind or just a seed of an idea, your input is welcome and appreciated: bit.ly/4flCMjl #ENDO2026 #endocrinology

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Reposted by Eva Estébanez-Perpiñá, Ph.D.

Nucleic Acids Research @narjournal.bsky.social · Aug 1

⭐NAR Breakthrough!⭐
Bonato et al. propose a model for how the yeast #condensin SMC complex drives persistent #DNAloopextrusion, using #atomicforcemicroscopy and #moleculardynamics.

Read the full article here: doi.org/10.1093/nar/...
#NARBreakthrough #SMC #biophysics #genomefolding #yeast

Spontaneously directed loop extrusion in SMC complexes emerges from broken detailed balance and anisotropic DNA search

Abstract. DNA loop formation by structural maintenance of chromosome (SMC) proteins, including cohesin, condensin, and the SMC5/6 complex, plays a pivotal

doi.org

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Reposted by Eva Estébanez-Perpiñá, Ph.D.

Maria Nuria Peralta-Moreno @peraltamnuria.bsky.social · Jul 25

We are very proud to support a new generation of brilliant students, and celebrate the excellent master thesis projects of Josep Ponsetí and Pilar Montanyà, from Eva Estébanez-Perpiñá lab! 🥳
@estebanezlab.bsky.social

We are very proud to be part of your research journey!! let's rock science!! 🥳🚀✨

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Reposted by Eva Estébanez-Perpiñá, Ph.D.

Axel Delamarre @axeldelamarre.bsky.social · Jul 17

Our paper is now out in Molecular Cell!

Check the thread in this former post:

www.cell.com/molecular-ce...

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