Lightnews — Scholar-powered news

Nucleic Acids Research

@narjournal.bsky.social

1.4K followers 18 following 76 posts

Nucleic Acids Research (NAR), from Oxford University Press, publishes the results of leading-edge research into physical, chemical, biochemical and biological aspects of nucleic acids and proteins involved in nucleic acid metabolism and/or interactions

Posts Media Videos Starter Packs

Pinned

Nucleic Acids Research @narjournal.bsky.social · Jan 31

Hello Everyone! 👋 Nucleic Acids Research is excited to be on Bluesky! Please follow us for the latest #Research, #Breakthrough articles, journal issues and more. Also, please consider adding us to your starter packs!

1 45 140

Nucleic Acids Research @narjournal.bsky.social · 1d

Five years ago, Dr. Doudna @jenniferdoudna.bsky.social and Dr. Charpentier won the #NobelPrize for #CRISPR/Cas9, revolutionizing gene editing and science as we know it. 🎉🎉Celebrate this milestone with our #specialcollections academic.oup.com/nar/pages/cr... and academic.oup.com/nar/pages/cr...

Nucleic Acids Research @narjournal.bsky.social · 14d

⭐ NAR Breakthrough! ⭐
New research highlights CHD1L in the chromosome 1q21.1 region—linked to #autism, head size & growth.
🧠 It controls #DNApackaging & genes for #braindevelopment, #cellfate & #connectivity.
Read more: doi.org/10.1093/nar/...
#NARBreakthrough #Neuroscience @igbmc.bsky.social

Disrupted transcriptional networks regulated by CHD1L during neurodevelopment underlie the mirrored neuroanatomical and growth phenotypes of the 1q21.1 copy number variant

Abstract. Distal 1q21.1 deletions and duplications are associated with variable phenotypes including autism, head circumference and height defects. To eluc

doi.org

2 4

Nucleic Acids Research @narjournal.bsky.social · 16d

🧬 New in NARGAB: authors compared human exome sequencing kits, showing how design differences impact capture efficiency and downstream analysis. Useful insights for choosing the right kit!

📖 Read: doi.org/10.1093/narg...

#ExomeSequencing #Genomics #Bioinformatics #NARGAB

1 3

Nucleic Acids Research @narjournal.bsky.social · 16d

🧬New in NARGAB: a composite hypothesis testing (CHT) method to find genetic regions affecting multiple traits is described which is efficient, scalable and applied to psychiatric disorders and viral resistance in cucumber.

Read here: doi.org/10.1093/narg...

#Genomics #CHT #Bioinformatics #NARGAB

Nucleic Acids Research @narjournal.bsky.social · 19d

🤰 New research in NARMME reveals that uterine glands, not just eggs, are sensitive to maternal aging. 🧬 FOXC1 marks early dysfunction, reshaping how we understand fertility decline.

📖 Read more: lnkd.in/eahrVbMt

#FertilityResearch #FOXC1 #ReproductiveScience #NARMME #OpenAccessPublication

1 2

Nucleic Acids Research @narjournal.bsky.social · 20d

💡 New in NARMME: TRL1 enzyme from Candida glabrata changes shape to control RNA repair, vital for fungal survival. Its absence in humans makes it a promising antifungal drug target.

📖 Read more: doi.org/10.1093/narm...

#TRL1 #RNARepair #AntifungalResearch #DrugDiscovery #NARMME #OpenAccess

Nucleic Acids Research @narjournal.bsky.social · 20d

🔬 New study in NARMME explores how azvudine (FNC) targets HIV-1 RT & SARS-CoV-2 RdRp🧬

📖 doi.org/10.1093/narm...

#Azvudine #AntiviralAgents #HIVResearch #SARSCoV2 #NARMolecularMedicine #OpenAccessPublication

Nucleic Acids Research @narjournal.bsky.social · 23d

💡A new RNAi strategy described in NARMME embeds miR-based shRNAs into a gamma-retroviral intron, enabling gene knockdown and protein coexpression with high viral titers.

📖 doi.org/10.1093/narm...

#RNAi #GeneTherapy #RetroviralVectors #MolecularBiology #NARMME #OpenAccessPublication

Nucleic Acids Research @narjournal.bsky.social · 23d

🧬 A new review in NARMME explores how chromatin preserves cell identity and how its breakdown may drive diseases like neurodegeneration and cancer.

📖 doi.org/10.1093/narm...

#Epigenetics #Chromatin #CellBiology #Genomics #Neuroscience #MolecularBiology #OpenAccess #NARMolecularMedicine

2 5

Nucleic Acids Research @narjournal.bsky.social · 26d

🐟 New in NARMME: malat1 in zebrafish triggers signaling for retinal repair guided by Notch, Wnt & TGF-β pathways. In mammals, TGF-β blocks regeneration revealing a key difference in healing potential.

🔗 doi.org/10.1093/narm...

#Zebrafish #RetinaRepair #Malat1 #MolecularBiology #NARMME #OpenAccess

Nucleic Acids Research @narjournal.bsky.social · 26d

🦟 New in NARMME: for the first time, microRNA in tsetse fly saliva carrying Trypanosoma brucei were profiled. Infected flies carry less diverse microRNAs, hinting roles in how the disease spreads.

🔗 doi.org/10.1093/narm...

#SleepingSickness #TsetseFly #MicroRNA #Trypanosomes #NARMME #OpenAccess

Nucleic Acids Research @narjournal.bsky.social · 27d

⭐ #NARBreakthrough in #RNAengineering!⭐
University of Utah @utah.edu chemists show that a single dye can emit two colors with engineered #Broccoli #aptamers (Golden = yellow, Red = red).
They built the first ratiometric biosensor to track #glycine dynamics!
Read more 👉 doi.org/10.1093/nar/...

1 1 12

Nucleic Acids Research @narjournal.bsky.social · 29d

🌟 Discover NARGAB Editor's Choice articles, hand-picked by our Editor-in-Chief for their quality and impact.

👉 All articles are free to read and download, explore the full collection now!

🔗 academic.oup.com/nargab/pages...

#NARGenomicsandBioinformatics #EditorsChoice #OpenAccess

Reposted by Nucleic Acids Research

Oxford Academic @oxfordacademic.bsky.social · Aug 29

@narjournal.bsky.social invites you to join the 2026 Early Career Investigator Advisory Board cohort!

You can collaborate with Executive Editors, influence the future of science, and elevate your career. Apply now or tag a colleague who might be interested: oxford.ly/47js8Ye

Join Early Career Investigator Advisory Board

Nucleic Acids Research (NAR) warmly welcomes you to join us in shaping the future of our research community. We recognize the vital role that NAR can play in nu

oxford.ly

2 2

Nucleic Acids Research @narjournal.bsky.social · Aug 29

⭐NAR Breakthrough!⭐

🧬 New study shows Prp22 has a dual role in #splicing—an ATP-independent function that promotes #exonligation by stabilizing Slu7, and an ATP-dependent role that drives Slu7 dissociation + #mRNArelease.
📖 ttps://doi.org/10.1093/nar/gkaf823

#NARBreakthrough #RNA #RNAHelicase

2 6

Nucleic Acids Research @narjournal.bsky.social · Aug 20

⭐NAR Breakthrough!⭐
🧬 New study shows that small activating RNAs can boost MBNL1 expression in #myotonicdystrophy cells, restoring splicing balance. This highlights #RNAactivation (RNAa) as a promising #therapeutic strategy for this #raredisease.
📖 doi.org/10.1093/nar/...
#NARBreakthrough

Promoter-targeted small RNA duplexes increase MBNL1 transcription and mitigate myotonic dystrophy-associated spliceopathy

Abstract. Functional depletion of Muscleblind-like (MBNL) proteins is a key trigger of myotonic dystrophy (DM)-associated alternative splicing (AltS) defec

doi.org

1 2

Nucleic Acids Research @narjournal.bsky.social · Aug 19

🧬 IQ2 could be a new approach to treating visceral leishmaniasis (VL) via c-MYC gene silencing and immune cell reactivation!🥊

📖 Read in NARMME: doi.org/10.1093/narm...

#VisceralLeishmaniasis #KalaAzar #Parasitology #MolecularBiology #OAPublication

Nucleic Acids Research @narjournal.bsky.social · Aug 19

🧬 DM1 is a complex genetic disease affecting multiple body systems. A fast, reliable method to measure DMPK & MBNL1 proteins across diverse cell models is described in NARMME: doi.org/10.1093/narm...
@varechavala.bsky.social
#DM1Research #MyotonicDystrophy #MolecularBiology #OAPublication

2 2

Reposted by Nucleic Acids Research

Bill Dynan - NAR Cancer Editor @nar-cancer-editor.bsky.social · Aug 15

N6-methyladenosine in R-loop homeostasis. Short review in NAR Cancer from Chun-Long Chen and coworkers. Effects on transcription, repair, centromere and telomere stability, and R-loop dynamics. Targeting as a cancer therapeutic strategy. academic.oup.com/narcancer/ar...

m6A modification in R-loop homeostasis: a potential target for cancer therapeutics

Abstract. R-loops or DNA–RNA hybrids are prominent nucleic acid structures that commonly arise during transcription. These structures play important biolog

academic.oup.com

2 3

Reposted by Nucleic Acids Research

Bill Dynan - NAR Cancer Editor @nar-cancer-editor.bsky.social · Aug 10

New insights into gene regulation in melanoma, the deadliest skin cancer: SETD6-catalyzed methylation of BRD4 and chromatin-localized interaction with MITF. From Tzofit Elbaz Biton, Dan Levy, and coworkers, published in NAR Cancer. academic.oup.com/narcancer/ar...

SETD6 mediates selective interaction and genomic occupancy of BRD4 and MITF in melanoma cells

Abstract. Aberrant transcriptional programs mediate malignant transformation of melanoma, the most aggressive form of skin cancer. The lysine methyltransfe

academic.oup.com

2 3

Reposted by Nucleic Acids Research

Bill Dynan - NAR Cancer Editor @nar-cancer-editor.bsky.social · Aug 14

Beyond BRCA status: machine-learning assisted multichannel imaging platform for cell-by-cell analysis of HR competency, enabling patient stratification. “Editor’s Choice” in NAR Cancer. academic.oup.com/narcancer/ar...

Automated machine learning profiling with MAP-HR for quantifying homologous recombination foci in patient samples

Abstract. Accurate visualization and quantification of homologous recombination (HR)-associated foci in readily available patient samples are critical for

academic.oup.com

3 4

Nucleic Acids Research @narjournal.bsky.social · Aug 4

Dr. Yoshikazu Hattori generated the mutants and performed NMR analysis, while Prof. Yoshiyuki Tanaka directed and conceptualized the entire project.

Nucleic Acids Research @narjournal.bsky.social · Aug 4

Prof. Masaki Unno led the crystallographic analysis, while Dr. Masayuki Morikawa contributed kinetics and mass spectrometry to uncover the mechanism.

1 1 4

Nucleic Acids Research @narjournal.bsky.social · Aug 4

⭐NAR Breakthrough!⭐
🧬 New structure reveals a hidden step in DNA repair.
Researchers captured a hemiaminal-type intermediate of hOGG1, shedding light on its catalytic mechanism.
📖 doi.org/10.1093/nar/...
#NARBreakthrough #DNArepair #StructuralBiology #hOGG1 #Crystallography #Enzymes

Capturing a glycosylase reaction intermediate in DNA repair by freeze-trapping of a pH-responsive hOGG1 mutant

Abstract. The human 8-oxoguanine DNA glycosylase 1 (hOGG1) is a bifunctional DNA repair enzyme that possesses both glycosylase and AP-lyase activity. Its A

doi.org

1 2 6

Nucleic Acids Research @narjournal.bsky.social · Aug 1

⭐NAR Breakthrough!⭐
Bonato et al. propose a model for how the yeast #condensin SMC complex drives persistent #DNAloopextrusion, using #atomicforcemicroscopy and #moleculardynamics.

Read the full article here: doi.org/10.1093/nar/...
#NARBreakthrough #SMC #biophysics #genomefolding #yeast

Spontaneously directed loop extrusion in SMC complexes emerges from broken detailed balance and anisotropic DNA search

Abstract. DNA loop formation by structural maintenance of chromosome (SMC) proteins, including cohesin, condensin, and the SMC5/6 complex, plays a pivotal

doi.org

2 3