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Bill Dynan - NAR Cancer Editor @nar-cancer-editor.bsky.social · 29d

New in NAR Cancer: Loss of uL14 downregulates antigen processing and presentation components in melanoma cell lines - alters peptide pool available for presentation to create an escape mechanism from immune surveillance. From Anna Dopler and coworkers.

Liam Faller @liamfaller.bsky.social · Sep 1

Here's the latest from the lab! In it we dive into the role of ribosomal proteins in antigen processing and presentation!

academic.oup.com/narcancer/ar...

Loss of ribosomal protein uL14 enables tumor escape from T cell immunosurveillance

Abstract. The presentation of peptides on HLA molecules is essential to CD8+ T cell responses. Here, we show that loss of uL14 significantly downregulates

academic.oup.com

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Bill Dynan - NAR Cancer Editor @nar-cancer-editor.bsky.social · Sep 8

Evaluation of 49 mRNA modification regulators across subtypes in human breast cancer reveals potential biomarkers and therapeutic targets. New in NAR Cancer, from Carlos Paula, Erik Dassi, Francesca Aguilo and coworkers at University of Trento and Umeå University. academic.oup.com/narcancer/ar...

Analysis of the mRNA modification machinery alterations in breast cancer through the SCAN-B cohort

Abstract. Epitranscriptomic modifications regulate gene expression and have been implicated in cancer, including breast cancer. Using the SCAN-B cohort, we

academic.oup.com

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Bill Dynan - NAR Cancer Editor @nar-cancer-editor.bsky.social · Aug 19

We described Ku-RNA binding in 1998, but had to wait 27 years for Zha and coworkers to discover the significance. A lesson in patience. 2/2 pubs.acs.org/doi/10.1021/...

Characterization of the RNA Binding Properties of Ku Protein†

Ku protein, a heterodimer of 70 and 83 kDa polypeptides, is the regulatory component of the DNA-dependent protein kinase (DNA-PK). Ku protein binds to DNA ends and is essential for DNA double-strand b...

pubs.acs.org

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Bill Dynan - NAR Cancer Editor @nar-cancer-editor.bsky.social · Aug 19

Congrats to our Editorial Board member Shan Zha for amazing study attributing essentiality of Ku protein in primates to modulation of RNA-driven innate immunity. 1/2 www.nature.com/articles/s41...

Ku limits RNA-induced innate immunity to allow Alu expansion in primates - Nature

Studies on the essentiality of Ku in human cells reveal that Ku interacts with diverse double-stranded RNA molecules, including antisense Alu, and enables tolerance of Alu sequence expansion in p...

www.nature.com

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Bill Dynan - NAR Cancer Editor @nar-cancer-editor.bsky.social · Aug 15

N6-methyladenosine in R-loop homeostasis. Short review in NAR Cancer from Chun-Long Chen and coworkers. Effects on transcription, repair, centromere and telomere stability, and R-loop dynamics. Targeting as a cancer therapeutic strategy. academic.oup.com/narcancer/ar...

m6A modification in R-loop homeostasis: a potential target for cancer therapeutics

Abstract. R-loops or DNA–RNA hybrids are prominent nucleic acid structures that commonly arise during transcription. These structures play important biolog

academic.oup.com

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Bill Dynan - NAR Cancer Editor @nar-cancer-editor.bsky.social · Aug 14

Beyond BRCA status: machine-learning assisted multichannel imaging platform for cell-by-cell analysis of HR competency, enabling patient stratification. “Editor’s Choice” in NAR Cancer. academic.oup.com/narcancer/ar...

Automated machine learning profiling with MAP-HR for quantifying homologous recombination foci in patient samples

Abstract. Accurate visualization and quantification of homologous recombination (HR)-associated foci in readily available patient samples are critical for

academic.oup.com

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Bill Dynan - NAR Cancer Editor @nar-cancer-editor.bsky.social · Aug 10

New insights into gene regulation in melanoma, the deadliest skin cancer: SETD6-catalyzed methylation of BRD4 and chromatin-localized interaction with MITF. From Tzofit Elbaz Biton, Dan Levy, and coworkers, published in NAR Cancer. academic.oup.com/narcancer/ar...

SETD6 mediates selective interaction and genomic occupancy of BRD4 and MITF in melanoma cells

Abstract. Aberrant transcriptional programs mediate malignant transformation of melanoma, the most aggressive form of skin cancer. The lysine methyltransfe

academic.oup.com

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Bill Dynan - NAR Cancer Editor @nar-cancer-editor.bsky.social · Aug 5

Our sister journal, Nucleic Acids Research, has opened a search for an Executive Editor. Great opportunity for mid-career or senior investigator looking to be part of a great team, handle 100-150 papers per year, and attend the annual EE meeting. Details at: academic.oup.com/nar/pages/ex...

NAR seeks a new Executive Editor

Overview of the Journal Nucleic Acids Research (NAR) is a leading open access molecular biology journal published by Oxford University Press. It provides rapid

academic.oup.com

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Bill Dynan - NAR Cancer Editor @nar-cancer-editor.bsky.social · May 12

Are key cancer driver mutations amenable to editing by endogenous ADAR enzymes? The scope of correctable mutations is charted for the first time in an Editor's Choice paper, newly published in NAR Cancer. From Rona Merdler-Rabinowicz and colleagues. academic.oup.com/narcancer/ar...

A systematic evaluation of the therapeutic potential of endogenous-ADAR editors in cancer prevention and treatment

Abstract. Adenosine deaminases acting on RNA (ADAR) enzymes constitute a natural cellular mechanism that induces A-to-I(G) editing, introducing genetic cha

academic.oup.com

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Bill Dynan - NAR Cancer Editor @nar-cancer-editor.bsky.social · Apr 26

New in NAR Cancer. A critical examination of mutations in conserved m6A motifs: low recurrence and maybe not a primary mechanism for altering gene function. From Luis A. Diaz and coworkers, @mskcancercenter.bsky.social academic.oup.com/narcancer/ar...

Bill Dynan - NAR Cancer Editor @nar-cancer-editor.bsky.social · Apr 18

Watch the replay of Elise Fouquerel and Rob Sobol's talks at today's NAR Cancer 5th anniversary symposium (offered in collaboration with Social DNAing). Special thanks to guest host Li Lan. Link to video at the Social DNAing website: www.cancer.columbia.edu/research/pro...

Social DNAing

Social DNAing Webinar Series, sponsored by the Cancer Genomics and Epigenomics Program at Columbia University, aims to provide a virtual meeting room for the genomic instability community worldwide.

www.cancer.columbia.edu

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Bill Dynan - NAR Cancer Editor @nar-cancer-editor.bsky.social · Apr 15

NAR Cancer 5th anniversary symposium on manipulating DNA repair and DDR for cancer therapy - 4th and final session, Thursday April 17, noon Eastern. Elise Fouquerel and Rob Sobol on emerging targets. Link to free registration: academic.oup.com/narcancer/pa...

Photos and titles for talks - Elise Fouquerel - PARP2 in the response to replication stress, Rob Sobol, BER enzymes and complexes as essential for PARP and PARG inhibitor response.

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Bill Dynan - NAR Cancer Editor @nar-cancer-editor.bsky.social · Mar 17

Replay of two great talks from last week's NAR Cancer 5th anniversary symposium on manipulating the DNA damage response. Dale Ramsden on DNA polymerase theta - what it repairs and when, and Katie Pawelczak on a first-in-class RPA inhibitor. Find the link at www.cancer.columbia.edu/research/pro...

Social DNAing

Social DNAing Webinar Series, sponsored by the Cancer Genomics and Epigenomics Program at Columbia University, aims to provide a virtual meeting room for the genomic instability community worldwide.

www.cancer.columbia.edu

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Bill Dynan - NAR Cancer Editor @nar-cancer-editor.bsky.social · Mar 10

NAR Cancer 5th Anniversary symposium in cooperation with Social DNAing: Thursday, March 13, noon US Eastern. Dale Ramsden on Pol theta and Katie Pawelczak on targeting RPA.
Program info and link to register: academic.oup.com/narcancer/pa...

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Bill Dynan - NAR Cancer Editor @nar-cancer-editor.bsky.social · Mar 10

Novel approach for simultaneous profiling of long-range genetic and epigenetic changes in matched cancer samples, focusing on clear cell renal cell carcinoma. New in NAR Cancer. From Sapir Margalit, Yuval Ebenstein, and others, Tel Aviv University. academic.oup.com/narcancer/ar...

Optical genome and epigenome mapping of clear cell renal cell carcinoma

Abstract. Cancer cells display complex genomic aberrations that include large-scale genetic rearrangements and epigenetic modulation that are not easily ca

academic.oup.com

Bill Dynan - NAR Cancer Editor @nar-cancer-editor.bsky.social · Mar 5

New Cancer Grand Challenges announced: mechanisms driving unassigned mutational signatures, the dark proteome, and more: www.cancergrandchallenges.org/new-challeng...

New challenges

Explore the challenges currently open for Expressions of Interest.

www.cancergrandchallenges.org

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Bill Dynan - NAR Cancer Editor @nar-cancer-editor.bsky.social · Mar 5

Reaching out to #earlycareerinvestigators @narjournal.bsky.social

Nucleic Acids Research @narjournal.bsky.social · Mar 5

🌟 Thrilled to welcome our new Early Career Investigators to NAR including Marta Montes (@mmontesr.bsky.social), a Principal investigator of the RNA and Senescence group at the University of Navarra! 🧬

#NucleicAcidsResearch #MolecularBiology #EarlyCareerInvestigators
#Mentorship #OpenAccessResearch

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Bill Dynan - NAR Cancer Editor @nar-cancer-editor.bsky.social · Feb 27

First in vivo DNA aptamer selection using an orthotopic patient-derived xenograft glioblastoma mouse model to identify tumor-homing DNA aptamers. From Caroline Doherty, LJ Maher and colleagues at Mayo Clinic. New in NAR Cancer. academic.oup.com/narcancer/ar...

In vivo selection of anti-glioblastoma DNA aptamers in an orthotopic patient-derived xenograft model

Abstract. Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumor of adults. Current therapeutic options yield dismal prognoses

academic.oup.com

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Bill Dynan - NAR Cancer Editor @nar-cancer-editor.bsky.social · Feb 22

New in NAR Cancer - Use of human artificial chromosome (HAC)-based assay to analyze chromosomal instability in IDH-mutant gliomas suggests a precision medicine approach to improve therapeutic outcomes - from Goncharov and coworkers. academic.oup.com/narcancer/ar...

Therapy enhancing chromosome instability may be advantageous for IDH1R132H/WT gliomas

Abstract. Recently revised brain tumor classification suggested a glioma treatment strategy that takes into consideration molecular variants in IDH1 and TP

academic.oup.com

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Bill Dynan - NAR Cancer Editor @nar-cancer-editor.bsky.social · Feb 14

In NAR Cancer: Loss of powerful G4 resolvase FANCJ sensitizes to G4-stabilizing ligand - shown in cancer cells and in C. elegans in vivo. Proof-of-principle for synthetic lethality-based therapeutic approach. Marcello Germoglio et al, IBBC and University of Naples. academic.oup.com/narcancer/ar...

Fluorescence micrograph of C. elegans dog-1-deficient worm labeled for G4 foci

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Bill Dynan - NAR Cancer Editor @nar-cancer-editor.bsky.social · Feb 14

Watch the replay - terrific and well attended talks from Kara Bernstein (RAD51 paralogs) and Joanna Loizou (pol theta) yesterday at the NAR Cancer 5th anniversary symposium. Link to "watch the latest replay" at www.cancer.columbia.edu/research/pro...

Title slides and headshots for Kara Bernstein and Joanna Loizou

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Bill Dynan - NAR Cancer Editor @nar-cancer-editor.bsky.social · Feb 14

This is terrific to see! Proud graduate student Dory Fawwal presents her new NAR Cancer paper to her peers and colleagues. Oncohistone H3E50K. academic.oup.com/narcancer/ar...

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Bill Dynan - NAR Cancer Editor @nar-cancer-editor.bsky.social · Feb 11

NAR Cancer 5th anniversary symposium on manipulating DNA repair and the DDR - Session 2 this Thursday, Feb 13, noon US Eastern time. Kara Bernstein and Joanna Loizou speaking. In collaboration with Social DNAing. Information and free registration link at academic.oup.com/narcancer/pa...

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Bill Dynan - NAR Cancer Editor @nar-cancer-editor.bsky.social · Feb 7

NAR Cancer 5th anniversary symposium with Social DNAing - Manipulating DNA repair for cancer therapy. 2nd session Feb. 13. Kara Bernstein (Penn) on insights from HR variants and Joann Loizou (ICR) on Pol theta gap processing and fork progression. Register at: columbiacuimc.zoom.us/webinar/regi...

Welcome! You are invited to join a webinar: Social DNAing Webinar. After registering, you will receive a confirmation email about joining the webinar.

columbiacuimc.zoom.us

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Bill Dynan - NAR Cancer Editor @nar-cancer-editor.bsky.social · Feb 6

New in NAR Cancer: Oncogenic histone variant H3E50K changes chromatin accessibility, dysregulates gene expression, and supports an EMT phenotype. From Kirti Sad, Anita Corbett, Jennifer Spangle and colleagues at Emory University Winship Cancer Institute. academic.oup.com/narcancer/ar...

bsky.app

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