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Reposted by Eric Van Nostrand Lab @ BCM

Kurianlab @kurianlab.bsky.social · Sep 8

Many conserved exons in the heart and brain utilize weak 5 ′ splice sites, yet they are accurately spliced. But how? We show that splicing fidelity is actively enforced through a QKI-U6 checkpoint at the U1→U6 handover in essential cardiac genes during organogenesis.
www.biorxiv.org/content/10.1...

QKI ensures splicing fidelity during cardiogenesis by engaging the U6 tri-snRNP to activate splicing at weak 5ʹ splice sites

During organogenesis, precise pre-mRNA splicing is essential to assemble tissue architecture. Many developmentally essential exons bear weak 5'splice sites (5'SS) yet are spliced with high precision, ...

www.biorxiv.org

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Eric Van Nostrand Lab @ BCM @evannostrandlab.bsky.social · Sep 8

Great work led by @maureenakinyi.bsky.social and Wenjie, with key help from multiple folks here & the Kurian lab (particularly Jakub, Clara, and Deniz)

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Eric Van Nostrand Lab @ BCM @evannostrandlab.bsky.social · Sep 8

Excited to share some new work from our group - www.biorxiv.org/content/10.1...

A great collaboration with @kurianlab.bsky.social that began with how an RBP (QKI) controls cardiomyocyte function, and led to uncovering a unique mechanism of direct interaction with U6 & the tri-snRNP at weak 5'SS

QKI ensures splicing fidelity during cardiogenesis by engaging the U6 tri-snRNP to activate splicing at weak 5ʹ splice sites

During organogenesis, precise pre-mRNA splicing is essential to assemble tissue architecture. Many developmentally essential exons bear weak 5'splice sites (5'SS) yet are spliced with high precision, ...

www.biorxiv.org

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Eric Van Nostrand Lab @ BCM @evannostrandlab.bsky.social · Aug 12

With pending NIH support, we also anticipate having at least 20 travel awards for trainees to attend – more details on that to follow soon

-Eric, @ruggerolab.bsky.social , Anna, Ly, Esther, & Gene

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Eric Van Nostrand Lab @ BCM @evannostrandlab.bsky.social · Aug 12

We’ve got a good mix of exciting talks on various aspects of how RNA biology both influences and is controlled by tumorigenesis, and we’d love to have more folks join our effort to continue cross-pollinating these exciting fields! Abstract deadline is Aug 25th

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Eric Van Nostrand Lab @ BCM @evannostrandlab.bsky.social · Aug 12

If you’re interested in the interplay between regulation (or mis-regulation) of RNA processing and cancer, please check out the 2025 FASEB RNA Processing in Cancer meeting Oct 5-9 2025 in Sacramento CA!
events.faseb.org/event/RNA-Pr...

RNA Processing in Cancer: From Bench to Bedside

events.faseb.org

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Eric Van Nostrand Lab @ BCM @evannostrandlab.bsky.social · May 27

From our lab, Joey will be presenting her snoRNA work in Concurrent session 5 (5/28 afternoon), and Maureen & Jen-Yun have posters on Wed evening

Also check out talks from other THINC RNA folks @amustoe.bsky.social lab (sessions 6 and 13) and Fazal lab (session 14)!

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Eric Van Nostrand Lab @ BCM @evannostrandlab.bsky.social · May 27

Looking forward to seeing everyone at the @rnasociety.bsky.social meeting!

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Eric Van Nostrand Lab @ BCM @evannostrandlab.bsky.social · Feb 25

Happy to say our paper with the Whipple lab on snoRNA target profiling with chimeric eCLIP is now out! Great work by co-first authors Joey & Min with the help of a bunch of other folks!

genomebiology.biomedcentral.com/articles/10....

Mapping snoRNA-target RNA interactions in an RNA-binding protein-dependent manner with chimeric eCLIP - Genome Biology

Background Small nucleolar RNAs (snoRNAs) are non-coding RNAs that function in ribosome and spliceosome biogenesis, primarily by guiding modifying enzymes to specific sites on ribosomal RNA (rRNA) and...

genomebiology.biomedcentral.com

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Eric Van Nostrand Lab @ BCM @evannostrandlab.bsky.social · Nov 10

Add please! Thanks!

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Eric Van Nostrand Lab @ BCM @evannostrandlab.bsky.social · Nov 10

(re-post) Happy to share that our preprint on using chimeric eCLIP to map snoRNA interactions (and find new non-canonical snoRNA:RBP subnetworks) is now up! A fun co-collaboration with the great @LabWhipple lab, and great work by Joey, Min, and others!

www.biorxiv.org/content/10.1...

Mapping snoRNA-target RNA interactions in an RNA binding protein-dependent manner with chimeric eCLIP

Small nucleolar RNAs (snoRNAs) are non-coding RNAs that function in ribosome and spliceosome biogenesis, primarily by guiding modifying enzymes to specific sites on ribosomal RNA (rRNA) and spliceosom...

www.biorxiv.org

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Eric Van Nostrand Lab @ BCM @evannostrandlab.bsky.social · Nov 10

Good to be here!

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