Eric Van Nostrand Lab @ BCM
@evannostrandlab.bsky.social
Eric Van Nostrand Lab
Therapeutic Innovation Center & the BMP Department, Baylor College of Medicine
Uncovering how RNA binding proteins control RNA processing
Therapeutic Innovation Center & the BMP Department, Baylor College of Medicine
Uncovering how RNA binding proteins control RNA processing
Happy to share Joey (Zhuoyi)'s review on technologies to map RBP:RNA and (especially) RBP-associated RNA:RNA interactions is now up at RNA! pubmed.ncbi.nlm.nih.gov/41535089
Progress and challenges in profiling protein-RNA and protein-associated RNA-RNA interactions - PubMed
RNA binding proteins (RBPs) play essential roles in post-transcriptional gene regulation by interacting with a wide range of RNA targets. In addition to regulating RNA processing via individual RBP-RNA interactions, there is a growing appreciation of the regulatory impact of protein-associated RNA-R …
pubmed.ncbi.nlm.nih.gov
January 18, 2026 at 3:29 AM
Happy to share Joey (Zhuoyi)'s review on technologies to map RBP:RNA and (especially) RBP-associated RNA:RNA interactions is now up at RNA! pubmed.ncbi.nlm.nih.gov/41535089
Some cool work with the www.daughertylab.org at UCSD is up! Started by looking at how IFIT2/3 inhibit VSV infection, wound up uncovering a new mechanism for translation inhibition of mRNAs with short 5'UTRs pubmed.ncbi.nlm.nih.gov/41093992
Daugherty Lab @ UCSD
www.daughertylab.org
October 16, 2025 at 4:20 PM
Some cool work with the www.daughertylab.org at UCSD is up! Started by looking at how IFIT2/3 inhibit VSV infection, wound up uncovering a new mechanism for translation inhibition of mRNAs with short 5'UTRs pubmed.ncbi.nlm.nih.gov/41093992
Reposted by Eric Van Nostrand Lab @ BCM
Many conserved exons in the heart and brain utilize weak 5 ′ splice sites, yet they are accurately spliced. But how? We show that splicing fidelity is actively enforced through a QKI-U6 checkpoint at the U1→U6 handover in essential cardiac genes during organogenesis.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
QKI ensures splicing fidelity during cardiogenesis by engaging the U6 tri-snRNP to activate splicing at weak 5ʹ splice sites
During organogenesis, precise pre-mRNA splicing is essential to assemble tissue architecture. Many developmentally essential exons bear weak 5'splice sites (5'SS) yet are spliced with high precision, ...
www.biorxiv.org
September 8, 2025 at 6:12 AM
Many conserved exons in the heart and brain utilize weak 5 ′ splice sites, yet they are accurately spliced. But how? We show that splicing fidelity is actively enforced through a QKI-U6 checkpoint at the U1→U6 handover in essential cardiac genes during organogenesis.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Excited to share some new work from our group - www.biorxiv.org/content/10.1...
A great collaboration with @kurianlab.bsky.social that began with how an RBP (QKI) controls cardiomyocyte function, and led to uncovering a unique mechanism of direct interaction with U6 & the tri-snRNP at weak 5'SS
A great collaboration with @kurianlab.bsky.social that began with how an RBP (QKI) controls cardiomyocyte function, and led to uncovering a unique mechanism of direct interaction with U6 & the tri-snRNP at weak 5'SS
QKI ensures splicing fidelity during cardiogenesis by engaging the U6 tri-snRNP to activate splicing at weak 5ʹ splice sites
During organogenesis, precise pre-mRNA splicing is essential to assemble tissue architecture. Many developmentally essential exons bear weak 5'splice sites (5'SS) yet are spliced with high precision, ...
www.biorxiv.org
September 8, 2025 at 4:43 PM
Excited to share some new work from our group - www.biorxiv.org/content/10.1...
A great collaboration with @kurianlab.bsky.social that began with how an RBP (QKI) controls cardiomyocyte function, and led to uncovering a unique mechanism of direct interaction with U6 & the tri-snRNP at weak 5'SS
A great collaboration with @kurianlab.bsky.social that began with how an RBP (QKI) controls cardiomyocyte function, and led to uncovering a unique mechanism of direct interaction with U6 & the tri-snRNP at weak 5'SS
If you’re interested in the interplay between regulation (or mis-regulation) of RNA processing and cancer, please check out the 2025 FASEB RNA Processing in Cancer meeting Oct 5-9 2025 in Sacramento CA!
events.faseb.org/event/RNA-Pr...
events.faseb.org/event/RNA-Pr...
RNA Processing in Cancer: From Bench to Bedside
events.faseb.org
August 12, 2025 at 9:08 PM
If you’re interested in the interplay between regulation (or mis-regulation) of RNA processing and cancer, please check out the 2025 FASEB RNA Processing in Cancer meeting Oct 5-9 2025 in Sacramento CA!
events.faseb.org/event/RNA-Pr...
events.faseb.org/event/RNA-Pr...
From our lab, Joey will be presenting her snoRNA work in Concurrent session 5 (5/28 afternoon), and Maureen & Jen-Yun have posters on Wed evening
Also check out talks from other THINC RNA folks @amustoe.bsky.social lab (sessions 6 and 13) and Fazal lab (session 14)!
Also check out talks from other THINC RNA folks @amustoe.bsky.social lab (sessions 6 and 13) and Fazal lab (session 14)!
May 27, 2025 at 7:39 PM
From our lab, Joey will be presenting her snoRNA work in Concurrent session 5 (5/28 afternoon), and Maureen & Jen-Yun have posters on Wed evening
Also check out talks from other THINC RNA folks @amustoe.bsky.social lab (sessions 6 and 13) and Fazal lab (session 14)!
Also check out talks from other THINC RNA folks @amustoe.bsky.social lab (sessions 6 and 13) and Fazal lab (session 14)!
Looking forward to seeing everyone at the @rnasociety.bsky.social meeting!
May 27, 2025 at 7:37 PM
Looking forward to seeing everyone at the @rnasociety.bsky.social meeting!
Happy to say our paper with the Whipple lab on snoRNA target profiling with chimeric eCLIP is now out! Great work by co-first authors Joey & Min with the help of a bunch of other folks!
genomebiology.biomedcentral.com/articles/10....
genomebiology.biomedcentral.com/articles/10....
Mapping snoRNA-target RNA interactions in an RNA-binding protein-dependent manner with chimeric eCLIP - Genome Biology
Background Small nucleolar RNAs (snoRNAs) are non-coding RNAs that function in ribosome and spliceosome biogenesis, primarily by guiding modifying enzymes to specific sites on ribosomal RNA (rRNA) and...
genomebiology.biomedcentral.com
February 25, 2025 at 6:17 PM
Happy to say our paper with the Whipple lab on snoRNA target profiling with chimeric eCLIP is now out! Great work by co-first authors Joey & Min with the help of a bunch of other folks!
genomebiology.biomedcentral.com/articles/10....
genomebiology.biomedcentral.com/articles/10....
(re-post) Happy to share that our preprint on using chimeric eCLIP to map snoRNA interactions (and find new non-canonical snoRNA:RBP subnetworks) is now up! A fun co-collaboration with the great @LabWhipple lab, and great work by Joey, Min, and others!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Mapping snoRNA-target RNA interactions in an RNA binding protein-dependent manner with chimeric eCLIP
Small nucleolar RNAs (snoRNAs) are non-coding RNAs that function in ribosome and spliceosome biogenesis, primarily by guiding modifying enzymes to specific sites on ribosomal RNA (rRNA) and spliceosom...
www.biorxiv.org
November 10, 2024 at 4:46 AM
(re-post) Happy to share that our preprint on using chimeric eCLIP to map snoRNA interactions (and find new non-canonical snoRNA:RBP subnetworks) is now up! A fun co-collaboration with the great @LabWhipple lab, and great work by Joey, Min, and others!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Good to be here!
November 10, 2024 at 4:45 AM
Good to be here!