EvE Bio
@evebio.bsky.social
EvE Bio is a nonprofit biomed research institute in Durham NC. We're a Focused Research Org on a 5-year mission to create the discipline of "pharmome mapping." What that means: https://evebio.org. Watch here for job & data drop announcements
As we continue EvE's mission, we're excited to see our work impact the drug development, ML, and AI communities. More to come!
November 18, 2025 at 7:48 PM
As we continue EvE's mission, we're excited to see our work impact the drug development, ML, and AI communities. More to come!
π₯ Leadership news: @ehouskee.bsky.social steps into the CEO role, leading us into our next phase, while founding CEO William Busa continues as EvE's Chief Scientific Officer.
November 18, 2025 at 7:48 PM
π₯ Leadership news: @ehouskee.bsky.social steps into the CEO role, leading us into our next phase, while founding CEO William Busa continues as EvE's Chief Scientific Officer.
π€ @futurehousesf.bsky.social used our data in the development of the ether0 chemistry reasoning model, showing the value of experimental group truth data for scientific AI models.
November 18, 2025 at 7:48 PM
π€ @futurehousesf.bsky.social used our data in the development of the ether0 chemistry reasoning model, showing the value of experimental group truth data for scientific AI models.
π» Our pharmome mapping data is now accessible to ML developers on @hf.co, making our purpose-built drug-target interaction data easily accessible for model development.
huggingface.co/blog/hugging...
huggingface.co/blog/hugging...
The Pharmome Map: a comprehensive public dataset for drug-target interaction modeling
A Blog post by Hugging Science on Hugging Face
huggingface.co
November 18, 2025 at 7:48 PM
π» Our pharmome mapping data is now accessible to ML developers on @hf.co, making our purpose-built drug-target interaction data easily accessible for model development.
huggingface.co/blog/hugging...
huggingface.co/blog/hugging...
π€ We're partnering with DrugBank to integrate our drug-target interaction data into their drug intelligence platform, bringing it directly to the drug development community with rich context and annotation. go.drugbank.com/evebio
Eve Bio and DrugBank
EvE Bio is now integrated into DrugBank, creating the largest public resource of drugβprotein interactions and making off-target biology searchable, connected, and actionable for the first time.
go.drugbank.com
November 18, 2025 at 7:48 PM
π€ We're partnering with DrugBank to integrate our drug-target interaction data into their drug intelligence platform, bringing it directly to the drug development community with rich context and annotation. go.drugbank.com/evebio
We're excited to share several new developments. Our pharmome mapping dataset is now more accessible and integrated than ever, and the use cases we imagined are coming to life! π§ͺ
evebio.org/pharmome-dat...
Here's what's new: π§΅
evebio.org/pharmome-dat...
Here's what's new: π§΅
Putting Pharmome Data in Researchers' Hands : EvE Bio
We've been busy at EvE Bio these last two years establishing the largest available pharmome mapping dataset. Now itβs making its way into the world to drive real discoveries.
evebio.org
November 18, 2025 at 7:48 PM
We're excited to share several new developments. Our pharmome mapping dataset is now more accessible and integrated than ever, and the use cases we imagined are coming to life! π§ͺ
evebio.org/pharmome-dat...
Here's what's new: π§΅
evebio.org/pharmome-dat...
Here's what's new: π§΅
Reposted by EvE Bio
E11 Bio is excited to unveil PRISM technology for mapping brain wiring with simple light microscopes. Today, brain mapping in humans and other mammals is bottlenecked by accurate neuron tracing. PRISM uses molecular ID codes and AI to help neurons trace themselves.
Read more: e11.bio/blog/prism
Read more: e11.bio/blog/prism
October 1, 2025 at 2:16 PM
E11 Bio is excited to unveil PRISM technology for mapping brain wiring with simple light microscopes. Today, brain mapping in humans and other mammals is bottlenecked by accurate neuron tracing. PRISM uses molecular ID codes and AI to help neurons trace themselves.
Read more: e11.bio/blog/prism
Read more: e11.bio/blog/prism
Yikes.
WTF? I was quoted in this story but I have never spoken to the reporter nor would I have said those things. Is everything just generated by LLMs these days?
cosmosmagazine.com/earth/oceans...
cosmosmagazine.com/earth/oceans...
July 29, 2025 at 8:10 PM
Yikes.
We've confirmed the capsaicin data w/ orthogonal assays, are diving deeper into it for a report, and have filed a provisional patent app to help preserve this indication's business oppty for any pharma willing to look into its clinical potential. Ping us if that's you. 4/4π§ͺ
July 22, 2025 at 4:01 PM
We've confirmed the capsaicin data w/ orthogonal assays, are diving deeper into it for a report, and have filed a provisional patent app to help preserve this indication's business oppty for any pharma willing to look into its clinical potential. Ping us if that's you. 4/4π§ͺ
Further, in light of research implicating reduced ESRRB expression in certain breast cancers' progression, our capsaicin data might suggest an interesting drug repurposing opportunity for this FDA-approved, off-patent drug with a sterling safety record. 3/4 π§ͺ
July 22, 2025 at 4:01 PM
Further, in light of research implicating reduced ESRRB expression in certain breast cancers' progression, our capsaicin data might suggest an interesting drug repurposing opportunity for this FDA-approved, off-patent drug with a sterling safety record. 3/4 π§ͺ
Capsaicin's agonistic action at the orphan receptor, estrogen-related receptor Ξ², is of some interest because it is the first ESRRB agonist with perfect specificity for this family member versus closely related ESRRA and ESRRG. 2/4 π§ͺ
July 22, 2025 at 4:01 PM
Capsaicin's agonistic action at the orphan receptor, estrogen-related receptor Ξ², is of some interest because it is the first ESRRB agonist with perfect specificity for this family member versus closely related ESRRA and ESRRG. 2/4 π§ͺ
Each of our bimonthly HTS data releases reveals previously unknown drug/off-target interactions, but some, like this snippet from last week's Release 5, showing that capsaicin is a highly selective agonist for the orphan nuclear receptor, ESRRB, deserves special note. 𧡠1/4 π§ͺ
July 22, 2025 at 4:01 PM
Each of our bimonthly HTS data releases reveals previously unknown drug/off-target interactions, but some, like this snippet from last week's Release 5, showing that capsaicin is a highly selective agonist for the orphan nuclear receptor, ESRRB, deserves special note. 𧡠1/4 π§ͺ
π§ͺExcited to learn that EvE Bio's unique pharmome-mapping data has been adopted by yet another biomedical reasoning model, Stanford's Biomni (biomni.stanford.edu). Awareness of and appreciation for our efforts is really snowballing. We're grateful to be of service to the community.
July 18, 2025 at 12:51 PM
π§ͺExcited to learn that EvE Bio's unique pharmome-mapping data has been adopted by yet another biomedical reasoning model, Stanford's Biomni (biomni.stanford.edu). Awareness of and appreciation for our efforts is really snowballing. We're grateful to be of service to the community.
π§ͺEvE will soon make our 1st announcement re: a potential drug repurposing opportunity open for licensing by orgs resourced to bring such things to the clinic. If your org would like early notice of such opptys, drop us a DM (or email [email protected]) w/ name, org name, & business email.
July 14, 2025 at 2:29 PM
π§ͺEvE will soon make our 1st announcement re: a potential drug repurposing opportunity open for licensing by orgs resourced to bring such things to the clinic. If your org would like early notice of such opptys, drop us a DM (or email [email protected]) w/ name, org name, & business email.
π§ͺ Thank-you to Abhi Mahajan for his long essay on EvE's efforts to map the pharmome. He did a good job of explaining a pretty arcane topic.
"EvE really exemplifies the thesis [that] smart people in biology should do more boring things." π€
www.owlposting.com/p/mapping-th...
"EvE really exemplifies the thesis [that] smart people in biology should do more boring things." π€
www.owlposting.com/p/mapping-th...
Mapping the off-target effects of every FDA-approved drug in existence (EvE Bio)
6.2k words, 29 minutes reading time
www.owlposting.com
July 14, 2025 at 2:02 PM
π§ͺ Thank-you to Abhi Mahajan for his long essay on EvE's efforts to map the pharmome. He did a good job of explaining a pretty arcane topic.
"EvE really exemplifies the thesis [that] smart people in biology should do more boring things." π€
www.owlposting.com/p/mapping-th...
"EvE really exemplifies the thesis [that] smart people in biology should do more boring things." π€
www.owlposting.com/p/mapping-th...
π§ͺ New toy! It's a robotic -20C freezer that can store 17,000 sample tubes, and upon command can spit out a rack containing just the tubes you've requested, in whatever pattern you want them. Everything is barcoded so the right sample always ends up in the right place. Or that's what they tell me.
June 6, 2025 at 1:25 PM
π§ͺ New toy! It's a robotic -20C freezer that can store 17,000 sample tubes, and upon command can spit out a rack containing just the tubes you've requested, in whatever pattern you want them. Everything is barcoded so the right sample always ends up in the right place. Or that's what they tell me.
π§ͺ Exciting to see EvE Bio's ever-expanding pharmome mapping dataset (data.evebio.org) cited as a source of training/test data for @futurehousesf.bsky.social's ether0 LLM, a new scientific reasoning model for chemistry. Preprint: storage.googleapis.com/aviary-publi...
Eve Bio: Pharmome Data
Browse/download data for 1,400 FDA drugs' actions on an ever-growing collection of gene products.
data.evebio.org
June 5, 2025 at 8:32 PM
π§ͺ Exciting to see EvE Bio's ever-expanding pharmome mapping dataset (data.evebio.org) cited as a source of training/test data for @futurehousesf.bsky.social's ether0 LLM, a new scientific reasoning model for chemistry. Preprint: storage.googleapis.com/aviary-publi...
π§ͺ EvE Bio's biggest public data release (#4) yet!
1.4k Rx drugs screened for 24 new potential off-targets including adrenergic, apelin, muscarinic, dopamine, gastrin-releasing, orexin, 5-HT, neuromedin, opioid, prostaglandin, sphingosine, somatostatin & neuromedin receptors. evebio.org/data
1.4k Rx drugs screened for 24 new potential off-targets including adrenergic, apelin, muscarinic, dopamine, gastrin-releasing, orexin, 5-HT, neuromedin, opioid, prostaglandin, sphingosine, somatostatin & neuromedin receptors. evebio.org/data
May 19, 2025 at 3:01 PM
π§ͺ EvE Bio's biggest public data release (#4) yet!
1.4k Rx drugs screened for 24 new potential off-targets including adrenergic, apelin, muscarinic, dopamine, gastrin-releasing, orexin, 5-HT, neuromedin, opioid, prostaglandin, sphingosine, somatostatin & neuromedin receptors. evebio.org/data
1.4k Rx drugs screened for 24 new potential off-targets including adrenergic, apelin, muscarinic, dopamine, gastrin-releasing, orexin, 5-HT, neuromedin, opioid, prostaglandin, sphingosine, somatostatin & neuromedin receptors. evebio.org/data
Reposted by EvE Bio
𧡠Today, IMPRINT, a pioneering new nonprofit initiative, is announcing $15 million in philanthropic funding to advance our work to decode the body's immune memory and uncover the causes of chronic diseases.
#Immunology #Biotech #BiotechResearch
#Immunology #Biotech #BiotechResearch
Press Release May 2025 β Imprint FRO
Imprint FRO launches with $15M in funding
www.imprint.org
May 15, 2025 at 1:01 PM
𧡠Today, IMPRINT, a pioneering new nonprofit initiative, is announcing $15 million in philanthropic funding to advance our work to decode the body's immune memory and uncover the causes of chronic diseases.
#Immunology #Biotech #BiotechResearch
#Immunology #Biotech #BiotechResearch
Wake up, babe. EvE Bio's data release #4 just dropped.
1.4k Rx drugs, 85 targets & counting:
237,490 combinations screened (mode/target/compound)
8 median agonists per target (potency < 1 uM)
31 median antagonists per target (potency < 1uM)
π§ͺBrowse or DL (for non-commercial use) at evebio.org/data
1.4k Rx drugs, 85 targets & counting:
237,490 combinations screened (mode/target/compound)
8 median agonists per target (potency < 1 uM)
31 median antagonists per target (potency < 1uM)
π§ͺBrowse or DL (for non-commercial use) at evebio.org/data
May 18, 2025 at 7:02 PM
Wake up, babe. EvE Bio's data release #4 just dropped.
1.4k Rx drugs, 85 targets & counting:
237,490 combinations screened (mode/target/compound)
8 median agonists per target (potency < 1 uM)
31 median antagonists per target (potency < 1uM)
π§ͺBrowse or DL (for non-commercial use) at evebio.org/data
1.4k Rx drugs, 85 targets & counting:
237,490 combinations screened (mode/target/compound)
8 median agonists per target (potency < 1 uM)
31 median antagonists per target (potency < 1uM)
π§ͺBrowse or DL (for non-commercial use) at evebio.org/data
Come work with us at EvE Bio in Durham, NC!
EvE's Assay Dev team is looking for a pharmacology scientist to develop new cell-based screening assays. While this is a temporary position (filling in for a scientist on family leave) it has potential to become permanent.
jobs.lever.co/convergentre...
EvE's Assay Dev team is looking for a pharmacology scientist to develop new cell-based screening assays. While this is a temporary position (filling in for a scientist on family leave) it has potential to become permanent.
jobs.lever.co/convergentre...
Convergent Research - Temporary Scientist, Receptor Pharmacologist in Cell-Based Assay Development
Durham NCβs EvE Bio is looking for a receptor biochemist/pharmacologist to join its assay development group at the scientist level. This is a temporary position (5 months) that has the potential to tr...
jobs.lever.co
May 5, 2025 at 4:44 PM
Come work with us at EvE Bio in Durham, NC!
EvE's Assay Dev team is looking for a pharmacology scientist to develop new cell-based screening assays. While this is a temporary position (filling in for a scientist on family leave) it has potential to become permanent.
jobs.lever.co/convergentre...
EvE's Assay Dev team is looking for a pharmacology scientist to develop new cell-based screening assays. While this is a temporary position (filling in for a scientist on family leave) it has potential to become permanent.
jobs.lever.co/convergentre...
Our data release #3, now live at data.evebio.org, adds 7 new nuclear receptors + 14 new 7TMs to our ever-growing list of human gene products screened against 1.4K FDA-approved drugs to ID off-targets, train AIs, repurpose drugs, and more. Enjoy! π§ͺ
April 1, 2025 at 7:52 PM
Our data release #3, now live at data.evebio.org, adds 7 new nuclear receptors + 14 new 7TMs to our ever-growing list of human gene products screened against 1.4K FDA-approved drugs to ID off-targets, train AIs, repurpose drugs, and more. Enjoy! π§ͺ
Apparently we need to add "You must be a human" to the job requirements.
February 13, 2025 at 3:41 PM
Apparently we need to add "You must be a human" to the job requirements.
Work with us!
We seek a data scientist in the Research Triangle w/ great R & Shiny experience, comfort making technical decisions, and some scientific bkgd. This is a hybrid position requiring 2d/wk in our Durham office. π§ͺhttps://jobs.lever.co/convergentresearch/ab999aec-2298-438a-bc54-d368b51cc6f4
We seek a data scientist in the Research Triangle w/ great R & Shiny experience, comfort making technical decisions, and some scientific bkgd. This is a hybrid position requiring 2d/wk in our Durham office. π§ͺhttps://jobs.lever.co/convergentresearch/ab999aec-2298-438a-bc54-d368b51cc6f4
February 13, 2025 at 3:35 PM
Work with us!
We seek a data scientist in the Research Triangle w/ great R & Shiny experience, comfort making technical decisions, and some scientific bkgd. This is a hybrid position requiring 2d/wk in our Durham office. π§ͺhttps://jobs.lever.co/convergentresearch/ab999aec-2298-438a-bc54-d368b51cc6f4
We seek a data scientist in the Research Triangle w/ great R & Shiny experience, comfort making technical decisions, and some scientific bkgd. This is a hybrid position requiring 2d/wk in our Durham office. π§ͺhttps://jobs.lever.co/convergentresearch/ab999aec-2298-438a-bc54-d368b51cc6f4
π§ͺ
EvE Data Release 2 now live! 1.4K drugs screened vs 21 7TMs: ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, DRD1, DRD2, GAL1, GAL2 GHSR, HRH1, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1F, HTR2A, HTR5, HTR6, and PTH1R in ag & antag modes. data.evebio.org
For data drop announcements via email sign up at evebio.org
For data drop announcements via email sign up at evebio.org
Eve Bio: Pharmome Data
Browse/download data for 1,400 FDA drugs' actions on an ever-growing collection of gene products. Data Release 1 now live.
data.evebio.org
February 10, 2025 at 8:37 PM
π§ͺ