Lightnews — Scholar-powered news

Ewart Kuijk @ewartkuijk.bsky.social · 2d

Huge Congrats to #iGEM Utrecht for their wiki. Check it out! Super impressive what this team has achieved. Go see them at the mini #jamboree in #Eindhoven and the grand #jamboree in #Paris if you are there!

2025.igem.wiki/utrecht/

@igemcommunity.bsky.social @igemhq.bsky.social

Home | Utrecht - iGEM 2025

2025.igem.wiki

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Ewart Kuijk @ewartkuijk.bsky.social · 2d

Huge thanks to @cysticfibrosis.org.uk, #NCFS, and #Skate4Air for funding this work—and to the Ina Sonnen lab for this great collaboration.

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Ewart Kuijk @ewartkuijk.bsky.social · 2d

How many healthy cells are needed to tip the balance in favor of recovery through hashtag#genetherapy? PhD-student Jari Bulkens is tackling this question and his innovative approach just earned him a poster prize at the #UKCFC in London!

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Reposted by Ewart Kuijk

Fran Martínez-Jiménez @franmj88.bsky.social · 7d

🚨 International Postdoctoral Positions Open at VHIO! 🚨
The VHIO VIDA Postdoctoral Program is now open!
We’re a fully funded position for international postdocs to work on cutting-edge exciting projects, develop professionally, and pave the way toward independence.
👉 vhiovidaprogramme.eu

Home - VIDA

vhiovidaprogramme.eu

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Reposted by Ewart Kuijk

James Briscoe @jamesbriscoe.bsky.social · 4d

Very sad news, John Gurdon has died.

A developmental biologist's developmental biologist, Nobel prize winner

His work is the foundation of much of today's dev & stem cell bio.

An inspiration to many, including me. Always asking questions & wanting the answers

www.magd.cam.ac.uk/news/profess...

Professor Sir John Gurdon FRS (1933-2025) | Magdalene College

Magdalene College is deeply saddened to announce the death of Professor Sir John Gurdon FRS, who served as Master of the College from 1995 to 2002.

www.magd.cam.ac.uk

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Ewart Kuijk @ewartkuijk.bsky.social · 9d

Apparently. Otherwise there would be no need to take the effort to change a colorful building to dull grey.

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Reposted by Ewart Kuijk

Femke Halsema @femkehalsema.bsky.social · 23d

Hulp aan ernstig zieke en gewonde kinderen uit Gaza door de Tweede Kamer verworpen met 75-74. Zo’n hele kleine daad van medemenselijkheid. Om te huilen, echt.

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Reposted by Ewart Kuijk

Mucosal Immunology @mucosalimmunol.bsky.social · Jul 2

Innate immunity of the gut epithelium: Blowing in the WNT?
From @ewartkuijk.bsky.social and colleagues: www.mucosalimmunology.org/article/S193...

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Ewart Kuijk @ewartkuijk.bsky.social · Jun 26

www.esgctcongress.com

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Ewart Kuijk @ewartkuijk.bsky.social · Jun 26

Esgct (includes also other na based therapies. Large industry section)

Reposted by Ewart Kuijk

bioRxiv Genetics @biorxiv-genetic.bsky.social · Jun 13

Distinct heterozygous TTC7A missense variants lead to different intestinal epithelial phenotypes in pediatric IBD https://www.biorxiv.org/content/10.1101/2025.06.11.659065v1

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Ewart Kuijk @ewartkuijk.bsky.social · Jun 13

Not all mutations in TTC7A have the same effect in the development of pediatric inflammatory bowel disease! Huge congrats to Zahra Shojaei Jeshvaghani for another milestone in her PhD.
@michalmokry.bsky.social
#IBD, #TTC7A
www.biorxiv.org/content/10.1...

Distinct heterozygous TTC7A missense variants lead to different intestinal epithelial phenotypes in pediatric IBD

Pathogenic mutations in Tetratricopeptide repeat domain 7A (TTC7A) result in gastrointestinal and immunological disorders of which the pathobiology is not fully understood. Previous case reports indic...

www.biorxiv.org

Ewart Kuijk @ewartkuijk.bsky.social · Jun 12

Is innate immunity the same across all intestinal epithelial cell types? We think this depends on crosstalk between WNT/BMP and NFκB/IFN pathways: "Innate immunity of the gut epithelium: Blowing in the WNT?" by Maaike de Vries.
@mucosalimmunol.bsky.social doi.org/10.1016/j.mu...

Redirecting

doi.org

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Ewart Kuijk @ewartkuijk.bsky.social · May 20

Iemand in Utrecht heeft blijkbaar liever een grijze saaie lelijke parkeergarage dan een kleurrijke. Jammer. #jaarbeurs #utrecht @jaarbeurs.bsky.social

Ewart Kuijk @ewartkuijk.bsky.social · May 20

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Reposted by Ewart Kuijk

Sebastiaan van Heesch @sebastiaanvheesch.bsky.social · May 16

### PhD position alert ###

Please repost!

I'm excited to announce a new *PhD position* within our group.

We are looking for a super-motivated candidate with a solid basis in wet- and dry-lab research. Apply now & make sure to include all docs!

werkenbijprinsesmaximacentrum.nl/en/vacancy/p...

PhD Position: Unraveling the Dark Proteome in Pediatric Cancer - Werken bij Prinses Maxima Centrum

Background For decades, vast stretches of the genome were dismissed as non-functional ‘junk’. However, our group and others have revealed that these regions harbor numerous non-canonical open reading ...

werkenbijprinsesmaximacentrum.nl

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Reposted by Ewart Kuijk

Tom-Jan Meeus @tomjanmeeus.bsky.social · Mar 27

Amerika 2025, ctd.
www.nature.com/articles/d41...

75% of US scientists who answered Nature poll consider leaving

More than 1,600 readers answered our poll; many said they were looking for jobs in Europe and Canada.

www.nature.com

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Ewart Kuijk @ewartkuijk.bsky.social · Feb 25

www.linkedin.com/posts/ewartk...

Ewart Kuijk on LinkedIn: Vacature — PhD candidate positions for developing Disease Models for…

www.linkedin.com

Reposted by Ewart Kuijk

Marion Koopmans @marionkoopmans.bsky.social · Feb 23

The European federation of Academies of Sciences has posted a statement of concern about the developments in the US. They now have added the option to endorse this statement as an organisation. Would be great if this could go viral. allea.org/portfolio-it...

ALLEA Statement on Threats to Academic Freedom and International Research Collaboration in the United States

allea.org

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Reposted by Ewart Kuijk

Sebastiaan van Heesch @sebastiaanvheesch.bsky.social · Feb 18

Hi everyone! We are still welcoming applicants for a computational postdoc position. If your profile fits our lab interests, please do reach out to me for more information or apply directly via the link below. I'm looking forward to reading your application! www.academictransfer.com/en/jobs/3488...

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Reposted by Ewart Kuijk

Snippert lab @hugosnippert.bsky.social · Feb 14

📢 Organoid enthusiast: We are preparing for the 3rd edition of OrganoidNL - April 11th!
🔥 Check amazing line up of speakers 🔥
Calvin Kuo @priscaliberali.bsky.social Nicolas Rivron, Ina Sonnen @kaikretzschmar.bsky.social Mina Gouti, and others. Be fast to register in time
amolf.nl/organoidnl-s...

OrganoidNL Symposium - AMOLF

OrganoidNL Symposium 2025 Friday, April 11

amolf.nl

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Ewart Kuijk @ewartkuijk.bsky.social · Feb 10

A huge shout-out to Maaike de Vries for getting our manuscript to this stage, and a BIG thanks to all co-authors involved: Claartje Meddens, Hemme Hijma, Anne-Claire Berrens, Suze Jansen, Berend Kooiman, Scott Snapper, Hans Clevers, Michal Mokry and Edward Nieuwenhuis

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Ewart Kuijk @ewartkuijk.bsky.social · Feb 10

Thus, epithelial responsiveness is coupled to cell identity, which is governed by the WNT pathway. These findings provide new insights into intestinal epithelial reponsiveness to microbes, which is relevant for our understanding of gut diseases such as IBD.
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Ewart Kuijk @ewartkuijk.bsky.social · Feb 10

What causes this switch when intestinal stem cells differentiate? The WNT pathway is a key determinant of intestinal cell identity, but its role in immuity is less well explored. Here we show that activation of the WNT pathway sensitizes differentiated cells to bacterial antigens.
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Ewart Kuijk @ewartkuijk.bsky.social · Feb 10

How is this differential responsiveness regulated? Our research indicates that enterocytes do not respond to bacterial antigens as a result of reduced NF-κB pathway activation and also post-transcriptional control of mRNA stability.
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