Mehmet Keles
LightNews LightNews
banner
flyman.bsky.social
Mehmet Keles
@flyman.bsky.social
170 followers 380 following 10 posts
fly brain stuff. www.keleslab.com
Posts Replies Media Videos
Reposted by Mehmet Keles
yvetteefisher.bsky.social
*First preprint from our lab* !!!!!
How does the brain learn to anchor its internal sense of direction to the outside world? 🧭
led by Mark Plitt @markplitt.bsky.social & Dan Turner-Evans, w/ Vivek Jayaraman:
“Octopamine instructs head direction plasticity” www.biorxiv.org/content/10.6...
Thread ⬇️
Schematic of how ER-EPG plasticity enables the bump of activity in EPGs to accurately track visual cues. As a fly makes a counter-clockwise turn (top to bottom) it will view visual cues (e.g. the sun) from a new angle and the EPG activity bump (red) will swing clockwise around the network by integrating self motion signals with these visual inputs. When the fly faces a different angle, distinct visual ER neurons are active. Plasticity forms a trough of weak synapses (large circles - strong synapses, small circles - weak synapses) that allow ER neurons with distinct visual tuning to move the EPG bump via disinhibition.
December 15, 2025 at 6:26 PM
Reposted by Mehmet Keles
tuthill.bsky.social
How do neural circuits generate the walking rhythm?

Using connectome simulations, @sarahpugly.bsky.social found a minimal central pattern generator (CPG) that produces oscillations in leg motor neurons. Same circuit motif for each 🪰 leg.

w @bingbrunton.bsky.social

www.biorxiv.org/content/10.1...
December 9, 2025 at 5:50 PM
Reposted by Mehmet Keles
thetransmitter.bsky.social
There is still “an urgent need for donations from the community,” says Eric Lai, president of the Fly Board.

By @callimcflurry.bsky.social

#neuroskyence

www.thetransmitter.org/community/fl...
FlyBase secures funding for year, but future still uncertain
The FlyBase team’s fundraising efforts have proven successful in the short term, but restoration of its federal grant remains uncertain.
www.thetransmitter.org
October 21, 2025 at 6:23 PM
Reposted by Mehmet Keles
natneuro.nature.com
Dynamics of glia and neurons regulate homeostatic rest, sleep and feeding behavior in Drosophila 🧪🧠

www.nature.com/articles/s41...
Dynamics of glia and neurons regulate homeostatic rest, sleep and feeding behavior in Drosophila - Nature Neuroscience
Animals alternate between active periods and periods of rest or sleep. This study in fruit flies points to brain metabolism as a cause for this and shows that a network of glial cells interacting with...
www.nature.com
April 21, 2025 at 3:48 PM
flyman.bsky.social
I am proud to share that our work of 4+ years has finally been published. We wondered if there are distinct behaviors that mark sleep in 🪰, where sleep has been defined as prolonged immobility.
🔗 www.science.org/doi/10.1126/...
FlyVISTA, an integrated machine learning platform for deep phenotyping of sleep in Drosophila
A machine learning platform identifies and characterizes the dynamics of microbehaviors during fly sleep.
www.science.org
April 8, 2025 at 5:12 PM