François Leulier
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francoisleulier.bsky.social
François Leulier
@francoisleulier.bsky.social
1.5K followers 550 following 190 posts
Scientist, Biologist @CNRS
Director and Group leader @IGFLyon @ENSLyon
We study how the #Microbiome together with #Nutrition influence #Juvenile #Physiology using #InMice and #Drosophila as models.
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francoisleulier.bsky.social
François Leulier @francoisleulier.bsky.social · Nov 23
After 11months on this platform, so happy to see the momentum finally happening!
Let’s repeat a proper introduction:
My lab studies how the #Microbiome together with #Nutrition influence #Development and Juvenile #Physiology using #Mice and #Drosophila as models… we also do lot’s of #Microbiology
Reposted by François Leulier
brunolemaitre.bsky.social
An open webinar on our reproducibility project 'WHAT 400 DROSOPHILA PAPERS Teach Us about Doing Better Science' on December 9th 2PM EEST time (1PM Swiss time). Registration below
November 24, 2025 at 4:31 PM
Reposted by François Leulier
cnrs.fr
#RejoignezLeCNRS 🫵 Les concours chercheurs CNRS 2026 ouvrent le 8/12 !
Envie de faire avancer la science au sein d’un des plus grands organismes de recherche ?
👉 carrieres.cnrs.fr/concours-...

#ConcoursChercheurs #Science #Recherche #Icicarecrute #recrutement
November 25, 2025 at 10:02 AM
Reposted by François Leulier
bibdiderotlyon.bsky.social
📅 Mardi 2/12, 17h45-19h | site Monod – Amphi Bio SVT @ensdelyon.bsky.social
#SciencesEnRésonance La 3e voie du vivant
Rencontre avec Olivier Hamant animée par Mathieu Couttenier.
Un contre-programme au modèle dominant de performance ?
➡️ urlr.me/bxR3VB
#Biologie #Économie #Société #RencontreBDL
Gros plan d'une feuille verte présentant de nombreux trous et des taches brunes, recouvert d'un texte : "La troisième voie du vivant".
November 18, 2025 at 3:10 PM
Reposted by François Leulier
aranzazuarias.bsky.social
Ever wonder how host genetics shape the microbiota? We found that heparan sulfate biosynthesis is a major host driver of L. plantarum levels. During infection, NF-κB increases HS, expanding commensals, enhancing resistance and maintaining gut homeostasis. www.cell.com/cell-reports...
Infection-induced elevation of gut glycosaminoglycans fosters microbiota expansion in Drosophila melanogaster
Arias-Rojas et al. performed a genome-wide association study in Drosophila melanogaster and identified host genetic variants, particularly in heparan sulfate synthesis genes, associated with increased...
www.cell.com
November 24, 2025 at 2:29 PM
Reposted by François Leulier
estherverheyen.bsky.social
Thanks for beating me to the punch! So so many times folks in vertebrate fields totally ignore findings from the 'lower organisms'. Let's value and respect the work across species!
November 24, 2025 at 3:09 AM
francoisleulier.bsky.social
Alongside our companion study (www.biorxiv.org/content/10.1...), this manuscript showcases the central findings of @longweibai.bsky.social ’s PhD journey. #Drosophila #Microbiota #DevoPhysio
A nutrient-sensitive enterokine coordinates developmental plasticity through inter-organ signalling
Animal survival in fluctuating environments depend on the ability to modulate their developmental pace in response to nutrient availability, a phenomenon known as developmental plasticity. In Drosophi...
www.biorxiv.org
November 23, 2025 at 6:25 AM
francoisleulier.bsky.social
Revised refereed preprint:
www.biorxiv.org/content/10.1...
Revision work lead by @longweibai.bsky.social

Our work reveals how the #microbiota helps buffer #malnutrition: L. plantarum sustains intestinal activity of the steroid hormone ecdysone, expanding the midgut and supporting systemic growth.
November 23, 2025 at 6:19 AM
Reposted by François Leulier
evolvedbiofilm.bsky.social
Editorial: Society journals matter—supporting science through renewed commitment

Editorial in @femsjournals.bsky.social microLife by @paulbrainey.bsky.social and colleagues

academic.oup.com/microlife/ad...
Editorial: Society journals matter—supporting science through renewed commitment
Paul B Rainey, Puri López-García, Zeynep Ceren Karahan, Paul Williams, Stipan Jonjić, Kenneth N Timmis; Editorial: Society journals matter—supporting scien
academic.oup.com
November 22, 2025 at 6:35 PM
Reposted by François Leulier
filipedevadder.bsky.social
New Neuron paper by Mitchell, Dahly, Bishop tears apart the “autism is caused by the microbiome” story. Tiny n, noisy 16S, contradictory taxa, vague “dysbiosis”. It reads like an autopsy of a hype bubble.
www.cell.com/neuron/fullt...
Conceptual and methodological flaws undermine claims of a link between the gut microbiome and autism
Claims that the gut microbiome causally contributes to autism regularly appear in the scientific literature and popular press. Mitchell et al. critically examine influential studies underpinning these...
www.cell.com
November 19, 2025 at 3:03 PM
Reposted by François Leulier
plosbiology.org
How does the #tumor #microenvironment modulate sensitivity to nutrient restriction? @joannaqd.bsky.social @chengflylab.bsky.social &co show that this is regulated by the SCL36 AA transporter Pathetic at #BloodBrainBarrier glial cells in #Drosophila #brain tumors @plosbiology.org 🧪 plos.io/4ibwXWY
Left: Maximum projection images of elavC155QF>QUAS-prosRi tumor brains stained with Repo and Dpn. The animals were moved from standard food to chemically defined diet (CDD) (top left), CDD minus Leu (top right), CDD minus Ile (bottom left), and CDD minus Met (bottom right) at 72hALH and dissected at 120hALH. Right: Schematic depicting the working model. Nutrient Restriction (NR) inhibits BBB glia expansion, which consequently limits brain tumor growth. The authors show that NR inhibits the expression of fat body and glia-derived Ilp6, causing downregulation of the InR/PI3K pathway in BBB glia. This results in a reduction in Path expression and the downstream mTOR-S6K pathway, causing a slowdown of BBB glial cell cycle progression. Path downregulation and defects in BBB expansion consequently led to a decrease in brain AAs, such as Leu, which hinders brain tumor protein synthesis to slow down tumor growth. Data information: ALH, after larvae hatching.
November 19, 2025 at 2:05 PM
Reposted by François Leulier
floravincent.bsky.social
A couple of days left to submit your abstract for the upcoming EMBO/EMBL Symposium on the Molecular Basis of Symbiosis ! Great line up of speakers :)
#ProtistsOnSky #SymbioSky
events.embl.org EMBL Events @events.embl.org · 7d
🧪 Submit your abstract for #EESSymbiosis and get the chance to present your research, receive qualified feedback and help develop our understanding of the complexities of symbiotic function.

You have until 25 Nov: https://s.embl.org/ees26-03-bl

🗓️ 17 – 20 Mar 2026
📍 EMBL Heidelberg and Virtual
November 19, 2025 at 3:28 PM
Reposted by François Leulier
fly-jedi.bsky.social
Preparations for the next JEDI meeting are underway! The upcoming Junior European #Drosophila Investigator / #NewPI meeting is planned for Portugal in June. Final dates and additional details will be announced soon - stay tuned for updates!​
AI-generated image of a lightsaber-wielding figure conquering Portugal.
October 28, 2025 at 10:14 PM
Reposted by François Leulier
plosbiology.org
Research into brain–body communication is being reinvigorated as the field unites under the umbrella of #interoception. Our new #Editorial highlights four Perspectives that show the breadth of this emerging field #neurosky 🧪 🧵 ⬇️
plos.io/4r2SRzL
Image showing a model of the internal organs. Image by Olena from Pixabay
November 17, 2025 at 1:55 PM
Reposted by François Leulier
zaycha.bsky.social
Very proud to have defended my HDR (« Habilitation à diriger les recherches ») at @ensdelyon.bsky.social. Many thanks to the jury for their constructive feedbacks @clairewyart.bsky.social @francoisleulier.bsky.social @FlorenceRuggiero @PaulineSpéder @stemdevevo.bsky.social @OlivierRaineteau!
November 16, 2025 at 5:23 PM
Reposted by François Leulier
plosbiology.org
Decoding the body’s internal signals could revolutionize Whole Person Health. This Perspective suggests a research framework linking brain, body and behavior to foster resilience, self-regulation and holistic well-being #neurosky #interoception 🧪
Interoception as a central mechanism in Whole Person Health
Decoding the body’s internal signals could revolutionize Whole Person Health. This Perspective suggests a research framework linking brain, body and behavior to foster resilience, self-regulation and…
plos.io
November 15, 2025 at 5:07 PM
Reposted by François Leulier
plosbiology.org
Interoceptive signals from organs such as heart, lungs and gut influence many aspects of organismal physiology and behavior. This Perspective argues that liver signaling via the vagal nerve is another avenue of body-brain communication that shapes metabolism and mood #neurosky 🧪
Does the liver talk to the brain? If so, how and why?
Interoceptive signals from visceral organs, such as heart, lungs and gut, are known to influence many aspects of organismal physiology and behavior. This Perspective argues that liver signaling via…
plos.io
November 15, 2025 at 5:10 PM
francoisleulier.bsky.social
Here is a follow up work by @memartino.bsky.social and @schwarzergnoto.bsky.social
Nice in host-evolution story!

bmcbiol.biomedcentral.com/articles/10....
Gut microbe Lactiplantibacillus plantarum undergoes different evolutionary trajectories between insects and mammals - BMC Biology
Background Animals form complex symbiotic associations with their gut microbes, whose evolution is determined by an intricate network of host and environmental factors. In many insects, such as Drosop...
bmcbiol.biomedcentral.com
November 15, 2025 at 7:32 PM
francoisleulier.bsky.social
But one-sided 😉

Cool results from your lab! Congrats
November 14, 2025 at 6:41 PM
francoisleulier.bsky.social
Indeed monoassociation!
November 14, 2025 at 6:39 PM
francoisleulier.bsky.social
Well @microbiome.bsky.social it has been done in flies with effect 😉

www.cell.com/cell-host-mi...
November 14, 2025 at 6:27 PM
Reposted by François Leulier
josetelesreis.bsky.social
Excited to share our new paper out in Cell Reports Methods! @cp-cellrepmethods.bsky.social
🎉🎉🎉
We present EyaHOST, a modular Drosophila genetic system that enables precise and independent manipulation of tumours and host tissues to dissect tumour-host interactions.
www.cell.com/cell-reports...
EyaHOST, a modular genetic system for investigation of intercellular and tumor-host interactions in Drosophila melanogaster
Teles-Reis et al. present EyaHOST, a modular Drosophila system that enables clone generation in the eye disc with independent genetic manipulation of other tissues. EyaHOST uses an Eya-KD “kick-out” s...
www.cell.com
November 5, 2025 at 11:07 PM
Reposted by François Leulier
hansonmark.bsky.social
We wrote the Strain on scientific publishing to highlight the problems of time & trust. With a fantastic group of co-authors, we present The Drain of Scientific Publishing:

a 🧵 1/n

Drain: arxiv.org/abs/2511.04820
Strain: direct.mit.edu/qss/article/...
Oligopoly: direct.mit.edu/qss/article/...
A table showing profit margins of major publishers. A snippet of text related to this table is below. 1. The four-fold drain 1.1 Money Currently, academic publishing is dominated by profit-oriented, multinational companies for whom scientific knowledge is a commodity to be sold back to the academic community who created it. The dominant four are Elsevier, Springer Nature, Wiley and Taylor & Francis, which collectively generated over US$7.1 billion in revenue from journal publishing in 2024 alone, and over US$12 billion in profits between 2019 and 2024 (Table 1A). Their profit margins have always been over 30% in the last five years, and for the largest publisher (Elsevier) always over 37%. Against many comparators, across many sectors, scientific publishing is one of the most consistently profitable industries (Table S1). These financial arrangements make a substantial difference to science budgets. In 2024, 46% of Elsevier revenues and 53% of Taylor & Francis revenues were generated in North America, meaning that North American researchers were charged over US$2.27 billion by just two for-profit publishers. The Canadian research councils and the US National Science Foundation were allocated US$9.3 billion in that year. A figure detailing the drain on researcher time. 1. The four-fold drain 1.2 Time The number of papers published each year is growing faster than the scientific workforce, with the number of papers per researcher almost doubling between 1996 and 2022 (Figure 1A). This reflects the fact that publishers’ commercial desire to publish (sell) more material has aligned well with the competitive prestige culture in which publications help secure jobs, grants, promotions, and awards. To the extent that this growth is driven by a pressure for profit, rather than scholarly imperatives, it distorts the way researchers spend their time. The publishing system depends on unpaid reviewer labour, estimated to be over 130 million unpaid hours annually in 2020 alone (9). Researchers have complained about the demands of peer-review for decades, but the scale of the problem is now worse, with editors reporting widespread difficulties recruiting reviewers. The growth in publications involves not only the authors’ time, but that of academic editors and reviewers who are dealing with so many review demands. Even more seriously, the imperative to produce ever more articles reshapes the nature of scientific inquiry. Evidence across multiple fields shows that more papers result in ‘ossification’, not new ideas (10). It may seem paradoxical that more papers can slow progress until one considers how it affects researchers’ time. While rewards remain tied to volume, prestige, and impact of publications, researchers will be nudged away from riskier, local, interdisciplinary, and long-term work. The result is a treadmill of constant activity with limited progress whereas core scholarly practices – such as reading, reflecting and engaging with others’ contributions – is de-prioritized. What looks like productivity often masks intellectual exhaustion built on a demoralizing, narrowing scientific vision. A table of profit margins across industries. The section of text related to this table is below: 1. The four-fold drain 1.1 Money Currently, academic publishing is dominated by profit-oriented, multinational companies for whom scientific knowledge is a commodity to be sold back to the academic community who created it. The dominant four are Elsevier, Springer Nature, Wiley and Taylor & Francis, which collectively generated over US$7.1 billion in revenue from journal publishing in 2024 alone, and over US$12 billion in profits between 2019 and 2024 (Table 1A). Their profit margins have always been over 30% in the last five years, and for the largest publisher (Elsevier) always over 37%. Against many comparators, across many sectors, scientific publishing is one of the most consistently profitable industries (Table S1). These financial arrangements make a substantial difference to science budgets. In 2024, 46% of Elsevier revenues and 53% of Taylor & Francis revenues were generated in North America, meaning that North American researchers were charged over US$2.27 billion by just two for-profit publishers. The Canadian research councils and the US National Science Foundation were allocated US$9.3 billion in that year. The costs of inaction are plain: wasted public funds, lost researcher time, compromised scientific integrity and eroded public trust. Today, the system rewards commercial publishers first, and science second. Without bold action from the funders we risk continuing to pour resources into a system that prioritizes profit over the advancement of scientific knowledge.
November 11, 2025 at 11:52 AM
Reposted by François Leulier
fly-eds.bsky.social
The European Drosophila Society #flyEDS extends the condolences on the passing of Antonio García-Bellido, considered the founder of the Spanish school of #Drosophila genetics and an influential figure in developmental biology research worldwide. May he rest in peace.
November 11, 2025 at 2:15 PM
Reposted by François Leulier
msumgi.bsky.social
The Long-Term Evolution Experiment has returned home. Led by Professors Richard Lenski (@relenski.bsky.social) and Jeffrey Barrick, this groundbreaking work continues to reveal how bacteria evolve in real time. 12 flasks. 1 legacy.

🔗https://tinyurl.com/f6vjyjvr
Rich Lenski adds information to the Long-Term Evolution Experiment lab notebook after restarting the experiment at MSU. Jeff Barrick and Devin Lake stand behind him.
November 10, 2025 at 3:25 PM
Reposted by François Leulier
maitrejl.bsky.social
Want to join a happy bunch 🥳 to organise meetings, outreach activities and other initiatives about developmental biology in France? Apply and/or vote 🗳️!
sfbd.bsky.social SFBD_BioDev @sfbd.bsky.social · 15d
🚨🚨🚨
The SFBD board needs to be renewed with 5 members
We wish to strengthen our board with young scientists

To apply: send a brief text introducing your research interests and motivations to [email protected] by December 4th
Elections will be held online from December 10th to 17th
Please share the info
November 10, 2025 at 12:00 PM