Ryo
@fujiryosan.bsky.social
Associate Professor at University of Tsukuba, Japan.Muscle biology, Muscle stem cell biology.
Pinned
Ryo
@fujiryosan.bsky.social
· Jul 29
Excited to share our new paper in Skeletal Muscle! We show that large Maf transcription factors can robustly induce MYH4, normally silent in humans.
In human muscle, Mafa and Maf expression correlate with fast fiber content. #myoblue
rdcu.be/ex0un
In human muscle, Mafa and Maf expression correlate with fast fiber content. #myoblue
rdcu.be/ex0un
Excited to share our new paper in Skeletal Muscle! We show that large Maf transcription factors can robustly induce MYH4, normally silent in humans.
In human muscle, Mafa and Maf expression correlate with fast fiber content. #myoblue
rdcu.be/ex0un
In human muscle, Mafa and Maf expression correlate with fast fiber content. #myoblue
rdcu.be/ex0un
July 29, 2025 at 2:20 PM
Excited to share our new paper in Skeletal Muscle! We show that large Maf transcription factors can robustly induce MYH4, normally silent in humans.
In human muscle, Mafa and Maf expression correlate with fast fiber content. #myoblue
rdcu.be/ex0un
In human muscle, Mafa and Maf expression correlate with fast fiber content. #myoblue
rdcu.be/ex0un
Our new review, “The Multifaceted Role of MyoD in Adult Skeletal Muscle: Homeostasis, Regeneration, and Diseases,” is now available online in AJP Cell Physiol.
journals.physiology.org/doi/abs/10.1...
@myoblue.bsky.social
journals.physiology.org/doi/abs/10.1...
@myoblue.bsky.social
The Multifaceted Role of MyoD in Adult Skeletal Muscle: Homeostasis, Regeneration, and Diseases | American Journal of Physiology-Cell Physiology | American Physiological Society
Myogenic regulatory factors, including myoblast determination protein 1 (MyoD1 or MyoD) and myogenic factor 5 (Myf5), crucially regulate skeletal muscle lineage specification and development. Although...
journals.physiology.org
June 8, 2025 at 5:16 PM
Our new review, “The Multifaceted Role of MyoD in Adult Skeletal Muscle: Homeostasis, Regeneration, and Diseases,” is now available online in AJP Cell Physiol.
journals.physiology.org/doi/abs/10.1...
@myoblue.bsky.social
journals.physiology.org/doi/abs/10.1...
@myoblue.bsky.social
Reposted by Ryo
Myogenesis gone awry: the role of developmental pathways in rhabdomyosarcoma
www.frontiersin.org/journals/cel...
www.frontiersin.org/journals/cel...
Frontiers | Myogenesis gone awry: the role of developmental pathways in rhabdomyosarcoma
www.frontiersin.org
February 4, 2025 at 4:45 PM
Myogenesis gone awry: the role of developmental pathways in rhabdomyosarcoma
www.frontiersin.org/journals/cel...
www.frontiersin.org/journals/cel...
Building upon our previous study published in Cell Rep (10.1016/j.celrep.2023.112289), which identified large Mafs as essential regulators of type IIb myofiber specification in mice, this work extends our understanding to humans. biorxiv.org/cgi/content/...
#Myotwitter
#Myotwitter
Large MAF Transcription Factors Reawaken Evolutionarily Dormant Fast-Glycolytic Type IIb Myofibers in Human Skeletal Muscle
Small mammals rely on type IIb myofibers, expressing the fastest myosin IIb (encoded by MYH4 ), for rapid muscle contraction. In contrast, larger mammals, including humans, show reduced or absent MYH4...
biorxiv.org
December 16, 2024 at 8:17 AM
Building upon our previous study published in Cell Rep (10.1016/j.celrep.2023.112289), which identified large Mafs as essential regulators of type IIb myofiber specification in mice, this work extends our understanding to humans. biorxiv.org/cgi/content/...
#Myotwitter
#Myotwitter