Rachel Helston
@fungalmom.bsky.social
Scientist in @Zanderslab studying meiosis in fission yeast. Fungi fanatic and mother of twins👩🏻🤝👨🏼. 🇬🇧 living in 🇺🇸 🍄
Found these delightful mushrooms over the weekend. Panellus stipticus - these have luminescent gills so I need to find a way to get back there at night! 🤞🏻🙄
February 4, 2025 at 2:40 PM
Found these delightful mushrooms over the weekend. Panellus stipticus - these have luminescent gills so I need to find a way to get back there at night! 🤞🏻🙄
Found some delightfully fuzzy contaminants on yeast nitrogen plates today ❤️ those on the right look like daisies! @contamclub.bsky.social any ideas on ID?
December 18, 2024 at 12:11 AM
Found some delightfully fuzzy contaminants on yeast nitrogen plates today ❤️ those on the right look like daisies! @contamclub.bsky.social any ideas on ID?
Sometimes all a girl needs is a short walk in the woods. #fungifriends
December 9, 2024 at 2:30 PM
Sometimes all a girl needs is a short walk in the woods. #fungifriends
Reposted by Rachel Helston
Distinct evolutionary trajectories following loss of RNA interference in Cryptococcus neoformans | PNAS www.pnas.org/doi/abs/10.1...
www.pnas.org
November 27, 2024 at 2:04 PM
Distinct evolutionary trajectories following loss of RNA interference in Cryptococcus neoformans | PNAS www.pnas.org/doi/abs/10.1...
Reposted by Rachel Helston
www.embopress.org/doi/full/10....
A non-coding RNA in fission yeast that also promotes longevity in flies.
A non-coding RNA in fission yeast that also promotes longevity in flies.
Ageing-associated long non-coding RNA extends lifespan and reduces translation in non-dividing cells | EMBO reports
imageimageThe long-non-coding RNA aal1 (ageing-associated lncRNA) promotes the longevity of
non-dividing cells likely by attenuating their translational capacity. aal1 localizes to the cytoplasm and ...
www.embopress.org
November 25, 2024 at 7:45 PM
www.embopress.org/doi/full/10....
A non-coding RNA in fission yeast that also promotes longevity in flies.
A non-coding RNA in fission yeast that also promotes longevity in flies.
Reposted by Rachel Helston
Hello Bluesky, for my first post here I'm happy to share our latest preprint reporting the first biochemical reconstitution of DNA double-strand break formation by SPO11.
SPO11 dimerization controls meiotic DNA double-strand break formation.
www.biorxiv.org/content/10.1...
SPO11 dimerization controls meiotic DNA double-strand break formation.
www.biorxiv.org/content/10.1...
SPO11 dimerization controls meiotic DNA double-strand break formation
SPO11 initiates meiotic recombination through the induction of programmed DNA double-strand breaks (DSBs), but this catalytic activity had never been reconstituted in vitro. Here, using Mus musculus S...
www.biorxiv.org
November 21, 2024 at 10:18 AM
Hello Bluesky, for my first post here I'm happy to share our latest preprint reporting the first biochemical reconstitution of DNA double-strand break formation by SPO11.
SPO11 dimerization controls meiotic DNA double-strand break formation.
www.biorxiv.org/content/10.1...
SPO11 dimerization controls meiotic DNA double-strand break formation.
www.biorxiv.org/content/10.1...
Reposted by Rachel Helston
Hi Bluesky. For my first post, I'd like to advertise the latest preprint from my lab, describing at long last our reconstitution of SPO11-dependent double-strand break formation from purified recombinant proteins. Outstanding work from PhD student Zhi (Zack) Zheng.
November 23, 2024 at 4:00 PM
Hi Bluesky. For my first post, I'd like to advertise the latest preprint from my lab, describing at long last our reconstitution of SPO11-dependent double-strand break formation from purified recombinant proteins. Outstanding work from PhD student Zhi (Zack) Zheng.
Beautiful!
For #FluorescentFriday enjoy this gorgeous video of fission yeast cells expressing Sla2-GFP and Bqt4-mCherry. Video taken by Dr. Dhanya Kalathil from the Das lab.
November 16, 2024 at 3:52 AM
Beautiful!
Reposted by Rachel Helston
Self-restrained sex chromosome drive through sequential asymmetric meiosis https://www.biorxiv.org/content/10.1101/2024.11.14.623699v1
Self-restrained sex chromosome drive through sequential asymmetric meiosis https://www.biorxiv.org/content/10.1101/2024.11.14.623699v1
Meiotic drivers are selfish genetic elements that bias their own transmission, violating Mendel's La
www.biorxiv.org
November 16, 2024 at 1:37 AM
Self-restrained sex chromosome drive through sequential asymmetric meiosis https://www.biorxiv.org/content/10.1101/2024.11.14.623699v1
Reposted by Rachel Helston
It's great to be back in the light!💙🦋 In case you missed it while on the dark side, check out our latest preprint on the heritability of RNAi epimutations mediating drug resistance 🧬 biorxiv.org/content/10.1.... More details? ▶️🧵
RNAi epimutations conferring antifungal drug resistance are inheritable
Epimutations modify gene expression and lead to phenotypic variation while the encoding DNA sequence remains unchanged. Epimutations mediated by RNA interference (RNAi) and/or chromatin modifications ...
biorxiv.org
November 14, 2024 at 9:35 PM
It's great to be back in the light!💙🦋 In case you missed it while on the dark side, check out our latest preprint on the heritability of RNAi epimutations mediating drug resistance 🧬 biorxiv.org/content/10.1.... More details? ▶️🧵
I’m back! For my first post in several months, feast your eyes upon these forest beauties ❤️🍄 #FungiFriends
November 13, 2024 at 7:39 AM
I’m back! For my first post in several months, feast your eyes upon these forest beauties ❤️🍄 #FungiFriends
Reposted by Rachel Helston
In latest issue of Science Magazine, Kinzig, de Lange, +al. report that human telomerase threatens genome integrity by adding telomeres to broken chromosomes and is held in check by ATR kinase signaling. Paper bit.ly/adg3224 accompanied by a Perspective by Arnoult and Cech bit.ly/adn7791
February 21, 2024 at 8:04 PM
In latest issue of Science Magazine, Kinzig, de Lange, +al. report that human telomerase threatens genome integrity by adding telomeres to broken chromosomes and is held in check by ATR kinase signaling. Paper bit.ly/adg3224 accompanied by a Perspective by Arnoult and Cech bit.ly/adn7791
Beautiful yeast 🤩😍 (color imparted by food dye)
February 21, 2024 at 7:05 PM
Beautiful yeast 🤩😍 (color imparted by food dye)
Found the motherload across the street - sadly the utility workers and springtails found them first :-( 🍄
December 6, 2023 at 10:45 PM
Found the motherload across the street - sadly the utility workers and springtails found them first :-( 🍄
Stunning reflections this morning ❤️
November 13, 2023 at 3:20 PM
Stunning reflections this morning ❤️
Our fission yeast are soooo happy 😊 #pombe #meiosis4eva
We've been working through the Cell Biology Module of the grad school the past 2 weeks. As part of that we did a timelapse experiment of S. Pombe meiosis with Hht1-mCherry expressed. Here is an avg. proj. showing two nuclei on top and one horsetailing meiotic cell on bottom. #Halloween 🧪
October 19, 2023 at 10:24 PM
Our fission yeast are soooo happy 😊 #pombe #meiosis4eva
Reposted by Rachel Helston
#RNABiology recent highlight, a thoroughly revised and streamlined RiboSeq method from @nickingolia.bsky.social
Streamlined and sensitive mono- and di-ribosome profiling in yeast and human cells. doi.org/10.1038/s415...
Streamlined and sensitive mono- and di-ribosome profiling in yeast and human cells. doi.org/10.1038/s415...
Streamlined and sensitive mono- and di-ribosome profiling in yeast and human cells - Nature Methods
A comprehensive redevelopment of the ribosome profiling workflow involves improved nuclease treatment and sequencing library preparation, enabling richer and more accurate translatome profiling with l...
doi.org
October 17, 2023 at 12:39 PM
#RNABiology recent highlight, a thoroughly revised and streamlined RiboSeq method from @nickingolia.bsky.social
Streamlined and sensitive mono- and di-ribosome profiling in yeast and human cells. doi.org/10.1038/s415...
Streamlined and sensitive mono- and di-ribosome profiling in yeast and human cells. doi.org/10.1038/s415...
New paper on meiotic drive from the Zanders lab!
Modeling the Evolution of Populations with Multiple Killer Meiotic Drivers https://www.biorxiv.org/content/10.1101/2023.09.28.560003v1
Modeling the Evolution of Populations with Multiple Killer Meiotic Drivers https://www.biorxiv.org/content/10.1101/2023.09.28.560003v1
Meiotic drivers are selfish genetic loci that can be transmitted to more than half of the viable gam
www.biorxiv.org
October 2, 2023 at 1:41 AM
New paper on meiotic drive from the Zanders lab!
Found the coolest fungi at the weekend but I am clueless about its ID. Any suggestions? 🍄🤩❤️
September 27, 2023 at 12:26 AM
Found the coolest fungi at the weekend but I am clueless about its ID. Any suggestions? 🍄🤩❤️
Excited for this upcoming meeting on ribosome heterogeneity and specialization
Deadline for abstract submission for the Ribosome heterogeneity and specialization meeting is on Friday! We have an incredible line up, and the meeting is free to attend!
royalsociety.org/science-even...
royalsociety.org/science-even...
Ribosome heterogeneity and specialisation | Royal Society
Ribosome heterogeneity and specialisation
royalsociety.org
September 20, 2023 at 12:10 PM
Excited for this upcoming meeting on ribosome heterogeneity and specialization
Great new fission yeast resource! www.biorxiv.org/content/10.1...
September 15, 2023 at 12:55 AM
Great new fission yeast resource! www.biorxiv.org/content/10.1...
Reposted by Rachel Helston
CALL for applicants to join the Genomely Internship in Genome Science (GIGS) Scholars program.
GIGS Scholars will remotely work w/ Genomely personnel to gain research experience in the genome sciences—namely, evo omics, bioinf & software eng Applications due Nov 15
GIGS Scholars will remotely work w/ Genomely personnel to gain research experience in the genome sciences—namely, evo omics, bioinf & software eng Applications due Nov 15
September 14, 2023 at 5:09 PM
CALL for applicants to join the Genomely Internship in Genome Science (GIGS) Scholars program.
GIGS Scholars will remotely work w/ Genomely personnel to gain research experience in the genome sciences—namely, evo omics, bioinf & software eng Applications due Nov 15
GIGS Scholars will remotely work w/ Genomely personnel to gain research experience in the genome sciences—namely, evo omics, bioinf & software eng Applications due Nov 15