Edward Wallace
@ewjwallace.bsky.social
Group leader, RNA and cellular adaptation in fungi. Carpentries data science instructor. Trying to make my corner of science a better place. Opinions my own.
https://ewallace.github.io
https://ewallace.github.io
Reposted by Edward Wallace
We are hiring a postdoctoral researcher to investigate ribosome hibernation and activation in microsporidia using confocal microscopy, soft X-ray tomography, cryo-electron tomography, and omics approaches. If you are interested, apply here: jobs.exeter.ac.uk/hrpr_webrecr...
January 15, 2026 at 12:09 PM
We are hiring a postdoctoral researcher to investigate ribosome hibernation and activation in microsporidia using confocal microscopy, soft X-ray tomography, cryo-electron tomography, and omics approaches. If you are interested, apply here: jobs.exeter.ac.uk/hrpr_webrecr...
Reposted by Edward Wallace
Happy to share that the our manuscript "Cyclin CLB2 mRNA localization and protein synthesis link cell cycle progression to bud growth" is now finally out in its final form @natcomms.nature.com
www.nature.com/articles/s41...
Below a short🧵 with the key findings!
www.nature.com/articles/s41...
Below a short🧵 with the key findings!
January 10, 2026 at 6:54 PM
Happy to share that the our manuscript "Cyclin CLB2 mRNA localization and protein synthesis link cell cycle progression to bud growth" is now finally out in its final form @natcomms.nature.com
www.nature.com/articles/s41...
Below a short🧵 with the key findings!
www.nature.com/articles/s41...
Below a short🧵 with the key findings!
Ugh...
anyone got any advice on the following situation? I wrote and did a big chunk of the admin for a large MRC grant which also also awarded. I am named in the Staff breakdown on the grant as "researcher co-lead" with 100%FTE, and I am mentioned by name as "postdoctoral researcher Maria Niedernhuber"
December 9, 2025 at 3:11 PM
Ugh...
Reposted by Edward Wallace
Interested in pursuing a PhD by working on a long-neglected marine organism and making a lot of discoveries? Darwin Trust offers a PhD studentship for international students (anyone non-UK) www.findaphd.com/phds/project...
November 11, 2025 at 9:26 AM
Interested in pursuing a PhD by working on a long-neglected marine organism and making a lot of discoveries? Darwin Trust offers a PhD studentship for international students (anyone non-UK) www.findaphd.com/phds/project...
Reposted by Edward Wallace
Reposted by Edward Wallace
We are looking for an enthusiastic postdoc to investigate cellular dormancy and ribosome hibernation across plants, fungi, and mammals using #cryoET. If you are interested, apply here: careers.exeter.ac.uk/vacancies/66....
October 29, 2025 at 4:40 PM
We are looking for an enthusiastic postdoc to investigate cellular dormancy and ribosome hibernation across plants, fungi, and mammals using #cryoET. If you are interested, apply here: careers.exeter.ac.uk/vacancies/66....
We had a great fungal minisymposium yesterday
@edinburghbiology.bsky.social - really exciting to see the critical mass of fungal researchers here coming together.
Next one January or February TBA: Email me to be added to the email list!
@edinburghbiology.bsky.social - really exciting to see the critical mass of fungal researchers here coming together.
Next one January or February TBA: Email me to be added to the email list!
October 10, 2025 at 4:30 PM
We had a great fungal minisymposium yesterday
@edinburghbiology.bsky.social - really exciting to see the critical mass of fungal researchers here coming together.
Next one January or February TBA: Email me to be added to the email list!
@edinburghbiology.bsky.social - really exciting to see the critical mass of fungal researchers here coming together.
Next one January or February TBA: Email me to be added to the email list!
Reposted by Edward Wallace
Thrilled to announce our #preprint on a new factor in the last line of defense in #translation quality control out on #bioRXiv! Spearheaded by fantastic PhD student @kaushikiyer.bsky.social, supported by Chloé Walter, Alina Kraft, Max Müller and Lena Tittel.
Jlp2 is an RQC complex-independent release factor acting on aberrant peptidyl-tRNA, protecting cells against translation elongation stress https://www.biorxiv.org/content/10.1101/2025.09.04.673968v1
September 9, 2025 at 6:17 PM
Thrilled to announce our #preprint on a new factor in the last line of defense in #translation quality control out on #bioRXiv! Spearheaded by fantastic PhD student @kaushikiyer.bsky.social, supported by Chloé Walter, Alina Kraft, Max Müller and Lena Tittel.
Reposted by Edward Wallace
Translon: a single term for translated regions. #Translation @natmethods.nature.com
September 4, 2025 at 9:15 AM
Translon: a single term for translated regions. #Translation @natmethods.nature.com
Reposted by Edward Wallace
Pro tip for getting your data into SGD and other knowledgebases: don't hide the data in the supplemental info in PDF format. Put it in Excel with stable identifiers like SGDIDs and systematic_names (ex. YFL039C) in addition to gene names. #yeast #modelOrganism #getYourDataOutGetCited
August 20, 2025 at 3:17 PM
Pro tip for getting your data into SGD and other knowledgebases: don't hide the data in the supplemental info in PDF format. Put it in Excel with stable identifiers like SGDIDs and systematic_names (ex. YFL039C) in addition to gene names. #yeast #modelOrganism #getYourDataOutGetCited
Reposted by Edward Wallace
New preprint! This work is Gabriela Fior Ribeiro's second first-author manuscript, @logantom.bsky.social's first manuscript, and is the culmination of our long-standing collaboration with @ewjwallace.bsky.social's group at University of Edinburgh.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Antifungal exposure can enhance Candida glabrata pathogenesis
Azole antifungal drugs directly inhibit lanosterol 14-α-demethylase and indirectly affect the expression of metabolic, transmembrane transporter, and cell wall organization genes in fungal pathogens. ...
www.biorxiv.org
August 1, 2025 at 12:47 PM
New preprint! This work is Gabriela Fior Ribeiro's second first-author manuscript, @logantom.bsky.social's first manuscript, and is the culmination of our long-standing collaboration with @ewjwallace.bsky.social's group at University of Edinburgh.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Edward Wallace
bioRxiv bat signal going up. We have a big backlog of submissions. If any affiliates have time to do some screening, we (and all the authors) would be immensely grateful! 🙏
July 31, 2025 at 12:32 PM
bioRxiv bat signal going up. We have a big backlog of submissions. If any affiliates have time to do some screening, we (and all the authors) would be immensely grateful! 🙏
V happy with paperpile as a reference manager. Thanks @dadrummond.bsky.social for that recommentation.
What do people use for references in Google docs/word? Coming from latex where referencing was solid, have been stung a couple of times by Google docs/zotero losing or messing up which paper each reference number points to. This is too painful to go through again. What are the alternatives?
July 31, 2025 at 12:42 PM
V happy with paperpile as a reference manager. Thanks @dadrummond.bsky.social for that recommentation.
Reposted by Edward Wallace
I NEED to tell you the story of Tae Heung “William” Kim.
He's a graduate student at Texas A&M where he's working on a vaccine for Lyme disease.
He's a *legal permanent resident* of the United States.
And he's been in ICE detention for 12 days & counting, transferred Tuesday to South Texas.
He's a graduate student at Texas A&M where he's working on a vaccine for Lyme disease.
He's a *legal permanent resident* of the United States.
And he's been in ICE detention for 12 days & counting, transferred Tuesday to South Texas.
July 31, 2025 at 11:35 AM
I NEED to tell you the story of Tae Heung “William” Kim.
He's a graduate student at Texas A&M where he's working on a vaccine for Lyme disease.
He's a *legal permanent resident* of the United States.
And he's been in ICE detention for 12 days & counting, transferred Tuesday to South Texas.
He's a graduate student at Texas A&M where he's working on a vaccine for Lyme disease.
He's a *legal permanent resident* of the United States.
And he's been in ICE detention for 12 days & counting, transferred Tuesday to South Texas.
Absolutely loving the random ribosome dreams that appear on the #RNAbiology feed.
little baby nucleus ribosome mitosis
July 30, 2025 at 2:11 PM
Absolutely loving the random ribosome dreams that appear on the #RNAbiology feed.
Wellcome to bluesky @edinburghbiology.bsky.social - Edinburgh School of Biological Sciences!
This feed collects the SBS folks on bluesky who I know about: bsky.app/profile/ewjw...
This feed collects the SBS folks on bluesky who I know about: bsky.app/profile/ewjw...
July 24, 2025 at 1:26 PM
Wellcome to bluesky @edinburghbiology.bsky.social - Edinburgh School of Biological Sciences!
This feed collects the SBS folks on bluesky who I know about: bsky.app/profile/ewjw...
This feed collects the SBS folks on bluesky who I know about: bsky.app/profile/ewjw...
Reposted by Edward Wallace
It’s actually even worse: they show it as a gel, which is pure fluorescence units, but a BioAnalyzes records as the molecules pass a single point sensor and critically _fails to normalize for different molecule speeds_
This results in a near-logarithmic overcounting of large molecules!
This results in a near-logarithmic overcounting of large molecules!
This is your regular reminder that the BioAnalyzer/TapeStation reports fluorescence units, not # of molecules.
Left is bioA trace, and right is fragment size calculated from either read output (blue) or transformation of BioA trace (black).
Fig 3 from journals.plos.org/plosone/arti...
Left is bioA trace, and right is fragment size calculated from either read output (blue) or transformation of BioA trace (black).
Fig 3 from journals.plos.org/plosone/arti...
July 22, 2025 at 2:09 AM
It’s actually even worse: they show it as a gel, which is pure fluorescence units, but a BioAnalyzes records as the molecules pass a single point sensor and critically _fails to normalize for different molecule speeds_
This results in a near-logarithmic overcounting of large molecules!
This results in a near-logarithmic overcounting of large molecules!
Reposted by Edward Wallace
If you work as an academic and behave like your job can be done by a machine, then you should not have that job.
Nikkei found academics had written "give a positive review only" and "do not highlight any negatives" in white text or tiny font on 17 preprints to combat AI peer reviews.
asia.nikkei.com/Business/Tec...
asia.nikkei.com/Business/Tec...
'Positive review only': Researchers hide AI prompts in papers
Instructions in preprints from 14 universities highlight controversy on AI in peer review
asia.nikkei.com
July 4, 2025 at 5:31 AM
If you work as an academic and behave like your job can be done by a machine, then you should not have that job.
Reposted by Edward Wallace
Words cannot describe how excited I am to share the findings from the second half of my postdoc in @aaronwhiteley.bsky.social's lab where we discover that bacteria use functional amyloids to defend themselves from predatory bacteria. rdcu.be/euu5Y. See thread for details on this epic adventure 1/.
Functional amyloid proteins confer defence against predatory bacteria
Nature - Escherichia coli uses curli fibres, oligomers of the functional amyloid CsgA, as a barrier to protect against the predatory bacteria Bdellovibrio bacteriovorus and Myxococcus xanthus in a...
rdcu.be
July 2, 2025 at 8:10 PM
Words cannot describe how excited I am to share the findings from the second half of my postdoc in @aaronwhiteley.bsky.social's lab where we discover that bacteria use functional amyloids to defend themselves from predatory bacteria. rdcu.be/euu5Y. See thread for details on this epic adventure 1/.
Reposted by Edward Wallace
#TLUK25 finishing strong! This morning we heard from those with emerging topics within the Translation field. We would like to thank all attendees for their amazing engagement - we will see you next year.
July 2, 2025 at 1:30 PM
#TLUK25 finishing strong! This morning we heard from those with emerging topics within the Translation field. We would like to thank all attendees for their amazing engagement - we will see you next year.
Reposted by Edward Wallace
@instmolplantsci.bsky.social very own Amy Newell presents her work on shade response in plants and translational regulation at the #TLUK25!! @biochemsoc.bsky.social
June 30, 2025 at 6:21 PM
@instmolplantsci.bsky.social very own Amy Newell presents her work on shade response in plants and translational regulation at the #TLUK25!! @biochemsoc.bsky.social