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Tobias Hohl, MD PhD

@fungalspore.bsky.social

1.8K followers 350 following 28 posts

Physician-Scientist at Memorial Sloan Kettering, Chief, ID Service Member, HOPP. Lab: Mycology & Immunology. Duke ‘93 and Tri-Institutional MD-PhD ‘01 Grad. Immigrant🇨🇭. ❤️ 🐕‍🦺, 🍄‍🟫, NPR, and Catskills. Comments = do not represent views of MSKCC.

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Tobias Hohl, MD PhD @fungalspore.bsky.social · Mar 21

So happy to see this story come together. Check it out! Kathleen Mills and many collaborators - GM-CSF–mediated epithelial-immune cell cross-talk orchestrates pulmonary immunity to Aspergillus fumigatus | Science Immunology www.science.org/doi/10.1126/...

GM-CSF–mediated epithelial-immune cell cross-talk orchestrates pulmonary immunity to Aspergillus fumigatus

During mold infection, epithelial-derived GM-CSF licenses neutrophil killing of fungal cells, leading to improved survival.

www.science.org

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Reposted by Tobias Hohl, MD PhD

Immunology & Microbial Pathogenesis (IMP) Program @wcm-imp.bsky.social · Jun 25

🎓 Huge congratulations to Kathleen Mills from the @fungalspore.bsky.social Hohl Lab on successfully defending her thesis: "Epithelial-Immune Cell Crosstalk Orchestrates Pulmonary Immunity to Aspergillus fumigatus" Her strong, dedicated presence in the program will truly be missed! 💫🧬

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Tobias Hohl, MD PhD @fungalspore.bsky.social · Mar 26

And a real doozy from the article:

"Most botanists from the mid-19th century viewed their study as a research backwater."

We're working hard here to change this long-held stereotype!

Tobias Hohl, MD PhD @fungalspore.bsky.social · Mar 26

"You are my only friend in the debatable land of fungi”

Wonderful quote from by Mary Elizabeth Banning, a self-taught mycologist who described 23 new species of fungi in Maryland in the 19th century.

www.nytimes.com/2025/03/25/s...

#MicroSky #IDSky #ImmunoSky

A Fungi Pioneer’s Lifelong Work on Exhibit

Mushrooms in 19th-century watercolors: The paintings of a self-taught female mycologist are featured at the New York State Museum.

www.nytimes.com

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Tobias Hohl, MD PhD @fungalspore.bsky.social · Mar 21

#MicroSky #ImmunoSky #IDSky

Tobias Hohl, MD PhD @fungalspore.bsky.social · Mar 21

GM-CSF–mediated epithelial-immune cell cross-talk orchestrates pulmonary immunity to Aspergillus fumigatus

During mold infection, epithelial-derived GM-CSF licenses neutrophil killing of fungal cells, leading to improved survival.

www.science.org

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Reposted by Tobias Hohl, MD PhD

StrictlyChristo 🦋🇺🇦🌻❌👑 @strictlychristo.bsky.social · Mar 12

Basel, Switzerland

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Tobias Hohl, MD PhD @fungalspore.bsky.social · Jan 24

Love the generations!!

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Tobias Hohl, MD PhD @fungalspore.bsky.social · Jan 21

A fantastic GRC on the Immunology of Fungal Infections. Gordon Brown, @slg1717.bsky.social, Bernie Hube, Mihai Netea, Ilse Jacobsen, Jay Vyas, Rob Wheeler, @lableibundgut.bsky.social - missing former/future 🪑 Luigina Romani, Rebecca Drummond, Bruce Klein, Neil Gow& George Deepe #MicroSky #ImmunoSky

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Reposted by Tobias Hohl, MD PhD

The LeibundGut-lab @lableibundgut.bsky.social · Jan 18

@fungalspore.bsky.social and @lableibundgut.bsky.social look forward seeing you in Ventura Beach!

The LeibundGut-lab @lableibundgut.bsky.social · Jan 18

Welcome in Ventura Beach to those of you joining us for the GRS/GRC Immunology of Fungal infections 2025!

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Tobias Hohl, MD PhD @fungalspore.bsky.social · Jan 10

doi.org/10.1093/infd...

Validate User

doi.org

Tobias Hohl, MD PhD @fungalspore.bsky.social · Jan 10

doi.org/10.1128/aac....

High Intracellular Concentrations of Posaconazole Do Not Impact on Functional Capacities of Human Polymorphonuclear Neutrophils and Monocyte-Derived Macrophages In Vitro | Antimicrobial Agents and Che...

ABSTRACT Posaconazole is a commonly used antifungal for the prophylaxis and treatment of invasive fungal infections. We previously demonstrated that the intracellular concentration of posaconazole in ...

doi.org

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Tobias Hohl, MD PhD @fungalspore.bsky.social · Jan 9

It's reasonable to give 5 mg/kg ambisone + posa up front since posa load takes time. I generally don't use prolonged (>2 weeks) dual therapy for mucormycosis. I don't use 10 mg/kg for mucormycosis due to toxicities. The key here is to get isolate and perform AST to optimize therapy quickly.

Tobias Hohl, MD PhD @fungalspore.bsky.social · Jan 9

If Mucorales are in the picture, I do not think that posa and isavu are equivalent. Posa IMHO is a better drug than isavu. For aspergillosis, posa and vori are my top choices, isavu OK too. I only use isavu when patient cannot tolerate posa or vori.

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Tobias Hohl, MD PhD @fungalspore.bsky.social · Jan 9

Acute-angle branching is mot consistent with aspergillosis. Were septations present? I would treat with posaconazole which is enriched in CNS-penetrating neutrophils. For a very, very long time. Would try to culture tissue for isolate for ID.

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Tobias Hohl, MD PhD @fungalspore.bsky.social · Dec 27

My family knows me all too well. This well-chosen gift hits close to home. May your science (funding) prayers be answered in 2025! #IDSky #ImmunoSky #MedSky #MicroSky

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Tobias Hohl, MD PhD @fungalspore.bsky.social · Dec 26

Merry Christmas! Happy Hanukah! Blending 🇨🇭tradition with 🕯️+ 🎄(Catskills grown and cut on Dec. 24).

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Tobias Hohl, MD PhD @fungalspore.bsky.social · Nov 26

Terrific opportunity with wonderful colleagues!

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Reposted by Tobias Hohl, MD PhD

Steven Pergam, MD, MPH @pergamic.bsky.social · Nov 26

📢 Brand new ID faculty position just posted @fredhutch.bsky.social in Seattle. Join our ID group that studies infections in immunocompromised hosts. The Emerald city has great academics, phenomenal facilities, outstanding collaborators - all in amazing surroundings.

apply.interfolio.com/159913

A photo of Fred Hutch Cancer Center in Seattle, with the Arnold buildling and "the Vessel" sculpture in front.

Mount Rainer surrounded by a field of wildflowers

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Tobias Hohl, MD PhD @fungalspore.bsky.social · Nov 23

No need to duplicate. You're much further along. Just grab from mine...

Tobias Hohl, MD PhD @fungalspore.bsky.social · Nov 22

Starting an MSKCC starter pack to build community on @bsky.app #MedSky #ImmunoSky

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Tobias Hohl, MD PhD @fungalspore.bsky.social · Nov 22

Welcome aboard!

Reposted by Tobias Hohl, MD PhD

Marc Swidergall @swidergall-lab.bsky.social · Nov 21

Candida auris Infectious by Lionakis & Chowdhary in NEJM
www.nejm.org/doi/full/10....

Candida auris Infections | NEJM

C. auris, a serious public health threat that may have emerged because of climate change, persists on human skin and inanimate objects, frequently causing difficult-to-control outbreaks in health c...

www.nejm.org

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Tobias Hohl, MD PhD @fungalspore.bsky.social · Nov 20

Would add @lableibundgut.bsky.social to the Mycology community.

Tobias Hohl, MD PhD @fungalspore.bsky.social · Nov 20

I'd start here...https://go.bsky.app/FYRJn6M

Reposted by Tobias Hohl, MD PhD

Norman van Rhijn @normanvanrhijn.bsky.social · Nov 18

With more #MycoSky arriving here by the day, lets gather everyone and rebuild.

Please let me know if I’ve missed out on you or anyone relevant 🍄‍🟫😎

go.bsky.app/FYRJn6M

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