Gastroenterology Advisor
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gastroadvisor.bsky.social
Gastroenterology Advisor
@gastroadvisor.bsky.social
15 followers 4 following 150 posts
Trusted knowledge base of practical information and resources focused on gastroenterology medicine.
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gastroadvisor.bsky.social
#Neurotoxicity rates were 46.3% in patients given CapOx, 2.5% in those treated with CapCar, and 0% in those assigned to F-Nal-IrI.

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Capecitabine-Carboplatin “Most Favorable” Backbone for Advanced Gastroesophageal Adenocarcinoma
Capecitabine plus oxaliplatin (CapOx) does not offer a progression-free survival (PFS) advantage over capecitabine plus carboplatin (CapCar), nor over nanoliposomal irinotecan, leucovorin and fluorour...
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February 13, 2026 at 5:00 AM
gastroadvisor.bsky.social
Initiation of #IRAs, specifically tirzepatide, is associated with a significantly lower risk for continuous positive airway pressure (#CPAP) use, all-cause hospitalization, and mortality compared with SGLT2 inhibitor use.

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Tirzepatide Linked to Reduced CPAP Use and Mortality in Patients With OSA
Use of tirzepatide, compared with SGLT2 inhibitors, is associated with a lower risk for CPAP use, hospitalization, and mortality among adults with obesity, T2D, and OSA.
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February 12, 2026 at 5:40 PM
gastroadvisor.bsky.social
A blood-based liquid biopsy accurately detects early-onset colorectal cancer across stages among adults aged younger than 50 years. #CRC

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Blood-Based Biopsy Accurately Detects Early-Onset Colorectal Cancer
A blood-based liquid biopsy using cell-free and exosome-derived microRNAs accurately detected early-onset colorectal cancer across stages, including early disease.
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February 11, 2026 at 5:34 PM
gastroadvisor.bsky.social
Low diastolic blood pressure and use of multiple hypertensive medications are associated with increased #ischemic #colitis risk among older women.

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Older Women With CVD, CVD Features at Higher Risk for Ischemic Colitis
Low diastolic blood pressure and multiple antihypertensive medications are linked to higher ischemic colitis risk, while higher fiber intake was protective.
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February 10, 2026 at 5:25 PM
gastroadvisor.bsky.social
GLP-1 therapy should be combined with structured physical activity with resistance training to allow patients to maintain lean body mass, enhance their metabolic health, and prevent their loss of functional independence.

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Pairing Weight Training With GLP-1 Therapy for Optimal Weight Management
By reinforcing exercise, health care providers can ensure that GLP-1 therapy leads to weight loss, sustains muscle mass, and improves health.
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February 9, 2026 at 5:21 PM
gastroadvisor.bsky.social
Saline-immersion #endoscopic submucosal dissection using the pocket-creation method enabled safe, minimally invasive en bloc resection of complex #colorectal lesions.

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Saline-Immersion ESD Achieves High Curative Resection Rates for Complex Colorectal Lesions
Saline-immersion endoscopic submucosal dissection using the pocket-creation method achieved high R0 and curative resection rates with low adverse events.
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February 9, 2026 at 1:31 AM
gastroadvisor.bsky.social
The coexistence of #IBD and PSC defines a high-risk phenotype with substantially increased colorectal and hepatobiliary cancer risk compared with either condition alone.

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IBD With PSC Confers Markedly High Risk for Colorectal, Hepatobiliary Malignancies
Patients with IBD and primary sclerosing cholangitis have markedly higher risks for colorectal and hepatobiliary cancers than those with isolated IBD or PSC.
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February 7, 2026 at 8:09 PM
gastroadvisor.bsky.social
Progression-free survival was significantly prolonged among patients who received zanidatamab and chemotherapy with or without trastuzumab vs trastuzumab and #chemotherapy only.

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ASCO GI: Zanidatamab Plus Chemo Beneficial in HER2-Positive Gastroesophageal Cancer
Zanidatamab added to chemotherapy with or without trastuzumab prolonged progression-free survival in gastroesophageal cancer.
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February 6, 2026 at 5:47 PM
gastroadvisor.bsky.social
Young adults with #IBD were more likely than adults and pediatric patient caregivers to experience step therapy mandates, to have difficulty addressing coverage problems, and to take on an extra job to afford their care.

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Young Adults With IBD Face Health Care Access Challenges, Financial Burden
Young adults with inflammatory bowel disease had more health care access challenges and financial burdens than adults and caregivers.
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February 5, 2026 at 5:35 PM
gastroadvisor.bsky.social
[H]olistic care — the integration of emotional, spiritual, and social support — emerged as a unifying theme, especially in #palliative and oncology settings.

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Nurse Assessment of Quality Care Shifting Toward Interpersonal Relationships, Holistic Care
A review of nursing quality assessment tools identified characteristics of commonly used instruments to measure nurse perception of care.
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February 4, 2026 at 5:35 PM
gastroadvisor.bsky.social
#Semaglutide 2.4 mg is associated with significant improvements in #insulin sensitivity and glycemic control among adolescents with obesity.

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Semaglutide 2.4 mg Improves Insulin Sensitivity in Adolescents With Obesity
Semaglutide 2.4 mg improves insulin sensitivity and glycemic outcomes in adolescents with obesity, according to a secondary analysis of STEP TEENS.
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February 3, 2026 at 5:17 PM
gastroadvisor.bsky.social
Adolescents with overweight or obesity who used #GLP-1 RAs had fewer prescriptions for systemic corticosteroids and for inhaled short-acting beta-2 agonists.

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GLP-1 RAs Linked to Reduced Acute Asthma Exacerbations in Adolescents With Overweight, Obesity
Acute asthma exacerbations were significantly less frequent among adolescents with overweight or obesity who used GLP-1 RAs.
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February 2, 2026 at 5:36 PM
gastroadvisor.bsky.social
All standard OTC and FDA-approved therapies for #constipation should be trialed, as well as off-label treatments, and only after confirming slow-transit constipation and excluding pelvic floor dysfunction should surgery be considered.

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Guidance Updated for Evaluation, Management of Refractory Constipation
Best practices for evaluating refractory constipation include excluding pelvic floor dysfunction and extensive pharmacological trials.
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February 2, 2026 at 1:54 AM
gastroadvisor.bsky.social
Higher blood pressure targets may be necessary to optimize outcomes among individuals with #cirrhosis and septic #shock.

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What Is the Optimal Mean Arterial Pressure Threshold for Septic Shock and Cirrhosis?
Lower arterial pressure during septic shock is associated with higher mortality and kidney injury among patients with cirrhosis.
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January 31, 2026 at 8:08 PM
gastroadvisor.bsky.social
#Lerochol prefilled syringes will be available in the spring of 2026.

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LDL-C-Lowering Therapy Lerochol Gains FDA Approval
The FDA approved Lerochol, a monthly PCSK9 inhibitor, for adults with hypercholesterolemia to reduce LDL-C levels alongside diet and exercise.
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January 30, 2026 at 5:00 AM
gastroadvisor.bsky.social
A dual-strain #probiotic combination provides earlier and broader symptom improvement and favorable shifts in gut #microbiota.

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Probiotic Combination Improves Symptoms in IBS Without Constipation
A dual-strain probiotic (L acidophilus LA-5 and B lactis BB-12) significantly improved global symptoms, symptom severity, and QOL in adults with nonconstipated IBS.
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January 29, 2026 at 6:34 PM
gastroadvisor.bsky.social
Switching to a different #iologic therapy postoperatively may help individuals with #CD have improved endoscopic outcomes.

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Switching Biologic Therapy After Resection Lowers Risk for Recurrence in CD
Individuals with CD who received treatment with biologics preoperatively have improved endoscopic outcomes when switching to a different biologic postoperatively.
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January 28, 2026 at 3:54 PM
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Dual immune checkpoint blockade is an optimal first-line treatment option for previously untreated, unresectable hepatocellular #carcinoma.

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Durvalumab Plus Tremelimumab Efficacious and Tolerable for HCC
Durvalumab plus tremelimumab significantly improves survival vs sorafenib in unresectable hepatocellular carcinoma.
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January 27, 2026 at 5:21 PM
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Gut microbiota profiles obtained at admission can predict postdischarge diabetes after acute #pancreatitis with high accuracy, independent of disease severity.

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Admission Gut Microbiota Predict Postdischarge Diabetes After Acute Pancreatitis
Admission gut microbiota accurately predicts postdischarge diabetes among patients with acute pancreatitis.
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January 26, 2026 at 5:21 PM
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Study findings support the consideration of earlier transition to needle-knife techniques by experienced #endoscopists once difficult #cannulation criteria are met.

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What Is the Best Strategy for Difficult Biliary Cannulation in ERCP?
Needle-knife techniques and EUS-RV may be optimal strategies for difficult biliary cannulation in endoscopic retrograde cholangiopancreatography.
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January 25, 2026 at 5:13 PM
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Ultrasound-derived #VAT independently predicts hepatic steatosis and outperforms #BMI and waist circumference for hepato-metabolic assessment in #MASLD.

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Ultrasound-Derived VAT Outperforms BMI for Hepato-Metabolic Risk Stratification in MASLD
Ultrasound-derived VAT is more strongly associated with hepatic steatosis and metabolic dysfunction than BMI or waist circumference among adults at risk for MASLD.
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January 24, 2026 at 7:45 PM
gastroadvisor.bsky.social
Individuals with #UC who discontinue 5-aminosalicylates have a significantly increased risk for relapse and shorter time to recurrence compared with those who continued therapy.

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5-ASA Monotherapy Discontinuation Increases Relapse Risk in Ulcerative Colitis
Individuals with UC who discontinue 5-aminosalicylates have an increased risk for relapse compared with those who maintain treatment.
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January 23, 2026 at 5:44 PM
gastroadvisor.bsky.social
Vonoprazan-amoxicillin dual therapy is a simplified first-line option for eradicating H pylori.

#hpylori

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Continuing 5-ASAs After Escalation Lowers Likelihood of Remission in Ulcerative Colitis
Continuing 5-ASA after escalation to advanced therapy in ulcerative colitis is associated with lower odds of clinical remission.
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January 22, 2026 at 5:43 PM
gastroadvisor.bsky.social
The first-line therapy for mild to moderate #UC is 5-ASA. Some patients require treatment escalation to advanced therapies after 5-ASA initiation.

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Continuing 5-ASAs After Escalation Lowers Likelihood of Remission in Ulcerative Colitis
Continuing 5-ASA after escalation to advanced therapy in ulcerative colitis is associated with lower odds of clinical remission.
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January 21, 2026 at 4:12 PM
gastroadvisor.bsky.social
Recurrence-free survival in #colorectal cancer with preexisting ulcerative #colitis depends on mucosal inflammation. #UC #CRC

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Prenatal and Childhood Tobacco Exposure Linked to Higher Autoimmune Risk
Early-life exposure to household tobacco smoking was associated with the development of juvenile- and adult-onset SARDs.
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January 20, 2026 at 5:44 PM