Gastroenterology Advisor
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gastroadvisor.bsky.social
Gastroenterology Advisor
@gastroadvisor.bsky.social
14 followers 4 following 130 posts
Trusted knowledge base of practical information and resources focused on gastroenterology medicine.
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gastroadvisor.bsky.social
Ultrasound-derived #VAT independently predicts hepatic steatosis and outperforms #BMI and waist circumference for hepato-metabolic assessment in #MASLD.

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Ultrasound-Derived VAT Outperforms BMI for Hepato-Metabolic Risk Stratification in MASLD
Ultrasound-derived VAT is more strongly associated with hepatic steatosis and metabolic dysfunction than BMI or waist circumference among adults at risk for MASLD.
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January 24, 2026 at 7:45 PM
gastroadvisor.bsky.social
Individuals with #UC who discontinue 5-aminosalicylates have a significantly increased risk for relapse and shorter time to recurrence compared with those who continued therapy.

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5-ASA Monotherapy Discontinuation Increases Relapse Risk in Ulcerative Colitis
Individuals with UC who discontinue 5-aminosalicylates have an increased risk for relapse compared with those who maintain treatment.
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January 23, 2026 at 5:44 PM
gastroadvisor.bsky.social
Vonoprazan-amoxicillin dual therapy is a simplified first-line option for eradicating H pylori.

#hpylori

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Continuing 5-ASAs After Escalation Lowers Likelihood of Remission in Ulcerative Colitis
Continuing 5-ASA after escalation to advanced therapy in ulcerative colitis is associated with lower odds of clinical remission.
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January 22, 2026 at 5:43 PM
gastroadvisor.bsky.social
The first-line therapy for mild to moderate #UC is 5-ASA. Some patients require treatment escalation to advanced therapies after 5-ASA initiation.

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Continuing 5-ASAs After Escalation Lowers Likelihood of Remission in Ulcerative Colitis
Continuing 5-ASA after escalation to advanced therapy in ulcerative colitis is associated with lower odds of clinical remission.
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January 21, 2026 at 4:12 PM
gastroadvisor.bsky.social
Recurrence-free survival in #colorectal cancer with preexisting ulcerative #colitis depends on mucosal inflammation. #UC #CRC

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Prenatal and Childhood Tobacco Exposure Linked to Higher Autoimmune Risk
Early-life exposure to household tobacco smoking was associated with the development of juvenile- and adult-onset SARDs.
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January 20, 2026 at 5:44 PM
gastroadvisor.bsky.social
Real-world data underscore the need for individualized strategies in #IBD management.

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Delayed IBD Remission With Advanced Therapies Does Not Compromise 1-Year Outcomes
Delayed remission with advanced therapies in IBD is not associated with worse 1-year clinical or endoscopic outcomes.
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January 19, 2026 at 3:34 PM
gastroadvisor.bsky.social
Inpatient costs associated with alcohol-associated liver disease (#ALD) increased from 2016 to 2019.

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Financial Burden for Alcohol-Associated Liver Disease Increasing
Hospitalizations and total costs for alcohol-associated liver disease increased from 2016 to 2019.
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January 18, 2026 at 5:09 PM
gastroadvisor.bsky.social
Engagement in #AUD treatment among patients with ALD remains low, despite evidence that treating AUD improves #liver-related outcomes.

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Barriers Continue to Limit AUD Treatment in Alcohol-Associated Liver Disease
AUD treatment engagement among patients with ALD remains low due to patient-provider discordance in need recognition, transplant-related stigma, and more.
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January 17, 2026 at 8:10 PM
gastroadvisor.bsky.social
Among patients with high #fecal #hemoglobin, ensuring follow-up completion may be more important than strict timing targets.

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Delayed Colonoscopy After Positive FIT Not Linked to Worse CRC Outcomes
There is no increased risk for colorectal cancer, advanced-stage cancer, or advanced adenoma when colonoscopy is delayed up to 24 months after a positive FIT result.
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January 16, 2026 at 6:08 PM
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More than 14.0% of women, those undergoing sleeve gastrectomy, and those with type 2 diabetes initiated GLP-1 RAs after bariatric surgery.

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14% of US Adults Initiate GLP-1 Receptor Agonist After Bariatric Surgery
Glucagon-like peptide 1 receptor agonists were initiated by 14.0% of patients who received bariatric surgery.
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January 15, 2026 at 6:16 PM
gastroadvisor.bsky.social
Those in the highest #tertiles of low- and no-calorie sweetener consumption had faster decline in verbal fluency and global cognition.

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Intake of Low-, No-Calorie Sweeteners Linked to Faster Cognitive Decline
Low- and no-calorie sweetener consumption was associated with faster decline in verbal fluency and global cognition.
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January 14, 2026 at 5:44 PM
gastroadvisor.bsky.social
Individuals with bowel #DGBI often feel ashamed about their symptoms, which makes their mental health and daily life worse.

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Shame Affects Symptom Severity and Psychosocial Outcomes in Bowel DGBI
Shame plays an important role in mediating and moderating symptom severity among individuals with bowel disorders of gut-brain interaction.
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January 13, 2026 at 5:21 PM
gastroadvisor.bsky.social
Mortality associated with #HIV and chronic liver disease (#CLD) has declined, but racial and geographic disparities persist.

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Racial and Geographic Disparities Persist Despite Decline in HIV, CLD-Related Mortality
Although HIV- and CLD-related mortality has declined from 1999 to 2020, racial and geographic disparities persist.
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January 12, 2026 at 5:27 PM
gastroadvisor.bsky.social
Oral #semaglutide was linked to reduced serum urate levels among patients with type 2 diabetes, particularly among individuals with hyperuricemia and those who switched from a DPP-4 inhibitor. #T2D

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Oral Semaglutide May Lower Serum Urate Levels in Patients With T2D
Oral semaglutide was linked to reduced SU levels among patients with T2D, particularly among individuals with hyperuricemia and those who switched from a DPP-4 inhibitor.
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January 11, 2026 at 5:35 PM
gastroadvisor.bsky.social
Those with high physical activity and those in the top quartile of the healthy eating index had lower #liver mortality risk than those with unhealthier lifestyles who drank the same amount of #alcohol.

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Healthy Eating, Physical Activity Reduce Risk for Alcohol-Related Liver Mortality
Alcohol-attributable liver-related mortality risk is lower among those who practice healthy eating and increased levels of physical activity.
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January 10, 2026 at 6:23 PM
gastroadvisor.bsky.social
#GLP-1 RA prescription is associated with a lower risk for uveitis compared with no treatment, metformin, or insulin, and slightly higher risk compared with SGLT2i prescription.

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GLP-1 Receptor Agonists Linked to Reduced Risk for Developing Uveitis
GLP-1 RAs was linked to lower risk for developing uveitis among those with type 2 diabetes and without diabetes.
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January 9, 2026 at 5:51 PM
gastroadvisor.bsky.social
Screening uptake or test completion did not differ with personalization, but stool testing rate was increased with personalization. #CRC

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Providing Personalized Risk Messages Has No Overall Effect on CRC Screening Uptake or Test Completion
Colorectal cancer (CRC) screening uptake or test completion does not differ with personalized risk in decision aid or provider notification.
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January 8, 2026 at 6:19 PM
gastroadvisor.bsky.social
The prevalence of #AILD and #IBD supports the gut-liver axis theory.

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Autoimmune Liver Disease and IBD: Is There a Bidirectional Link in Prevalence?
There is a significant bidirectional association in the prevalence of IBD and autoimmune liver disease.
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January 7, 2026 at 5:40 PM
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Statistically significantly greater proportion of #saroglitazar-treated patients achieved a biochemical response vs placebo.

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Saroglitazar Demonstrates Efficacy in Primary Biliary Cholangitis
Topline data were announced from a phase 2b/3 trial evaluating saroglitazar in patients with PBC who had an inadequate response or intolerance to UDCA.
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January 6, 2026 at 5:43 PM
gastroadvisor.bsky.social
ndividuals at high genetic risk for #Alzheimer disease (#AD) and AD-related #dementias (ADRDs) derive benefit from a Mediterranean diet,

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Mediterranean Diet Beneficial in Those With High Alzheimer Disease Risk
Associations between 57 metabolites and dementia risk varied by APOE4 genotype or other AD/ADRD risk variants.
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January 5, 2026 at 5:35 PM
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Hemoglobin #A1c under 6.5% without glucose-lowering medications, except #metformin, was achieved by 71.0% of intervention participants vs 2.4% of usual care participants.

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AI-Enabled Bundle of Sensors, Coaching Aids Type 2 Diabetes Outcomes
Significant improvements were seen in glycemic control, weight, and pharmacotherapy use with an AI-enabled sensor and coaching intervention.
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January 4, 2026 at 5:05 PM
gastroadvisor.bsky.social
#Sleep quality was a stronger and more consistent predictor of next-day well-being than dietary choices or physical activity.

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Three Health Behaviors Positively Affect Mental Well-Being in Young Adults
Sleep quality, physical activity, and dietary choices were significantly associated with well-being at the between- and within-person levels
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January 3, 2026 at 6:06 PM
gastroadvisor.bsky.social
Heart failure event-related greenhouse gas emissions were 9.45 and 9.70 kg carbon dioxide equivalents per patient per year among GLP-1 RA and placebo users, respectively. #heartfailure

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Environmental Benefit Seen With GLP-1 Receptor Agonist Use in Heart Failure
GLP-1 RA users with heart failure had lower annual carbon dioxide equivalent greenhouse gas emissions than placebo users.
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January 3, 2026 at 2:38 AM
gastroadvisor.bsky.social
Adolescents with underweight #BMI demonstrated higher risk for #osteoporosis in adulthood, especially those who remained underweight into adulthood.

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Underweight Adolescent BMI Heightens Adult Osteoporosis Risk
Underweight adolescent BMI was associated with an increased risk for osteoporosis in adulthood, with a stronger association among men.
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January 1, 2026 at 6:15 PM
gastroadvisor.bsky.social
Findings support the safety profile of #FTD/TPI in patients with metastatic colorectal cancer, though clinicians should remain alert for early cardiac symptoms and monitor hemoglobin levels. #CRC

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Low Cardiotoxicity Risk With FTD/TPI Does Not Eliminate Need for Vigilance
These study findings show clinically significant cardiotoxicity was low, but not negligible, among patients with CRC receiving trifluridine/tipiracil.
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December 31, 2025 at 5:24 PM