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George Burslem @gburslem.bsky.social · 22d

How long until someone uses these to degrade BRD4?!

George Burslem @gburslem.bsky.social · Sep 5

Congratulations to my great friend and colleague @bradylabupenn.bsky.social for this well deserved award!
@pennmedcso.bsky.social @penncancer.bsky.social

American Society for Biochemistry and Molecular Biology @asbmb.bsky.social · Sep 5

Congratulations to the 2026 ASBMB Award Winners!

Through their pioneering work, these scientists are advancing discovery, driving innovation, and shaping the future of molecular life sciences.

Read more about their work: ow.ly/x05f50WSbax. #ASBMB26 #MakeItPossible

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Reposted by George Burslem

Emily Goldberg @dremilygoldberg.bsky.social · Aug 20

Thrilled to finally write up a little thread on our recent paper with @gburslem.bsky.social describing how HDACs reversibility contributes to protein lactylation!

www.jbc.org/article/S002...

Cartoon illustrating our proposed pathway of HDAC reversibility to act as both a "writer" and "eraser" for protein acyl modifications

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George Burslem @gburslem.bsky.social · Aug 18

New paper online from our long-standing collaboration with @dremilygoldberg.bsky.social on lysine lactylation catalysed by HDACs! www.jbc.org/article/S002...

Class I histone deacetylases catalyze lysine lactylation

Metabolism and post-translational modifications (PTMs) are intrinsically linked and the number of identified metabolites that can covalently modify proteins continues to increase. This metabolism/PTM ...

www.jbc.org

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George Burslem @gburslem.bsky.social · Jul 2

New paper online at ACS Bio & Med Chem Au with @taabaman.bsky.social! New peptide probes and inhibitors for caspase 8
pubs.acs.org/doi/10.1021/...

A Potent Inhibitor of Caspase-8 Based on the IL-18 Tetrapeptide Sequence Reveals Shared Specificities between Inflammatory and Apoptotic Initiator Caspases

Caspases are a family of cysteine proteases that act as molecular scissors to cleave substrates and regulate biological processes, such as programmed cell death and inflammation. Extensive efforts hav...

pubs.acs.org

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George Burslem @gburslem.bsky.social · Jun 22

I’ve been many times and always leave feeling this way!

Neel Shah @nshahlab.bsky.social · Jun 21

Despite ~20 years in/around #chembio research, I went to my first Bioorganic GRC this week. This community is amazing and so supportive. I feel energized (and tired, lol) and find myself rooting for the next generation of chemical biologists. Sooooo much awesome science - We can’t/won’t be stopped!

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Reposted by George Burslem

Research Trainee Affairs at Penn Medicine @rtaatpennmed.bsky.social · Jun 19

Juneteenth is a story of freedom hard-won & resilience hard-kept—honoring Black history & the ongoing fight for justice. At Penn Medicine, Research Trainee Affairs advances discovery rooted in respect, access & opportunity—values that shape our comprehensive education, training & outreach mission.

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Reposted by George Burslem

Brianna Hill-Payne @briehp.bsky.social · Jun 16

Truly grateful and honored to have had the opportunity to share my work at the Bioorganic GRC and represent the Burslem lab 💙

George Burslem @gburslem.bsky.social · Jun 16

Congratulations to @briehp.bsky.social who gave an awesome Knowles award talk at the Bioorganic GRC! Very proud PI!

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George Burslem @gburslem.bsky.social · Jun 16

Congratulations to @briehp.bsky.social who gave an awesome Knowles award talk at the Bioorganic GRC! Very proud PI!

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Reposted by George Burslem

PennMedCSO @pennmedcso.bsky.social · May 30

Molecular basis of influenza ribonucleoprotein complex assembly & processive RNA synthesis ft. Ruchao Peng, Xin Xu, Yikang Gong, Fenglin Li, Max Ferretti, Mingyang Zhou, Kristen Lynch, @gburslem.bsky.social, @MarmorsteinLab & @yiweichang.bsky.social (@BB_Upenn) www.science.org/doi/10.1126/...

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Reposted by George Burslem

Yi-Wei Chang @yiweichang.bsky.social · May 15

Excited to share our new @science.org paper! Led by postdocs Ruchao Peng and Xin Xu, we used cryo-EM/ET to reveal the influenza ribonucleoprotein complex structure and its strand-sliding mechanism for RNA synthesis, paving the way for new antivirals.
www.science.org/doi/10.1126/...

Molecular basis of influenza ribonucleoprotein complex assembly and processive RNA synthesis

Influenza viruses replicate and transcribe their genome in the context of a conserved ribonucleoprotein (RNP) complex. By integrating cryo–electron microscopy single-particle analysis and cryo–electro...

www.science.org

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Reposted by George Burslem

UPenn Institute of Structural Biology @isbupenn.bsky.social · May 15

Congratulations to Drs. Lynch, Burslem, Marmorstein, Yi-Wei, and the entire research team on the publication of your latest research article in the newest issue of Science magazine! | Science www.science.org/doi/10.1126/...

Molecular basis of influenza ribonucleoprotein complex assembly and processive RNA synthesis

Influenza viruses replicate and transcribe their genome in the context of a conserved ribonucleoprotein (RNP) complex. By integrating cryo–electron microscopy single-particle analysis and cryo–electro...

www.science.org

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Reposted by George Burslem

PennMedCSO @pennmedcso.bsky.social · May 14

Intracellular protein editing & noncanonical residues in endogenous proteins ft. J. Beyer, K. Toy, M. Najar, N. Raniszewski, @gburslem.bsky.social (@BB_UPenn), @ysereb.bsky.social, @efeierman.bsky.social, @korblab & @ophirshalem.bsky.social (@penngenetics.bsky.social) www.science.org/doi/10.1126/...

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George Burslem @gburslem.bsky.social · May 2

Feel free to reach out anytime!

George Burslem @gburslem.bsky.social · May 2

Oh no! Sorry! We want people to read it but not at the expense of getting home! We’ll make sure to write less interesting papers from now on 🤣

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George Burslem @gburslem.bsky.social · May 1

News and Views in @nature.com too with comments from @miketilapia.bsky.social
www.nature.com/articles/d41...

Powerful protein editors offer new ways of probing living cells

Scientists deploy self-splicing protein subunits to insert strange new additions into target proteins.

www.nature.com

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George Burslem @gburslem.bsky.social · May 1

Great collaboration with @ophirshalem.bsky.social and @korblab.bsky.social labs and thanks to Wenshe Liu for writing an excellent news and views www.science.org/doi/10.1126/...

Editing proteins inside a cell

Pairs of split protein segments can modify a variety of target proteins in a living cell

www.science.org

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George Burslem @gburslem.bsky.social · May 1

Excited to see this out in @science.org today!! www.science.org/doi/10.1126/...

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Reposted by George Burslem

TrumpsTaxes @trumpstaxes.com · Apr 26

Honestly, if there is just one article that you are going to share far-and-wide today, it's this one:

'Trump Has Now Deported Multiple U.S. Citizen Children With Cancer'

The headline says it all, and everyone needs to know about this.

www.rollingstone.com/politics/pol...

Trump Has Now Deported Multiple U.S. Citizen Children With Cancer

Two families who had lived in the United States for years, including a child with cancer and a pregnant mother, were deported by ICE on Friday.

www.rollingstone.com

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Reposted by George Burslem

Yevgeniy Serebrenik @ysereb.bsky.social · Apr 23

Thrilled to see our work now in @cp-molcell.bsky.social! It was an incredible privilege to do my postdoc with @ophirshalem.bsky.social and work alongside the super talented Steph Sansbury and our amazing co-authors. Excited to keep building on this research in our new lab at @rwjms.bsky.social!

Ophir Shalem @ophirshalem.bsky.social · Apr 23

Check out our paper, now extensively revised and published in @cp-molcell.bsky.social! This has been a real tour de force led by Stephanie Sansbury and @ysereb.bsky.social and we are very excited about the findings and future potential of this approach
www.cell.com/molecular-ce...

Pooled tagging and hydrophobic targeting of endogenous proteins for unbiased mapping of unfolded protein responses

Sansbury and Serebrenik et al. use pooled gene tagging with in situ sequencing and high-throughput image analysis to generate a cell pool with endogenous HaloTag fusions. Hydrophobic targeting is then...

www.cell.com

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Reposted by George Burslem

Ophir Shalem @ophirshalem.bsky.social · Apr 23

Check out our paper, now extensively revised and published in @cp-molcell.bsky.social! This has been a real tour de force led by Stephanie Sansbury and @ysereb.bsky.social and we are very excited about the findings and future potential of this approach
www.cell.com/molecular-ce...

Pooled tagging and hydrophobic targeting of endogenous proteins for unbiased mapping of unfolded protein responses

Sansbury and Serebrenik et al. use pooled gene tagging with in situ sequencing and high-throughput image analysis to generate a cell pool with endogenous HaloTag fusions. Hydrophobic targeting is then...

www.cell.com

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Reposted by George Burslem

Luke Lavis @rhodamine110.bsky.social · Apr 11

We're looking for 1-2 enthusiastic early career chemists to join our Open Chemistry team at @hhmijanelia.bsky.social. Come help us create amazing dyes and share them with the world. Please share with the best recent/soon-to-be B.S. chemists you know! bit.ly/42w8C6N

Research Technician - Open Chemistry

Primary Work Address: 19700 Helix Drive, Ashburn, VA, 20147 Current HHMI Employees, click here to apply via your Workday account. Summary: Open Chemistry is a collaborative research group whose missio...

bit.ly

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Reposted by George Burslem

Jordan Meier @doc-jlmeier.bsky.social · Apr 10

Great news: NIH postbac program is recruiting again! If your grad school plans were affected by program cutbacks or admissions freezes this year I highly encourage you to apply, this could be a perfect opportunity. Please repost.

www.training.nih.gov/research-tra...

www.training.nih.gov

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George Burslem @gburslem.bsky.social · Apr 6

Excited to be co-chairing the Chemical tools to reveal new biology theme with @davidlabmsk.bsky.social!

Dr. Donita C. Brady of Brady Lab UPenn @bradylabupenn.bsky.social · Apr 6

"Chemical tools to reveal new biology" curated by @gburslem.bsky.social & @davidlabmsk.bsky.social.

"Interorganellar signaling and communication" designed by Navdeep Chandel & Isha Jain.

"Lipids and membranes" selected by @judisimcox.bsky.social & @gerryhammond.bsky.social

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Ashani Weeraratna @ashi-w.bsky.social · Apr 1

I am sending so much love to my colleagues at NIH today. They are incredible people and scientists and don’t serve any of this. 💔

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