Different types of SETBP1 variants cause variable developmental syndromes with only partial clinical and functional overlaps. Here, the authors report that SETBP1 variants outside the degron region impair DNA-binding, transcription, and neuronal differentiation capacity and morphologies.

In a recent series of experiments, Boger and Firestone ask: How do we perceive style?’. Their findings suggest that style perception relies on basic p…

Guest lecture by Matt Keller

Scientific Reports - Transformation starts at the periphery of networks where pushback is less

Nature Communications - Here the authors present a method to transform polygenic scores into disorder probabilities using only GWAS summary statistics, genotype data and a prior - no tuning sample...

Wouter Peyrot, Assistant Professor of Statistical Genetics at Amsterdam UMC, has been awarded a European Research Council (ERC) Starting Grant worth €1.5 million for his research project PersonalRiskProfile. This ambitious project aims to develop advanced genetic methods to identify individuals at increased risk of serious mental illness (SMI).

Human populations differ in disease prevalences and in average values of phenotypes, but the extent to which differences are caused by genetic or environmental factors is unknown for most complex trai...