Giulio Maria Pasinetti, MD, PhD
@giuliompasinetti.bsky.social
Creating a culture of innovation that emphasizes creativity, disruptive thinking, and interdisciplinary collaboration to understand and promote neuroresilience.
Pinned
IN CASE YOU'VE MISSED IT, the #PasinettiLab is excited to share that its new manuscript, "Role of dietary polyphenols in NAD+-dependent deacetylase SIRT 1 in stress-induced depression", is OUT NOW in Molecular Neurobiology. CHECK IT OUT 👉 link.springer.com/article/10.1...
Here, researchers Dylan Williams, Sami Heikkinen, Mikko Hiltunen, et al. estimated extents to which clinically diagnosed #Alzheimers (AD), AD neuropathology & all-cause #Dementia attributable to common APOE alleles in four large studies.
@ucl.ac.uk
npj | dementia
www.nature.com/articles/s44...
@ucl.ac.uk
npj | dementia
www.nature.com/articles/s44...
The proportion of Alzheimer’s disease attributable to apolipoprotein E - npj Dementia
npj Dementia - The proportion of Alzheimer’s disease attributable to apolipoprotein E
www.nature.com
January 23, 2026 at 5:51 PM
Here, researchers Dylan Williams, Sami Heikkinen, Mikko Hiltunen, et al. estimated extents to which clinically diagnosed #Alzheimers (AD), AD neuropathology & all-cause #Dementia attributable to common APOE alleles in four large studies.
@ucl.ac.uk
npj | dementia
www.nature.com/articles/s44...
@ucl.ac.uk
npj | dementia
www.nature.com/articles/s44...
Here, Alaina Durant, Shubhabrata Mukherjee, Michael L. Lee, et al. investigated frequency of APOE genotypes in #SuperAgers compared to middle‐aged and older adults. Learn More in #Alzheimers & #Dementia | Journal of @alzassociation.bsky.social
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Evaluating the association of apolipoprotein E genotype and cognitive resilience in SuperAgers
INTRODUCTION “SuperAgers” are oldest-old adults (ages 80+) whose memory performance more closely resembles middle-aged adults. The present study examined apolipoprotein E (APOE) allele frequency in ...
alz-journals.onlinelibrary.wiley.com
January 22, 2026 at 4:06 PM
Here, Alaina Durant, Shubhabrata Mukherjee, Michael L. Lee, et al. investigated frequency of APOE genotypes in #SuperAgers compared to middle‐aged and older adults. Learn More in #Alzheimers & #Dementia | Journal of @alzassociation.bsky.social
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
The cPLA2 enzyme is a critical mediator of inflammatory lipid signaling pathways. Here, Anastasiia Sadybekov, et al. at USC investigated therapeutic potential of novel cPLA2 inhibitors in modulating #Neuroinflammation in #Alzheimers. Learn More in npj Drug Discovery 👉 www.nature.com/articles/s44...
Development of potent, selective cPLA2 inhibitors for targeting neuroinflammation in Alzheimer’s disease and other neurodegenerative disorders - npj Drug Discovery
npj Drug Discovery - Development of potent, selective cPLA2 inhibitors for targeting neuroinflammation in Alzheimer’s disease and other neurodegenerative disorders
www.nature.com
January 21, 2026 at 3:58 PM
The cPLA2 enzyme is a critical mediator of inflammatory lipid signaling pathways. Here, Anastasiia Sadybekov, et al. at USC investigated therapeutic potential of novel cPLA2 inhibitors in modulating #Neuroinflammation in #Alzheimers. Learn More in npj Drug Discovery 👉 www.nature.com/articles/s44...
Researchers @unmhsc.bsky.social have shown OTULIN, an enzyme known for regulating immune activity, plays major role in producing tau. Disabling OTULIN stopped tau production & removed existing tau from neurons @uthsc.bsky.social @genomicpress.bsky.social👉 genomicpress.kglmeridian.com/view/journal...
January 20, 2026 at 2:11 PM
Researchers @unmhsc.bsky.social have shown OTULIN, an enzyme known for regulating immune activity, plays major role in producing tau. Disabling OTULIN stopped tau production & removed existing tau from neurons @uthsc.bsky.social @genomicpress.bsky.social👉 genomicpress.kglmeridian.com/view/journal...
"Darkness cannot drive out darkness; only light can do that… the time is always right to do what is right”. - Dr. Martin Luther King Jr.
On January 19th, celebrate the life and legacy of Dr. Martin Luther King Jr., a great American hero!
On January 19th, celebrate the life and legacy of Dr. Martin Luther King Jr., a great American hero!
January 18, 2026 at 2:34 PM
"Darkness cannot drive out darkness; only light can do that… the time is always right to do what is right”. - Dr. Martin Luther King Jr.
On January 19th, celebrate the life and legacy of Dr. Martin Luther King Jr., a great American hero!
On January 19th, celebrate the life and legacy of Dr. Martin Luther King Jr., a great American hero!
Brian Kennedy, et al. of National University of Singapore report calcium alpha-ketoglutarate (CaAKG), naturally occurring & well studied metabolite linked to healthy aging, can reverse several memory related brain functions disrupted in #Alzheimers Aging Cell👉 onlinelibrary.wiley.com/doi/10.1111/...
January 16, 2026 at 6:52 PM
Brian Kennedy, et al. of National University of Singapore report calcium alpha-ketoglutarate (CaAKG), naturally occurring & well studied metabolite linked to healthy aging, can reverse several memory related brain functions disrupted in #Alzheimers Aging Cell👉 onlinelibrary.wiley.com/doi/10.1111/...
Researchers Victoria Garfield, et al. report new evidence suggesting sharp increases in blood sugar following meals may raise #Alzheimers risk. Overview 👉 www.sciencedaily.com/releases/202... Learn More in #Diabetes #Obesity & #Metabolism 👉 dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/...
This after-meal blood sugar spike may raise Alzheimer’s risk
Spikes in blood sugar after eating may be more dangerous for the brain than previously thought. In a massive genetic study, people with higher post-meal blood sugar had a much greater risk of Alzheime...
www.sciencedaily.com
January 15, 2026 at 7:07 PM
Researchers Victoria Garfield, et al. report new evidence suggesting sharp increases in blood sugar following meals may raise #Alzheimers risk. Overview 👉 www.sciencedaily.com/releases/202... Learn More in #Diabetes #Obesity & #Metabolism 👉 dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/...
An international research effort combining brain imaging and memory testing from thousands of adults is offering a clearer picture of how age-related brain changes affect memory. @andersfjell.bsky.social Learn More in Nature Communications @natureportfolio.nature.com 👉 www.nature.com/articles/s41...
January 14, 2026 at 6:54 PM
An international research effort combining brain imaging and memory testing from thousands of adults is offering a clearer picture of how age-related brain changes affect memory. @andersfjell.bsky.social Learn More in Nature Communications @natureportfolio.nature.com 👉 www.nature.com/articles/s41...
In this study, Qiwen Cheng, Rosa Krajmalnik-Brown, Diego Mastroeni, et al. @arizonastateuni.bsky.social aimed to characterize gut proteome and #Microbiome differences associated with #AlzheimersDisease. @alzdemjournals.bsky.social 👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Gut proteome and microbiome alterations: Analysis of transverse colon samples from pathologically confirmed Alzheimer's disease patients
INTRODUCTION Alzheimer's disease (AD) has been regarded as a brain-first disorder. Emerging evidence suggests that the gut may influence central nervous system pathology, but the mechanisms remain u...
alz-journals.onlinelibrary.wiley.com
January 13, 2026 at 3:28 PM
In this study, Qiwen Cheng, Rosa Krajmalnik-Brown, Diego Mastroeni, et al. @arizonastateuni.bsky.social aimed to characterize gut proteome and #Microbiome differences associated with #AlzheimersDisease. @alzdemjournals.bsky.social 👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Researchers Xingyu Su, et al. at Waseda University sought to determine if elevated levels of bone morphogenetic proteins, or BMPs, in brains of #AlzheimersDisease patients are assoc w/ impaired neurogenesis & play a role in sex differences observed in AD. Learn More link.springer.com/article/10.1...
January 12, 2026 at 2:58 PM
Researchers Xingyu Su, et al. at Waseda University sought to determine if elevated levels of bone morphogenetic proteins, or BMPs, in brains of #AlzheimersDisease patients are assoc w/ impaired neurogenesis & play a role in sex differences observed in AD. Learn More link.springer.com/article/10.1...
Your daily rhythm may matter more for #BrainHealth than previously thought. Research by Wendy Wang, et al. points to the body clock as possible early warning sign for cognitive decline. @aanbrainhealth.bsky.social 👉 www.neurology.org/doi/10.1212/... ScienceDaily👉 www.sciencedaily.com/releases/202...
January 8, 2026 at 1:54 PM
Your daily rhythm may matter more for #BrainHealth than previously thought. Research by Wendy Wang, et al. points to the body clock as possible early warning sign for cognitive decline. @aanbrainhealth.bsky.social 👉 www.neurology.org/doi/10.1212/... ScienceDaily👉 www.sciencedaily.com/releases/202...
Here, Cleveland Clinic's Noah Lorincz-Comi & Feixiong Cheng introduce a general Bayesian method which returns posterior probabilities that a gene is only assoc w/ #Alzheimers or additionally assoc w/ other phenotypes @alzdemjournals.bsky.social 👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
January 6, 2026 at 4:09 PM
Here, Cleveland Clinic's Noah Lorincz-Comi & Feixiong Cheng introduce a general Bayesian method which returns posterior probabilities that a gene is only assoc w/ #Alzheimers or additionally assoc w/ other phenotypes @alzdemjournals.bsky.social 👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Scientists @ki.se & RIKEN Center for Brain Science have uncovered two somatostatin receptors, known as SST1 & SST4, that help regulate how #Amyloid beta is broken down, a process disrupted in #AlzheimersDisease.
Learn More in Journal of Alzheimer’s Disease
journals.sagepub.com/doi/10.1177/...
Learn More in Journal of Alzheimer’s Disease
journals.sagepub.com/doi/10.1177/...
Somatostatin receptor subtypes 1 and 4 regulate neprilysin, the major amyloid-β degrading enzyme in brain - Per Nilsson, Karin Sörgjerd, Naomasa Kakiya, Hiroki Sasaguri, Naoto Watamura, Lovisa Johanss...
Background Alzheimer's disease (AD) brains are characterized by increased levels of the pathogenic amyloid-β (Aβ) peptide, which accumulates into extracell...
journals.sagepub.com
January 5, 2026 at 2:33 PM
Scientists @ki.se & RIKEN Center for Brain Science have uncovered two somatostatin receptors, known as SST1 & SST4, that help regulate how #Amyloid beta is broken down, a process disrupted in #AlzheimersDisease.
Learn More in Journal of Alzheimer’s Disease
journals.sagepub.com/doi/10.1177/...
Learn More in Journal of Alzheimer’s Disease
journals.sagepub.com/doi/10.1177/...
Lindsay Farrer, et al. @bumedicine.bsky.social, studying #Alzheimers in African Americans, have uncovered a striking genetic clue that may cut across racial lines and open the door to new treatment strategies. @alzassociation.bsky.social 👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
January 2, 2026 at 8:32 PM
Lindsay Farrer, et al. @bumedicine.bsky.social, studying #Alzheimers in African Americans, have uncovered a striking genetic clue that may cut across racial lines and open the door to new treatment strategies. @alzassociation.bsky.social 👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
May the New Year bring you joy, happiness, peace and good health! 🎉
December 31, 2025 at 9:44 PM
May the New Year bring you joy, happiness, peace and good health! 🎉
Interesting Research! For more than a century, people have considered #AlzheimersDisease irreversible. Researchers Andrew Pieper, et al. have now challenged this dogma testing whether brains already badly afflicted w/ #Alzheimers could recover @cp-cellrepmed.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Pharmacologic reversal of advanced Alzheimer’s disease in mice and identification of potential therapeutic nodes in human brain
Chaubey et al. demonstrate that restoration of brain resilience reverses advanced
disease in two different mouse models of Alzheimer’s disease (AD), challenging the
century-long dogma of AD irreversib...
www.cell.com
December 29, 2025 at 7:24 PM
Interesting Research! For more than a century, people have considered #AlzheimersDisease irreversible. Researchers Andrew Pieper, et al. have now challenged this dogma testing whether brains already badly afflicted w/ #Alzheimers could recover @cp-cellrepmed.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Experimental drug dvlpd @nufeinbergmed.bsky.social has demonstrated promise as early intervention for #Alzheimers. CHECK OUT: Identification of a glia-associated amyloid β oligomer subtype & the rescue from reactive astrogliosis by inhibitor NU-9👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
December 29, 2025 at 7:08 PM
Experimental drug dvlpd @nufeinbergmed.bsky.social has demonstrated promise as early intervention for #Alzheimers. CHECK OUT: Identification of a glia-associated amyloid β oligomer subtype & the rescue from reactive astrogliosis by inhibitor NU-9👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Experimental drug developed by researchers Daniel Kranz, William Klein, et al. @nufeinbergmed.bsky.social has shown further promise as an early intervention for #AlzheimersDisease. Learn More in #Alzheimers & #Dementia @alzassociation.bsky.social
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
December 26, 2025 at 3:15 PM
Experimental drug developed by researchers Daniel Kranz, William Klein, et al. @nufeinbergmed.bsky.social has shown further promise as an early intervention for #AlzheimersDisease. Learn More in #Alzheimers & #Dementia @alzassociation.bsky.social
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
The #PasinettiLab’s family wishes you and your loved ones an AMAZING HOLIDAY filled with #Peace, #Joy, #Love and #Happiness! Most importantly, we wish you the best of HEALTH. Please #StaySafe as you gather for holiday festivities.
December 23, 2025 at 6:10 PM
The #PasinettiLab’s family wishes you and your loved ones an AMAZING HOLIDAY filled with #Peace, #Joy, #Love and #Happiness! Most importantly, we wish you the best of HEALTH. Please #StaySafe as you gather for holiday festivities.
Researchers Huntington Potter, et al. @cuanschutz.bsky.social discovered while brain neuron changes may begin in early life, sargramostim might be repurposed to slow damage, offering new hope for those w/ #Alzheimers & other cognition issues @cp-cellreports.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
December 23, 2025 at 3:56 PM
Researchers Huntington Potter, et al. @cuanschutz.bsky.social discovered while brain neuron changes may begin in early life, sargramostim might be repurposed to slow damage, offering new hope for those w/ #Alzheimers & other cognition issues @cp-cellreports.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
IN CASE YOU'VE MISSED IT, the #PasinettiLab is excited to share that its new manuscript, "Role of dietary polyphenols in NAD+-dependent deacetylase SIRT 1 in stress-induced depression", is OUT NOW in Molecular Neurobiology. CHECK IT OUT 👉 link.springer.com/article/10.1...
December 22, 2025 at 1:31 PM
IN CASE YOU'VE MISSED IT, the #PasinettiLab is excited to share that its new manuscript, "Role of dietary polyphenols in NAD+-dependent deacetylase SIRT 1 in stress-induced depression", is OUT NOW in Molecular Neurobiology. CHECK IT OUT 👉 link.springer.com/article/10.1...
Researchers Nicole F. O. Green, Gavin Sutton, Irina Voineagu, et al. at UNSW have revealed so-called “junk DNA” contains powerful switches that help control brain cells linked to #AlzheimersDisease. Learn More In Nature Neuroscience @natureportfolio.nature.com 👉
www.nature.com/articles/s41...
www.nature.com/articles/s41...
CRISPRi screening in cultured human astrocytes uncovers distal enhancers controlling genes dysregulated in Alzheimer’s disease - Nature Neuroscience
This study reveals how distal DNA ‘switches’ control gene activity in human astrocytes. Using CRISPRi screens and single-cell RNA-seq, we map enhancer–gene links, highlight Alzheimer’s disease-related...
www.nature.com
December 19, 2025 at 7:11 PM
Researchers Nicole F. O. Green, Gavin Sutton, Irina Voineagu, et al. at UNSW have revealed so-called “junk DNA” contains powerful switches that help control brain cells linked to #AlzheimersDisease. Learn More In Nature Neuroscience @natureportfolio.nature.com 👉
www.nature.com/articles/s41...
www.nature.com/articles/s41...
NEW RESEARCH from Jo Mhairi Hale, et al. 👉 Disentangling #SocialIsolation, #Loneliness & later-life cognitive function for older adults in United States: Evidence from causal inference modeling. @uniofstandrews.bsky.social @emoryuniversity.bsky.social FULL STUDY ➡️ academic.oup.com/psychsocgero...
December 18, 2025 at 2:44 PM
NEW RESEARCH from Jo Mhairi Hale, et al. 👉 Disentangling #SocialIsolation, #Loneliness & later-life cognitive function for older adults in United States: Evidence from causal inference modeling. @uniofstandrews.bsky.social @emoryuniversity.bsky.social FULL STUDY ➡️ academic.oup.com/psychsocgero...
The #PasinettiLab is excited to share its REVIEW "Role of dietary polyphenols in NAD+-dependent deacetylase SIRT 1 in stress-induced depression" ➡️ OUT NOW in Molecular Neurobiology👉 link.springer.com/article/10.1...
@mountsinainyc.bsky.social @ufabcoficial.bsky.social @deptvetaffairs.bsky.social
@mountsinainyc.bsky.social @ufabcoficial.bsky.social @deptvetaffairs.bsky.social
December 17, 2025 at 4:24 PM
The #PasinettiLab is excited to share its REVIEW "Role of dietary polyphenols in NAD+-dependent deacetylase SIRT 1 in stress-induced depression" ➡️ OUT NOW in Molecular Neurobiology👉 link.springer.com/article/10.1...
@mountsinainyc.bsky.social @ufabcoficial.bsky.social @deptvetaffairs.bsky.social
@mountsinainyc.bsky.social @ufabcoficial.bsky.social @deptvetaffairs.bsky.social
Society for Brain Mapping & Therapeutics's 23rd Annual Neurotech Conference is COMING UP FAST🚀 Looking forward to connecting w/ Rudolph Castellani, George Perry & Christopher Wheeler to discuss latest #Neurotech innovations in #Alzheimers & #Dementia. JOIN US! Register Now👉 www.worldBrainMapping.org
December 17, 2025 at 2:45 PM
Society for Brain Mapping & Therapeutics's 23rd Annual Neurotech Conference is COMING UP FAST🚀 Looking forward to connecting w/ Rudolph Castellani, George Perry & Christopher Wheeler to discuss latest #Neurotech innovations in #Alzheimers & #Dementia. JOIN US! Register Now👉 www.worldBrainMapping.org