GlycoShape
@glycoshape.org
Glycan 3D database and toolbox for the reconstruction of glycoproteins from the RCSB PDB and EMBL-EBI AlphaFold repositories or own. Find us at https://glycoshape.org. Curated by head chef @elisafadda.bsky.social and sous chef @ojas-singh.bsky.social
Phenomenal #glycotime by Lorenzo Rossi, @j-a-n-alexander.bsky.social, @asramirez.bsky.social and Kaspar Locher ⬇️ shows a pipeline for building THE glycoform you want with unprecedented yields!
Now you can design your glycoform with GlycoShape and make it with Glyco-BUILD 👏
doi.org/10.1038/s414...
Now you can design your glycoform with GlycoShape and make it with Glyco-BUILD 👏
doi.org/10.1038/s414...
GLYCO-BUILD: an enzymatic pipeline for the synthesis of peptides carrying eukaryotic N-glycans - Nature Communications
Rossi and colleagues assemble an in vitro enzymatic pipeline using enzymes from distinct domains of life to recapitulate eukaryotic N-glycosylation. This work advances the synthesis of bespoke glycope...
doi.org
January 15, 2026 at 2:46 PM
Phenomenal #glycotime by Lorenzo Rossi, @j-a-n-alexander.bsky.social, @asramirez.bsky.social and Kaspar Locher ⬇️ shows a pipeline for building THE glycoform you want with unprecedented yields!
Now you can design your glycoform with GlycoShape and make it with Glyco-BUILD 👏
doi.org/10.1038/s414...
Now you can design your glycoform with GlycoShape and make it with Glyco-BUILD 👏
doi.org/10.1038/s414...
Happy new year 2026 #glycotime! 🥳 We just introduced some useful options to Re-Glyco Ensemble.
In the Advanced Settings you can now select a seed (positive integer) to reproduce structural ensemble of your favourite glycoforms such as the one below that you will see soon in an upcoming paper,
In the Advanced Settings you can now select a seed (positive integer) to reproduce structural ensemble of your favourite glycoforms such as the one below that you will see soon in an upcoming paper,
January 3, 2026 at 7:53 PM
Happy new year 2026 #glycotime! 🥳 We just introduced some useful options to Re-Glyco Ensemble.
In the Advanced Settings you can now select a seed (positive integer) to reproduce structural ensemble of your favourite glycoforms such as the one below that you will see soon in an upcoming paper,
In the Advanced Settings you can now select a seed (positive integer) to reproduce structural ensemble of your favourite glycoforms such as the one below that you will see soon in an upcoming paper,
Happy birthday to us! 🥂🎂🥳 We are only 2 yo, but so much #glycotime happened since Dec 2023! ⬇️🧵
We truly appreciate your support, you fabulous glycoengineers around the world and we have so many exciting new tools for you coming up in 2026 to make your 3D glycoforms even better and faster! 🤩
We truly appreciate your support, you fabulous glycoengineers around the world and we have so many exciting new tools for you coming up in 2026 to make your 3D glycoforms even better and faster! 🤩
December 15, 2025 at 10:37 AM
Happy birthday to us! 🥂🎂🥳 We are only 2 yo, but so much #glycotime happened since Dec 2023! ⬇️🧵
We truly appreciate your support, you fabulous glycoengineers around the world and we have so many exciting new tools for you coming up in 2026 to make your 3D glycoforms even better and faster! 🤩
We truly appreciate your support, you fabulous glycoengineers around the world and we have so many exciting new tools for you coming up in 2026 to make your 3D glycoforms even better and faster! 🤩
Reposted by GlycoShape
I love this thread by @glycoshape.org, this is @bsky.app at its best!
Super interesting work from @carolynbertozzi.bskyverified.social group about the effects of glycosylation in protein structure and function at the proteome scale 🤯💥🤩
Results show that sialylation and fucosylation are crucial, which makes a lot of sense. We did some extra bits 🧐 with GlycoShape ⬇️🧵
Results show that sialylation and fucosylation are crucial, which makes a lot of sense. We did some extra bits 🧐 with GlycoShape ⬇️🧵
Congratulations former postdoc @jfhevler.bsky.social (in transit to Roche) and the team on their work using thermal proteome profiling along with glycosylation perturbagens to discover glycan-dependent protein functions at the proteome scale 👏
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
December 11, 2025 at 4:25 PM
I love this thread by @glycoshape.org, this is @bsky.app at its best!
Super interesting work from @carolynbertozzi.bskyverified.social group about the effects of glycosylation in protein structure and function at the proteome scale 🤯💥🤩
Results show that sialylation and fucosylation are crucial, which makes a lot of sense. We did some extra bits 🧐 with GlycoShape ⬇️🧵
Results show that sialylation and fucosylation are crucial, which makes a lot of sense. We did some extra bits 🧐 with GlycoShape ⬇️🧵
Congratulations former postdoc @jfhevler.bsky.social (in transit to Roche) and the team on their work using thermal proteome profiling along with glycosylation perturbagens to discover glycan-dependent protein functions at the proteome scale 👏
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Discovering Glycosylation-Dependent Protein Function by Thermal Proteome Profiling
Protein glycosylation regulates essential cellular processes including protein folding, stability, and cell-cell interactions; however, how aberrant glycosylation impacts protein function and interact...
www.biorxiv.org
December 11, 2025 at 11:34 AM
Super interesting work from @carolynbertozzi.bskyverified.social group about the effects of glycosylation in protein structure and function at the proteome scale 🤯💥🤩
Results show that sialylation and fucosylation are crucial, which makes a lot of sense. We did some extra bits 🧐 with GlycoShape ⬇️🧵
Results show that sialylation and fucosylation are crucial, which makes a lot of sense. We did some extra bits 🧐 with GlycoShape ⬇️🧵
We just did some maintenance and updates to glycoshape.org,
✅ Fancy background with floating SNFG symbols 🤩
✅ 'Latest Updates' feed from this account on bsky 🤩
✅ Download PDB with SASA values in Re-Glyco Ensemble 🤩
Check it out!
✅ Fancy background with floating SNFG symbols 🤩
✅ 'Latest Updates' feed from this account on bsky 🤩
✅ Download PDB with SASA values in Re-Glyco Ensemble 🤩
Check it out!
December 5, 2025 at 12:23 PM
We just did some maintenance and updates to glycoshape.org,
✅ Fancy background with floating SNFG symbols 🤩
✅ 'Latest Updates' feed from this account on bsky 🤩
✅ Download PDB with SASA values in Re-Glyco Ensemble 🤩
Check it out!
✅ Fancy background with floating SNFG symbols 🤩
✅ 'Latest Updates' feed from this account on bsky 🤩
✅ Download PDB with SASA values in Re-Glyco Ensemble 🤩
Check it out!
For some unique #glycotime: C-man is a rare (but evolutionarily very old[1]) post translational modification of proteins, where the C2 of Trp in W-x-x-W/C sequons are linked to a single man through a C-C bond 🤯 This and its position within the structure stabilises the (unusual for man) 1C4 chair[2]
December 4, 2025 at 6:52 PM
For some unique #glycotime: C-man is a rare (but evolutionarily very old[1]) post translational modification of proteins, where the C2 of Trp in W-x-x-W/C sequons are linked to a single man through a C-C bond 🤯 This and its position within the structure stabilises the (unusual for man) 1C4 chair[2]
Tuesday #glycotime 🥄🍬
Glycans are a 🔝 example of "disordered" molecules. Inherent flexibility prevents sugars from adopting fixed, unique 3D positions relative to the crystal lattice, so they often are invisible to X-ray diffraction, unless they are bound and thus restrained in place 1/3 🧵
Glycans are a 🔝 example of "disordered" molecules. Inherent flexibility prevents sugars from adopting fixed, unique 3D positions relative to the crystal lattice, so they often are invisible to X-ray diffraction, unless they are bound and thus restrained in place 1/3 🧵
December 2, 2025 at 5:36 PM
Tuesday #glycotime 🥄🍬
Glycans are a 🔝 example of "disordered" molecules. Inherent flexibility prevents sugars from adopting fixed, unique 3D positions relative to the crystal lattice, so they often are invisible to X-ray diffraction, unless they are bound and thus restrained in place 1/3 🧵
Glycans are a 🔝 example of "disordered" molecules. Inherent flexibility prevents sugars from adopting fixed, unique 3D positions relative to the crystal lattice, so they often are invisible to X-ray diffraction, unless they are bound and thus restrained in place 1/3 🧵
Today we are attending the @biochemsoc.bsky.social International Glycoimmunology Online Symposium, enjoying brilliant talks and discussions around the key role of glycans in regulating our immune system in health and disease Phenomenal #glycotime 👏👏🤩
a close up of a woman 's face with a surprised look on her face .
ALT: a close up of a woman 's face with a surprised look on her face .
media.tenor.com
December 1, 2025 at 5:32 PM
Today we are attending the @biochemsoc.bsky.social International Glycoimmunology Online Symposium, enjoying brilliant talks and discussions around the key role of glycans in regulating our immune system in health and disease Phenomenal #glycotime 👏👏🤩
It's Fucose Friday 🔺, the best #glycotime of the week!
Fucose is commonly found as a glycan modification, but it can be linked directly to proteins as O-fucose 😎
Here ⬇️ O-fucosylation of TSR1 by POFUT2 in the ER stabilises the TSRs characteristic fold 🤩
pmc.ncbi.nlm.nih.gov/articles/PMC...
Fucose is commonly found as a glycan modification, but it can be linked directly to proteins as O-fucose 😎
Here ⬇️ O-fucosylation of TSR1 by POFUT2 in the ER stabilises the TSRs characteristic fold 🤩
pmc.ncbi.nlm.nih.gov/articles/PMC...
November 28, 2025 at 7:07 PM
It's Fucose Friday 🔺, the best #glycotime of the week!
Fucose is commonly found as a glycan modification, but it can be linked directly to proteins as O-fucose 😎
Here ⬇️ O-fucosylation of TSR1 by POFUT2 in the ER stabilises the TSRs characteristic fold 🤩
pmc.ncbi.nlm.nih.gov/articles/PMC...
Fucose is commonly found as a glycan modification, but it can be linked directly to proteins as O-fucose 😎
Here ⬇️ O-fucosylation of TSR1 by POFUT2 in the ER stabilises the TSRs characteristic fold 🤩
pmc.ncbi.nlm.nih.gov/articles/PMC...
To wish our friend and main O-glycan 3D structure contributor extraordinaire @silviadandrea.bsky.social all the best with the submission of her PhD thesis tomorrow, today's 🥄🍬 is dedicated to sialic acid 💜 with a mini 🧵 about all the wonderful functions Silvia worked on
November 27, 2025 at 6:14 PM
To wish our friend and main O-glycan 3D structure contributor extraordinaire @silviadandrea.bsky.social all the best with the submission of her PhD thesis tomorrow, today's 🥄🍬 is dedicated to sialic acid 💜 with a mini 🧵 about all the wonderful functions Silvia worked on
Today we used Re-Glyco to rebuild human EPO from AF-P01588 with glycosylation selected from Lippold et al [10.1021/acs.analchem.0c01794] From the 3D structure we identified ideal locations for extra N-glycans, some of which are actually in NESP [10.1054/bjoc.2001.1746]
Super fun 3D edu #glycotime!
Super fun 3D edu #glycotime!
![title slide of the workshop held today for the Advance Pharmacology module at the University of Southampton (E. Fadda lecturer and coordinator) right-hand side in the bubble, human EPO (grey) with glycosylation reconstructed according to [10.1021/acs.analchem.0c01794] bound to the EPO receptor (cyan) in PDB 1CN4. Slide background is blue](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:xorrvcukxonsyeoudfzmnmhz/bafkreiactex7lfbmup6a3e7ezk4rao6zq4zvnbpprgkvuk4buvghhbqy6a@jpeg)
November 26, 2025 at 3:28 PM
Today we used Re-Glyco to rebuild human EPO from AF-P01588 with glycosylation selected from Lippold et al [10.1021/acs.analchem.0c01794] From the 3D structure we identified ideal locations for extra N-glycans, some of which are actually in NESP [10.1054/bjoc.2001.1746]
Super fun 3D edu #glycotime!
Super fun 3D edu #glycotime!
To welcome our new friends, first spoonful of sugar 🥄🍬
Glycan structures can be very complex and deceivingly similar, yet they have unique GlyTouCan IDs[1] that you can find by drawing the glycan you need in gb.glytoucan.org or in the glycoshape.org sugar drawer 1/3 🧵
Glycan structures can be very complex and deceivingly similar, yet they have unique GlyTouCan IDs[1] that you can find by drawing the glycan you need in gb.glytoucan.org or in the glycoshape.org sugar drawer 1/3 🧵
November 25, 2025 at 9:02 AM
To welcome our new friends, first spoonful of sugar 🥄🍬
Glycan structures can be very complex and deceivingly similar, yet they have unique GlyTouCan IDs[1] that you can find by drawing the glycan you need in gb.glytoucan.org or in the glycoshape.org sugar drawer 1/3 🧵
Glycan structures can be very complex and deceivingly similar, yet they have unique GlyTouCan IDs[1] that you can find by drawing the glycan you need in gb.glytoucan.org or in the glycoshape.org sugar drawer 1/3 🧵
Hello bsky 🦋 GlycoShape is now here to give you updates on our glycan 3D database, toolbox, glyco fun-facts and news!
We just updated server, so clear your browser's cache, and build some glycoproteins with us 🍬
We'll have great new tools coming up soon, so follow us for some exciting #glycotime
We just updated server, so clear your browser's cache, and build some glycoproteins with us 🍬
We'll have great new tools coming up soon, so follow us for some exciting #glycotime
a close up of a feather on a rock with the words `` hello '' written in white letters .
ALT: a close up of a feather on a rock with the words `` hello '' written in white letters .
media.tenor.com
November 24, 2025 at 4:50 PM
Hello bsky 🦋 GlycoShape is now here to give you updates on our glycan 3D database, toolbox, glyco fun-facts and news!
We just updated server, so clear your browser's cache, and build some glycoproteins with us 🍬
We'll have great new tools coming up soon, so follow us for some exciting #glycotime
We just updated server, so clear your browser's cache, and build some glycoproteins with us 🍬
We'll have great new tools coming up soon, so follow us for some exciting #glycotime