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Reposted by Gregor Gorjanc

April Wei @aprilwei.bsky.social · Dec 5

Our work w/ two co-first authors Drew DeHaas and Ziqing Pan is now published. GRG allows large amounts of WGS polymorphism data to be analyzed in RAM via graph traversal & algebra operations & has some intrinsic connection w/ popgen data generating process & is different from ARG

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Reposted by Gregor Gorjanc

April Wei @aprilwei.bsky.social · Feb 12

Our work (by Drew DeHaas) on an extremely simple yet efficient binary genotype format - designed to facilitate scalable bioinformatics tool development. www.biorxiv.org/content/10.1...

IGD: A simple, efficient genotype data format

Motivation While there are a variety of file formats for storing reference-sequence-aligned genotype data, many are complex or inefficient. Programming language support for such formats is often limit...

www.biorxiv.org

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Reposted by Gregor Gorjanc

April Wei @aprilwei.bsky.social · Aug 25

Very proud of this manuscript with two talented undergraduate students, Aditya Syam and Chris Adonizio. We are continuing to push towards more scalable statistical genetics with Genotype Representation Graphs, and this is the start. www.biorxiv.org/content/10.1...

Fast Phenotype Simulation for Genotype Representation Graphs

Motivation The Genotype Representation Graph (GRG) [[DeHaas et al., 2025][1]] is a graph representation of whole genome polymorphisms, designed to encode the variant hard-call information in phased wh...

www.biorxiv.org

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Reposted by Gregor Gorjanc

April Wei @aprilwei.bsky.social · 3d

Method works from simple and complex scenarios in jointly estimating epoch time, population size, migration rate (symmetric or asymmetric), growth rate, and admixture proportion. Software integrated with msprime, demes, tsinfer/tsdate, relate, and singer. github.com/aprilweilab/...

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Reposted by Gregor Gorjanc

April Wei @aprilwei.bsky.social · 3d

Excited to preprint our latest work (w/ Drew DeHaas, Zhibai Jia, Leo Speidel) on using ARGs for demographic inference. w/ applications using data from 1000 Genomes Project. www.biorxiv.org/content/10.1...

Inference of complex demographic history using composite likelihood based on whole-genome genealogies

Accurate parametric inference on complex demographic models is a continuing challenge in population genetics. Ancestral recombination graphs (ARGs) provide richer information than simple population ge...

www.biorxiv.org

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Reposted by Gregor Gorjanc

Ewan Birney @ewanbirney.bsky.social · 1d

I am hiring! - looking for a Staff Scientist to co-run my research group with me. Staff Scientist is a senior professional scientist role at EMBL. Please forward to people you might know who could be interested! embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

Staff Scientist

About EMBL-EBI EMBL’s European Bioinformatics Institute is a data powerhouse, utilised on a global scale to advance scientific discovery through bioinformatics and solutions to some of the world’s mos...

embl.wd103.myworkdayjobs.com

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Reposted by Gregor Gorjanc

Jonathan Pritchard @jkpritch.bsky.social · 4d

I want to try something again at #ASHG25 this year: I'll block some time on Thursday and Friday afternoons to meet with trainees who would be interested to chat on any topic.

I did this last year and it was great to meet a whole bunch of new people, at all career stages!

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Reposted by Gregor Gorjanc

Hanbin Lee @epigenci.bsky.social · 2d

Our paper (Brieuc Lehmann is the first author) is now online in Genetics.

academic.oup.com/genetics/adv...

On ARGs, pedigrees, and genetic relatedness matrices

Abstract. Genetic relatedness is a central concept in genetics, underpinning studies of population and quantitative genetics in human, animal, and plant se

academic.oup.com

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Reposted by Gregor Gorjanc

Ana Ignatieva @anaignatieva.bsky.social · 8d

Delighted that our paper about the distribution of genomic spans of clades/edges in genealogies (ARGs), and using this for detecting inversions and other SVs (and other phenomena that cause local disruption of recombination) is out in MBE academic.oup.com/mbe/article/... (1/n)

The Length of Haplotype Blocks and Signals of Structural Variation in Reconstructed Genealogies

Abstract. Recent breakthroughs have enabled the accurate inference of large-scale genealogies. Through modelling the impact of recombination on the correla

academic.oup.com

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Reposted by Gregor Gorjanc

Kyle Horton @kyle-horton.bsky.social · 16d

Truly impressive number of birds migrating tonight. More than 800 MILLION birds up in the air right now❗ #BirdMigration

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Gregor Gorjanc @gregorgorjanc.bsky.social · 17d

@epigenci.bsky.social this is a frequentist version of the Lara et al paper I shared on estimating genetic variance when using genomic data;)

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Reposted by Gregor Gorjanc

Simon Kuestenmacher @simongerman600.bsky.social · 17d

English is only my second language so I had no idea about many of the gendered animal names. Peahen is so obvious but I never had heard of it before. What’s news to you? HT @Iearnenglishtip

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Reposted by Gregor Gorjanc

Hanbin Lee @epigenci.bsky.social · 21d

Despite this being true, I feel that a lot of gems from the old days are lost in the present literature. People just do things as if those early findings don't exist.

José Cerca @naturalselection.bsky.social · 22d

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Reposted by Gregor Gorjanc

medRxivpreprint @medrxivpreprint.bsky.social · 22d

Within-family heritability estimates for behavioural and disease phenotypes from 500,000 sibling pairs of diverse ancestries https://www.medrxiv.org/content/10.1101/2025.09.17.25336022v1

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Reposted by Gregor Gorjanc

bioRxivpreprint @biorxivpreprint.bsky.social · Sep 2

SimHumanity: Using SLiM 5.0 to run whole-genome simulations of human evolution https://www.biorxiv.org/content/10.1101/2025.09.01.673541v1

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Reposted by Gregor Gorjanc

Hannes Becher @h-a-n.bsky.social · Sep 7

PCA for visualising large #pedigrees? Check out this brief and accessible blog post wp.me/pbTxyW-1ve @roslininstitute.bsky.social @highlanderlab.bsky.social Thanks to co-authors @epigenci.bsky.social @gregorgorjanc.bsky.social and Ros Craddock!

Visualising large pedigrees with PCA

Here is a brief post about our recent paper on using PCA to visualise large pedigrees. This is the result of a collaboration between Hanbin Lee (University of Michigan) and colleagues at the Roslin…

wp.me

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Reposted by Gregor Gorjanc

Hanbin Lee @epigenci.bsky.social · Sep 4

www.biorxiv.org/content/10.1...

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Reposted by Gregor Gorjanc

Jeffrey Ross-Ibarra @jrossibarra.bsky.social · Sep 3

Save the date! #PEQG26 June 9-12 2026 in Asilomar, CA. Happens only every 2yrs, but is my favorite conference. Full website coming soon, and registration and abstract submission opens November 14, but I'm allowed to tease that keynotes will be @jnovembre.bsky.social @jennytung.bsky.social and me!

Homepage - Population, Evolutionary, and Quantitative Genetics Conference

Visit our website to learn more.

genetics-gsa.org

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Reposted by Gregor Gorjanc

Chase W. Nelson 倪誠志 @chasewnelson.bsky.social · Sep 3

Announcing SimHumanity, a baseline SLiM 5.0 model of the full human genome, replete with demographic history, autosomes, X/Y, and mtDNA. A shared starting point for reproducible evolutionary simulations. We’d love your feedback! #SLiM #evolution #genomics www.biorxiv.org/content/10.1...

SimHumanity: Using SLiM 5.0 to run whole-genome simulations of human evolution

The reconstruction of human evolutionary history has undergone repeated advances, each made possible by methodological innovations. In recent decades, genetic and genomic data played a central role in...

www.biorxiv.org

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Reposted by Gregor Gorjanc

Hannes Becher @h-a-n.bsky.social · Aug 28

Our pedigree PCA article is now online on GSE: doi.org/10.1186/s127... Thanks @epigenci.bsky.social , @gregorgorjanc.bsky.social , Rosalind Craddock!

randPedPCA: rapid approximation of principal components from large pedigrees - Genetics Selection Evolution

Background Pedigrees continue to be extremely important in agriculture and conservation genetics, with the pedigrees of modern breeding programmes easily comprising millions of records. This size can ...

doi.org

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Reposted by Gregor Gorjanc

Jeffrey Ross-Ibarra @jrossibarra.bsky.social · Aug 27

This always blows my mind. Dude mapped qtl for a quantitative trait to a chromosome in 1923!

Jeffrey Ross-Ibarra @jrossibarra.bsky.social · Aug 27

Related but cool combo of cytogenetics and phenotype. Know when the first QTL was mapped?

Sax, K. 1923. The association of size differences with seed coat pattern and pigmentation in Phaseolus vulgaris. Genetics 8:552-560.

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Reposted by Gregor Gorjanc

Luis Apiolaza @ojala.bsky.social · Aug 26

I'll be advertising a couple of PhD scholarships (breeding/wood quality, breeding/remote sensing) in the next couple of weeks, working with me and even cooler people at the School of Forestry, University of Canterbury, Christchurch, New Zealand. They cover uni fees + stipend for 3 years.

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Gregor Gorjanc @gregorgorjanc.bsky.social · Aug 21

Whoop whoop

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Reposted by Gregor Gorjanc

bioRxiv Genetics @biorxiv-genetic.bsky.social · Aug 17

Assessment of segregation variance estimates from derivation, simulations, and empirical data in autotetraploid species exemplified in potato https://www.biorxiv.org/content/10.1101/2025.08.13.670171v1

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Gregor Gorjanc @gregorgorjanc.bsky.social · Aug 11

Can you say more?

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