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Guilhem Faure

@guilhemfaure.bsky.social

52 followers 14 following 2 posts

Senior Group Leader Computational Biology at Zhang Lab, Broad Institute Biological Systems Discovery - Structure/Sequence/Evolution/AI - RNA guided systems CRISPR/TIGR/more :)

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Guilhem Faure @guilhemfaure.bsky.social · Mar 1

🎬 More about TIGR-Tas, featuring THE first TIGR-Tas movie by @maxewilkinson.bsky.social

Absolutely thrilled to work alongside Max Wilkinson, Makoto Saito, and an incredible team, under the fantastic leadership of Feng Zhang! 🔬✨

🚀 Exciting times ahead!
More soon :)

Max Wilkinson @maxewilkinson.bsky.social · Mar 1

we recently found some really neat RNA-guided DNA-cutting systems in phages. Despite remarkable similarities to CRISPR systems, including encoding guide RNAs in arrays, they appear entirely evolutionarily distinct (but definitely related to snoRNAs 🤓)
We decided to call them TIGR-Tas systems 🐯

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Guilhem Faure @guilhemfaure.bsky.social · Feb 28

🚀 Thrilled to share our latest work from Zhang Lab, now published in Science (www.science.org/doi/10.1126/...)

We introduce TIGR-Tas, a PAM-free, compact, modular RNA-guided DNA-targeting system in prokaryotes & their viruses.

More details coming soon 👀

#TIGR #RNA #GeneEditing #CRISPR

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