Guy Nir
@guynir.bsky.social
Assistant professor in the department of Biochemistry and Molecular Biology, UTMB, TX. Studying 3D genome topology at the single cell level
Reposted by Guy Nir
How to represent genomes in 3D?
In this paper (and video), we propose Geometric Diagrams of Genomes (GDG)—a visual grammar that aims at emulating the effect ribbon diagrams (Richardson et al 1981) had in protein structural biology. Time will tell.😅
👉🏼 genomebiology.biomedcentral.com/articles/10....
In this paper (and video), we propose Geometric Diagrams of Genomes (GDG)—a visual grammar that aims at emulating the effect ribbon diagrams (Richardson et al 1981) had in protein structural biology. Time will tell.😅
👉🏼 genomebiology.biomedcentral.com/articles/10....
June 27, 2025 at 8:13 AM
How to represent genomes in 3D?
In this paper (and video), we propose Geometric Diagrams of Genomes (GDG)—a visual grammar that aims at emulating the effect ribbon diagrams (Richardson et al 1981) had in protein structural biology. Time will tell.😅
👉🏼 genomebiology.biomedcentral.com/articles/10....
In this paper (and video), we propose Geometric Diagrams of Genomes (GDG)—a visual grammar that aims at emulating the effect ribbon diagrams (Richardson et al 1981) had in protein structural biology. Time will tell.😅
👉🏼 genomebiology.biomedcentral.com/articles/10....
Reposted by Guy Nir
The proposed budget slashes NIH by ~40%, devastating medical research, clinical trials, treatment breakthroughs—life-saving work.
Thousands of lives at risk for tax cuts for the rich? NO THANKS.
Tell your senators to oppose the cuts HERE:
zurl.co/qiKdX
zurl.co/RCR0y
#CutsCostLives
Thousands of lives at risk for tax cuts for the rich? NO THANKS.
Tell your senators to oppose the cuts HERE:
zurl.co/qiKdX
zurl.co/RCR0y
#CutsCostLives
Will the Senate Save NIH?
Rescuing biomedical research is every bit as important as saving Medicaid.
zurl.co
June 29, 2025 at 1:57 PM
The proposed budget slashes NIH by ~40%, devastating medical research, clinical trials, treatment breakthroughs—life-saving work.
Thousands of lives at risk for tax cuts for the rich? NO THANKS.
Tell your senators to oppose the cuts HERE:
zurl.co/qiKdX
zurl.co/RCR0y
#CutsCostLives
Thousands of lives at risk for tax cuts for the rich? NO THANKS.
Tell your senators to oppose the cuts HERE:
zurl.co/qiKdX
zurl.co/RCR0y
#CutsCostLives
Our new preprint is out on bioRxiv! We show that restoring rigidity sensing via Tpm2.1 is not enough to trigger anoikis in cancer cells, thanks to compensatory AKT signaling and cell–cell adhesion.
With Anat, Nehal, and in memory of Mike Sheetz. www.biorxiv.org/content/10.1...
With Anat, Nehal, and in memory of Mike Sheetz. www.biorxiv.org/content/10.1...
www.biorxiv.org
June 16, 2025 at 11:50 AM
Our new preprint is out on bioRxiv! We show that restoring rigidity sensing via Tpm2.1 is not enough to trigger anoikis in cancer cells, thanks to compensatory AKT signaling and cell–cell adhesion.
With Anat, Nehal, and in memory of Mike Sheetz. www.biorxiv.org/content/10.1...
With Anat, Nehal, and in memory of Mike Sheetz. www.biorxiv.org/content/10.1...
Reposted by Guy Nir
How to find Evolutionary Conserved Enhancers in 2025? 🐣-🐭
Check out our paper - fresh off the press!!!
We find widespread functional conservation of enhancers in absence of sequence homology
Including: a bioinformatic tool to map sequence-diverged enhancers!
rdcu.be/enVDN
github.com/tobiaszehnde...
Check out our paper - fresh off the press!!!
We find widespread functional conservation of enhancers in absence of sequence homology
Including: a bioinformatic tool to map sequence-diverged enhancers!
rdcu.be/enVDN
github.com/tobiaszehnde...
Conservation of regulatory elements with highly diverged sequences across large evolutionary distances
Nature Genetics - Combining functional genomic data from mouse and chicken with a synteny-based strategy identifies positionally conserved cis-regulatory elements in the absence of direct sequence...
rdcu.be
May 27, 2025 at 12:19 PM
How to find Evolutionary Conserved Enhancers in 2025? 🐣-🐭
Check out our paper - fresh off the press!!!
We find widespread functional conservation of enhancers in absence of sequence homology
Including: a bioinformatic tool to map sequence-diverged enhancers!
rdcu.be/enVDN
github.com/tobiaszehnde...
Check out our paper - fresh off the press!!!
We find widespread functional conservation of enhancers in absence of sequence homology
Including: a bioinformatic tool to map sequence-diverged enhancers!
rdcu.be/enVDN
github.com/tobiaszehnde...