Hannelore Longin
@hannelorelongin.bsky.social
PhD student @ Computational Systems Biology & Lab of Gene Technology. Investigating PTMs in viruses and bacteria with bioinformatics 💻🦠
Pinned
Fold first, ask later: structure-informed function annotation of Pseudomonas phage proteins
Phages, the viruses of bacteria, harbor an incredibly diverse repertoire of proteins capable of manipulating their bacterial hosts, inspiring many medical and biotechnological applications. However, t...
doi.org
📣 New preprint alert!
Happy to share the first results from our effort to reannotate Pseudomonas #phage proteins of unknown function, using structural bioinformatics.
📄 doi.org/10.1101/2025...
Happy to share the first results from our effort to reannotate Pseudomonas #phage proteins of unknown function, using structural bioinformatics.
📄 doi.org/10.1101/2025...
Reposted by Hannelore Longin
Protein domains have no single definition, so why stick to one segmentation? 🧩
Instead of forcing structures into rigid classifications, we built AFragmenter. It uses AlphaFold PAE networks for a tuneable approach to domain parsing.
You control the granularity. 👇
🔗 doi.org/10.1093/bioi...
Instead of forcing structures into rigid classifications, we built AFragmenter. It uses AlphaFold PAE networks for a tuneable approach to domain parsing.
You control the granularity. 👇
🔗 doi.org/10.1093/bioi...
November 24, 2025 at 4:01 PM
Protein domains have no single definition, so why stick to one segmentation? 🧩
Instead of forcing structures into rigid classifications, we built AFragmenter. It uses AlphaFold PAE networks for a tuneable approach to domain parsing.
You control the granularity. 👇
🔗 doi.org/10.1093/bioi...
Instead of forcing structures into rigid classifications, we built AFragmenter. It uses AlphaFold PAE networks for a tuneable approach to domain parsing.
You control the granularity. 👇
🔗 doi.org/10.1093/bioi...
Reposted by Hannelore Longin
Stoked to finally have a preprint out for Phold, our tool that uses protein structural information to enhance phage genome annotation #phagesky 1/n
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Protein Structure Informed Bacteriophage Genome Annotation with Phold
Bacteriophage (phage) genome annotation is essential for understanding their functional potential and suitability for use as therapeutic agents. Here we introduce Phold, an annotation framework utilis...
www.biorxiv.org
August 8, 2025 at 7:11 AM
Stoked to finally have a preprint out for Phold, our tool that uses protein structural information to enhance phage genome annotation #phagesky 1/n
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Hannelore Longin
🚨 New preprint 🚨
My phage annotation tool, Phynteny, finally has a preprint and a brand new version powered by a cool AI transformer architecture and protein language models! #phagesky
www.biorxiv.org/content/10.1...
My phage annotation tool, Phynteny, finally has a preprint and a brand new version powered by a cool AI transformer architecture and protein language models! #phagesky
www.biorxiv.org/content/10.1...
Synteny-aware functional annotation of bacteriophage genomes with Phynteny
Accurate genome annotation is fundamental to decoding viral diversity and understanding bacteriophage biology; yet, the majority of bacteriophage genes remain functionally uncharacterised. Bacteriopha...
www.biorxiv.org
July 30, 2025 at 6:01 AM
🚨 New preprint 🚨
My phage annotation tool, Phynteny, finally has a preprint and a brand new version powered by a cool AI transformer architecture and protein language models! #phagesky
www.biorxiv.org/content/10.1...
My phage annotation tool, Phynteny, finally has a preprint and a brand new version powered by a cool AI transformer architecture and protein language models! #phagesky
www.biorxiv.org/content/10.1...
📣 New preprint alert!
Happy to share the first results from our effort to reannotate Pseudomonas #phage proteins of unknown function, using structural bioinformatics.
📄 doi.org/10.1101/2025...
Happy to share the first results from our effort to reannotate Pseudomonas #phage proteins of unknown function, using structural bioinformatics.
📄 doi.org/10.1101/2025...
Fold first, ask later: structure-informed function annotation of Pseudomonas phage proteins
Phages, the viruses of bacteria, harbor an incredibly diverse repertoire of proteins capable of manipulating their bacterial hosts, inspiring many medical and biotechnological applications. However, t...
doi.org
July 21, 2025 at 6:51 AM
📣 New preprint alert!
Happy to share the first results from our effort to reannotate Pseudomonas #phage proteins of unknown function, using structural bioinformatics.
📄 doi.org/10.1101/2025...
Happy to share the first results from our effort to reannotate Pseudomonas #phage proteins of unknown function, using structural bioinformatics.
📄 doi.org/10.1101/2025...
Reposted by Hannelore Longin
We've folded a lot of proteins! You can see some of them here @linsalrob.bsky.social @gbouras13.bsky.social
We made structural predictions of representatives of each #PHROG from #phage genomes, and put the whole lot online. You can browse through montages or go to your favourite phrog directly and download its PDB.
💻🧬 #phagesky
linsalrob.github.io/PHROG_struct...
💻🧬 #phagesky
linsalrob.github.io/PHROG_struct...
PHROG Structure Gallery
linsalrob.github.io
July 7, 2025 at 8:49 AM
We've folded a lot of proteins! You can see some of them here @linsalrob.bsky.social @gbouras13.bsky.social
Hip hip hooray: our #PTM conservation tool FLAMS turns 1 🎂
To celebrate, we have added handy new features to FLAMS web, incl. 3D visualization of hit proteins & PTM sites with known active/binding sites.
Come check it out @ tinyurl.com/flamsweb & let us know what you think!
To celebrate, we have added handy new features to FLAMS web, incl. 3D visualization of hit proteins & PTM sites with known active/binding sites.
Come check it out @ tinyurl.com/flamsweb & let us know what you think!
FLAMS – Find Lysine Acylations & other Modification Sites
www.biw.kuleuven.be
January 28, 2025 at 8:55 AM
Hip hip hooray: our #PTM conservation tool FLAMS turns 1 🎂
To celebrate, we have added handy new features to FLAMS web, incl. 3D visualization of hit proteins & PTM sites with known active/binding sites.
Come check it out @ tinyurl.com/flamsweb & let us know what you think!
To celebrate, we have added handy new features to FLAMS web, incl. 3D visualization of hit proteins & PTM sites with known active/binding sites.
Come check it out @ tinyurl.com/flamsweb & let us know what you think!
Reposted by Hannelore Longin
1/11 - With Karin Mitosch and Clément Potel + colleagues in Savitski lab and @typaslab.bsky.social @embl.org, I’m very happy to share our discovery of a hyper-promiscuous phage protein kinase (T7K) which broadly deactivates bacterial defenses! 🦠
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
December 23, 2024 at 7:29 AM
1/11 - With Karin Mitosch and Clément Potel + colleagues in Savitski lab and @typaslab.bsky.social @embl.org, I’m very happy to share our discovery of a hyper-promiscuous phage protein kinase (T7K) which broadly deactivates bacterial defenses! 🦠
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...