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Hannelore Longin

@hannelorelongin.bsky.social

100 followers 120 following 3 posts

PhD student @ Computational Systems Biology & Lab of Gene Technology. Investigating PTMs in viruses and bacteria with bioinformatics 💻🦠

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Hannelore Longin @hannelorelongin.bsky.social · Jul 21

📣 New preprint alert!

Happy to share the first results from our effort to reannotate Pseudomonas #phage proteins of unknown function, using structural bioinformatics.

📄 doi.org/10.1101/2025...

Fold first, ask later: structure-informed function annotation of Pseudomonas phage proteins

Phages, the viruses of bacteria, harbor an incredibly diverse repertoire of proteins capable of manipulating their bacterial hosts, inspiring many medical and biotechnological applications. However, t...

doi.org

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Reposted by Hannelore Longin

George Bouras @gbouras13.bsky.social · Aug 8

Stoked to finally have a preprint out for Phold, our tool that uses protein structural information to enhance phage genome annotation #phagesky 1/n

www.biorxiv.org/content/10.1...

Protein Structure Informed Bacteriophage Genome Annotation with Phold

Bacteriophage (phage) genome annotation is essential for understanding their functional potential and suitability for use as therapeutic agents. Here we introduce Phold, an annotation framework utilis...

www.biorxiv.org

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Reposted by Hannelore Longin

Susie Grigson @susiegriggo.bsky.social · Jul 30

🚨 New preprint 🚨

My phage annotation tool, Phynteny, finally has a preprint and a brand new version powered by a cool AI transformer architecture and protein language models! #phagesky

www.biorxiv.org/content/10.1...

Synteny-aware functional annotation of bacteriophage genomes with Phynteny

Accurate genome annotation is fundamental to decoding viral diversity and understanding bacteriophage biology; yet, the majority of bacteriophage genes remain functionally uncharacterised. Bacteriopha...

www.biorxiv.org

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Hannelore Longin @hannelorelongin.bsky.social · Jul 21

Curious about our findings and where we're headed? Happen to be at #ISMB2025 ? Come check out
my poster (A-229, function COSI) today!

Hannelore Longin @hannelorelongin.bsky.social · Jul 21

Fold first, ask later: structure-informed function annotation of Pseudomonas phage proteins

doi.org

1 17 41

Reposted by Hannelore Longin

Susie Grigson @susiegriggo.bsky.social · Jul 7

We've folded a lot of proteins! You can see some of them here @linsalrob.bsky.social @gbouras13.bsky.social

Rob Edwards @linsalrob.bsky.social · Jul 7

We made structural predictions of representatives of each #PHROG from #phage genomes, and put the whole lot online. You can browse through montages or go to your favourite phrog directly and download its PDB.

💻🧬 #phagesky

linsalrob.github.io/PHROG_struct...

PHROG Structure Gallery

linsalrob.github.io

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Hannelore Longin @hannelorelongin.bsky.social · Jan 28

Hip hip hooray: our #PTM conservation tool FLAMS turns 1 🎂

To celebrate, we have added handy new features to FLAMS web, incl. 3D visualization of hit proteins & PTM sites with known active/binding sites.

Come check it out @ tinyurl.com/flamsweb & let us know what you think!

FLAMS – Find Lysine Acylations & other Modification Sites

www.biw.kuleuven.be

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Reposted by Hannelore Longin

Tara Bartolec @tarabartolec.bsky.social · Dec 23

1/11 - With Karin Mitosch and Clément Potel + colleagues in Savitski lab and @typaslab.bsky.social @embl.org, I’m very happy to share our discovery of a hyper-promiscuous phage protein kinase (T7K) which broadly deactivates bacterial defenses! 🦠
www.biorxiv.org/content/10.1...

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