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HDBuzz @hdbuzzfeed.bsky.social · 1d

The Huntington Study Group (HSG) Clinical Research Congress is this weekend in Nashville. HDBuzz will be front and center, live posting updates from the event on Bluesky!

Keep your eyes on our Bluesky account this weekend to follow along with the exciting HD research updates!

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HDBuzz @hdbuzzfeed.bsky.social · 7d

We’re proud to announce Chloe Langridge as a 2025 HDBuzz Prize winner! Her article covers work that shows that boosting a protein called SGTA can ease signs of Huntington’s disease, opening a potential new therapeutic path.

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2025 HDBuzz Prize: On the Frontlines: Trusting the Hall Monitors of the Cell – HDBuzz

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HDBuzz @hdbuzzfeed.bsky.social · 9d

September’s research highlights: gene therapy that may slow HD, new biomarkers for tracking, deeper mechanistic understanding, and advances in mental health. Progress in HD science continues to accelerate with your support!

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September 2025: This Month in Huntington’s Disease Research – HDBuzz

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HDBuzz @hdbuzzfeed.bsky.social · 12d

Hope is building—over $10k raised toward our $30,000 goal! Every dollar helps bring clear science to the HD community. Spread the word or donate to keep the momentum!

Donate here: en.hdbuzz.net/donate

Donate – HDBuzz

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HDBuzz @hdbuzzfeed.bsky.social · 15d

uniQure reports promising results from a key clinical study, showing that its experimental gene therapy, AMT-130, may slow the progress of Huntington's disease

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HDBuzz @hdbuzzfeed.bsky.social · 20d

SKY-0515, an oral drug, safely lowers huntingtin in people with HD—and may also reduce PMS1, a DNA repair protein. This two-pronged approach could open new doors for HD treatment. A larger Phase 2/3 trial is now underway.

Full article: en.hdbuzz.net/sky-0515-low...

SKY-0515 Lowers Huntingtin In People With Huntington’s Disease In Trial Update – HDBuzz

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HDBuzz @hdbuzzfeed.bsky.social · 24d

We’re proud to announce Jenna Hanrahan as a 2025 HDBuzz Prize winner!
She covers research showing that people with HD may not always recognize their symptoms, not from denial, but because of real brain changes. New MRI scans are helping uncover why.

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2025 HDBuzz Prize: MR-“why” am I feeling this way? How MRI is helping us understand why people with HD may sometimes be unaware of their symptoms – HDBuzz

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Reposted by HDBuzz

UK Dementia Research Institute @ukdri.ac.uk · 29d

Webinar: Could DNA repair hold the key to treating Huntingtons disease?🧬

Join UK DRI Group Leaders Profs Sarah Tabrizi & Gabriel Balmus as they dig into the latest discoveries and therapeutic breakthroughs from the field

🗓️ Mon 29 Sep 🕓 4-5pm (BST)

Register free 👉 www.ukdri.ac.uk/events/rethi...

Rethinking neurodegeneration: Could DNA repair hold the key to treating Huntington's disease?

With Prof Sarah Tabrizi & Prof Prof Gabriel Balmus

www.ukdri.ac.uk

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HDBuzz @hdbuzzfeed.bsky.social · 29d

Pridopidine has been studied for decades as a possible treatment for Huntington’s disease. The PROOF-HD trial didn’t meet its primary goals, but its full results are now published—making valuable data available for the HD community.

en.hdbuzz.net/proof-in-the...

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HDBuzz @hdbuzzfeed.bsky.social · Sep 8

We’re proud to announce Nicolo Zarotti as a 2025 HDBuzz Prize winner! He covers a case study shows that Acceptance & Commitment Therapy (ACT) can lift mood, improve quality of life for people with HD, and offer real support for caregivers too.

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2025 HDBuzz Prize: ACTing on HD: Exploring Acceptance and Commitment Therapy to Improve Mental Health in People with Huntington’s Disease and Their Caregiver – HDBuzz

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HDBuzz @hdbuzzfeed.bsky.social · Sep 4

We’re thrilled to announce Eva Woods as a 2025 HDBuzz Prize winner! She covers how a team discovered subtle brainwave shifts in people with HD before symptoms appear. These early electrical “whispers” of HD could one day help track the disease years ahead of diagnosis.

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2025 HDBuzz Prize: Calm Before the Storm: Early Clues of Huntington’s Disease Found in Brainwaves – HDBuzz

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HDBuzz @hdbuzzfeed.bsky.social · Sep 2

This fall, we’re excited to launch our Falling Into Hope campaign! Our goal: raise $30,000 in just 8 weeks, by October 28.

Learn more about the fundraiser here: en.hdbuzz.net/falling-into...

Falling Into Hope: HDBuzz Fundraising Campaign 2025 – HDBuzz

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HDBuzz @hdbuzzfeed.bsky.social · Aug 28

From gut microbes to muscle health, August’s HD research uncovered new biomarkers, protein maps, and lifestyle clues. Each finding brings us closer to earlier detection and smarter treatments.

Full Article: en.hdbuzz.net/august-2025-...

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Reposted by HDBuzz

Molly Gracey @molly648.bsky.social · Aug 27

Check out my latest article with @hdbuzzfeed.bsky.social l on a very important, but under researched area in the HD field. 💜

HDBuzz @hdbuzzfeed.bsky.social · Aug 12

Full article: en.hdbuzz.net/carried-from...

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HDBuzz @hdbuzzfeed.bsky.social · Aug 26

Two studies reveal how a tiny change in FAN1—a DNA repair protein—weakens its hold on DNA, fueling repeat expansions and speeding up Huntington’s disease symptoms.

en.hdbuzz.net/when-dna-rep...

#HDAwareness #huntingtonsdiseaseawareness #huntingtonsdisease #HDResearch

When DNA Repair Goes Off Script: How a Small Change in FAN1 Can Accelerate Huntington’s Disease – HDBuzz

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Reposted by HDBuzz

Molly Gracey @molly648.bsky.social · Aug 11

👪 In my latest piece with @hdbuzzfeed.bsky.social, I explore an important study that puts words to something many of us from families with HD have felt. This study investigates how emotional experiences in childhood can shape our mental health well into adulthood.

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Carried from Childhood: Childhood Experiences and Adult Mental Health in Families with Huntington’s Disease – HDBuzz

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HDBuzz @hdbuzzfeed.bsky.social · Aug 21

Scientists have captured detailed images of the toxic clumps formed by huntingtin. These insights reveal how the fibers assemble—and how their structure might be altered—opening new doors for potential therapies.

Full article; en.hdbuzz.net/cracking-the...

Cracking the Protein Puzzle in HD: New Blueprints Offer Hope for Stopping Damage Early – HDBuzz

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HDBuzz @hdbuzzfeed.bsky.social · Aug 18

Biomarkers are a powerful tool in Huntington’s disease research. A new blood study highlights two proteins, CAP1 and CAPZB, that could one day help track the disease—even before symptoms appear

Full article: en.hdbuzz.net/city-under-t...

City Under the Microscope: How Two Proteins Could Help Track Huntington’s Disease – HDBuzz

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HDBuzz @hdbuzzfeed.bsky.social · Aug 15

The gut and brain talk nonstop along a busy two-way superhighway. In Huntington’s disease, this route can get jammed, rerouted, or even carry harmful cargo — connecting gut microbes, inflammation, and brain health in unexpected ways.

en.hdbuzz.net/the-gut-brai...

HDBuzz @hdbuzzfeed.bsky.social · Aug 12

Full article: en.hdbuzz.net/carried-from...

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HDBuzz @hdbuzzfeed.bsky.social · Aug 7

Huntington’s isn’t just a brain disease — it affects the whole body. New research shows that muscle, fat, and nutrition changes can happen early in HD, even before symptoms are obvious. Keeping an eye on these shifts could help to receive better care.

Full Article: shorturl.at/j0Xgc

HDBuzz @hdbuzzfeed.bsky.social · Aug 6

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Do Antidepressants Affect Cognitive Decline? There's More To The Story For Huntington's Disease – HDBuzz

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HDBuzz @hdbuzzfeed.bsky.social · Aug 6

Today we're spotlighting an article from April 2025 highlighting how research links antidepressant use to faster cognitive decline in people with dementia, but don’t jump to conclusions for Huntington’s disease. HD is different, and more research is needed before applying these findings.

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HDBuzz @hdbuzzfeed.bsky.social · Aug 4

Can timing your meals help the brain? A new review looks at time-restricted eating (TRE) as a potential way to support brain health in Huntington’s disease. While early animal research is exciting, there are real risks to consider for people with HD.

Full Article:
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Appetite for Answers: Does Eating on a Schedule Help with Huntington’s Disease? – HDBuzz

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HDBuzz @hdbuzzfeed.bsky.social · Aug 2