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Huntington’s disease research news. In plain language. Written by scientists. hdbuzz.net
Editors - @sjh508 @rjharding
Editors - @sjh508 @rjharding
Reposted by HDBuzz
There’s still time to join the movement! Add your name to the Hope on Hold petition by THIS SUNDAY, 1/18 to ensure you are included, before HD Reach, HDF, HDSA, Help4HD and HDYO head to DC soon to formally submit this petition to the FDA.
✍️Sign today - bit.ly/Hope4HD
#curehd #huntingtondisease
✍️Sign today - bit.ly/Hope4HD
#curehd #huntingtondisease
January 15, 2026 at 4:00 PM
There’s still time to join the movement! Add your name to the Hope on Hold petition by THIS SUNDAY, 1/18 to ensure you are included, before HD Reach, HDF, HDSA, Help4HD and HDYO head to DC soon to formally submit this petition to the FDA.
✍️Sign today - bit.ly/Hope4HD
#curehd #huntingtondisease
✍️Sign today - bit.ly/Hope4HD
#curehd #huntingtondisease
Vaccines don’t just prevent infection, they may also protect brain health. Studies suggest vaccination could reduce dementia risk by 20%. In Huntington’s disease, where mitochondrial function is compromised, preventing infection-related stress may be especially critical
en.hdbuzz.net/vaccines-and...
en.hdbuzz.net/vaccines-and...
Vaccines and Neurodegeneration: Lessons for Huntington’s Disease? – HDBuzz
en.hdbuzz.net
January 15, 2026 at 4:26 PM
Vaccines don’t just prevent infection, they may also protect brain health. Studies suggest vaccination could reduce dementia risk by 20%. In Huntington’s disease, where mitochondrial function is compromised, preventing infection-related stress may be especially critical
en.hdbuzz.net/vaccines-and...
en.hdbuzz.net/vaccines-and...
uniQure has been granted a Type A meeting with the FDA, reserved for urgent issues. Within 30 days, both sides will discuss what kind of data package could support advancing AMT-130 in the US.
Full article: en.hdbuzz.net/uniqure-secu...
Full article: en.hdbuzz.net/uniqure-secu...
UniQure Secures Type A Meeting with FDA: What This Means for AMT-130 – HDBuzz
en.hdbuzz.net
January 12, 2026 at 3:28 PM
uniQure has been granted a Type A meeting with the FDA, reserved for urgent issues. Within 30 days, both sides will discuss what kind of data package could support advancing AMT-130 in the US.
Full article: en.hdbuzz.net/uniqure-secu...
Full article: en.hdbuzz.net/uniqure-secu...
Neuro-HD compared three commonly used medications for Huntington’s disease symptoms. Over one year, no single “best” drug emerged, but important differences did. The findings support a personalised, symptom-by-symptom approach to treatment.
Full Article: en.hdbuzz.net/putting-hunt...
Full Article: en.hdbuzz.net/putting-hunt...
Putting Huntington’s disease medications to the test: results from the Neuro-HD trial – HDBuzz
en.hdbuzz.net
January 8, 2026 at 3:35 PM
Neuro-HD compared three commonly used medications for Huntington’s disease symptoms. Over one year, no single “best” drug emerged, but important differences did. The findings support a personalised, symptom-by-symptom approach to treatment.
Full Article: en.hdbuzz.net/putting-hunt...
Full Article: en.hdbuzz.net/putting-hunt...
We’re entering a new chapter. HDBuzz is now an independent organisation, strengthening our ability to report clearly, critically, and responsibly on HD research.
en.hdbuzz.net/hdbuzz-is-of...
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HDBuzz Is Officially Independent: What This Means, and Why It Matters – HDBuzz
en.hdbuzz.net
January 5, 2026 at 10:31 PM
We’re entering a new chapter. HDBuzz is now an independent organisation, strengthening our ability to report clearly, critically, and responsibly on HD research.
en.hdbuzz.net/hdbuzz-is-of...
en.hdbuzz.net/hdbuzz-is-of...
A new Swiss study provides important insight into how CAG repeats in the Huntington’s disease gene can grow or shrink within our cells over time, improving our understanding of the forces that shape HD progression.
Full Article: en.hdbuzz.net/a-tug-of-war...
Full Article: en.hdbuzz.net/a-tug-of-war...
A tug-of-war at the DNA: how Huntington’s repeats grow and shrink – HDBuzz
en.hdbuzz.net
December 11, 2025 at 5:48 PM
A new Swiss study provides important insight into how CAG repeats in the Huntington’s disease gene can grow or shrink within our cells over time, improving our understanding of the forces that shape HD progression.
Full Article: en.hdbuzz.net/a-tug-of-war...
Full Article: en.hdbuzz.net/a-tug-of-war...
uniQure received FDA’s meeting minutes on AMT-130. While there were no new updates, the community’s response has been powerful, with 41K+ petition signatures & unified advocacy from major HD orgs.
Full Article: en.hdbuzz.net/uniqure-rece...
Full Article: en.hdbuzz.net/uniqure-rece...
UniQure Receives FDA Meeting Minutes on AMT-130 While Community Support Remains Strong – HDBuzz
en.hdbuzz.net
December 8, 2025 at 2:25 PM
uniQure received FDA’s meeting minutes on AMT-130. While there were no new updates, the community’s response has been powerful, with 41K+ petition signatures & unified advocacy from major HD orgs.
Full Article: en.hdbuzz.net/uniqure-rece...
Full Article: en.hdbuzz.net/uniqure-rece...
Studies in mice that model Huntington’s disease suggest that prebiotics – the food that feeds our gut bacteria – might improve gut health and neurological symptoms.
Full Article: en.hdbuzz.net/feeding-the-...
Full Article: en.hdbuzz.net/feeding-the-...
Feeding the Brain Through the Gut: How Prebiotics Might Shape Huntington’s Disease – HDBuzz
en.hdbuzz.net
December 4, 2025 at 9:08 PM
Studies in mice that model Huntington’s disease suggest that prebiotics – the food that feeds our gut bacteria – might improve gut health and neurological symptoms.
Full Article: en.hdbuzz.net/feeding-the-...
Full Article: en.hdbuzz.net/feeding-the-...
New research suggests sertraline might support brain function in HD, prevent motor issues in mice, and steady protein production. Could this everyday antidepressant be helping HD from multiple angles?
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en.hdbuzz.net/an-old-drug-...
An Old Drug, New Tricks: Sertraline May Lighten the Load in HD by Targeting Protein Production – HDBuzz
en.hdbuzz.net
December 1, 2025 at 4:19 PM
New research suggests sertraline might support brain function in HD, prevent motor issues in mice, and steady protein production. Could this everyday antidepressant be helping HD from multiple angles?
en.hdbuzz.net/an-old-drug-...
en.hdbuzz.net/an-old-drug-...
November brought a wave of HD research updates, from fresh genetic insights to new therapeutic ideas and ongoing trial progress. Science keeps pushing forward.
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November 2025: This Month in Huntington’s Disease Research – HDBuzz
en.hdbuzz.net
November 28, 2025 at 10:23 PM
November brought a wave of HD research updates, from fresh genetic insights to new therapeutic ideas and ongoing trial progress. Science keeps pushing forward.
en.hdbuzz.net/november-202...
en.hdbuzz.net/november-202...
Proteins = shirts. Chaperones = the pressers. HD = chaos in the whole factory.
New research digs into whether engineered chaperones can improve protein folding in HD, and maybe help keep the cellular wardrobe in order.
en.hdbuzz.net/folding-a-sh...
New research digs into whether engineered chaperones can improve protein folding in HD, and maybe help keep the cellular wardrobe in order.
en.hdbuzz.net/folding-a-sh...
Folding A Shirt With 12-Foot Arms: Understanding Protein Folding in Huntington’s Disease – HDBuzz
en.hdbuzz.net
November 24, 2025 at 3:27 PM
Proteins = shirts. Chaperones = the pressers. HD = chaos in the whole factory.
New research digs into whether engineered chaperones can improve protein folding in HD, and maybe help keep the cellular wardrobe in order.
en.hdbuzz.net/folding-a-sh...
New research digs into whether engineered chaperones can improve protein folding in HD, and maybe help keep the cellular wardrobe in order.
en.hdbuzz.net/folding-a-sh...
A newly revealed structure of the MutSβ molecular machine offers fresh insight into how CAG repeats expand, and how we might one day stop them.
en.hdbuzz.net/unzipping-th...
en.hdbuzz.net/unzipping-th...
Unzipping the Secrets of DNA Repair – HDBuzz
en.hdbuzz.net
November 13, 2025 at 2:42 PM
A newly revealed structure of the MutSβ molecular machine offers fresh insight into how CAG repeats expand, and how we might one day stop them.
en.hdbuzz.net/unzipping-th...
en.hdbuzz.net/unzipping-th...
To close out 2025, we're celebrating those who move Huntington's disease research forward, from scientists to families, closing this year with the gratitude we feel for the HD community.
November 11, 2025 at 5:18 PM
To close out 2025, we're celebrating those who move Huntington's disease research forward, from scientists to families, closing this year with the gratitude we feel for the HD community.
November 10, 2025 at 4:28 PM
A new study uses ultra-sensitive tools to map DNA changes across the full range of CAG repeat lengths, shedding light on where intermediate repeats fit within the genetic landscape of Huntington’s disease.
en.hdbuzz.net/new-insights...
en.hdbuzz.net/new-insights...
New insights into intermediate CAG repeats: Mapping the expansion continuum – HDBuzz
en.hdbuzz.net
November 6, 2025 at 7:43 PM
A new study uses ultra-sensitive tools to map DNA changes across the full range of CAG repeat lengths, shedding light on where intermediate repeats fit within the genetic landscape of Huntington’s disease.
en.hdbuzz.net/new-insights...
en.hdbuzz.net/new-insights...
October 20, 2025 at 2:02 PM
Welcome back for the final day of #HDCongress2025! We’re rested, well caffeinated, and excited to share the first session with you on translational issues in HD - how we get research to people that need it most, HD families.
October 13, 2025 at 1:53 PM
Welcome back for the final day of #HDCongress2025! We’re rested, well caffeinated, and excited to share the first session with you on translational issues in HD - how we get research to people that need it most, HD families.
Welcome to Day 2 of #HDCongress2025! Daniel Claassen from HSG and Cristina Sampaio from CHDI kick off the meeting with an overview of what we’ll hear about today in HD clinical research and discovery.
October 12, 2025 at 2:10 PM
Welcome to Day 2 of #HDCongress2025! Daniel Claassen from HSG and Cristina Sampaio from CHDI kick off the meeting with an overview of what we’ll hear about today in HD clinical research and discovery.
Good morning from Nashville, Tennessee, where HDBuzz is attending the first Huntington’s Disease Clinical Research Congress, where hundreds of scientists, doctors, and industry representatives have gathered to talk about HD clinical research and care. #HDCongress2025
October 11, 2025 at 2:43 PM
Good morning from Nashville, Tennessee, where HDBuzz is attending the first Huntington’s Disease Clinical Research Congress, where hundreds of scientists, doctors, and industry representatives have gathered to talk about HD clinical research and care. #HDCongress2025
Scientists have found small molecules that can target a crucial DNA repair machine, paving the way for therapies that could delay the onset of Huntington’s disease.
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Controlling DNA Scanning Machines to Slow Expansion of CAG Repeats – HDBuzz
en.hdbuzz.net
October 10, 2025 at 6:14 PM
Scientists have found small molecules that can target a crucial DNA repair machine, paving the way for therapies that could delay the onset of Huntington’s disease.
en.hdbuzz.net/controlling-...
en.hdbuzz.net/controlling-...
The Huntington Study Group (HSG) Clinical Research Congress is this weekend in Nashville. HDBuzz will be front and center, live posting updates from the event on Bluesky!
Keep your eyes on our Bluesky account this weekend to follow along with the exciting HD research updates!
tinyurl.com/5h6hcssx
Keep your eyes on our Bluesky account this weekend to follow along with the exciting HD research updates!
tinyurl.com/5h6hcssx
Unsupported client – Canva
Unsupported client – Canva
tinyurl.com
October 8, 2025 at 10:13 PM
The Huntington Study Group (HSG) Clinical Research Congress is this weekend in Nashville. HDBuzz will be front and center, live posting updates from the event on Bluesky!
Keep your eyes on our Bluesky account this weekend to follow along with the exciting HD research updates!
tinyurl.com/5h6hcssx
Keep your eyes on our Bluesky account this weekend to follow along with the exciting HD research updates!
tinyurl.com/5h6hcssx
We’re proud to announce Chloe Langridge as a 2025 HDBuzz Prize winner! Her article covers work that shows that boosting a protein called SGTA can ease signs of Huntington’s disease, opening a potential new therapeutic path.
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2025 HDBuzz Prize: On the Frontlines: Trusting the Hall Monitors of the Cell – HDBuzz
en.hdbuzz.net
October 2, 2025 at 7:38 PM
We’re proud to announce Chloe Langridge as a 2025 HDBuzz Prize winner! Her article covers work that shows that boosting a protein called SGTA can ease signs of Huntington’s disease, opening a potential new therapeutic path.
en.hdbuzz.net/2025-hdbuzz-...
en.hdbuzz.net/2025-hdbuzz-...
September’s research highlights: gene therapy that may slow HD, new biomarkers for tracking, deeper mechanistic understanding, and advances in mental health. Progress in HD science continues to accelerate with your support!
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en.hdbuzz.net/september-20...
September 2025: This Month in Huntington’s Disease Research – HDBuzz
en.hdbuzz.net
September 30, 2025 at 8:13 PM
September’s research highlights: gene therapy that may slow HD, new biomarkers for tracking, deeper mechanistic understanding, and advances in mental health. Progress in HD science continues to accelerate with your support!
en.hdbuzz.net/september-20...
en.hdbuzz.net/september-20...
Hope is building—over $10k raised toward our $30,000 goal! Every dollar helps bring clear science to the HD community. Spread the word or donate to keep the momentum!
Donate here: en.hdbuzz.net/donate
Donate here: en.hdbuzz.net/donate
Donate – HDBuzz
en.hdbuzz.net
September 27, 2025 at 10:34 PM
Hope is building—over $10k raised toward our $30,000 goal! Every dollar helps bring clear science to the HD community. Spread the word or donate to keep the momentum!
Donate here: en.hdbuzz.net/donate
Donate here: en.hdbuzz.net/donate