Sheffield Hearing Group
@hearingshef.bsky.social
World-leading research group at The University of Sheffield. We specialise in research on the development, function and ageing of the auditory systems.
sheffield.ac.uk/hearing
sheffield.ac.uk/hearing
Pinned
Feedback to the cochlea from the lateral superior olive of the brainstem following noise exposure at University of Sheffield on FindAPhD.com
PhD Project - Feedback to the cochlea from the lateral superior olive of the brainstem following noise exposure at University of Sheffield, listed on FindAPhD.com
www.findaphd.com
📢Howdy all, I'm excited to announce a new PhD opening within the Carlton lab in the hearing research group! This project will use primarily electrophysiology to investigate how noise influences feedback to the cochlea from the brainstem! More details can be found at:
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
Happy #MicroscopyMonday everyone!🔬 Today's image comes from Alice and it's a great fluorescent image of inner hair cells (stained with Phalloidin, magenta) from a 2-months old mutant.🐁 In this photo the expression of Baiap2l2 (green) was successfully restored with AAV-gene therapy.💉🧪
#NeuroSkyence
#NeuroSkyence
November 24, 2025 at 12:51 PM
Happy #MicroscopyMonday everyone!🔬 Today's image comes from Alice and it's a great fluorescent image of inner hair cells (stained with Phalloidin, magenta) from a 2-months old mutant.🐁 In this photo the expression of Baiap2l2 (green) was successfully restored with AAV-gene therapy.💉🧪
#NeuroSkyence
#NeuroSkyence
💚 🏆 We’re very happy to have received the Sustainability Lab Leaf Silver Award for creating an even greener, more sustainable research environment! 🧪 🥬 Many many thanks to everyone in the lab for their efforts #Sustainability #GreenLabs #SheffieldHearingGroup
November 19, 2025 at 8:01 AM
💚 🏆 We’re very happy to have received the Sustainability Lab Leaf Silver Award for creating an even greener, more sustainable research environment! 🧪 🥬 Many many thanks to everyone in the lab for their efforts #Sustainability #GreenLabs #SheffieldHearingGroup
Rinta Mathew: Postdoc
Research: Investigating regulation of signal processing in developing and ageing mouse cochlea in vivo and how these influence central auditory neuronal pathways.
Method: 2-photon imaging & AAV-gene delivery
Twitter: x.com/MathewRinta
Lab snack: Nature Valley Peanut & Chocolate
Research: Investigating regulation of signal processing in developing and ageing mouse cochlea in vivo and how these influence central auditory neuronal pathways.
Method: 2-photon imaging & AAV-gene delivery
Twitter: x.com/MathewRinta
Lab snack: Nature Valley Peanut & Chocolate
November 12, 2025 at 8:01 AM
Rinta Mathew: Postdoc
Research: Investigating regulation of signal processing in developing and ageing mouse cochlea in vivo and how these influence central auditory neuronal pathways.
Method: 2-photon imaging & AAV-gene delivery
Twitter: x.com/MathewRinta
Lab snack: Nature Valley Peanut & Chocolate
Research: Investigating regulation of signal processing in developing and ageing mouse cochlea in vivo and how these influence central auditory neuronal pathways.
Method: 2-photon imaging & AAV-gene delivery
Twitter: x.com/MathewRinta
Lab snack: Nature Valley Peanut & Chocolate
Happy #MicroscopyMonday everyone! 🌟🔬 Here’s an image from Ivy of outer hair cells (OHCs) and inner hair cells (IHCs) from a P20 mouse.. 🐁✨#Microscopy #HearingResearch #Cochlea #Neuroscience #Neuroskyence
November 10, 2025 at 8:01 AM
Happy #MicroscopyMonday everyone! 🌟🔬 Here’s an image from Ivy of outer hair cells (OHCs) and inner hair cells (IHCs) from a P20 mouse.. 🐁✨#Microscopy #HearingResearch #Cochlea #Neuroscience #Neuroskyence
🌿🏅 We’re proud to announce the Sheffield Hearing Group has been awarded the Sustainability Lab Leaf Bronze Award for creating a greener, more sustainable research environment! 🌎🔬Huge thanks to everyone in the lab for their efforts🌱👏 #Sustainability #GreenLabs #SheffieldHearingGroup
November 8, 2025 at 8:00 AM
🌿🏅 We’re proud to announce the Sheffield Hearing Group has been awarded the Sustainability Lab Leaf Bronze Award for creating a greener, more sustainable research environment! 🌎🔬Huge thanks to everyone in the lab for their efforts🌱👏 #Sustainability #GreenLabs #SheffieldHearingGroup
Howdy all, today's spotlight comes from Saman Hussain and was published in September. This (very pretty) paper identifies spontaneous calcium activity within the sound-detecting stereocilia driven by the MET channel, and independent from the usual calcium waves!
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
November 7, 2025 at 4:15 PM
Howdy all, today's spotlight comes from Saman Hussain and was published in September. This (very pretty) paper identifies spontaneous calcium activity within the sound-detecting stereocilia driven by the MET channel, and independent from the usual calcium waves!
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
Happy #MicroscopyMonday everyone!🔬🌟Nic has taken a cross-section image of the retina under the microscope: red shows the Retinal Pigment Epithelial cells, orange shows photoreceptor cell bodies with cilia & green shows the outer nuclear layer with just photoreceptor cell bodies 👁️✨
#neuroskyence
#neuroskyence
November 3, 2025 at 9:01 AM
Happy #MicroscopyMonday everyone!🔬🌟Nic has taken a cross-section image of the retina under the microscope: red shows the Retinal Pigment Epithelial cells, orange shows photoreceptor cell bodies with cilia & green shows the outer nuclear layer with just photoreceptor cell bodies 👁️✨
#neuroskyence
#neuroskyence
📢Howdy all, I'm excited to announce a new PhD opening within the Carlton lab in the hearing research group! This project will use primarily electrophysiology to investigate how noise influences feedback to the cochlea from the brainstem! More details can be found at:
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
Feedback to the cochlea from the lateral superior olive of the brainstem following noise exposure at University of Sheffield on FindAPhD.com
PhD Project - Feedback to the cochlea from the lateral superior olive of the brainstem following noise exposure at University of Sheffield, listed on FindAPhD.com
www.findaphd.com
October 31, 2025 at 8:36 AM
📢Howdy all, I'm excited to announce a new PhD opening within the Carlton lab in the hearing research group! This project will use primarily electrophysiology to investigate how noise influences feedback to the cochlea from the brainstem! More details can be found at:
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
Lillian Smith | PhD student
Research focus: Understanding the mechanisms associated with mitochondria dysfunction underpinning ARHL and neurodegenerative diseases using in vivo physiology, 2-photon functional imaging, RNA sequencing, and immunolabeling
Fun fact: My go-to lab snack is mini cheddars
Research focus: Understanding the mechanisms associated with mitochondria dysfunction underpinning ARHL and neurodegenerative diseases using in vivo physiology, 2-photon functional imaging, RNA sequencing, and immunolabeling
Fun fact: My go-to lab snack is mini cheddars
October 29, 2025 at 8:03 AM
Lillian Smith | PhD student
Research focus: Understanding the mechanisms associated with mitochondria dysfunction underpinning ARHL and neurodegenerative diseases using in vivo physiology, 2-photon functional imaging, RNA sequencing, and immunolabeling
Fun fact: My go-to lab snack is mini cheddars
Research focus: Understanding the mechanisms associated with mitochondria dysfunction underpinning ARHL and neurodegenerative diseases using in vivo physiology, 2-photon functional imaging, RNA sequencing, and immunolabeling
Fun fact: My go-to lab snack is mini cheddars
Happy #MicroscopyMonday everyone!🌟🔬 Today's photo comes from Alice showing an scanning electron microscopy image of outer hair cells lacking many stereocilia due to abnormal expression of a protein important for hair bundle maintenance! 🧪🐁
October 27, 2025 at 8:02 AM
Happy #MicroscopyMonday everyone!🌟🔬 Today's photo comes from Alice showing an scanning electron microscopy image of outer hair cells lacking many stereocilia due to abnormal expression of a protein important for hair bundle maintenance! 🧪🐁
Last week we said goodbye and good luck to Francesca, who’s been an amazing part of the Sheffield Hearing Group! Thank you, Fran, for everything — the lab won’t be the same without you! 🧪🌟
October 22, 2025 at 7:02 AM
Last week we said goodbye and good luck to Francesca, who’s been an amazing part of the Sheffield Hearing Group! Thank you, Fran, for everything — the lab won’t be the same without you! 🧪🌟
Howdy all. Recently one of our PIs (Adam) appeared on The Naked Scientists podcast to discuss hearing loss and tinnitus! The free full recording can be found on their website at: www.thenakedscientists.com/podcasts/nak...
Worth a listen if you're interested in hearing!
Worth a listen if you're interested in hearing!
Hearing loss, and what we can do about it
From bypassing bones to borrowing from birds...
www.thenakedscientists.com
October 15, 2025 at 9:41 AM
Howdy all. Recently one of our PIs (Adam) appeared on The Naked Scientists podcast to discuss hearing loss and tinnitus! The free full recording can be found on their website at: www.thenakedscientists.com/podcasts/nak...
Worth a listen if you're interested in hearing!
Worth a listen if you're interested in hearing!
Happy #MicroscopyMonday everyone!🌟🔬 Today's photo comes from Zoë and shows the inner and outer hair cells in the organ of Corti of a mouse stained with Phalloidin (in red), the supporting cells outlined with connexin 30 (in green), and the cell nuclei stained with DAPI (in blue).🧪🐁
October 13, 2025 at 3:30 PM
Happy #MicroscopyMonday everyone!🌟🔬 Today's photo comes from Zoë and shows the inner and outer hair cells in the organ of Corti of a mouse stained with Phalloidin (in red), the supporting cells outlined with connexin 30 (in green), and the cell nuclei stained with DAPI (in blue).🧪🐁
A quick video on how we Immunolabel proteins in the organ of corti 😊🧪
October 8, 2025 at 7:02 AM
A quick video on how we Immunolabel proteins in the organ of corti 😊🧪
Happy #MicroscopyMonday 🌟🔬 Todays photo comes from Ginny and shows pre and post synapses from inner hair cells. White stains the nucleus, red stains CtBP2, green stains Shank1 and blue stains GluR2🧪🐁
October 6, 2025 at 7:01 AM
Happy #MicroscopyMonday 🌟🔬 Todays photo comes from Ginny and shows pre and post synapses from inner hair cells. White stains the nucleus, red stains CtBP2, green stains Shank1 and blue stains GluR2🧪🐁
We've had a busy few weeks as we have returned from an amazing Inner Ear Biology conference in Tübingen!👂 It was inspiring to hear cutting-edge research and disseminate our own—Adam, Alice, and Char gave talks, while Ginny, Federico, Yan, and Andrea presented their latest work in poster sessions!🧑🔬🧪
October 2, 2025 at 1:09 PM
We've had a busy few weeks as we have returned from an amazing Inner Ear Biology conference in Tübingen!👂 It was inspiring to hear cutting-edge research and disseminate our own—Adam, Alice, and Char gave talks, while Ginny, Federico, Yan, and Andrea presented their latest work in poster sessions!🧑🔬🧪
Reposted by Sheffield Hearing Group
Ceriani et al. (2025). A machine-learning-based approach to predict early hallmarks of progressive hearing loss. Hearing Research 464, 109328.
doi.org/10.1016/j.he...
@hearingshef.bsky.social
doi.org/10.1016/j.he...
@hearingshef.bsky.social
September 17, 2025 at 2:54 PM
Ceriani et al. (2025). A machine-learning-based approach to predict early hallmarks of progressive hearing loss. Hearing Research 464, 109328.
doi.org/10.1016/j.he...
@hearingshef.bsky.social
doi.org/10.1016/j.he...
@hearingshef.bsky.social
Today's spotlight comes from Hubert Lee and was published just last month. This clever paper shows that TMC1/2, the channels responsible for all hearing in mammals, can flip lipids between the membrane leaflets! The function is unknown, but it sure is interesting! www.biorxiv.org/content/10.1...
September 3, 2025 at 3:24 PM
Today's spotlight comes from Hubert Lee and was published just last month. This clever paper shows that TMC1/2, the channels responsible for all hearing in mammals, can flip lipids between the membrane leaflets! The function is unknown, but it sure is interesting! www.biorxiv.org/content/10.1...
Happy #MicroscopyMonday everyone!🔬🌟 Today's image comes from Alice and it is a beautiful SEM (Scanning electron microscope) picture showing both the inner hair cells (at the bottom) and the three rows of outer hair cells (at the top)!🐀🧪
September 1, 2025 at 1:56 PM
Happy #MicroscopyMonday everyone!🔬🌟 Today's image comes from Alice and it is a beautiful SEM (Scanning electron microscope) picture showing both the inner hair cells (at the bottom) and the three rows of outer hair cells (at the top)!🐀🧪
Happy #MicroscopyMonday everyone! 🔬🌟Today's image is from Andrea, showing his first attempt at phalloidin staining of a 4 day-old zebrafish saccular macula - the main hearing organ of the fish.🐟 In the centre of the photo you can see the hair cells, with a few examples highlighted by white arrows!🧪
August 18, 2025 at 2:17 PM
Happy #MicroscopyMonday everyone! 🔬🌟Today's image is from Andrea, showing his first attempt at phalloidin staining of a 4 day-old zebrafish saccular macula - the main hearing organ of the fish.🐟 In the centre of the photo you can see the hair cells, with a few examples highlighted by white arrows!🧪
Today's #TraceTuesday comes from Charlie! This trace was recorded towards the start of his PhD, showing spontaneous activity in neurons of the zebrafish lateral line. This spontaneous activity is a key feature during normal development of the zebrafish lateral line and the mammalian cochlea! 🐟🧪📈
August 12, 2025 at 5:43 PM
Today's #TraceTuesday comes from Charlie! This trace was recorded towards the start of his PhD, showing spontaneous activity in neurons of the zebrafish lateral line. This spontaneous activity is a key feature during normal development of the zebrafish lateral line and the mammalian cochlea! 🐟🧪📈
Happy #MicroscopyMonday everyone! 🔬Today’s image is from Alice. She injected this adult cochlea in vivo with an adeno-associated virus (AAV).🧬 We can see the AAV was able to transduce green fluorescent protein (GFP) into inner hair cells (brightly-labelled) and outer hair cells (dimly-labelled)🐀🧪
August 11, 2025 at 2:54 PM
Happy #MicroscopyMonday everyone! 🔬Today’s image is from Alice. She injected this adult cochlea in vivo with an adeno-associated virus (AAV).🧬 We can see the AAV was able to transduce green fluorescent protein (GFP) into inner hair cells (brightly-labelled) and outer hair cells (dimly-labelled)🐀🧪
Reposted by Sheffield Hearing Group
Goodrich Lab manager and RA is making great progress with cochlea cleareing and imaging, getting closer and closer to single fiber resolution! 🥳 Perfect for #FluorescenceFriday
June 6, 2025 at 8:02 PM
Goodrich Lab manager and RA is making great progress with cochlea cleareing and imaging, getting closer and closer to single fiber resolution! 🥳 Perfect for #FluorescenceFriday
JWST just released a new image of the red planet!
Just kidding, this is an image of the organ of Corti stained red that I've badly photoshopped 👩🚀 Have a great weekend all!
Just kidding, this is an image of the organ of Corti stained red that I've badly photoshopped 👩🚀 Have a great weekend all!
August 1, 2025 at 2:45 PM
JWST just released a new image of the red planet!
Just kidding, this is an image of the organ of Corti stained red that I've badly photoshopped 👩🚀 Have a great weekend all!
Just kidding, this is an image of the organ of Corti stained red that I've badly photoshopped 👩🚀 Have a great weekend all!
Happy #MicroscopyMonday everyone!🌟🔬 Today's photos from Nic show a cross section of the retinal layers in mice eyes.🐀👀 Here we can see (from the bottom), the photoreceptor layer, the middle layer (containing bipolar, horizontal, and amacrine cells), and the ganglion cell layer!🧪
July 28, 2025 at 12:53 PM
Happy #MicroscopyMonday everyone!🌟🔬 Today's photos from Nic show a cross section of the retinal layers in mice eyes.🐀👀 Here we can see (from the bottom), the photoreceptor layer, the middle layer (containing bipolar, horizontal, and amacrine cells), and the ganglion cell layer!🧪