Ute Hellmich
@hellmichgroup.bsky.social
Biochemistry/Structural Bio at Uni Jena and Cluster of Excellence 'Balance of the Microverse'
(Membrane) protein dynamics admirer, parasite aficionado and coffee addict.
Action against #NTDs!
www.hellmich-group.de
(Membrane) protein dynamics admirer, parasite aficionado and coffee addict.
Action against #NTDs!
www.hellmich-group.de
🧪How does an ABC transporter 'know' nucleotides & substrates bound to far apart binding sites? Using 1H15N, 19F NMR, HDX-MS, PET-FCS & activity assays with Neuweiler, Marcoux, Orelle & Jault labs, we found a communication hinge! 😍🥳
@microverse.bsky.social @lifeprofile.bsky.social
rdcu.be/ePm4C
@microverse.bsky.social @lifeprofile.bsky.social
rdcu.be/ePm4C
Bidirectional communication between nucleotide and substrate binding sites in a type IV multidrug ABC transporter
Nature Communications - The communication hinge, found in type IV ABC transporters, forms a bidirectional communication between ATP- and substrate-binding sites. This is an unexplored allosteric...
rdcu.be
November 12, 2025 at 11:15 AM
🧪How does an ABC transporter 'know' nucleotides & substrates bound to far apart binding sites? Using 1H15N, 19F NMR, HDX-MS, PET-FCS & activity assays with Neuweiler, Marcoux, Orelle & Jault labs, we found a communication hinge! 😍🥳
@microverse.bsky.social @lifeprofile.bsky.social
rdcu.be/ePm4C
@microverse.bsky.social @lifeprofile.bsky.social
rdcu.be/ePm4C
Our newest lab member has arrived! 😍🥳
Meet James, starring in our new production From Jena with Love. 🎬
#YouOnlyPatchTwice
#TRPChannelsRule
@naniontech.bsky.social
Meet James, starring in our new production From Jena with Love. 🎬
#YouOnlyPatchTwice
#TRPChannelsRule
@naniontech.bsky.social
November 4, 2025 at 1:59 PM
Our newest lab member has arrived! 😍🥳
Meet James, starring in our new production From Jena with Love. 🎬
#YouOnlyPatchTwice
#TRPChannelsRule
@naniontech.bsky.social
Meet James, starring in our new production From Jena with Love. 🎬
#YouOnlyPatchTwice
#TRPChannelsRule
@naniontech.bsky.social
We proudly present:
the 2025 Halloween Lab Pumpkin Carving Edition!!! 😁🥳👻
the 2025 Halloween Lab Pumpkin Carving Edition!!! 😁🥳👻
October 29, 2025 at 11:13 PM
We proudly present:
the 2025 Halloween Lab Pumpkin Carving Edition!!! 😁🥳👻
the 2025 Halloween Lab Pumpkin Carving Edition!!! 😁🥳👻
Confirming both sample integrity and quantifying homodimer interactions? Not so easy - unless you have native MS! ⚖️
Check out our new preprint with Morgner lab using homomeric models and chemically induced dimers of an essential T. brucei enzyme!🧪🥳
@crc1507.bsky.social
arxiv.org/abs/2510.08324
Check out our new preprint with Morgner lab using homomeric models and chemically induced dimers of an essential T. brucei enzyme!🧪🥳
@crc1507.bsky.social
arxiv.org/abs/2510.08324
Quantification of protein homodimer affinity using native mass spectrometry
Biological processes rely on finely tuned homo- and heteromeric interactions between (biomacro)molecules. The strength of an interaction, typically given by the dissociation constant (KD), plays a cru...
arxiv.org
October 10, 2025 at 6:20 PM
Confirming both sample integrity and quantifying homodimer interactions? Not so easy - unless you have native MS! ⚖️
Check out our new preprint with Morgner lab using homomeric models and chemically induced dimers of an essential T. brucei enzyme!🧪🥳
@crc1507.bsky.social
arxiv.org/abs/2510.08324
Check out our new preprint with Morgner lab using homomeric models and chemically induced dimers of an essential T. brucei enzyme!🧪🥳
@crc1507.bsky.social
arxiv.org/abs/2510.08324
Reposted by Ute Hellmich
Our new PNAS paper "Enhanced PIEZO1 function contributes to the pathogenesis of sickle cell disease" is out: www.pnas.org/doi/10.1073/... 1/3
Enhanced PIEZO1 function contributes to the pathogenesis of sickle cell disease | PNAS
Sickle cell disease (SCD), an inherited blood disorder caused by a mutation in the
β-globin gene, is characterized by sickle erythrocytes that are ...
www.pnas.org
October 3, 2025 at 4:53 PM
Our new PNAS paper "Enhanced PIEZO1 function contributes to the pathogenesis of sickle cell disease" is out: www.pnas.org/doi/10.1073/... 1/3
Reposted by Ute Hellmich
The final version of our article about PLD3 AMPylation is now out shorturl.at/iTxWx. One protein, many proteoforms. Congratulations to Laura and thanks to @marleenberouti.bsky.social @v-hornung.bsky.social @jaelab.bsky.social @hellmichgroup.bsky.social
September 23, 2025 at 7:11 AM
The final version of our article about PLD3 AMPylation is now out shorturl.at/iTxWx. One protein, many proteoforms. Congratulations to Laura and thanks to @marleenberouti.bsky.social @v-hornung.bsky.social @jaelab.bsky.social @hellmichgroup.bsky.social
Reposted by Ute Hellmich
We're organizing a new CARTA symposium this November 7 on "Ancient DNA: New Revelations"! We have an amazing lineup of speakers who will showcase the biggest discoveries in ancient DNA over the past 5 years - and offer a sneak peek of what's next. Mark your calendars and don't miss it!
September 15, 2025 at 5:40 PM
We're organizing a new CARTA symposium this November 7 on "Ancient DNA: New Revelations"! We have an amazing lineup of speakers who will showcase the biggest discoveries in ancient DNA over the past 5 years - and offer a sneak peek of what's next. Mark your calendars and don't miss it!
Took a TRP to beautiful Leuven and the sensory neurons are all firing....
Came for the Belgian 🍫,
stayed for the🌶🧅 🧊
#TRPChannels #LipidLove
Came for the Belgian 🍫,
stayed for the🌶🧅 🧊
#TRPChannels #LipidLove
September 17, 2025 at 1:43 PM
Took a TRP to beautiful Leuven and the sensory neurons are all firing....
Came for the Belgian 🍫,
stayed for the🌶🧅 🧊
#TRPChannels #LipidLove
Came for the Belgian 🍫,
stayed for the🌶🧅 🧊
#TRPChannels #LipidLove
Reposted by Ute Hellmich
🔬 In our new “3 Questions for…” episode, junior group leader @mlakemeyer.bsky.social reveals how chemical biology tools help decode microbial interactions & gut microbiota’s role in health & disease – and how this could inspire new therapies. Watch here: www.youtube.com/watch?v=CS54...
@uni-jena.de
@uni-jena.de
THREE QUESTIONS FOR ... Markus Lakemeyer
YouTube video by Universität Jena
www.youtube.com
August 15, 2025 at 2:45 PM
🔬 In our new “3 Questions for…” episode, junior group leader @mlakemeyer.bsky.social reveals how chemical biology tools help decode microbial interactions & gut microbiota’s role in health & disease – and how this could inspire new therapies. Watch here: www.youtube.com/watch?v=CS54...
@uni-jena.de
@uni-jena.de
Reposted by Ute Hellmich
I had a great time visiting beautiful Jena this week and learning more about the excellent #ChemBio environment they are building at the @uni-jena.de and the Hans-Knöll-Institut. (1/3)
August 24, 2025 at 4:30 AM
I had a great time visiting beautiful Jena this week and learning more about the excellent #ChemBio environment they are building at the @uni-jena.de and the Hans-Knöll-Institut. (1/3)
Reposted by Ute Hellmich
Imaging lipids! The dream! How cool is that!
Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
August 21, 2025 at 11:13 AM
Imaging lipids! The dream! How cool is that!
Reposted by Ute Hellmich
Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
August 21, 2025 at 5:19 AM
Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Ready to go!!! 🥳 So looking forward to reconnecting with the membrane peeps at Weill Cornell and making new friends at the Cell Biology of Metals GRC!!! 🤩
It's a brand new world for us, but we will try to Fe-rrociously immerse ourselves in it... 😅
It's a brand new world for us, but we will try to Fe-rrociously immerse ourselves in it... 😅
July 30, 2025 at 9:30 AM
Ready to go!!! 🥳 So looking forward to reconnecting with the membrane peeps at Weill Cornell and making new friends at the Cell Biology of Metals GRC!!! 🤩
It's a brand new world for us, but we will try to Fe-rrociously immerse ourselves in it... 😅
It's a brand new world for us, but we will try to Fe-rrociously immerse ourselves in it... 😅
A one day double whammy for our very own Eric in #trypanosome research! 🧪🥳
Backbone assignments of the essential oxidoreductase from T. cruzi (Chagas disease): tinyurl.com/ywshhxjt 🧲🦟
and his master piece on the role of fluorine in chemically induced dimerization:
www.biorxiv.org/content/10.1...
Backbone assignments of the essential oxidoreductase from T. cruzi (Chagas disease): tinyurl.com/ywshhxjt 🧲🦟
and his master piece on the role of fluorine in chemically induced dimerization:
www.biorxiv.org/content/10.1...
Inhibitor fluorination pattern tunes chemically induced protein dimerization
Chemically induced dimerization of proteins is a powerful approach to regulate biomolecular functions through small molecule ligands acting as 'molecular glues'. Here, we demonstrate that simple, thie...
www.biorxiv.org
July 28, 2025 at 2:56 PM
A one day double whammy for our very own Eric in #trypanosome research! 🧪🥳
Backbone assignments of the essential oxidoreductase from T. cruzi (Chagas disease): tinyurl.com/ywshhxjt 🧲🦟
and his master piece on the role of fluorine in chemically induced dimerization:
www.biorxiv.org/content/10.1...
Backbone assignments of the essential oxidoreductase from T. cruzi (Chagas disease): tinyurl.com/ywshhxjt 🧲🦟
and his master piece on the role of fluorine in chemically induced dimerization:
www.biorxiv.org/content/10.1...
Reposted by Ute Hellmich
Very happy to Share that my First paper has been uploaded on bioRxiv 🥳 This was a large team effort together with Jagdeep! We took the next steps into understanding how lipopolysaccharides are transported by the LptB2FGC complex with NMR🧲
Conformational plasticity of LptC regulates lipopolysaccharide transportby the LptB2FGC complex https://www.biorxiv.org/content/10.1101/2025.07.09.663713v1
July 12, 2025 at 4:58 PM
Very happy to Share that my First paper has been uploaded on bioRxiv 🥳 This was a large team effort together with Jagdeep! We took the next steps into understanding how lipopolysaccharides are transported by the LptB2FGC complex with NMR🧲
So screaming at cells if they don't express my favorite protein should work, no? 😂🧪
July 12, 2025 at 1:21 PM
So screaming at cells if they don't express my favorite protein should work, no? 😂🧪
Reposted by Ute Hellmich
I'm very excited to announce the funding of a new DFG research unit FOR 5872 "Chaperone-mediated regulation of the emergence of disease-causing amyloids inside biomolecular condensates" that I lead together with Simon Alberti. More information can be found here: www.leibniz-fli.de/news-events/...
Chaperones in focus: FLI heads new DFG research group on protein folding
The German Research Foundation (DFG) is funding seven new research groups (FOR) with a total of €33 million. One of these, DFG-FOR 5872, is dedicated to the role of molecular chaperones in the regulat...
www.leibniz-fli.de
July 4, 2025 at 10:16 AM
I'm very excited to announce the funding of a new DFG research unit FOR 5872 "Chaperone-mediated regulation of the emergence of disease-causing amyloids inside biomolecular condensates" that I lead together with Simon Alberti. More information can be found here: www.leibniz-fli.de/news-events/...
🧪Beyond cool! This has everything you need to sniff out a fabulous weekend read! 🐽😍
Moths in love, membrane receptors, hydrophobic pockets and covalent bonds! 🪰💕🪢
(also, we need more insect emoji...)
Moths in love, membrane receptors, hydrophobic pockets and covalent bonds! 🪰💕🪢
(also, we need more insect emoji...)
New preprint in the lab combining what we like best: insects, love, chemistry and the olfactory system! 1/8
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A covalent recognition strategy enables conspecific mate identification
The olfactory system can detect an uncountable number of volatile molecules while retaining the ability to discriminate amongst very similar ones. We identified a unique mechanism employed by insect o...
www.biorxiv.org
June 21, 2025 at 5:29 AM
🧪Beyond cool! This has everything you need to sniff out a fabulous weekend read! 🐽😍
Moths in love, membrane receptors, hydrophobic pockets and covalent bonds! 🪰💕🪢
(also, we need more insect emoji...)
Moths in love, membrane receptors, hydrophobic pockets and covalent bonds! 🪰💕🪢
(also, we need more insect emoji...)
We are ready for the last and BEST session of the GRC Mechanism of Membrane Transport!!!! 😉
The secret dynamic lives of channels and transporters...
with Benjamin Orlando, @delemottelab.bsky.social @popstarlab.bsky.social and our amazing chair Dimitrios Stamou!!!
The secret dynamic lives of channels and transporters...
with Benjamin Orlando, @delemottelab.bsky.social @popstarlab.bsky.social and our amazing chair Dimitrios Stamou!!!
May 29, 2025 at 4:05 PM
We are ready for the last and BEST session of the GRC Mechanism of Membrane Transport!!!! 😉
The secret dynamic lives of channels and transporters...
with Benjamin Orlando, @delemottelab.bsky.social @popstarlab.bsky.social and our amazing chair Dimitrios Stamou!!!
The secret dynamic lives of channels and transporters...
with Benjamin Orlando, @delemottelab.bsky.social @popstarlab.bsky.social and our amazing chair Dimitrios Stamou!!!
Bonjour Genève!
So looking forward to seeing all the membrane transport peeps again in a few hours at the GRC Mechanism of Membrane Transport! But first need ro get up that mountain to Les Diablerets 😅 🗻
So looking forward to seeing all the membrane transport peeps again in a few hours at the GRC Mechanism of Membrane Transport! But first need ro get up that mountain to Les Diablerets 😅 🗻
May 25, 2025 at 8:11 AM
Bonjour Genève!
So looking forward to seeing all the membrane transport peeps again in a few hours at the GRC Mechanism of Membrane Transport! But first need ro get up that mountain to Les Diablerets 😅 🗻
So looking forward to seeing all the membrane transport peeps again in a few hours at the GRC Mechanism of Membrane Transport! But first need ro get up that mountain to Les Diablerets 😅 🗻
Both Jena Clusters got funded!!!! 🥳 The emotions are overwhelming!!!
Here's to amazing future science with this incredible team and the amazing people that made it possible!!!
Here's to amazing future science with this incredible team and the amazing people that made it possible!!!
We are ready.... 😬
2 Clusters, 1 community.... everyone on edge 😅
Go Jena!!!!! @microverse.bsky.social @uni-jena.de
2 Clusters, 1 community.... everyone on edge 😅
Go Jena!!!!! @microverse.bsky.social @uni-jena.de
May 22, 2025 at 3:14 PM
Both Jena Clusters got funded!!!! 🥳 The emotions are overwhelming!!!
Here's to amazing future science with this incredible team and the amazing people that made it possible!!!
Here's to amazing future science with this incredible team and the amazing people that made it possible!!!
We are ready.... 😬
2 Clusters, 1 community.... everyone on edge 😅
Go Jena!!!!! @microverse.bsky.social @uni-jena.de
2 Clusters, 1 community.... everyone on edge 😅
Go Jena!!!!! @microverse.bsky.social @uni-jena.de
May 22, 2025 at 2:37 PM
We are ready.... 😬
2 Clusters, 1 community.... everyone on edge 😅
Go Jena!!!!! @microverse.bsky.social @uni-jena.de
2 Clusters, 1 community.... everyone on edge 😅
Go Jena!!!!! @microverse.bsky.social @uni-jena.de
Reposted by Ute Hellmich
Very much enjoyed yesterday's Firmenlauf in Jena. Go Team @uni-jena.de and @microverse.bsky.social with @hellmichgroup.bsky.social Would be great to represent @leibnizfli.bsky.social next year
May 22, 2025 at 4:44 AM
Very much enjoyed yesterday's Firmenlauf in Jena. Go Team @uni-jena.de and @microverse.bsky.social with @hellmichgroup.bsky.social Would be great to represent @leibnizfli.bsky.social next year
Reposted by Ute Hellmich
Meet GEQO: Genetically-encoded biosensors for absolute small-molecule quantification in single cells brought to you by @sascha-kuhn.bsky.social. For simple absolute quantification of your favourite small molecule or ion, head on over to @bioarxiv and read our new preprint: doi.org/10.1101/2025...
May 13, 2025 at 8:40 AM
Meet GEQO: Genetically-encoded biosensors for absolute small-molecule quantification in single cells brought to you by @sascha-kuhn.bsky.social. For simple absolute quantification of your favourite small molecule or ion, head on over to @bioarxiv and read our new preprint: doi.org/10.1101/2025...
Sweeeeeet, the corresponding author is called 'Zuker' affiliated with the Zuckerman Institute!!!! 🧪
What else could they have worked on?!? 😂
First structures of human sweet receptor are mindblowingly beautiful!! 🍰🍭😍 And very inspired paper title...
www.cell.com/cell/fulltex...
What else could they have worked on?!? 😂
First structures of human sweet receptor are mindblowingly beautiful!! 🍰🍭😍 And very inspired paper title...
www.cell.com/cell/fulltex...
The structure of human sweetness
A single taste receptor initiates our reactions to both sugars and artificial sweeteners,
triggering a signaling process that drives our intense attraction to sweet foods.
Single-particle cryo-EM reve...
www.cell.com
May 8, 2025 at 1:17 PM
Sweeeeeet, the corresponding author is called 'Zuker' affiliated with the Zuckerman Institute!!!! 🧪
What else could they have worked on?!? 😂
First structures of human sweet receptor are mindblowingly beautiful!! 🍰🍭😍 And very inspired paper title...
www.cell.com/cell/fulltex...
What else could they have worked on?!? 😂
First structures of human sweet receptor are mindblowingly beautiful!! 🍰🍭😍 And very inspired paper title...
www.cell.com/cell/fulltex...