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Fred Hutch Basic Sciences Division @hutchbasicsci.bsky.social · 2d

For this Current Biology Seminar series, we’re hosting local luminaries from the pacific northwest. For the first talk of the series, we’re excited to have Dr. Eric Holland speaking today at noon in Pelton. For all our @FredHutch.org colleagues, don’t miss a great talk!

Eric Holland, MD, PhD
Senior Vice President and Director
Human Biology Division
Fred Hutch

Title: "Big data visualization and mouse models of cancer"

12:00pm on Tuesday, October 7, 2025
Pelton Auditorium, Weintraub Building, Fred Hutch

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Fred Hutch Basic Sciences Division @hutchbasicsci.bsky.social · 8d

The Weintraub Award is seeking nominations for 2026! The award recognizes the outstanding achievements of grad students in biology and was established to honor the bold, creative, pioneering spirit embodied by Dr. Hal Weintraub. www.fredhutch.org/en/research/...

Harold M. Weintraub Graduate Student Award

Annual award to honor the bold, creative, pioneering spirit embodied by Hal Weintraub. The Harold M. Weintraub Graduate Student Award recognizes outstanding achievements during graduate studies in the...

www.fredhutch.org

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Fred Hutch Basic Sciences Division @hutchbasicsci.bsky.social · 10d

Congrats to Rina Hirano, postdoc in the Tsukiyama Lab, for receiving the Japan Society for the Promotion of Science's Overseas Research Fellowship in support of excellent young Japanese scientists working abroad! The fellowship helps further her research on how cells go in and out of quiescence.

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Fred Hutch Basic Sciences Division @hutchbasicsci.bsky.social · 14d

It's National Research Administrator Day! On behalf of everyone in the division, we thank our research administrators for their vital role in advancing Basic Sciences. From managing labs and funding to resolving problems big and small, our division's success is thanks to their many contributions.

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Reposted by Fred Hutch Basic Sciences Division

Fred Hutch @fredhutch.org · 18d

Fred Hutch immunologist Dr. Meghan Koch discovers a biological mechanism sprung in the first week of life that trains a mouse pup’s immune system to tolerate harmless gut bugs and new foods — insights that could lead to potential therapies for food allergies in newborns and infants.

Oh, the microbes you’ll meet!

A Fred Hutch Cancer Center study shows maternal antibodies in breastmilk help newborn mice develop immune tolerance, offering insights into human immunity and potential therapies for infant food aller...

www.fredhutch.org

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Reposted by Fred Hutch Basic Sciences Division

Fred Hutch @fredhutch.org · 17d

This year, Fred Hutch Cancer Center turned the big 5-0 and celebrated all year long with stories highlighting the people and moments that have truly defined the organization. 👉 https://bit.ly/4nengsC #FH50

Fred Hutch is 50

This year, Fred Hutch Cancer Center turned the big 5-0 and celebrated all year long with stories highlighting the people and moments that have truly defined the organization. From groundbreaking scien...

bit.ly

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Fred Hutch Basic Sciences Division @hutchbasicsci.bsky.social · 20d

The 2025 Basic Sciences retreat continues today with talks from division faculty. Can’t wait to meet the first-year postbacs and @mcbseattle.bsky.social students. Excited for another great day of science!

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Fred Hutch Basic Sciences Division @hutchbasicsci.bsky.social · 21d

The 2025 Basic Sciences retreat kicks off today at 2:00 p.m. with the main poster session in the Behnke Suites in Arnold Building. Can’t wait to hear about all the latest research happening in the division!

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Reposted by Fred Hutch Basic Sciences Division

Harmit Singh Malik @harmitmalik.bsky.social · 23d

My awesome Drosophila colleague Akhila Rajan at Fred Hutch (Seattle) is recruiting both a staff scientist and a postdoc to study fat–brain communication, innate immunity, mitochondrial signaling, and brain senescence. Great team, great environment. Apply here: careers-fhcrc.icims.com/jobs/30062/j...

Fred Hutchinson Cancer Center

Fred Hutch is dedicated to the elimination of cancer and related diseases as causes of human suffering and death.

careers-fhcrc.icims.com

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Reposted by Fred Hutch Basic Sciences Division

Jane Coffin Childs Fund for Medical Research @jcchildsfund.bsky.social · 22d

Changkun Hu, PhD, is our featured fellow! Dr. Hu uses in vitro reconstitution and TIRF microscopy (😍😍) to investigate the kinetochore, a protein complex that's required for the proper segregation of chromosomes.
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Reposted by Fred Hutch Basic Sciences Division

Jeremy Hollis @jeremyahollis.bsky.social · 29d

So excited to see the first part of my thesis work with @harmitmalik.bsky.social and @melodygcampbell.bsky.social in print! www.science.org/doi/10.1126/... We have a bit of evolution and a whole lotta structure to figure out how new protein domains work

Molecular exaptation by the integrin αI domain

An ancient protein domain insertion seamlessly preserved conformational signaling while providing a novel surface for adaptation.

www.science.org

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Reposted by Fred Hutch Basic Sciences Division

Bloom lab @jbloomlab.bsky.social · Sep 4

In new study led by Xiaohui Ju, we define how mutations to Chikungunya virus envelope proteins affect entry in human vs mosquito cells.

Sheds light on functional constraints & enables us to make loss-of-tropism mutants, which could be of use for vaccines.

www.biorxiv.org/content/10.1...

Determinants of human versus mosquito cell entry by the Chikungunya virus envelope proteins

Chikungunya virus (CHIKV) infects both humans and mosquitoes during its transmission cycle. How the virus’s envelope proteins mediate entry in cells from such different species is unclear. MXRA8 is a ...

www.biorxiv.org

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Fred Hutch Basic Sciences Division @hutchbasicsci.bsky.social · Aug 27

Drs. Steve Hahn and Lakshmi Mahendrawada sit down with the Double-stranded Podcast. Check out a great conversation and learn about their recent @nature.com paper that’s rewriting our understanding of transcription factors: youtu.be/lXgdvmveA_k?...

Low overlap of transcription factor DNA binding and regulatory targets

YouTube video by Double-stranded Podcast

youtu.be

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Reposted by Fred Hutch Basic Sciences Division

Harmit Singh Malik @harmitmalik.bsky.social · Aug 26

Preparing to say goodbye to two outstanding scientists from the lab: Ching-Ho Chang (‪@ching-hochang.bsky.social‬) and Yu-Ying Phoebe Hsieh (‪@hsiehyp.bsky.social‬) who are both leaving the lab at the end of the month to start their own independent labs at the prestigious Academia Sinica in Taipei

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Reposted by Fred Hutch Basic Sciences Division

Bloom lab @jbloomlab.bsky.social · Aug 20

In new study led by @bdadonaite.bsky.social, we measure how spike mutations affect function & antigenicity of spike of KP.3.1.1 strain of SARS-CoV-2.

Sheds light on how key neutralizing epitopes are changing & importance of RBD up/down motion.

www.biorxiv.org/content/10.1...

Spike mutations that affect the function and antigenicity of recent KP.3.1.1-like SARS-CoV-2 variants

SARS-CoV-2 is under strong evolutionary selection to acquire mutations in its spike protein that reduce neutralization by human polyclonal antibodies. Here we use pseudovirus-based deep mutational sca...

www.biorxiv.org

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Reposted by Fred Hutch Basic Sciences Division

Bloom lab @jbloomlab.bsky.social · Aug 20

Our lab has an opening for a research technician to contribute to our efforts to understand RSV evolution & its impact on antibody countermeasures (see journals.asm.org/doi/full/10....). The tech will also help w lab management.

If interested, apply here: careers-fhcrc.icims.com/jobs/29940/job

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Reposted by Fred Hutch Basic Sciences Division

Bloom lab @jbloomlab.bsky.social · Aug 4

Wanted to flag this interesting study led by our collaborators
@kinglabipd.bsky.social suggesting that at least in some contexts, the immunogenicity of H5 influenza vaccines can be improved by mutations that stabilize the HA protein.

King Lab @kinglabipd.bsky.social · Aug 4

🚨 New paper alert! 🚨

Here we show that stabilized influenza hemagglutinin HPAI H5 immunogens improve the quality of elicited antibody responses. Thank you to @open_phil for funding this work! bit.ly/4lgr0rM

Stabilization of H5 highly pathogenic avian influenza hemagglutinin improves vaccine-elicited neutralizing antibody responses

Transmission of highly pathogenic avian influenza from H5 clade 2.3.4.4b has expanded in recent years to infect large populations of birds and mammals, heightening the risk of a human pandemic. Influe...

bit.ly

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Reposted by Fred Hutch Basic Sciences Division

Bloom lab @jbloomlab.bsky.social · Jul 28

Final version of this paper is published in Journal of Virology: journals.asm.org/doi/10.1128/...

If you are interested in implementing RSV pseudovirus neutralization assays, the plasmids are now available in AddGene (www.addgene.org/browse/artic...) and we are happy to share the 293T-TIM1 cells.

RSV F evolution escapes some monoclonal antibodies but does not strongly erode neutralization by human polyclonal sera | Journal of Virology

We describe an efficient approach to measure how antibodies inhibit infection by historical and recent human strains of respiratory syncytial virus (RSV). This approach is useful for understanding how...

journals.asm.org

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Reposted by Fred Hutch Basic Sciences Division

Fred Hutch @fredhutch.org · Jul 14

During his 36-year career at Fred Hutch, @memerman.bsky.social made fundamental discoveries about HIV, co-founded the field of paleovirology and mentored generations of scientists. bit.ly/4nMqOmr @hutchbasicsci.bsky.social

Virologist and HIV expert Dr. Michael Emerman retires

During his 36-year career at Fred Hutch Cancer Center, Michael Emerman, PhD, made fundamental discoveries about HIV, the retrovirus that causes AIDS. He co-founded the field of paleovirology and consi...

bit.ly

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Fred Hutch Basic Sciences Division @hutchbasicsci.bsky.social · Jul 14

"Signals, forces and cells: Force sensing in epithelial tissues"

We’re excited to have Dr. Jennifer Zallen joining us from @mskcancercenter.bsky.social for a special guest seminar. For all our @FredHutch.bsky.social colleagues, don’t miss a great talk today at noon!

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Reposted by Fred Hutch Basic Sciences Division

Fred Hutch @fredhutch.org · Jul 11

Staff, faculty, providers and furry friends 🐶 came out to celebrate Fred Hutch's 50th Anniversary at the South Lake Union campus.
#fredhutch #fh50 #cancer #cancerresearch #cancertreatment #seattle

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Reposted by Fred Hutch Basic Sciences Division

Fred Hutch @fredhutch.org · Jun 30

Scenes from the 51st @seattlepride.bsky.social!
#fredhutch

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Fred Hutch Basic Sciences Division @hutchbasicsci.bsky.social · Jun 26

For all our @FredHutch.bsky.social colleagues, don’t miss a special talk today at noon hosted by the Fred Hutch Chromatin Club. We’re excited to have Dr. Zhiguo Zhang joining us from @columbiamed.bsky.social to share his latest discoveries on chromatin replication.

Zhiguo Zhang, PhD
Institute for Cancer Genetics
Professor of Epigenomics and Molecular Biology
Department of Pediatrics
Department of Genetics and Development
Columbia University Irving Medical Center

Title: “A Tale of Two Strands: Mechanistic Insights into Chromatin Replication Through Strand-Specific Sequencing”

12:00pm on Thursday, June 26, 2025
Pelton Auditorium, Weintraub Building, Fred Hutch

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Reposted by Fred Hutch Basic Sciences Division

Sue Biggins @suebiggins.bsky.social · Jun 20

Grateful to the lab for celebrating 25 years and to @hutchbasicsci.bsky.social for being such a great place to do science!

Fred Hutch Basic Sciences Division @hutchbasicsci.bsky.social · Jun 18

Celebrating 25 years of curiosity, kinetochores, and cutting-edge science! Congratulations to the @suebiggins.bsky.social Lab @fredhutch.bsky.social on their 25th anniversary. Cheers to all the amazing colleagues that have made it such a wonderful place to do research over its past and present!

Biggins Lab 25th anniversary celebration

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Reposted by Fred Hutch Basic Sciences Division

Fred Hutch @fredhutch.org · Jun 19

Fred Hutch joins the nation in commemorating Juneteenth National Independence Day, a time to honor the emancipation of enslaved African Americans in the United States. We celebrate the resilience and strength of those early Americans who never gave up hope during uncertain times.

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