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Ian Mellis

@ianmellis.bsky.social

44 followers 62 following 3 posts

host-virus interactions, gene regulation and genetic engineering, gene and cell therapies | transfusion medicine and virology @columbiauniversity https://ianmellis.github.io/

ianmellis.github.io

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Ian Mellis @ianmellis.bsky.social · 22d

Highly productive and innovative group doing elegant quantitative bio spanning theory, experimental and computational methods, and actual applications. If you're interested in a postdoctoral position studying cancer, development, or single cell biology, reach out to Yogesh!

Yogesh Goyal @goyallab.bsky.social · 23d

**POSTDOC POSITION** My lab (www.goyallab.org) at Northwestern and CZ Biohub Chicago looking for a postdoctoc in quantitative biology. We work on a range of topics, including single-cell cancer plasticity, modeling single-cell perturbations, theory, and stem-embryo models. contact via email. Pls RT

Goyal Lab

www.goyallab.org

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Reposted by Ian Mellis

Adam Ameur @adameur.bsky.social · Sep 10

New preprint! With PureTarget we achieved >1000× coverage of targets with ~5kb PacBio reads at QV39. This enabled high-resolution analysis of CRISPR-Cas9 outcomes

Key finding: Some CRISPR-mutations may only emerge in the second generation, due to germ cell mosaicism

www.biorxiv.org/content/10.1...

Accurate characterization of CRISPR-Cas9 genome editing outcomes and mosaicism with near-perfect long reads

Background: Genetic mosaicism is a consequence of CRISPR-Cas9 genome editing that is difficult to study, especially when it involves structural variants occurring at low frequency. A comprehensive ana...

www.biorxiv.org

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Ian Mellis @ianmellis.bsky.social · Sep 9

Great case, Naveen! Will definitely keep this in mind

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Reposted by Ian Mellis

Yogesh Goyal @goyallab.bsky.social · Jul 6

Excited to share our latest by my postdoc Ben KS: we use statistical physics & Bayesian inference to model genome-wide perturbation outcomes. Remarkably, perturbation responses are encoded in gene "chatter" even before the perturbation–a fundamental insight with broad implications
shorturl.at/2LHbw

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Reposted by Ian Mellis

William DeWitt @wsdewitt.github.io · Jun 7

I'm stoked to have this long-term and highly collaborative effort out in the wild. We present an experimental evolution system to quantitatively study the rapid evolutionary dynamics of B-cell affinity maturation. These evolutionary mechanisms underpin antibody responses and immune memory formation.

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Reposted by Ian Mellis

Bloom lab @jbloomlab.bsky.social · Jan 21

In new study, we find dramatic differences in specificities of serum neutralizing antibodies in infants w single infection by a recent SARS-CoV-2 strain versus adults/children imprinted by an early viral strain.

www.biorxiv.org/content/10.1...

SARS-CoV-2 neutralizing antibody specificities differ dramatically between recently infected infants and immune-imprinted individuals

The immune response to viral infection is shaped by past exposures to related virus strains, a phenomenon known as imprinting. For SARS-CoV-2, much of the population has been imprinted by a viral spik...

www.biorxiv.org

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Reposted by Ian Mellis

Tuuli Lappalainen @tuuliel.bsky.social · Jan 6

It's an honor to be part of this lecture series to honor Casey's legacy.

Shweta Ramdas @shwetaramdas.bsky.social · Jan 4

Our mentor Casey Brown, apart from being an extraordinary scientist, was a brilliant teacher who loved everything genetics. In his honor, some of the world's leading experts came together to create the 'Casey Brown Lecture Series' on human genetics 1/ shorturl.at/eCm7S

Casey Brown Lecture Series - YouTube

shorturl.at

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Ian Mellis @ianmellis.bsky.social · Dec 12

Amazing work from @yogogurt.bsky.social lab and Arispe lab on vascular development. Tour de force of quantitative dev bio with thoughtful applications of high-throughput techniques, imaging, stochastic modeling, and more. Congrats to @daniellepi.bsky.social, Jonas, and the team!