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igflyon.bsky.social
IGFL
@igflyon.bsky.social
640 followers 88 following 32 posts
A strong focus on integrative, organism-level research at the interfaces of evolution, development & integrative physiology studied in lots of model systems
igfl.ens-lyon.fr
Posts Replies Media Videos
Reposted by IGFL
zaycha.bsky.social
Such a pleasant moment listening to the original science from @audeber.bsky.social today at @igflyon.bsky.social @ensdelyon.bsky.social. Out of the box ideas, Outstanding tools, Out of my comfort zone… Totally great!
February 2, 2026 at 1:04 PM
Reposted by IGFL
dev-journal.bsky.social
Bacteria-dependent ecdysone lengthens hungry stomachs

This Research Highlight showcases work from Longwei Bai (@longweibai.bsky.social), François Leulier (@francoisleulier.bsky.social) and colleagues at @igflyon.bsky.social

journals.biologists.com/dev/article/...
Supp. Fig. 1 - LpWJL mediates midgut growth through cell area increase. Representative images of anterior and posterior midguts from size-matched LpWJL-associated (D7) and GF (D11) yw larvae. Midguts were dissected and stained for Discs large (Dlg, red), a septate junction marker, and DAPI (blue) to mark nuclei. Scale bar represents 100μm.
January 27, 2026 at 2:36 PM
igflyon.bsky.social
IGFL external seminar
Birds keep losing their penises, repeatedly. Not by chance. Anamaria Necsulea (LBBE Lyon) shows how changes in gene regulation and non-coding DNA drive convergent developmental loss of the male phallus across avian evolution.
White IGFL seminar flyer. Top left: IGFL logo in pink. Center top: title “External seminars – IGFL” above a stylized blue question mark. Speaker name: Anamaria Necsulea. Laboratory of the speaker: Laboratoire de biométrie et biologie évolutive (LBBE, Lyon). Invited by: Eglantine Heude. Date: 29/01/2026. Title: “Convergent evolution of genomes and phenotypes in birds.” Abstract summarizes comparative and functional evolutionary genomics in birds, focusing on convergent phenotypic evolution. Main case study: repeated reduction or loss of the intermittent male phallus in multiple avian lineages. The work analyzes hundreds of bird genomes to identify parallel changes in protein-coding genes, non-coding regulatory elements, and gene expression associated with this developmental and evolutionary transition. Bottom section: short CV detailing PhD (University of Lyon), postdoc in Lausanne, junior group leader at EPFL, and current CNRS researcher at LBBE studying evolution of gene regulation and phenotypes. Right side: portrait photo of the speaker outdoors, smiling, short hair, wearing a dark top.
January 29, 2026 at 12:04 PM
Reposted by IGFL
francoisleulier.bsky.social
Latest from the lab. MS previously preprinted (see below) and finally published in print @dev-journal.bsky.social
journals.biologists.com/dev/article/...

Review process via @reviewcommons.org and @dev-journal.bsky.social
1/3
January 26, 2026 at 12:44 PM
Reposted by IGFL
cnrsbiologie.bsky.social
#ResultatScientifique🔎| Et si le microbiote intestinal pouvait agir comme un régulateur hormonal pour lutter contre la malnutrition ?

✍️ @francoisleulier.bsky.social
🤝 @cnrs-rhoneauvergne.bsky.social @igflyon.bsky.social @ensdelyon.bsky.social
📕 @dev-journal.bsky.social

▶️ buff.ly/R1VJvDm
Le microbiote active les stéroïdes intestinaux pour contrecarrer la malnutrition
Et si le microbiote intestinal pouvait agir comme un régulateur hormonal pour lutter contre la malnutrition ? Une étude publiée dans Developm
buff.ly
January 26, 2026 at 2:30 PM
Reposted by IGFL
francoisleulier.bsky.social
Plus que quelques jours pour candidater. Rejoignez-nous!
igflyon.bsky.social IGFL @igflyon.bsky.social · Dec 4
Mobilité interne CNRS : l’IGFL recrute un·e assistant·e ingé pour renforcer ses travaux sur modèles aquatiques et biologie cellulaire. Environnement technologique solide, missions variées recherche/élevages. Candidatures jusqu’au 15/01/2026.
emploi.cnrs.fr/Offres/MOBIN...
Portail Emploi CNRS - Offre d'emploi - Assistant-e ingénieur-e en expérimentation et élevage de modèles aquatiques H/F
Au sein d'une nouvelle équipe de l'IGFL, « Morphogenèse des algues brunes » : Etudier différents échantillons biologiques (histologie, imagerie, biologie moléculaire.) dans le cadre des activités de recherche de l'équipe (50%) et assurer un soutien opérationnel à l'activité de l'équipe.Au sein du pôle « expérimentation du vivant » de l'IGFL : assurer le suivi des élevages et cultures des organismes aquatiques (cichlidés, oïkopleura, algues brunes), et un soutien expérimental à leur utilisation (50%).
emploi.cnrs.fr
January 11, 2026 at 1:17 PM
Reposted by IGFL
zaycha.bsky.social
Amazing to have @alainchedotal.bsky.social with us today @igflyon.bsky.social in front of a full room of people from all over the @ensdelyon.bsky.social campus! Very happy start of 2026 🤯
January 5, 2026 at 10:08 AM
Reposted by IGFL
zaycha.bsky.social
Very very excited to have Elly Tanaka from @imbavienna.bsky.social for our external seminar series @igflyon.bsky.social! Thanks Eglantine Heude for hosting 🤯
December 8, 2025 at 10:11 AM
igflyon.bsky.social
Mobilité interne CNRS : l’IGFL recrute un·e assistant·e ingé pour renforcer ses travaux sur modèles aquatiques et biologie cellulaire. Environnement technologique solide, missions variées recherche/élevages. Candidatures jusqu’au 15/01/2026.
emploi.cnrs.fr/Offres/MOBIN...
Portail Emploi CNRS - Offre d'emploi - Assistant-e ingénieur-e en expérimentation et élevage de modèles aquatiques H/F
Au sein d'une nouvelle équipe de l'IGFL, « Morphogenèse des algues brunes » : Etudier différents échantillons biologiques (histologie, imagerie, biologie moléculaire.) dans le cadre des activités de recherche de l'équipe (50%) et assurer un soutien opérationnel à l'activité de l'équipe.Au sein du pôle « expérimentation du vivant » de l'IGFL : assurer le suivi des élevages et cultures des organismes aquatiques (cichlidés, oïkopleura, algues brunes), et un soutien expérimental à leur utilisation (50%).
emploi.cnrs.fr
December 4, 2025 at 9:07 PM
Reposted by IGFL
zaycha.bsky.social
Very proud to have defended my HDR (« Habilitation à diriger les recherches ») at @ensdelyon.bsky.social. Many thanks to the jury for their constructive feedbacks @clairewyart.bsky.social @francoisleulier.bsky.social @FlorenceRuggiero @PaulineSpéder @stemdevevo.bsky.social @OlivierRaineteau!
November 16, 2025 at 5:23 PM
Reposted by IGFL
baalberti.bsky.social
It's done! I am now a PhD for real!

I defended my PhD thesis last week and what an incredible day it was. I am very grateful to all the members of @igflyon.bsky.social who made these last 4 years and 8 months so memorable. I will cherish all these memories 😊
November 12, 2025 at 3:15 PM
Reposted by IGFL
michalis-averof.bsky.social
What are these?

You are looking at embryos of a sea squirt. Each of the 'soap bubbles' is a living cell, about a fourtieth of a millimetre in size. The outlines of the cells are visible thanks to fluorescent markers identified by Hitoyoshi Yasuo @hitoyas.bsky.social

see doi.org/10.1101/2024... 🧵
October 26, 2025 at 8:55 AM
igflyon.bsky.social
When the clock’s feedback loop breaks, chromatin keeps ticking 🕒
Work from @clocklab-igfl.bsky.social reveals how H3.3-linked PBAF/cBAF shifts sustain BMAL1 activity and reshape circadian chromatine, linking epigenetics to metabolic and ageing control.
🔗 nature.com/articles/s41467-025-64045-2
PBAF/cBAF reorganization on H3.3 chromatin regulates BMAL1 activity in the absence of circadian negative feedback - Nature Communications
Rhythms in chromatin state guide circadian gene expression. Here, the authors show that histone H3.3 coordinates BMAL1 activity along with cBAF/PBAF remodelers. Circadian disruption promotes remodeler...
nature.com
October 18, 2025 at 1:15 PM
Reposted by IGFL
yghavi.bsky.social
Ever wondered what drives enhancer-promoter specificity? Why would an enhancer activate one gene rather than another neighboring one?

Check our latest preprint, led by @mmasoura.bsky.social, to find out!
www.biorxiv.org/content/10.1...
Promoter-proximal gatekeepers restrict pleiotropic enhancer inputs to achieve tissue specificity
Developmental enhancers are central regulatory elements that can activate multiple genes, yet how they selectively regulate one gene over its neighbours remains unclear. Using the Drosophila twist E3 ...
www.biorxiv.org
October 16, 2025 at 12:34 PM
Reposted by IGFL
brownalgaedev.bsky.social
📣 SBIS, a new vital fluorescent probe for live imaging of #brownalgae #kelp in 4D. Just published in J. Cell Science by the Charrier team at the @igflyon.bsky.social. Download PDF on our team webpage here ➡️ shorturl.at/H5A9p
with first author Marie Zilliox featured here ➡️ shorturl.at/AMMoH
Developping Fucus embryo labelled with the orange fluorescent probe SBIS (autofluorescent chloroplasts in red).
October 11, 2025 at 9:28 AM
Reposted by IGFL
filipedevadder.bsky.social
Our new study, just accepted in the Journal of the Endocrine Society
👉 doi.org/10.1210/jend...
We found that semaglutide, beyond its metabolic effects, can exacerbate growth stunting in juvenile mice by reducing energy metabolism, a context-dependent effect of GLP-1 signaling.
pendingpublications
Pending Publication
doi.org
October 9, 2025 at 4:09 PM
Reposted by IGFL
michalis-averof.bsky.social
Here it is! Postdoctoral position to identify the progenitors sensory organs in the regenerating legs of Parhyale

apply here: www.averof-lab.org/pages/tracman

1/3
michalis-averof.bsky.social Michalis Averof @michalis-averof.bsky.social · Jul 13
We've just been awarded a grant to study the cellular basis of regeneration – to track the progenitors of sensory organs in the context of leg regeneration, in our favourite crustacean tinyurl.com/parhyale, based on live imaging and cell tracking. The project involves some cool collaborations... 1/3
October 3, 2025 at 10:47 AM
igflyon.bsky.social
Comme tous les ans, l’IGFL accueillera la fête de la science la semaine prochaine. Le public général est bienvenu le samedi 4 octobre. Nous espérons vous voir nombreux!

www.ens-lyon.fr/indexation/a...
Fête de la science 2025 | École normale supérieure de Lyon
Consultez les prochains événements organisés à l'ENS de Lyon en lien avec la formation.
www.ens-lyon.fr
September 26, 2025 at 1:29 PM
Reposted by IGFL
cnrs-rhoneauvergne.bsky.social
Ces travaux impliquent l'Institut de génomique fonctionnelle de Lyon. @igflyon.bsky.social 👏
September 22, 2025 at 6:50 AM
Reposted by IGFL
zaycha.bsky.social
So happy to have Dafni @drosostalis.bsky.social at @igflyon.bsky.social today, for an exciting fly physiology talk! “Mind the gut”!
September 4, 2025 at 10:26 AM
Reposted by IGFL
michalis-averof.bsky.social
Latest paper elifesciences.org/articles/107... closes an important cycle in our efforts to study regeneration: week-long recordings allow us to observe the behaviour of cells during the entire course of regeneration in a crustacean leg – bright objects in movie are fluorescent nuclei of cells. 1/6
August 8, 2025 at 5:39 PM
Reposted by IGFL
cnrs-rhoneauvergne.bsky.social
Ces travaux impliquent notamment des scientifiques de l' @igflyon.bsky.social 👏

cc @ensdelyon.bsky.social
July 28, 2025 at 2:07 PM
Reposted by IGFL
yghavi.bsky.social
Now available in its final form @narjournal.bsky.social !
doi.org/10.1093/nar/...
Find out how we can reconstruct enhancer activity in vivo in the Drosophila embryo using scRNAseq data and Optimal Transport.
July 23, 2025 at 7:44 AM
igflyon.bsky.social
Excited to host Jean Livet (Institut de la Vision) at IGFL Lyon on June 30th! He’ll share how multicolor labeling and large-volume microscopy reveal the topography and topology of central sensory circuits. A must for connectomics fans! 🧠🔬✨
Flyer announcing a seminar by Jean Livet from the Institut de la Vision, hosted by Jonathan Enriquez at IGFL Lyon on June 30th, 2025. The talk is titled “Topography and topology in a central sensory neuronal projection.” The abstract explains that in the vertebrate brain, sensory pathways connect neuronal relays with high precision over long distances. To study these circuits, dense single-neuron tracing and large-volume microscopy are used. Jean Livet will discuss their efforts in connectomic mapping using multicolor labeling, focusing on an auditory relay to reveal its topographical and topological organization. The flyer also includes a short bio: Jean Livet completed his PhD on motor neuron development at IBDM Marseille, developed the Brainbow labeling method during his postdoc with Jeff W. Lichtman in the USA, and has led the “neurogenesis and circuit development” team at the Institut de la Vision since 2008.
June 23, 2025 at 1:38 PM
igflyon.bsky.social
🦋 Butterflies and beyond! Steven Van Belleghem is now at IGFL revealing how genomes evolve into pangenomes, shaping adaptation and gene regulation in butterflies and Daphnia. Don’t miss this dive into the mysteries of evolution! #EvolutionaryGenomics
Cartoon of Steven Van Belleghem riding a giant beetle over green islands, holding a camera and flying scientific papers. A hawk and butterfly accompany him, symbolizing his evolutionary genomics research on butterflies, Daphnia, and beetles.
June 2, 2025 at 9:15 AM